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1. 发明授权

US5913998A Method of making an implantable containment apparatus for a therapeutical device 失效
标题翻译：制造用于治疗装置的可植入容纳装置的方法
公开(公告)号：US5913998A
公开(公告)日：1999-06-22
申请号：US781119
申请日：1997-01-09
申请人： Mark D. Butler , Daniel F. Davidson , Stanley L. Mish
发明人： Mark D. Butler , Daniel F. Davidson , Stanley L. Mish
IPC分类号： A61M37/00 , A61F2/00 , A61F2/02 , A61K9/00 , A61K9/22 , A61K9/52 , A61L31/04 , A61L31/14 , A61N5/10 , A61M31/00 , B32B31/04
CPC分类号： A61K9/0024 , A61F2/0004 , A61F2/022 , A61L31/048 , A61L31/145 , A61L31/146 , A61N5/1007
摘要： This invention relates generally to an implantable containment apparatus made of selectively permeable material. In particular, the implantable containment apparatus is used to contain a therapeutical device, such as a drug delivery device, a cell encapsulation device, or a gene therapy device. A therapeutical device can be easily placed and replaced in an apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.
摘要翻译：本发明一般涉及由选择性渗透材料制成的可植入容纳装置。特别地，可植入的容纳装置用于包含治疗装置，例如药物递送装置，细胞包封装置或基因治疗装置。可以在本发明的装置中容易地放置和替换治疗装置，而不损害与装置的选择性渗透性材料相关联的组织。

2. 发明授权

US06471687B2 Implantable containment apparatus for a therapeutical device 有权
标题翻译：用于治疗装置的可植入容纳装置
公开(公告)号：US06471687B2
公开(公告)日：2002-10-29
申请号：US09201173
申请日：1998-11-30
申请人： Mark D. Butler , Daniel F. Davidson , Stanley L. Mish , James W. Moore, III
发明人： Mark D. Butler , Daniel F. Davidson , Stanley L. Mish , James W. Moore, III
IPC分类号： A61K922
CPC分类号： A61K9/0024 , A61F2/0004 , A61F2/022 , A61L31/048 , A61L31/145 , A61L31/146 , A61N5/1007 , C08L27/18 , C08L89/06 , C08L39/06 , C08L33/22 , C08L33/14 , C08L29/04 , C08L5/04 , C08L5/00
摘要： This invention relates generally to an implantable containment apparatus made of selectively permeable material. In particular, the implantable containment apparatus is used to contain a therapeutical device, a cell encapsulation device, or a gene therapy device. A therapeutical device can be easily placed and replaced in an apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.
摘要翻译：本发明一般涉及由选择性渗透材料制成的可植入容纳装置。特别地，可植入的容纳装置用于包含治疗装置，细胞包封装置或基因治疗装置。可以在本发明的装置中容易地放置和替换治疗装置，而不损害与装置的选择性渗透性材料相关联的组织。

3. 发明授权

US5843069A Implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein 失效
标题翻译：用于治疗装置的植入式容纳装置和用于在其中装载和重新装载装置的方法
公开(公告)号：US5843069A
公开(公告)日：1998-12-01
申请号：US891119
申请日：1997-07-10
申请人： Mark D. Butler , Daniel F. Davidson , Stanley L. Mish , James W. Moore, III
发明人： Mark D. Butler , Daniel F. Davidson , Stanley L. Mish , James W. Moore, III
IPC分类号： A61M37/00 , A61F2/00 , A61F2/02 , A61K9/00 , A61K9/22 , A61K9/52 , A61L31/04 , A61L31/14 , A61N5/10
CPC分类号： A61K9/0024 , A61F2/0004 , A61F2/022 , A61L31/048 , A61L31/145 , A61L31/146 , A61N5/1007
摘要： This invention relates generally to an implantable containment apparatus made of selectively permeable material. In particular, the implantable containment apparatus is used to contain a therapeutical device, such as a drug delivery device, a cell encapsulation device, or a gene therapy device. A therapeutical device can be easily placed and replaced in an apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.
摘要翻译：本发明一般涉及由选择性渗透材料制成的可植入容纳装置。特别地，可植入的容纳装置用于包含治疗装置，例如药物递送装置，细胞包封装置或基因治疗装置。可以在本发明的装置中容易地放置和替换治疗装置，而不损害与装置的选择性渗透性材料相关联的组织。

