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1. 发明申请

US20210060316A1 SUBMUCOSAL BIORESORBABLE DRUG ELUTING PLATFORM 有权
公开(公告)号：US20210060316A1
公开(公告)日：2021-03-04
申请号：US17004753
申请日：2020-08-27
申请人： Intersect ENT, Inc.
发明人： John Joseph STANKUS , James SU , Anthony J. ABBATE , Tu Duc NGO , Diego Javier GARNICA
IPC分类号： A61M31/00 , A61K31/58 , A61K47/34 , A61K9/70
摘要： Described here are systems and methods for delivering an active agent to target tissues of the ear, nose, or throat using a drug delivery platform having the therapeutic drug embedded as part of the drug delivery platform. The drug delivery platform is implanted into a target tissue, and the active agent elutes out of the body of the drug delivery platform for a target period of time, delivering a therapeutic dose of the drug for that period of time. The duration of therapy for an implant into a sinus tissue can be from 3 to 12 months, or longer, thereby providing relief for the full duration of an allergy season. Moreover, the duration of therapy can provide relief to individuals with chronic paranasal sinus condition symptoms for a period of time longer than presently available therapies, thus allowing for only semi-annual or annual applications of the therapy.

2. 发明授权

US09585681B2 Device and methods for treating paranasal sinus conditions 有权
标题翻译：用于治疗鼻旁窦病症的装置和方法
公开(公告)号：US09585681B2
公开(公告)日：2017-03-07
申请号：US12883087
申请日：2010-09-15
申请人： Donald J. Eaton , Thomas R. Tice , David B. Downie , Patrick A. Arensdorf , Rodney A. Brenneman , Danielle L. Biggs
发明人： Donald J. Eaton , Thomas R. Tice , David B. Downie , Patrick A. Arensdorf , Rodney A. Brenneman , Danielle L. Biggs
IPC分类号： A61B17/24 , A61K9/00 , A61K9/70 , A61K31/573 , A61K31/58 , A61F2/18 , A61K9/16
CPC分类号： A61B17/24 , A61F2/186 , A61K9/0043 , A61K9/1647 , A61K9/70 , A61K31/573 , A61K31/58 , A61K47/14 , A61K47/34 , A61M29/00
摘要： Described here are paranasal sinus devices for treating paranasal sinus conditions. The devices include a cavity member, ostial member, and nasal portion. One or more of the cavity member, ostial member, and nasal portion may deliver an active agent for sustained release to treat the paranasal sinus condition. Exemplary paranasal sinus conditions are sinus inflammation due to functional endoscopic sinus surgery (FESS) and rhinosinusitis.
摘要翻译：这里描述了用于治疗鼻旁窦状况的鼻旁窦装置。这些装置包括空腔构件，口部构件和鼻部。空腔构件，口腔构件和鼻部分中的一个或多个可以递送用于持续释放的活性剂以治疗鼻旁窦状况。由于功能性内镜鼻窦手术（FESS）和鼻鼻窦炎，示例性的鼻旁窦状况是鼻窦炎症。

3. 发明申请

US20140154236A1 DEVICES AND METHODS FOR TREATING PAIN ASSOCIATED WITH TONSILLECTOMIES 审中-公开
标题翻译：用于治疗与苯硫酚相关的疼痛的装置和方法
公开(公告)号：US20140154236A1
公开(公告)日：2014-06-05
申请号：US14174709
申请日：2014-02-06
申请人： INTERSECT ENT, INC.
发明人： Jerome E. HESTER , Anthony J. ABBATE , Richard E. KAUFMAN , David C. GALE , Gail M. ZALER , Bin HUANG , Lisa EARNHARDT , Vijaykumar RAJASEKHAR
IPC分类号： A61L31/16 , A61L17/10 , A61B17/08 , A61M31/00 , A61B17/04
CPC分类号： A61L31/16 , A61B17/04 , A61B17/06166 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/08 , A61B17/083 , A61B17/26 , A61B17/3468 , A61B2017/0073 , A61B2017/00893 , A61B2017/06176 , A61B2017/0641 , A61B2017/0647 , A61B2017/0649 , A61B2090/3987 , A61B2090/3991 , A61L17/10 , A61M31/00 , A61M31/002 , A61M37/0069
摘要： Described here are devices and methods for treating one or more conditions or symptoms associated with a tonsil procedure. In some variations, a drug-releasing device may be at least partially delivered to one or more tonsillar tissues before, during, or after a tonsil procedure. In some variations, the drug-releasing device may be configured to be biodegradable. In other variations, the drug-releasing device may comprise one or more hemostatic materials or one or more adhesives. The drug-releasing device may be configured to release one or more drugs or agents, such as, for example, one or more analgesics, local anesthetics, vasoconstrictors, antibiotics, combinations thereof and the like.
摘要翻译：这里描述了用于治疗与扁桃体过程相关的一种或多种病症或症状的装置和方法。在一些变型中，药物释放装置可以在扁桃体手术之前，期间或之后至少部分递送至一个或多个扁桃体组织。在一些变型中，药物释放装置可以被配置为可生物降解的。在其它变型中，药物释放装置可以包括一种或多种止血材料或一种或多种粘合剂。药物释放装置可以被配置为释放一种或多种药物或药剂，例如一种或多种止痛剂，局部麻醉剂，血管收缩剂，抗生素，其组合等。

