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1. 发明授权

US09037205B2 Implantable optical glucose sensing 有权
标题翻译：植入式光学葡萄糖感测
公开(公告)号：US09037205B2
公开(公告)日：2015-05-19
申请号：US13173831
申请日：2011-06-30
申请人： Tamir Gil , Yossi Gross , Orly Grinberg , Itamar Weisman , Tehila Hyman , Boaz Hyman
发明人： Tamir Gil , Yossi Gross , Orly Grinberg , Itamar Weisman , Tehila Hyman , Boaz Hyman
IPC分类号： A61B5/1455 , A61B5/1459 , A61B5/145 , A61B5/00
CPC分类号： A61B5/1459 , A61B5/0071 , A61B5/14532
摘要： Apparatus is provided for detecting an analyte, configured to be implanted in a body of a subject. The apparatus includes an optical fiber having a distal portion and also a membrane permeable to the analyte. The membrane is coupled to the distal portion of the fiber and surrounding a sampling region at least in part, by being fitted over the distal portion of the fiber. Other embodiments are also described.
摘要翻译：提供了用于检测分析物的装置，其被配置为植入受试者的身体。该装置包括具有远端部分的光纤以及可分析物透过的膜。膜通过装配在纤维的远端部分上至少部分地耦合到纤维的远端部分并且围绕取样区域。还描述了其它实施例。

2. 发明申请

US20120059232A1 IMPLANTABLE OPTICAL GLUCOSE SENSING 审中-公开
标题翻译：可植入光学葡萄糖感测
公开(公告)号：US20120059232A1
公开(公告)日：2012-03-08
申请号：US13141936
申请日：2009-12-24
申请人： Yossi Gross , Tehila Hyman , Tamir Gil
发明人： Yossi Gross , Tehila Hyman , Tamir Gil
IPC分类号： A61B5/1455
CPC分类号： A61B5/1459 , A61B5/14532 , A61B5/14556 , A61B5/14558 , A61B5/686 , A61B5/6862
摘要： Apparatus is provided, including a support (21) configured to be implanted within a body of a subject and a sampling region (30, 1430) coupled to the support (21). The apparatus is configured to passively allow passage through the sampling region (30, 1430) of at least a portion of fluid from the subject. The apparatus also includes an optical measuring device in optical communication with the sampling region (30, 1430). The optical measuring device comprises at least one light source (40) configured to transmit light through at least a portion of the fluid, and at least one sensor (42) configured to measure a parameter of the fluid by detecting light passing through the fluid. Other applications are also described.
摘要翻译：提供了一种设备，包括被配置为植入受试者的身体内的支撑件（21）和联接到支撑件（21）的取样区域（30，1430）。该装置被配置为被动地允许通过来自受试者的至少一部分流体的取样区域（30,1430）。该装置还包括与采样区域（30,1430）光学通信的光学测量装置。所述光学测量装置包括被配置为透过至少一部分流体的光的至少一个光源（40）和被配置成通过检测穿过流体的光来测量流体参数的至少一个传感器（42）。还描述了其它应用。

3. 发明申请

US20100160749A1 IMPLANTABLE OPTICAL GLUCOSE SENSING 审中-公开
标题翻译：可植入光学葡萄糖感测
公开(公告)号：US20100160749A1
公开(公告)日：2010-06-24
申请号：US12344103
申请日：2008-12-24
申请人： Yossi GROSS , Tehila Hyman , Tamir Gil
发明人： Yossi GROSS , Tehila Hyman , Tamir Gil
IPC分类号： A61B5/1459
CPC分类号： A61B5/14532 , A61B5/14558 , A61B5/1459 , A61B5/6846
摘要： Apparatus is provided, including a support configured to be implanted within a body of a subject and a sampling region coupled to the support. The apparatus is configured to passively allow passage through the sampling region of at least a portion of fluid from the subject. The apparatus also comprises an optical measuring device in optical communication with the sampling region. The optical measuring device comprises at least one light source configured to transmit light through at least a portion of the fluid, and at least one sensor configured to measure a parameter of the fluid by detecting light passing through the fluid. Other embodiments are also described.
摘要翻译：提供了一种装置，包括被配置为植入受试者的身体内的支撑体和连接到支撑件的采样区域。该装置被配置为被动地允许通过来自受试者的至少一部分流体的采样区域。该装置还包括与采样区域光学通信的光学测量装置。所述光学测量装置包括至少一个光源，所述至少一个光源被配置为透过至少一部分所述流体的光;以及至少一个传感器，被配置为通过检测穿过所述流体的光来测量所述流体的参数。还描述了其它实施例。

4. 发明申请

US20090225277A1 Snapshot Spectral Imaging of the Eye 有权
标题翻译：快照光谱成像的眼睛
公开(公告)号：US20090225277A1
公开(公告)日：2009-09-10
申请号：US12398255
申请日：2009-03-05
申请人： Tamir Gil
发明人： Tamir Gil
IPC分类号： A61B3/14
CPC分类号： G01J3/0208 , A61B3/10 , A61B5/14555 , G01J3/02 , G01J3/0256 , G01J3/2823 , G01J3/36 , G01J2003/1213
摘要： Obtaining spectral images of an eye includes taking an optical system that images eye tissue onto a digital sensor array and optically fitting a multi-spectral filter array and the digital sensor array, wherein the multi-spectral filter array is disposed between the digital sensor array and an optics portion of the optical system. The resulting system facilitates acquisition of a snap-shot image of the eye tissue with the digital sensor array. The snap shot images support estimation of blood oxygen saturation in a retinal tissue. The resulting system can be based on a non-mydriatic fundus camera designed to obtain the retinal images without administration of pupil dilation drops.
摘要翻译：获得眼睛的光谱图像包括拍摄将眼睛组织成像到数字传感器阵列上的光学系统，以及光学拟合多光谱滤光器阵列和数字传感器阵列，其中多光谱滤光器阵列设置在数字传感器阵列和光学系统的光学部分。所得到的系统便于利用数字传感器阵列获取眼睛组织的快照图像。快照图像支持视网膜组织中血氧饱和度的估计。所得到的系统可以基于设计用于获得视网膜图像的非散瞳眼底照相机，而不施加瞳孔扩张液滴。

