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1. 发明授权

US07332331B2 Plasmid shuttle vector between Escherichia coli and Brevibacillus 有权
标题翻译：质粒穿梭载体在大肠杆菌和短杆菌之间
公开(公告)号：US07332331B2
公开(公告)日：2008-02-19
申请号：US10467930
申请日：2002-02-07
申请人： Koji Yashiro
发明人： Koji Yashiro
IPC分类号： C07H21/04 , C12N1/20 , C12N15/00 , C12P21/06
CPC分类号： C12N15/77 , C12N15/70 , C12N15/74
摘要： The invention provides a plasmid shuttle vector characterized by being replicable in both of bacteria of the genus Brevibacillus and Escherichia coli, and by comprising a promoter capable of functioning in bacteria of the genus Brevibacillus and a DNA sequence(s) capable of functioning as a selective marker(s) for Escherichia coli and bacteria of the genus Brevibacillus, and a method of transforming bacteria of the genus Brevibacillus using the said plasmid shuttle vector. The plasmid shuttle vector enables the efficient transformation of bacteria of the genus Brevibacillus. Further, since plasmid shuttle vector pNCMO2 of the invention in particular has a gene expression control region which efficiently expresses and secretes an objective gene in bacteria of the genus Brevibacillus but significantly suppresses the expression in Escherichia coli, a recombinant gene expression plasmid can efficiently be constructed using Escherichia coli, and it is suited for protein production in bacteria of the genus Brevibacillus.
摘要翻译：本发明提供了一种质粒穿梭载体，其特征在于可以在短杆菌属和大肠杆菌属的细菌中复制，并且包含能够在短杆菌属细菌中起作用的启动子和能够作为选择性的DNA序列用于大肠杆菌的标记物和Brevibacillus属的细菌，以及使用所述质粒穿梭载体转化短杆菌属细菌的方法。质粒穿梭载体能够有效转化Brevibacillus属的细菌。此外，由于本发明的质粒穿梭载体pNCMO2特别具有有效表达并分泌短杆菌属细菌中的目标基因但显着抑制大肠杆菌表达的基因表达控制区，因此能够有效地构建重组基因表达质粒使用大肠杆菌，适用于短杆菌属细菌中的蛋白质生产。

2. 发明授权

US6090610A Macrolide compound 0406 失效
标题翻译：大环内酯类化合物0406
公开(公告)号：US6090610A
公开(公告)日：2000-07-18
申请号：US239812
申请日：1999-01-29
申请人： Yasushi Tanaka , Hisayuki Komaki , Yuzuru Mikami , Katsukiyo Yazawa , Jun'ichi Kobayashi
发明人： Yasushi Tanaka , Hisayuki Komaki , Yuzuru Mikami , Katsukiyo Yazawa , Jun'ichi Kobayashi
IPC分类号： A01N43/02 , A61K31/35 , A61P37/06 , C07D493/18 , C07H19/01 , C12N1/20 , C12P19/58 , C12R1/365
CPC分类号： C07H19/01 , C12P19/58 , C12R1/365 , Y10S435/872
摘要： Compound 0406 having a chemical structural formula represented by the chemical formula (1) below and having an excellent immuno suppressive activity, and pharmaceutically acceptable salts thereof. ##STR1## (wherein R.sub.1 is --COCH.sub.2 COOH or H; R.sub.2 is --CO(CH.sub.2).sub.3 CH.sub.3 or --CO(CH.sub.2).sub.4 CH.sub.3 or H.)
摘要翻译：具有由下述化学式（1）表示的化学结构式并且具有优异的免疫抑制活性的化合物0406及其药学上可接受的盐。（其中R 1是-COCH 2 COOH或H; R 2是-CO（CH 2）3 CH 3或-CO（CH 2）4 CH 3或H.

3. 发明授权

US5965407A Anthracycline compound 0624 失效
标题翻译：蒽环类化合物0624
公开(公告)号：US5965407A
公开(公告)日：1999-10-12
申请号：US33856
申请日：1998-03-03
申请人： Yasushi Tanaka , Yuzuru Mikami , Katsukiyo Yazawa
发明人： Yasushi Tanaka , Yuzuru Mikami , Katsukiyo Yazawa
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P31/04 , A61P35/00 , C07H15/252 , C12P19/56 , C12R1/365 , A61K31/71 , C07H15/24
CPC分类号： C07H15/252 , C12P19/56
摘要： The present invention relates to compound 0624 having excellent antitumor activity and antimicrobial activity, which is represented by the general formula (1), and a pharmaceutically acceptable salt thereof. ##STR1## (wherein R represents H or COCH.sub.3.)
摘要翻译：本发明涉及由通式（1）表示的具有优异的抗肿瘤活性和抗菌活性的化合物0624及其药学上可接受的盐。（其中R表示H或COCH 3。