4. 发明授权

US5787900A Method for loading and reloading a therapeutical device in a vascularized implantable containment apparatus 失效
标题翻译：用于在血管化植入式容纳装置中装载和重新装载治疗装置的方法
公开(公告)号：US5787900A
公开(公告)日：1998-08-04
申请号：US731353
申请日：1996-10-11
申请人： Mark D. Butler , Stanley L. Mish
发明人： Mark D. Butler , Stanley L. Mish
IPC分类号： A61M37/00 , A61F2/02 , A61K9/00 , A61B19/00
CPC分类号： A61F2/022
摘要： This invention relates generally to a method of loading and reloading a therapeutical device in a vascularized implantable containment apparatus made of selectively permeable material. Suitable therapeutical devices for use in the present invention include devices such as drug delivery devices, cell encapsulation devices, or gene therapy devices. A therapeutical device can be easily placed and replaced in a vascularized apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.
摘要翻译：本发明一般涉及在选择性渗透性材料制成的血管化可植入容纳装置中加载和重新加载治疗装置的方法。用于本发明的合适的治疗装置包括诸如药物递送装置，细胞包封装置或基因治疗装置的装置。治疗装置可以容易地在本发明的血管化装置中放置和替换，而不损害与装置的选择性渗透性材料相关联的组织。

5. 发明授权

US06426214B1 Cell encapsulating device containing a cell displacing core for maintaining cell viability 有权
标题翻译：包含用于维持细胞活力的细胞置换核心的细胞包封装置
公开(公告)号：US06426214B1
公开(公告)日：2002-07-30
申请号：US09435510
申请日：1999-11-08
申请人： Mark D. Butler , Stanley L. Mish
发明人： Mark D. Butler , Stanley L. Mish
IPC分类号： C12M300
CPC分类号： A61K9/0092 , A61K9/0024 , A61K9/0085
摘要： Cell encapsulating devices capable of maintaining large numbers of viable cells are provided containing an inert, substantially cell-free core that displaces cells, a permeable membrane and a zone for maintaining cells. The permeable membrane surrounds the core such that the zone of cells is bounded by the core and the permeable membrane. A preferred device contains a polytetrafluoroethylene permeable membrane and a flexible polymer core having a plurality of ridges and valleys running lengthwise along the core. The cell zone may contain support means for cell attachment and the core may have an outer boundary containing a material that promotes cell adhesion. Preferably, the cell zone has a thickness such that at least about 10% of the cells, more preferably at least about 50% or 80%, in a cell layer located closest to the outer boundary of the core remain viable. The thickness is preferably less than 500 microns such as 25 to 250 microns or 50 to 100 microns. The devices are suitable for implantation into an individual in need of treatment and are capable of supplying therapeutic substances to such individuals.
摘要翻译：提供能够维持大量活细胞的细胞包封装置，其包含置换细胞，可渗透膜和用于维持细胞的区域的惰性，基本上无细胞的核。渗透膜围绕核心，使得细胞区域被核心和可渗透膜界定。优选的装置包含聚四氟乙烯可渗透膜和柔性聚合物芯，其具有沿着芯纵向延伸的多个脊和谷。细胞区域可以包含用于细胞附着的支持装置，并且核心可以具有包含促进细胞粘附的材料的外边界。优选地，细胞区具有这样的厚度，使得位于最靠近核的外边界的细胞层中至少约10％的细胞，更优选至少约50％或80％保持活性。厚度优选小于500微米，例如25至250微米或50至100微米。该装置适于植入需要治疗的个体中，并且能够向这些个体供应治疗物质。

