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1. 发明授权

US10871487B2 FRET-based glucose-detection molecules 有权
公开(公告)号：US10871487B2
公开(公告)日：2020-12-22
申请号：US16094759
申请日：2017-04-19
申请人： GLUSENSE LTD.
发明人： Zohar Biron-Sorek , Uriel Barkai
IPC分类号： G01N33/542 , G01N33/66 , C12Q1/54
CPC分类号： G01N33/542 , C12Q1/54 , G01N33/66
摘要： Proteins (20) having glucose-binding sites (28) that bind to glucose (30) are described.

2. 发明授权

US10575765B2 Analyte-sensing device 有权
公开(公告)号：US10575765B2
公开(公告)日：2020-03-03
申请号：US15517318
申请日：2015-10-13
申请人： GLUSENSE LTD.
发明人： Boaz Brill
IPC分类号： A61B5/1455 , A61B5/145 , A61B5/00 , A61B5/1459 , G01N21/64
摘要： An implantable unit includes fluorescent sensor molecules, each of which includes a binding site for an analyte, a donor fluorophore, and an acceptor fluorophore; and a first light source. An external system includes an external reading unit, which includes a light sensor; and a processor, which is configured to (i) during a first time period: (a) drive the first light source to generate light having a first illumination peak wavelength appropriate for excitation of the donor fluorophore, and (b) receive, from the light sensor, a first measurement of the fluorescent light emitted from the acceptor fluorophore, (ii) during a second time period: (a) drive a second light source to generate light having a second illumination peak wavelength appropriate for direct excitation of the acceptor fluorophore, and (b) receive, from the light sensor, a second measurement of the fluorescent light emitted from the acceptor fluorophore, and (iii) calculate the concentration of the analyte based on the measurements.

3. 发明申请

US20150343093A1 CONTROLLED DEATH OF IMPLANTED CELLS 审中-公开
标题翻译：植入细胞的控制性死亡
公开(公告)号：US20150343093A1
公开(公告)日：2015-12-03
申请号：US14825123
申请日：2015-08-12
申请人： Tehila HYMAN , Boaz BRILL
发明人： Tehila HYMAN , Boaz BRILL
IPC分类号： A61K49/00
CPC分类号： A61B5/14503 , A61B5/0031 , A61B5/14507 , A61B5/14532 , A61B5/14546 , A61B2560/0214 , A61K49/0045 , A61K49/0047 , A61K49/0056 , C07K14/43595 , C07K2319/60
摘要： A method is provided, including implanting a chamber containing cells in a subject, and subsequently administering, to the subject, a drug capable of killing the cells. For example, the drug may be administered after the cells cease to function for their intended purpose, or if the cells escape from the implanted chamber. Alternatively, the drug may be administered to kill the cells while the cells are in the implanted chamber. Other embodiments are also described.
摘要翻译：提供了一种方法，包括将包含细胞的腔室植入受试者中，随后向受试者施用能够杀死细胞的药物。例如，药物可以在细胞停止其预期目的的功能之后，或者如果细胞从注射室逸出，则可以给药。或者，可以施用药物以在细胞处于植入室中时杀死细胞。还描述了其它实施例。

4. 发明申请

US20100160749A1 IMPLANTABLE OPTICAL GLUCOSE SENSING 审中-公开
标题翻译：可植入光学葡萄糖感测
公开(公告)号：US20100160749A1
公开(公告)日：2010-06-24
申请号：US12344103
申请日：2008-12-24
申请人： Yossi GROSS , Tehila Hyman , Tamir Gil
发明人： Yossi GROSS , Tehila Hyman , Tamir Gil
IPC分类号： A61B5/1459
CPC分类号： A61B5/14532 , A61B5/14558 , A61B5/1459 , A61B5/6846
摘要： Apparatus is provided, including a support configured to be implanted within a body of a subject and a sampling region coupled to the support. The apparatus is configured to passively allow passage through the sampling region of at least a portion of fluid from the subject. The apparatus also comprises an optical measuring device in optical communication with the sampling region. The optical measuring device comprises at least one light source configured to transmit light through at least a portion of the fluid, and at least one sensor configured to measure a parameter of the fluid by detecting light passing through the fluid. Other embodiments are also described.
摘要翻译：提供了一种装置，包括被配置为植入受试者的身体内的支撑体和连接到支撑件的采样区域。该装置被配置为被动地允许通过来自受试者的至少一部分流体的采样区域。该装置还包括与采样区域光学通信的光学测量装置。所述光学测量装置包括至少一个光源，所述至少一个光源被配置为透过至少一部分所述流体的光;以及至少一个传感器，被配置为通过检测穿过所述流体的光来测量所述流体的参数。还描述了其它实施例。

