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1. 发明授权

US5913998A Method of making an implantable containment apparatus for a therapeutical device 失效
标题翻译：制造用于治疗装置的可植入容纳装置的方法
公开(公告)号：US5913998A
公开(公告)日：1999-06-22
申请号：US781119
申请日：1997-01-09
申请人： Mark D. Butler , Daniel F. Davidson , Stanley L. Mish
发明人： Mark D. Butler , Daniel F. Davidson , Stanley L. Mish
IPC分类号： A61M37/00 , A61F2/00 , A61F2/02 , A61K9/00 , A61K9/22 , A61K9/52 , A61L31/04 , A61L31/14 , A61N5/10 , A61M31/00 , B32B31/04
CPC分类号： A61K9/0024 , A61F2/0004 , A61F2/022 , A61L31/048 , A61L31/145 , A61L31/146 , A61N5/1007
摘要： This invention relates generally to an implantable containment apparatus made of selectively permeable material. In particular, the implantable containment apparatus is used to contain a therapeutical device, such as a drug delivery device, a cell encapsulation device, or a gene therapy device. A therapeutical device can be easily placed and replaced in an apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.
摘要翻译：本发明一般涉及由选择性渗透材料制成的可植入容纳装置。特别地，可植入的容纳装置用于包含治疗装置，例如药物递送装置，细胞包封装置或基因治疗装置。可以在本发明的装置中容易地放置和替换治疗装置，而不损害与装置的选择性渗透性材料相关联的组织。

2. 发明授权

US5897955A Materials and methods for the immobilization of bioactive species onto polymeric substrates 有权
标题翻译：将生物活性物质固定在聚合物基材上的材料和方法
公开(公告)号：US5897955A
公开(公告)日：1999-04-27
申请号：US138197
申请日：1998-08-21
申请人： Paul D. Drumheller
发明人： Paul D. Drumheller
IPC分类号： A61L27/34 , C07K17/08 , C12N5/00 , C12N11/08 , B32B27/00 , B32B17/06 , G01N33/53
CPC分类号： C07K17/08 , A61L27/34 , C12N11/08 , C12N5/0068 , C12N2533/30 , C12N2533/50 , Y10T428/249958 , Y10T428/31544
摘要： The present invention is directed to support members having surfaces that are rendered hydrophilic for use as a substrate for the immobilization of bioactive species thereon. The hydrophilic surfaces are chemically stable on the support member. The surfaces are also chemically variable to provide a variety of chemically functional groups for immobilization of bioactive species thereto. The surfaces comprise polymeric surfactants attached onto the surfaces of a support member and covalently cross-linked thereon to form a first layer. Hydrophilic polymers are then attached to the first layer on the support member to form a second layer thereon. The second layer is used to enhance the hydrophilicity of a support member, as well as, to provide a substrate for immobilizing bioactive species thereto. Methods for forming the first and second layers are also provided. In addition, methods for attaching bioactive substances to the hydrophilic polymers are provided.
摘要翻译：本发明涉及具有使其具有亲水性的表面的支撑构件，其用作固定生物活性物质的基底。亲水表面在支撑构件上是化学稳定的。表面也是化学变化的，以提供用于将生物活性物质固定化的各种化学官能团。表面包括附着在支撑构件的表面上并且共价交联在其上以形成第一层的聚合物表面活性剂。然后将亲水性聚合物连接到支撑构件上的第一层上以在其上形成第二层。第二层用于增强支撑构件的亲水性，以及提供用于固定生物活性物质的基底。还提供了形成第一层和第二层的方法。此外，提供了将生物活性物质附着到亲水性聚合物上的方法。

3. 发明授权

US5787900A Method for loading and reloading a therapeutical device in a vascularized implantable containment apparatus 失效
标题翻译：用于在血管化植入式容纳装置中装载和重新装载治疗装置的方法
公开(公告)号：US5787900A
公开(公告)日：1998-08-04
申请号：US731353
申请日：1996-10-11
申请人： Mark D. Butler , Stanley L. Mish
发明人： Mark D. Butler , Stanley L. Mish
IPC分类号： A61M37/00 , A61F2/02 , A61K9/00 , A61B19/00
CPC分类号： A61F2/022
摘要： This invention relates generally to a method of loading and reloading a therapeutical device in a vascularized implantable containment apparatus made of selectively permeable material. Suitable therapeutical devices for use in the present invention include devices such as drug delivery devices, cell encapsulation devices, or gene therapy devices. A therapeutical device can be easily placed and replaced in a vascularized apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.
摘要翻译：本发明一般涉及在选择性渗透性材料制成的血管化可植入容纳装置中加载和重新加载治疗装置的方法。用于本发明的合适的治疗装置包括诸如药物递送装置，细胞包封装置或基因治疗装置的装置。治疗装置可以容易地在本发明的血管化装置中放置和替换，而不损害与装置的选择性渗透性材料相关联的组织。

