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1. 发明申请

US20210060316A1 SUBMUCOSAL BIORESORBABLE DRUG ELUTING PLATFORM 有权
公开(公告)号：US20210060316A1
公开(公告)日：2021-03-04
申请号：US17004753
申请日：2020-08-27
申请人： Intersect ENT, Inc.
发明人： John Joseph STANKUS , James SU , Anthony J. ABBATE , Tu Duc NGO , Diego Javier GARNICA
IPC分类号： A61M31/00 , A61K31/58 , A61K47/34 , A61K9/70
摘要： Described here are systems and methods for delivering an active agent to target tissues of the ear, nose, or throat using a drug delivery platform having the therapeutic drug embedded as part of the drug delivery platform. The drug delivery platform is implanted into a target tissue, and the active agent elutes out of the body of the drug delivery platform for a target period of time, delivering a therapeutic dose of the drug for that period of time. The duration of therapy for an implant into a sinus tissue can be from 3 to 12 months, or longer, thereby providing relief for the full duration of an allergy season. Moreover, the duration of therapy can provide relief to individuals with chronic paranasal sinus condition symptoms for a period of time longer than presently available therapies, thus allowing for only semi-annual or annual applications of the therapy.

2. 发明申请

US20200276422A1 SYSTEMS AND METHODS FOR SINUS ACCESS 审中-公开
公开(公告)号：US20200276422A1
公开(公告)日：2020-09-03
申请号：US16877146
申请日：2020-05-18
申请人： Intersect ENT, Inc.
发明人： Sean FINSON , John Joseph STANKUS
IPC分类号： A61M25/10 , A61K31/58 , A61M29/02 , A61B1/07 , A61M25/09
摘要： This application is generally related to systems and methods for accessing the paranasal sinuses and other passages of the nose, ear, and throat. The systems and methods generally employ devices capable of maintaining a fixed handle orientation with respect to the patient while generating the appropriate applicator deflection angle required to rotationally align or orient the applicator tip to the intended target tissue/anatomy for treatment. Methods are also described for deploying drug delivery devices within these body structures using the systems to treat medical conditions associated therewith.

3. 发明申请

US20190374751A1 SYSTEMS AND METHODS FOR SINUS ACCESS 审中-公开
公开(公告)号：US20190374751A1
公开(公告)日：2019-12-12
申请号：US16436363
申请日：2019-06-10
申请人： Intersect ENT, Inc.
发明人： Sean FINSON , John Joseph STANKUS
IPC分类号： A61M25/10 , A61K31/58 , A61M29/02 , A61M25/09 , A61B1/07
摘要： This application is generally related to systems and methods for accessing the paranasal sinuses and other passages of the nose, ear, and throat. The systems and methods generally employ devices capable of maintaining a fixed handle orientation with respect to the patient while generating the appropriate applicator deflection angle required to rotationally align or orient the applicator tip to the intended target tissue/anatomy for treatment. Methods are also described for deploying drug delivery devices within these body structures using the systems to treat medical conditions associated therewith.

4. 发明申请

US20200179659A1 DRUG-COATED BALLOON 审中-公开
公开(公告)号：US20200179659A1
公开(公告)日：2020-06-11
申请号：US16790464
申请日：2020-02-13
申请人： Intersect ENT, Inc.
发明人： Richard E. KAUFMAN , John Joseph STANKUS , James SU
IPC分类号： A61M25/10 , A61L29/16 , A61L29/08 , A61M29/02
摘要： Described here are devices, systems, and methods for treating conditions or diseases of the nose, ear, or throat with an expandable device having a drug coating. The expandable devices may be delivered to a body cavity in a low-profile configuration and expanded to contact surrounding tissue. The expandable devices may deliver or release the drug coating to the tissue. Multiple expansions of a single device may be employed during treatment. Various coating excipients and manufacturing parameters for the expandable devices may also be adjusted to enhance or slow transfer of the drug coating and/or release of the drug to the target tissue site. The drug transferred to the tissue may act as an in situ depot that enables maintenance of a therapeutic level of locally delivered drug for a desired time period after removal of the expandable devices.