5. 发明申请

US20160324449A1 IMPLANTABLE SENSORS 审中-公开
标题翻译：可植入传感器
公开(公告)号：US20160324449A1
公开(公告)日：2016-11-10
申请号：US15222158
申请日：2016-07-28
申请人： GLUSENSE LTD.
发明人： Yossi GROSS , Tehila HYMAN
IPC分类号： A61B5/1459 , A61B5/1473 , A61B5/145
CPC分类号： A61B5/1459 , A61B5/14532 , A61B5/1473
摘要： An implantable unit is provided that is configured to be implanted in a body of a subject, and comprises (a) a case, which is shaped so as to define (i) an external wall, (ii) a measurement chamber, and (iii) an aging chamber; (b) a self-sealing entry port in the external wall, which is accessible from outside the implantable unit, and which is softer than the external wall; (c) a first one-way valve, which is disposed between the measurement chamber and the aging chamber, and is arranged to allow one-way flow from the measurement chamber into the aging chamber; and (d) a second one-way valve, which is arranged to allow one-way flow from the aging chamber to outside the implantable unit. Other embodiments are also described.
摘要翻译：提供了一种植入式单元，其被配置为植入受试者的身体，并且包括（a）壳体，其被成形为限定（i）外壁，（ii）测量室，和（iii ）老化室; （b）外壁上的自密封进入口，其可从可植入单元的外部接近并且比外壁更软; （c）第一单向阀，其设置在测量室和老化室之间，并且被布置成允许从测量室单向流入老化室; 和（d）第二单向阀，其被布置成允许从老化室单向流动到可植入单元外部。还描述了其它实施例。

6. 发明授权

US09037205B2 Implantable optical glucose sensing 有权
标题翻译：植入式光学葡萄糖感测
公开(公告)号：US09037205B2
公开(公告)日：2015-05-19
申请号：US13173831
申请日：2011-06-30
申请人： Tamir Gil , Yossi Gross , Orly Grinberg , Itamar Weisman , Tehila Hyman , Boaz Hyman
发明人： Tamir Gil , Yossi Gross , Orly Grinberg , Itamar Weisman , Tehila Hyman , Boaz Hyman
IPC分类号： A61B5/1455 , A61B5/1459 , A61B5/145 , A61B5/00
CPC分类号： A61B5/1459 , A61B5/0071 , A61B5/14532
摘要： Apparatus is provided for detecting an analyte, configured to be implanted in a body of a subject. The apparatus includes an optical fiber having a distal portion and also a membrane permeable to the analyte. The membrane is coupled to the distal portion of the fiber and surrounding a sampling region at least in part, by being fitted over the distal portion of the fiber. Other embodiments are also described.
摘要翻译：提供了用于检测分析物的装置，其被配置为植入受试者的身体。该装置包括具有远端部分的光纤以及可分析物透过的膜。膜通过装配在纤维的远端部分上至少部分地耦合到纤维的远端部分并且围绕取样区域。还描述了其它实施例。

7. 发明申请

US20130006069A1 IMPLANTABLE OPTICAL GLUCOSE SENSING 有权
标题翻译：可植入光学葡萄糖感测
公开(公告)号：US20130006069A1
公开(公告)日：2013-01-03
申请号：US13173831
申请日：2011-06-30
申请人： Tamir GIL , Yossi GROSS , Orly GRINBERG , Itamar WEISMAN , Tehila HYMAN , Boaz HYMAN
发明人： Tamir GIL , Yossi GROSS , Orly GRINBERG , Itamar WEISMAN , Tehila HYMAN , Boaz HYMAN
IPC分类号： A61B5/1459
CPC分类号： A61B5/1459 , A61B5/0071 , A61B5/14532
摘要： Apparatus is provided for detecting an analyte, configured to be implanted in a body of a subject. The apparatus includes an optical fiber having a distal portion and also a membrane permeable to the analyte. The membrane is coupled to the distal portion of the fiber and surrounding a sampling region at least in part, by being fitted over the distal portion of the fiber. Other embodiments are also described.
摘要翻译：提供了用于检测分析物的装置，其被配置为植入受试者的身体。该装置包括具有远端部分的光纤以及可分析物透过的膜。膜通过装配在纤维的远端部分上至少部分地耦合到纤维的远端部分并且围绕取样区域。还描述了其它实施例。