4. 发明授权

US5843069A Implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein 失效
标题翻译：用于治疗装置的植入式容纳装置和用于在其中装载和重新装载装置的方法
公开(公告)号：US5843069A
公开(公告)日：1998-12-01
申请号：US891119
申请日：1997-07-10
申请人： Mark D. Butler , Daniel F. Davidson , Stanley L. Mish , James W. Moore, III
发明人： Mark D. Butler , Daniel F. Davidson , Stanley L. Mish , James W. Moore, III
IPC分类号： A61M37/00 , A61F2/00 , A61F2/02 , A61K9/00 , A61K9/22 , A61K9/52 , A61L31/04 , A61L31/14 , A61N5/10
CPC分类号： A61K9/0024 , A61F2/0004 , A61F2/022 , A61L31/048 , A61L31/145 , A61L31/146 , A61N5/1007
摘要： This invention relates generally to an implantable containment apparatus made of selectively permeable material. In particular, the implantable containment apparatus is used to contain a therapeutical device, such as a drug delivery device, a cell encapsulation device, or a gene therapy device. A therapeutical device can be easily placed and replaced in an apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.
摘要翻译：本发明一般涉及由选择性渗透材料制成的可植入容纳装置。特别地，可植入的容纳装置用于包含治疗装置，例如药物递送装置，细胞包封装置或基因治疗装置。可以在本发明的装置中容易地放置和替换治疗装置，而不损害与装置的选择性渗透性材料相关联的组织。

5. 发明授权

US5626561A Implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein 失效
标题翻译：用于治疗装置的植入式容纳装置和用于在其中装载和重新装载装置的方法
公开(公告)号：US5626561A
公开(公告)日：1997-05-06
申请号：US479932
申请日：1995-06-07
申请人： Mark D. Butler , Stanley L. Mish
发明人： Mark D. Butler , Stanley L. Mish
IPC分类号： A61M37/00 , A61F2/02 , A61K9/00 , A61M31/00
CPC分类号： A61F2/022
摘要： This invention relates generally to an implantable containment apparatus made of selectively permeable material. In particular, the implantable containment apparatus is used to contain a therapeutical device, such as a drug delivery device, a cell encapsulation device, or a gene therapy device. A therapeutical device can be easily placed and replaced in an apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.
摘要翻译：本发明一般涉及由选择性渗透材料制成的可植入容纳装置。特别地，可植入的容纳装置用于包含治疗装置，例如药物递送装置，细胞包封装置或基因治疗装置。可以在本发明的装置中容易地放置和替换治疗装置，而不损害与装置的选择性渗透性材料相关联的组织。

6. 发明授权

US5980889A Cell encapsulating device containing a cell displacing core for maintaining cell viability 失效
标题翻译：包含用于维持细胞活力的细胞置换核心的细胞包封装置
公开(公告)号：US5980889A
公开(公告)日：1999-11-09
申请号：US906367
申请日：1997-08-05
申请人： Mark D. Butler , Stanley L. Mish
发明人： Mark D. Butler , Stanley L. Mish
IPC分类号： A61K9/00 , C12P21/04 , A01N63/00 , C12N5/00 , C12N11/04
CPC分类号： A61K9/0092 , A61K9/0024 , A61K9/0085
摘要： Cell encapsulating devices capable of maintaining large numbers of viable cells are provided containing an inert, substantially cell-free core that displaces cells, a permeable membrane and a zone for maintaining cells. The permeable membrane surrounds the core such that the zone of cells is bounded by the core and the permeable membrane. The cell zone may contain a support means for cell attachment and the core may have an outer boundary containing a material that promotes cell adhesion. Preferably, the cell zone has a thickness such that at least about 10% of the cells, more preferably at least about 50% or 80%, in a cell layer located closest to the outer boundary of the core remain viable. The thickness is preferably less than 500 microns such as 25 to 250 microns or 50 to 100 microns. The devices are suitable for implantation into an individual in need of treatment and are capable of supplying therapeutic substances to such individuals.
摘要翻译：提供能够维持大量活细胞的细胞包封装置，其包含置换细胞，可渗透膜和用于维持细胞的区域的惰性，基本上无细胞的核。渗透膜围绕核心，使得细胞区域被核心和可渗透膜界定。细胞区域可以包含用于细胞附着的支持装置，并且核心可以具有包含促进细胞粘附的材料的外边界。优选地，细胞区具有这样的厚度，使得位于最靠近核的外边界的细胞层中至少约10％的细胞，更优选至少约50％或80％保持活性。厚度优选小于500微米，例如25至250微米或50至100微米。该装置适于植入需要治疗的个体中，并且能够向这些个体供应治疗物质。