4. 发明授权

US5494809A Method of producing iturin A and antifungal agent for profound mycosis 失效
公开(公告)号：US5494809A
公开(公告)日：1996-02-27
申请号：US395308
申请日：1995-02-28
申请人： Yasushi Tanaka , Takashi Tojo , Kazuhiko Uchida , Jun Uno , Yasushi Uchida , Osamu Shida
发明人： Yasushi Tanaka , Takashi Tojo , Kazuhiko Uchida , Jun Uno , Yasushi Uchida , Osamu Shida
IPC分类号： A01N43/713 , A01N63/00 , A61K38/00 , A61P31/04 , C07K7/56 , C12P21/04 , C12R1/07
CPC分类号： A01N63/00 , A01N43/713 , C07K7/56 , Y10S435/832
摘要： The present invention is a method of producing iturin A, in which cells of Bacillus amyloliquefaciens are incubated and iturin A is collected from the culture. It also relates to an antifungal agent for profound mycosis, containing iturin A as the active ingredient. Heretofore, there have been known few medicines effective against profound mycosis, but iturin A may be an effective antifungal agent for profound mycosis.

5. 发明授权

US5470827A Method of producing iturin A and antifungal agent for profound mycosis 失效
标题翻译：产生神经蛋白A的方法和深层真菌病的抗真菌剂
公开(公告)号：US5470827A
公开(公告)日：1995-11-28
申请号：US312911
申请日：1994-09-29
申请人： Yasushi Tanaka , Takashi Tojo , Kazuhiko Uchida , Jun Uno , Yasushi Uchida , Osamu Shida
发明人： Yasushi Tanaka , Takashi Tojo , Kazuhiko Uchida , Jun Uno , Yasushi Uchida , Osamu Shida
IPC分类号： A01N43/713 , A01N63/00 , A61K38/00 , A61P31/04 , C07K7/56 , C12P21/04 , C12R1/07 , A61K38/12
CPC分类号： A01N63/00 , A01N43/713 , C07K7/56 , Y10S435/832
摘要： The present invention is a method of producing iturin A, in which cells of Bacillus amyloliquefaciens are incubated and iturin A is collected from the culture. It also relates to an antifungal agent for profound mycosis, containing iturin A as the active ingredient. Heretofore, there have been known few medicines effective against profound mycosis, but iturin A may be an effective antifungal agent for profound mycosis.
摘要翻译：本发明是一种生产神经蛋白A的方法，其中培养解淀粉芽孢杆菌的细胞并从培养物中收集神经蛋白A. 它还涉及含有神经蛋白A作为活性成分的深度真菌病的抗真菌剂。迄今为止，已知有几种对深层真菌病有效的药物，但是，对于深层真菌病，神经蛋白A可能是有效的抗真菌剂。

6. 发明授权

US4946789A Bacillus brevis strains and application thereof 失效
标题翻译：短芽孢杆菌菌株及其应用
公开(公告)号：US4946789A
公开(公告)日：1990-08-07
申请号：US43459
申请日：1987-04-28
申请人： Shigezo Udaka , Hiroaki Takagi , Kiyoshi Kadowaki
发明人： Shigezo Udaka , Hiroaki Takagi , Kiyoshi Kadowaki
IPC分类号： C12N15/09 , C12N1/20 , C12N9/28 , C12N15/00 , C12N15/75 , C12P21/00 , C12R1/08
CPC分类号： C12N9/2417 , C12N15/75 , C12R1/08
摘要： Bacillus brevis strains which produce a large amount of protein but no protease out of the cells are disclosed. These strains are highly useful as hosts in genetic engineering.
摘要翻译：公开了产生大量蛋白质但不含细胞蛋白酶的短芽孢杆菌菌株。这些菌株在基因工程中作为宿主非常有用。

7. 发明授权

US4837313A Polygalactosamine PF-192 and salts thereof 失效
标题翻译：聚半乳糖胺PF-192及其盐
公开(公告)号：US4837313A
公开(公告)日：1989-06-06
申请号：US10305
申请日：1987-02-02
申请人： Jun-ichi Tamura , Hiroaki Takagi
发明人： Jun-ichi Tamura , Hiroaki Takagi
IPC分类号： C12P21/00 , B01D21/01 , C07K14/005 , C07K14/195 , C07K14/37 , C07K14/41 , C12P19/28 , C12R1/79
CPC分类号： C12P19/28 , Y10S435/932
摘要： A natural polymer material PF-102 and salts thereof are widely available as a convenient flocculant for fine suspended matters. PF-102 can be produced by, for example, an imperfect fungus Paecilomyces I-1 (FERM BP-1180).
摘要翻译：天然聚合物材料PF-102及其盐可广泛用作细小悬浮物质的方便絮凝剂。 PF-102可以通过例如不完美的真菌拟青霉I-1（FERM BP-1180）产生。