5. 发明申请

US20200016377A1 DRUG-COATED BALLOON 审中-公开
公开(公告)号：US20200016377A1
公开(公告)日：2020-01-16
申请号：US16523836
申请日：2019-07-26
申请人： Intersect ENT, Inc.
发明人： Richard E. KAUFMAN , John Joseph STANKUS , James SU
IPC分类号： A61M25/10
摘要： Described here are devices, systems, and methods for treating conditions or diseases of the nose, ear, or throat with an expandable device having a drug coating. The expandable devices may be delivered to a body cavity in a low-profile configuration and expanded to contact surrounding tissue. The expandable devices may deliver or release the drug coating to the tissue. Multiple expansions of a single device may be employed during treatment. Various coating excipients and manufacturing parameters for the expandable devices may also be adjusted to enhance or slow transfer of the drug coating and/or release of the drug to the target tissue site. The drug transferred to the tissue may act as an in situ depot that enables maintenance of a therapeutic level of locally delivered drug for a desired time period after removal of the expandable devices.

6. 发明申请

US20220054405A1 SUBMUCOSAL BIORESORBABLE DRUG ELUTING PLATFORM 有权
公开(公告)号：US20220054405A1
公开(公告)日：2022-02-24
申请号：US17459861
申请日：2021-08-27
申请人： Intersect ENT, Inc.
发明人： John Joseph STANKUS , James SU , Anthony J. ABBATE , Tu Duc NGO , Diego Javier GARNICA , Yiwen TANG
IPC分类号： A61K9/00 , A61K47/34 , A61K45/06
摘要： Described here are systems and methods for delivering an active agent to target tissues of the ear, nose, or throat using a drug delivery platform having the therapeutic drug embedded as part of the drug delivery platform. The drug delivery platform is implanted into a target tissue, and the active agent elutes out of the body of the drug delivery platform for a target period of time, delivering a therapeutic dose of the drug for that period of time. The duration of therapy for an implant into a sinus tissue can be from 3 to 12 months, or longer, thereby providing relief for the full duration of an allergy season. Moreover, the duration of therapy can provide relief to individuals with chronic paranasal sinus condition symptoms for a period of time longer than presently available therapies, thus allowing for only semi-annual or annual applications of the therapy.

7. 发明申请

US20200230373A1 EXPANDABLE MEMBER SYSTEMS AND METHODS FOR DRUG DELIVERY 审中-公开
公开(公告)号：US20200230373A1
公开(公告)日：2020-07-23
申请号：US16745110
申请日：2020-01-16
申请人： Intersect ENT, Inc.
发明人： John Joseph STANKUS , James SU
IPC分类号： A61M25/10 , A61K31/58 , A61L29/06 , A61L29/16
摘要： Described here are systems and methods for delivering an active agent to target tissues of the ear, nose, or throat using an expandable member having drug crystals layered thereon, and methods for manufacturing such systems. The expandable member can be delivered to the target tissues in a low-profile configuration and expanded to contact and/or dilate surrounding tissue. Expansion of the expandable member transfers the drug crystals to the target tissues, which then act as an in situ depot that enables maintenance of a therapeutic level of an active agent for a desired time period after removal of the expandable member. Multiple expansions of a single expandable member can be employed during treatment. For example, the systems and methods can be useful when it is desired to treat multiple paranasal sinuses with a single expandable member.

8. 发明申请

US20160213890A1 DRUG-COATED BALLOON 审中-公开
标题翻译：药物包裹的气球
公开(公告)号：US20160213890A1
公开(公告)日：2016-07-28
申请号：US15004807
申请日：2016-01-22
申请人： Intersect ENT, Inc.
发明人： Richard E. KAUFMAN , John Joseph STANKUS , James SU
IPC分类号： A61M25/10 , A61L31/10 , A61L31/08
摘要： Described here are devices, systems, and methods for treating conditions or diseases of the nose, ear, or throat with an expandable device having a drug coating. The expandable devices may be delivered to a body cavity in a low-profile configuration and expanded to contact surrounding tissue. The expandable devices may deliver or release the drug coating to the tissue. Multiple expansions of a single device may be employed during treatment. Various coating excipients and manufacturing parameters for the expandable devices may also be adjusted to enhance or slow transfer of the drug coating and/or release of the drug to the target tissue site. The drug transferred to the tissue may act as an in situ depot that enables maintenance of a therapeutic level of locally delivered drug for a desired time period after removal of the expandable devices.
摘要翻译：这里描述的是用具有药物包衣的可扩张装置来治疗鼻，耳或咽喉病症或疾病的装置，系统和方法。可扩张装置可以以低轮廓构造递送到体腔，并且扩张以接触周围组织。可扩张装置可以将药物涂层递送或释放到组织。在治疗期间可以使用单个装置的多次膨胀。还可以调节用于可扩张装置的各种涂层赋形剂和制造参数，以增强或缓慢地将药物涂层的转移和/或将药物释放到靶组织部位。转移到组织的药物可以作为原位贮库，其能够在移除可扩张装置之后的期望时间段内维持治疗水平的局部递送的药物。

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