7. 发明授权

US5902745A Cell encapsulation device 失效
标题翻译：细胞封装装置
公开(公告)号：US5902745A
公开(公告)日：1999-05-11
申请号：US859946
申请日：1997-05-21
申请人： Mark D. Butler , Paul D. Drumheller , Stanley L. Mish
发明人： Mark D. Butler , Paul D. Drumheller , Stanley L. Mish
IPC分类号： A61F2/02 , A61K9/00 , C12G1/073 , C12M1/40 , C12M3/06
CPC分类号： A61K9/0024 , A61F2/022 , C12G1/064 , C12M23/08 , C12M23/22 , C12M23/34 , C12M23/38 , C12M25/16 , C12M33/14
摘要： The present invention is directed to a cell encapsulation device that permits rapid and straightforward cell transfer into the device. The preferred device includes components that allow a user to quickly transfer cells into the device with minimal risk to the cells. Among the most important improvements of the present invention are: automatic filtration of excess solution during cell transfer; an instantly wettable cover, allowing ready view into the cell chamber; and a swellable core, allowing cells to be transferred with minimal shear force while assuring optimal cell placement in the device during use. The device of the present invention may be used either in vivo, such as to deliver therapeutic substances, or in vitro, such as to serve as a bioreactor.
摘要翻译：本发明涉及允许快速且直接的细胞转移到装置中的细胞封装装置。优选的设备包括允许用户以最小的细胞风险将细胞快速传送到设备中的组件。本发明最重要的改进之一是：在细胞转移过程中过量溶液的自动过滤; 立即可湿的盖子，允许准备观察细胞室; 和可膨胀的芯，允许以最小剪切力转移细胞，同时确保在使用期间在装置中最佳的细胞放置。本发明的装置可以在体内使用，例如递送治疗物质，或体外使用，例如用作生物反应器。

8. 发明授权

US5914182A Materials and methods for the immobilization of bioactive species onto polymeric substrates 失效
标题翻译：将生物活性物质固定在聚合物基材上的材料和方法
公开(公告)号：US5914182A
公开(公告)日：1999-06-22
申请号：US660698
申请日：1996-06-03
申请人： Paul D. Drumheller
发明人： Paul D. Drumheller
IPC分类号： A61L27/34 , C07K17/08 , C12N5/00 , C12N11/08 , B32B5/14
CPC分类号： C07K17/08 , A61L27/34 , C12N11/08 , C12N5/0068 , C12N2533/30 , C12N2533/50 , Y10T428/249958 , Y10T428/31544
摘要： The present invention is directed to support members having surfaces that are rendered hydrophilic for use as a substrate for the immobilization of bioactive species thereon. The hydrophilic surfaces are chemically stable on the support member. The surfaces are also chemically variable to provide a variety of chemically functional groups for immobilization of bioactive species thereto. The surfaces comprise polymeric surfactants attached onto the surfaces of a support member and covalently cross-linked thereon to form a first layer. Hydrophilic polymers are then attached to the first layer on the support member to form a second layer thereon. The second layer is used to enhance the hydrophilicity of a support member, as well as, to provide a substrate for immobilizing bioactive species thereto. Methods for forming the first and second layers are also provided. In addition methods for attaching bioactive substances to the hydrophilic polymers are provided.
摘要翻译：本发明涉及具有使其具有亲水性的表面的支撑构件，其用作固定生物活性物质的基底。亲水表面在支撑构件上是化学稳定的。表面也是化学变化的，以提供用于将生物活性物质固定化的各种化学官能团。表面包括附着在支撑构件的表面上并且共价交联在其上以形成第一层的聚合物表面活性剂。然后将亲水性聚合物连接到支撑构件上的第一层上以在其上形成第二层。第二层用于增强支撑构件的亲水性，以及提供用于固定生物活性物质的基底。还提供了形成第一层和第二层的方法。另外提供了将生物活性物质附着到亲水性聚合物上的方法。

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