4. 发明申请

US20140074238A1 SELF-EXPANDING DEVICES AND METHODS THEREFOR 有权
标题翻译：自扩展设备及其方法
公开(公告)号：US20140074238A1
公开(公告)日：2014-03-13
申请号：US14082010
申请日：2013-11-15
申请人： Intersect ENT, Inc.
发明人： Anthony J. ABBATE , Bin HUANG , Gail M. ZALER , David C. GALE , Richard E. KAUFMAN
IPC分类号： A61F2/18 , A61L31/14 , A61F2/04 , A61L31/16
CPC分类号： A61L31/022 , A61B17/24 , A61B17/3468 , A61B17/3478 , A61B2017/3454 , A61F2/04 , A61F2/18 , A61F2/186 , A61F2/82 , A61F2/86 , A61F2/89 , A61F2/95 , A61F5/08 , A61F2002/048 , A61F2002/91508 , A61F2002/9522 , A61F2210/0004 , A61F2210/0076 , A61F2220/005 , A61F2220/0058 , A61F2230/0091 , A61F2240/001 , A61F2250/003 , A61F2250/006 , A61F2250/0067 , A61K9/70 , A61L31/10 , A61L31/148 , A61L31/16 , A61M29/00
摘要： Described here are self-expanding devices and methods of using and making them. The devices may be useful in a variety of locations within the body, for a number of different uses. In some variations, the devices have a first compressed configuration enabling low profile delivery through a delivery device, a second expanded configuration for apposition against tissue, and comprise either a single continuous filament or at least two non-intersecting filaments. In some variations, the device is formed into a shape having a series of peaks and valleys. At least one of the peaks and valleys may have a loop at then end thereof. At least a portion of these devices may be capable of biodegrading over a predetermined period of time, and the devices may be configured for drug delivery. Methods of treating one or more sinus cavities are also described here.
摘要翻译：这里描述的是自扩张装置以及使用和制造它们的方法。对于许多不同的用途，这些装置可能在身体内的各种位置中是有用的。在一些变型中，装置具有能够通过输送装置进行低轮廓输送的第一压缩构型，用于与组织相对的第二扩展构型，并且包括单个连续细丝或至少两个不相交的长丝。在一些变型中，该装置形成具有一系列峰和谷的形状。峰和谷中的至少一个可以在其末端具有环。这些装置的至少一部分可能能够在预定时间段内生物降解，并且该装置可被配置用于药物递送。还描述了治疗一个或多个窦腔的方法。

5. 发明授权

US08277504B2 Stent for irrigation and delivery of medication 有权
公开(公告)号：US08277504B2
公开(公告)日：2012-10-02
申请号：US12437382
申请日：2009-05-07
申请人： Francois Lavigne
发明人： Francois Lavigne
IPC分类号： A61F2/18
CPC分类号： A61M25/0041 , A61M25/007 , A61M31/00
摘要： A stent comprises a flexible tube having a proximal end, a distal end, and a passageway extending from said proximal end toward said distal end. A first generally straight tube segment extends from the proximal end while a first generally curved segment extends from an end region of the first generally straight tube segment disposed away from the proximal end of the stent. A second generally straight tube segment extends from an end region of the first curved segment away from the first generally straight tube segment and is arranged at an acute angle relative to the first generally straight tube segment. A second generally curved tube segment extends from one end of the second generally straight tube segment and includes a channel on an exterior surface of the second generally curved tube segment. The first generally curved tube segment and the second generally straight tube segment further include at least one cavity irrigation hole extending from the tube passageway, for providing irrigation fluids into the cavity into which the stent is inserted. At least one segments includes a channel on an exterior surface. The channel is sized to serve as a reservoir to contain a predetermined amount of at least one form of medication for delivery, over a period of time, of the medication to a cavity region proximate which the stent has been inserted.

6. 发明授权

US08109918B2 Sinus delivery of sustained release therapeutics 有权
标题翻译：持续释放治疗药物的窦炎
公开(公告)号：US08109918B2
公开(公告)日：2012-02-07
申请号：US12479794
申请日：2009-06-06
申请人： Donald J. Eaton , Mary L. Moran , Rodney Brenneman
发明人： Donald J. Eaton , Mary L. Moran , Rodney Brenneman
IPC分类号： A61M31/00
CPC分类号： A61M31/007 , A61K9/0024 , A61K9/0043 , A61K31/43 , A61K31/573 , A61K31/58 , A61K47/34
摘要： The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.
摘要翻译：本发明提供用于治疗鼻窦炎的可生物降解植入物。可生物降解的植入物具有尺寸，形状，密度，粘度和/或粘膜粘附性，防止在预期治疗期间鼻窦的粘膜纤毛内衬基本上被其清除。可生物降解的植入物包括持续释放治疗剂，例如抗生素，甾族抗炎药或两者。可生物降解的植入物可以采取各种形式，例如棒，丸，珠，条或微粒，并且可以递送到各种药学上可接受的载体中的窦内。