8. 发明申请

US20120059232A1 IMPLANTABLE OPTICAL GLUCOSE SENSING 审中-公开
标题翻译：可植入光学葡萄糖感测
公开(公告)号：US20120059232A1
公开(公告)日：2012-03-08
申请号：US13141936
申请日：2009-12-24
申请人： Yossi Gross , Tehila Hyman , Tamir Gil
发明人： Yossi Gross , Tehila Hyman , Tamir Gil
IPC分类号： A61B5/1455
CPC分类号： A61B5/1459 , A61B5/14532 , A61B5/14556 , A61B5/14558 , A61B5/686 , A61B5/6862
摘要： Apparatus is provided, including a support (21) configured to be implanted within a body of a subject and a sampling region (30, 1430) coupled to the support (21). The apparatus is configured to passively allow passage through the sampling region (30, 1430) of at least a portion of fluid from the subject. The apparatus also includes an optical measuring device in optical communication with the sampling region (30, 1430). The optical measuring device comprises at least one light source (40) configured to transmit light through at least a portion of the fluid, and at least one sensor (42) configured to measure a parameter of the fluid by detecting light passing through the fluid. Other applications are also described.
摘要翻译：提供了一种设备，包括被配置为植入受试者的身体内的支撑件（21）和联接到支撑件（21）的取样区域（30，1430）。该装置被配置为被动地允许通过来自受试者的至少一部分流体的取样区域（30,1430）。该装置还包括与采样区域（30,1430）光学通信的光学测量装置。所述光学测量装置包括被配置为透过至少一部分流体的光的至少一个光源（40）和被配置成通过检测穿过流体的光来测量流体参数的至少一个传感器（42）。还描述了其它应用。

9. 发明申请

US20110251471A1 IMPLANTABLE POWER SOURCES AND SENSORS 审中-公开
标题翻译：可植入电源和传感器
公开(公告)号：US20110251471A1
公开(公告)日：2011-10-13
申请号：US13089096
申请日：2011-04-18
申请人： Yossi Gross , Ben-Tsion Williger , Tehila Hyman , Tova Neufeld
发明人： Yossi Gross , Ben-Tsion Williger , Tehila Hyman , Tova Neufeld
IPC分类号： A61B5/1473 , H01M8/16
CPC分类号： C07K14/43595 , A61B5/14532 , A61K49/0045 , A61K49/0047 , A61K49/0056 , C07K2319/60 , G01N33/54373
摘要： A protein is provided, including a glucose binding site, cyan fluorescent protein (CFP), and yellow fluorescent protein (YFP). The protein is configured such that binding of glucose to the glucose binding site causes a reduction in a distance between the CFP and the YFP. Substance monitoring apparatus (210) is also provided, including a semi-permeable barrier (212), adapted to be implanted in a body of a subject and to allow passage therethrough of a substance, while inhibiting passage therethrough of immune cells; and microorganisms (214), disposed within the semi-permeable barrier (212) so as to produce a measurable response to a level of the substance. A sensor (220) is adapted to measure the measurable response and not to measure a response of any mammalian cells that may be disposed within the semi-permeable barrier (212).
摘要翻译：提供蛋白质，包括葡萄糖结合位点，青色荧光蛋白（CFP）和黄色荧光蛋白（YFP）。配置蛋白质使得葡萄糖与葡萄糖结合位点的结合导致CFP和YFP之间的距离减小。还提供了物质监测设备（210），其包括半渗透屏障（212），其适于植入受试者体内并允许物质通过，同时抑制免疫细胞通过; 和微生物（214），其设置在半渗透屏障（212）内，以便产生对物质水平的可测量响应。传感器（220）适于测量可测量的响应并且不测量可以设置在半渗透屏障（212）内的任何哺乳动物细胞的响应。

10. 发明申请

US20190128879A1 FRET-BASED GLUCOSE-DETECTION MOLECULES 审中-公开
公开(公告)号：US20190128879A1
公开(公告)日：2019-05-02
申请号：US16094759
申请日：2017-04-19
申请人： GLUSENSE LTD.
发明人： Zohar BIRON-SOREK , Uriel BARKAI
IPC分类号： G01N33/542 , G01N33/66
摘要： Proteins (20) having glucose-binding sites (28) that bind to glucose (30) are described.

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