6. 发明授权

US5980889A Cell encapsulating device containing a cell displacing core for maintaining cell viability 失效
标题翻译：包含用于维持细胞活力的细胞置换核心的细胞包封装置
公开(公告)号：US5980889A
公开(公告)日：1999-11-09
申请号：US906367
申请日：1997-08-05
申请人： Mark D. Butler , Stanley L. Mish
发明人： Mark D. Butler , Stanley L. Mish
IPC分类号： A61K9/00 , C12P21/04 , A01N63/00 , C12N5/00 , C12N11/04
CPC分类号： A61K9/0092 , A61K9/0024 , A61K9/0085
摘要： Cell encapsulating devices capable of maintaining large numbers of viable cells are provided containing an inert, substantially cell-free core that displaces cells, a permeable membrane and a zone for maintaining cells. The permeable membrane surrounds the core such that the zone of cells is bounded by the core and the permeable membrane. The cell zone may contain a support means for cell attachment and the core may have an outer boundary containing a material that promotes cell adhesion. Preferably, the cell zone has a thickness such that at least about 10% of the cells, more preferably at least about 50% or 80%, in a cell layer located closest to the outer boundary of the core remain viable. The thickness is preferably less than 500 microns such as 25 to 250 microns or 50 to 100 microns. The devices are suitable for implantation into an individual in need of treatment and are capable of supplying therapeutic substances to such individuals.
摘要翻译：提供能够维持大量活细胞的细胞包封装置，其包含置换细胞，可渗透膜和用于维持细胞的区域的惰性，基本上无细胞的核。渗透膜围绕核心，使得细胞区域被核心和可渗透膜界定。细胞区域可以包含用于细胞附着的支持装置，并且核心可以具有包含促进细胞粘附的材料的外边界。优选地，细胞区具有这样的厚度，使得位于最靠近核的外边界的细胞层中至少约10％的细胞，更优选至少约50％或80％保持活性。厚度优选小于500微米，例如25至250微米或50至100微米。该装置适于植入需要治疗的个体中，并且能够向这些个体供应治疗物质。

7. 发明授权

US5902745A Cell encapsulation device 失效
标题翻译：细胞封装装置
公开(公告)号：US5902745A
公开(公告)日：1999-05-11
申请号：US859946
申请日：1997-05-21
申请人： Mark D. Butler , Paul D. Drumheller , Stanley L. Mish
发明人： Mark D. Butler , Paul D. Drumheller , Stanley L. Mish
IPC分类号： A61F2/02 , A61K9/00 , C12G1/073 , C12M1/40 , C12M3/06
CPC分类号： A61K9/0024 , A61F2/022 , C12G1/064 , C12M23/08 , C12M23/22 , C12M23/34 , C12M23/38 , C12M25/16 , C12M33/14
摘要： The present invention is directed to a cell encapsulation device that permits rapid and straightforward cell transfer into the device. The preferred device includes components that allow a user to quickly transfer cells into the device with minimal risk to the cells. Among the most important improvements of the present invention are: automatic filtration of excess solution during cell transfer; an instantly wettable cover, allowing ready view into the cell chamber; and a swellable core, allowing cells to be transferred with minimal shear force while assuring optimal cell placement in the device during use. The device of the present invention may be used either in vivo, such as to deliver therapeutic substances, or in vitro, such as to serve as a bioreactor.
摘要翻译：本发明涉及允许快速且直接的细胞转移到装置中的细胞封装装置。优选的设备包括允许用户以最小的细胞风险将细胞快速传送到设备中的组件。本发明最重要的改进之一是：在细胞转移过程中过量溶液的自动过滤; 立即可湿的盖子，允许准备观察细胞室; 和可膨胀的芯，允许以最小剪切力转移细胞，同时确保在使用期间在装置中最佳的细胞放置。本发明的装置可以在体内使用，例如递送治疗物质，或体外使用，例如用作生物反应器。