8. 发明授权

US07655452B1 Brevibacillus choshinensis and process for prodcuing protein wtih use of the microbe as host 有权
标题翻译：使用微生物作为宿主生产蛋白质的短杆菌（Brevibacillus choshinensis）及其制备方法
公开(公告)号：US07655452B1
公开(公告)日：2010-02-02
申请号：US10578781
申请日：2004-11-08
申请人： Hiroshi Hanagata , Takayuki Nishijyo
发明人： Hiroshi Hanagata , Takayuki Nishijyo
IPC分类号： C12N1/20
CPC分类号： C12P21/02 , C12R1/01
摘要： Brevibacillus choshinensis is characterized in that its extracellular proteolytic activity is extremely low and its protein secretion productivity is excellent, but it is desired that not only the extracellular proteolytic activity of the strain is further reduced but also the intracellular proteolytic activity thereof is further reduced. When Brevibacillus choshinensis is used as a host for the production of protein pharmaceuticals and the like, it is also desired that it does not form spores and is readily sterilized. The above problems have been solved by inactivating the sporulation-associated gene thereof and by cloning and inactivating the extracellular and intracellular protease genes thereof.
摘要翻译：特征在于其细胞外蛋白水解活性极低，其蛋白质分泌生产性优异，但是不仅要进一步降低菌株的细胞外蛋白水解活性，而且进一步降低其细胞内的蛋白水解活性。当将短杆菌属（Clovibacillus choshinensis）用作生产蛋白质药物等的宿主时，也希望它不形成孢子并容易灭菌。通过灭活其孢子形成相关基因并通过克隆和灭活其细胞外和细胞内的蛋白酶基因来解决上述问题。

9. 发明授权

US6004995A Macrolide compound 0406 失效
公开(公告)号：US6004995A
公开(公告)日：1999-12-21
申请号：US847413
申请日：1997-04-24
申请人： Yasushi Tanaka , Hisayuki Komaki , Yuzuru Mikami , Katsukiyo Yazawa , Jun'ichi Kobayashi
发明人： Yasushi Tanaka , Hisayuki Komaki , Yuzuru Mikami , Katsukiyo Yazawa , Jun'ichi Kobayashi
IPC分类号： A01N43/02 , A61K31/35 , A61P37/06 , C07D493/18 , C07H19/01 , C12N1/20 , C12P19/58 , C12R1/365
CPC分类号： C07H19/01 , C12P19/58 , C12R1/365 , Y10S435/872
摘要： Compound 0406 having a chemical structural formula represented by the chemical formula (1) below and having an excellent immuno suppressive activity, and pharmaceutically acceptable salts thereof. ##STR1## (wherein R.sub.1 is --COCH.sub.2 COOH or H; R.sub.2 is --CO(CH.sub.2).sub.3 CH.sub.3 or --CO(CH.sub.2).sub.4 CH.sub.3 or H.)

10. 发明授权

US5932555A Terpenoid compound 0406TP-1 失效
标题翻译：萜类化合物0406TP-1
公开(公告)号：US5932555A
公开(公告)日：1999-08-03
申请号：US10589
申请日：1998-01-22
申请人： Hisayuki Komaki , Akira Nemoto , Yasushi Tanaka , Yuzuru Mikami , Katsukiyo Yazawa , Jun'ichi Kobayashi
发明人： Hisayuki Komaki , Akira Nemoto , Yasushi Tanaka , Yuzuru Mikami , Katsukiyo Yazawa , Jun'ichi Kobayashi
IPC分类号： C12P19/56 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P35/00 , A61P37/06 , C07H3/04 , C07H15/256 , C12N1/20 , C12P19/58 , C12R1/365 , C12P19/35 , A61K31/71 , C07M15/00
CPC分类号： C07H3/04 , C12N1/20 , C12P19/58
摘要： The present invention relates to compound 0406TP-1 represented by the general formula (I): ##STR1## wherein Ac represents an acetyl group and Me represents a methyl group, or a pharmaceutically acceptable salt thereof, having excellent antitumor activity and immunosuppressive activity.
摘要翻译：本发明涉及由通式（I）表示的化合物0406TP-1：其中Ac表示乙酰基，Me表示甲基，或其药学上可接受的盐，具有优异的抗肿瘤活性和免疫抑制活性。

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