7. 发明授权

US07951132B2 Sinus delivery of sustained release therapeutics 有权
标题翻译：持续释放治疗药物的窦炎
公开(公告)号：US07951132B2
公开(公告)日：2011-05-31
申请号：US12258277
申请日：2008-10-24
申请人： Donald J. Eaton , Mary Lynn Moran , Rodney A. Brenneman
发明人： Donald J. Eaton , Mary Lynn Moran , Rodney A. Brenneman
IPC分类号： A61M31/00 , A61F13/00
CPC分类号： A61M31/007 , A61K9/0024 , A61K9/0043 , A61K31/43 , A61K31/573 , A61K31/58 , A61K47/34
摘要： The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.
摘要翻译：本发明提供用于治疗鼻窦炎的可生物降解植入物。可生物降解的植入物具有尺寸，形状，密度，粘度和/或粘膜粘附性，防止在预期治疗期间鼻窦的粘膜纤毛内衬基本上被其清除。可生物降解的植入物包括持续释放治疗剂，例如抗生素，甾族抗炎药或两者。可生物降解的植入物可以采取各种形式，例如棒，丸，珠，条或微粒，并且可以递送到各种药学上可接受的载体中的窦内。

8. 发明公开

US20240050632A1 SELF-EXPANDING DEVICES AND METHODS THEREFOR 审中-公开
公开(公告)号：US20240050632A1
公开(公告)日：2024-02-15
申请号：US18493950
申请日：2023-10-25
申请人： Intersect ENT, Inc.
发明人： Donald J. Eaton , Bin Huang , Anthony J. Abbate , Gail M. Zaler , David C. Gale
IPC分类号： A61L31/02 , A61F2/86 , A61F2/95 , A61F5/08 , A61L31/14 , A61B17/24 , A61B17/34 , A61K9/70 , A61F2/89 , A61L31/16 , A61F2/04 , A61F2/18 , A61L31/10 , A61F2/82 , A61M29/00
CPC分类号： A61L31/022 , A61F2/86 , A61F2/95 , A61F5/08 , A61L31/148 , A61B17/24 , A61B17/3468 , A61B17/3478 , A61K9/70 , A61F2/89 , A61L31/16 , A61F2/04 , A61F2/18 , A61L31/10 , A61F2/82 , A61M29/00 , A61F2/186 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61B2017/3454 , A61F2002/048 , A61F2210/0076 , A61F2002/91508
摘要： Described here are delivery devices for delivering one or more implants to the body, and methods of using. The delivery devices may deliver implants to a variety of locations within the body, for a number of different uses. In some variations, the delivery devices have a cannula with one or more curved sections. In some variations, a pusher may be used to release one or more implants from the cannula. In some variations, one or more of the released implants may be a self-expanding device. Methods of delivering implants to one or more sinus cavities are also described here.

9. 发明申请

US20230046852A1 EXPANDABLE DEVICES AND METHODS THEREFOR 有权
公开(公告)号：US20230046852A1
公开(公告)日：2023-02-16
申请号：US17978032
申请日：2022-10-31
申请人： Intersect ENT, Inc.
发明人： Anthony J. Abbate
IPC分类号： A61M31/00 , A61F2/18 , A61F5/08 , A61K9/00
摘要： Described here are expandable devices and methods for using them. The devices generally comprise a hub and a plurality of legs extending therefrom. In some variations, the hub may comprise one or more domed portions, tapered portions, or the like. The legs may comprise one or more straight segments, one or more curved segments, or a combination thereof. The devices may comprise one or more polymers, and/or one or more portions of the device may be configured to biodegrade. In other variations, the device may be configured to release one or more drugs therefrom. Additionally, in some variations the devices may be configured to be self-expandable from a low-profile configuration to an expanded configuration.

10. 发明授权

US11497835B2 Self-expanding devices and methods therefor 有权
公开(公告)号：US11497835B2
公开(公告)日：2022-11-15
申请号：US16588294
申请日：2019-09-30
申请人： Intersect ENT, Inc.
发明人： Donald J. Eaton , Bin Huang , Anthony J. Abbate , Gail M. Zaler , David C. Gale
IPC分类号： A61L31/02 , A61F2/86 , A61F2/95 , A61F5/08 , A61L31/14 , A61B17/24 , A61B17/34 , A61K9/70 , A61F2/89 , A61L31/16 , A61F2/04 , A61F2/18 , A61L31/10 , A61F2/82 , A61M29/00 , A61F2/915
摘要： Described here are delivery devices for delivering one or more implants to the body, and methods of using. The delivery devices may deliver implants to a variety of locations within the body, for a number of different uses. In some variations, the delivery devices have a cannula with one or more curved sections. In some variations, a pusher may be used to release one or more implants from the cannula. In some variations, one or more of the released implants may be a self-expanding device. Methods of delivering implants to one or more sinus cavities are also described here.

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