8. 发明授权

US5626561A Implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein 失效
标题翻译：用于治疗装置的植入式容纳装置和用于在其中装载和重新装载装置的方法
公开(公告)号：US5626561A
公开(公告)日：1997-05-06
申请号：US479932
申请日：1995-06-07
申请人： Mark D. Butler , Stanley L. Mish
发明人： Mark D. Butler , Stanley L. Mish
IPC分类号： A61M37/00 , A61F2/02 , A61K9/00 , A61M31/00
CPC分类号： A61F2/022
摘要： This invention relates generally to an implantable containment apparatus made of selectively permeable material. In particular, the implantable containment apparatus is used to contain a therapeutical device, such as a drug delivery device, a cell encapsulation device, or a gene therapy device. A therapeutical device can be easily placed and replaced in an apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.
摘要翻译：本发明一般涉及由选择性渗透材料制成的可植入容纳装置。特别地，可植入的容纳装置用于包含治疗装置，例如药物递送装置，细胞包封装置或基因治疗装置。可以在本发明的装置中容易地放置和替换治疗装置，而不损害与装置的选择性渗透性材料相关联的组织。

9. 发明授权

US5472081A Needle holder for a suture package 失效
标题翻译：用于缝合包的针架
公开(公告)号：US5472081A
公开(公告)日：1995-12-05
申请号：US243439
申请日：1994-05-16
申请人： Bret J. Kilgrow , Stanley L. Mish
发明人： Bret J. Kilgrow , Stanley L. Mish
IPC分类号： A61B17/06 , B29C51/10
CPC分类号： A61B17/06133 , A61B2017/06142 , A61B2017/06157 , B29C2791/006 , B29C51/10 , B29L2031/753
摘要： A suture needle holder for a suture package intended to contain an armed suture, comprising a sheet of planar plastic having at least one raised pedestal formed therein, said at least one raised pedestal having at least one slot therein oriented orthogonal to the sheet of planar plastic, said at least one slot having an open portion and a needle-holding portion releasably holding a portion of the length of a suture needle therein with the length of the suture needle lying in a plane parallel to the sheet of planar plastic, wherein the open portion of the slot is of a width narrower than the diameter of the length portion of the suture needle held within the needle-holding portion of the slot. A method of forming the suture needle holder is also described.
摘要翻译：一种用于缝合包装的缝合针保持器，其用于容纳布置的缝合线，包括一片平面塑料片，其具有形成在其中的至少一个凸起的基座，所述至少一个凸起的基座具有至少一个狭槽，所述至少一个狭槽定向成垂直于所述平面塑料片所述至少一个狭槽具有开口部分和针保持部分，其可释放地将缝合针的长度的一部分保持在其中，其中缝合针的长度位于平行于平面塑料片的平面中，其中开口槽的部分的宽度比保持在槽的针保持部内的缝合线的长度部分的直径窄。还描述了形成缝合针保持器的方法。

10. 发明授权

US5192483A Method of thermoforming a sheet around a suture needle to form a holder 失效
标题翻译：在缝合针周围热成形片材以形成保持器的方法
公开(公告)号：US5192483A
公开(公告)日：1993-03-09
申请号：US801552
申请日：1991-12-02
申请人： Bret J. Kilgrow , Stanley L. Mish
发明人： Bret J. Kilgrow , Stanley L. Mish
IPC分类号： A61B17/06 , B29C51/10 , B29C51/12
CPC分类号： B29C51/12 , A61B17/06133 , A61B2017/06142 , A61B2017/06157 , B29C2791/006 , B29C51/10 , B29L2031/753 , B29L2031/7546
摘要： A method of forming a suture needle holder for a suture needle. A suture needle is placed in a trough cut into the surface of a die. This trough intersects a cavity within the die. A sheet is placed onto the surface of the die after the needle is placed in the trough. The sheet is then thermoformed into the cavity to form a pedestal around the needle. During thermoforming the needle is captured by the sheet and a slot is formed about the suture needle.
摘要翻译：一种形成用于缝合针的缝合针保持器的方法。将缝合针放置在切入模具表面的槽中。该槽与模具内的空腔相交。将针放置在槽中后，将片材放置在模具的表面上。然后将片材热成型为空腔，以在针周围形成基座。在热成型期间，针被片材捕获，并且围绕缝合针形成狭槽。

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