5. 发明授权

US08109634B2 Snapshot spectral imaging of the eye 有权
标题翻译：快照光谱成像的眼睛
公开(公告)号：US08109634B2
公开(公告)日：2012-02-07
申请号：US12398255
申请日：2009-03-05
申请人： Tamir Gil
发明人： Tamir Gil
IPC分类号： A61B3/14 , A61B3/10 , A61B3/00
CPC分类号： G01J3/0208 , A61B3/10 , A61B5/14555 , G01J3/02 , G01J3/0256 , G01J3/2823 , G01J3/36 , G01J2003/1213
摘要： Obtaining spectral images of an eye includes taking an optical system that images eye tissue onto a digital sensor array and optically fitting a multi-spectral filter array and the digital sensor array, wherein the multi-spectral filter array is disposed between the digital sensor array and an optics portion of the optical system. The resulting system facilitates acquisition of a snap-shot image of the eye tissue with the digital sensor array. The snap shot images support estimation of blood oxygen saturation in a retinal tissue. The resulting system can be based on a non-mydriatic fundus camera designed to obtain the retinal images without administration of pupil dilation drops.
摘要翻译：获得眼睛的光谱图像包括拍摄将眼睛组织成像到数字传感器阵列上的光学系统，以及光学拟合多光谱滤光器阵列和数字传感器阵列，其中多光谱滤光器阵列设置在数字传感器阵列和光学系统的光学部分。所得到的系统便于利用数字传感器阵列获取眼睛组织的快照图像。快照图像支持视网膜组织中血氧饱和度的估计。所得到的系统可以基于设计用于获得视网膜图像的非散瞳眼底照相机，而不施加瞳孔扩张液滴。

6. 发明申请

US20070159600A1 Transcleral opthalmic illumination method and system 审中-公开
标题翻译：经视眼光照射法和系统
公开(公告)号：US20070159600A1
公开(公告)日：2007-07-12
申请号：US10552269
申请日：2004-04-08
申请人： Tamir Gil , Oded Wigderson , Amit Sasson , Zvi Nizani
发明人： Tamir Gil , Oded Wigderson , Amit Sasson , Zvi Nizani
IPC分类号： A61B3/10
CPC分类号： A61B3/12 , A61B3/0008 , A61B3/13
摘要： A method and apparatus for illuminating the interior of the eye through the sclera without any contact to the eye. The apparatus contains a lamp element and optics that focus the light on the eye sclera. One or more fiber optics bundles may be used to convey the light from the light source close to the illuminated eye, ending with condensing optical elements. Alternatively, light could be conveyed by sharing the optics of an imaging system. It is useful for observing or imaging the interior of the eye, the retina, or the choroid. The observation or the imaging of the interior of the eye, the retina, or the choroid by applying the disclosed illumination method can be done in conjunction with any system that includes optics for that purpose, e.g., fundus cameras and ophthalmoscopes, without using those systems' illumination elements.
摘要翻译：一种用于通过巩膜照射眼睛内部而不与眼睛接触的方法和装置。该装置包括将光聚焦在眼睛巩膜上的灯元件和光学元件。可以使用一个或多个光纤束来将来自光源的光传递到靠近被照射的眼睛，以聚光光学元件结束。或者，可以通过共享成像系统的光学器件来传送光。用于观察或成像眼睛，视网膜或脉络膜的内部。通过应用所公开的照明方法对眼睛，视网膜或脉络膜内部的观察或成像可以结合包括用于该目的的光学系统的任何系统，例如眼底照相机和眼镜，而不使用这些系统 '照明元素。

7. 发明申请

US20060268231A1 Illumination method and system for obtaining color images by transcleral ophthalmic illumination 审中-公开
标题翻译：照明方法和系统通过超声眼科照明获得彩色图像
公开(公告)号：US20060268231A1
公开(公告)日：2006-11-30
申请号：US10563293
申请日：2004-07-02
申请人： Tamir Gil , Oded Wigderson , Amit Sasson , Dan Laor
发明人： Tamir Gil , Oded Wigderson , Amit Sasson , Dan Laor
IPC分类号： A61B3/10
CPC分类号： A61B3/135 , A61B3/12 , A61B3/14 , G02B26/008 , G02B26/023 , G02B27/1006 , G02B27/1046 , G02B27/144 , G02B27/145 , G02B27/149
摘要： An illumination system for fundus imaging apparatus employing transcleral illumination of the interior of the eye. Color images of the interior of the eye are obtained by illuminating the sclera successively with red, yellow and green light. Those images are then treated as red, green and blue images by a post processing unit, which combines them to give a color image. This is useful for observing or imaging the interior of the eye, the retina, or the choroid. The observation or the imaging of the interior of the eye, the retina, or the choroid by applying the disclosed illumination method can be performed in conjunction with any system that includes optics for that purpose.
摘要翻译：一种用于眼底成像装置的照明系统，其采用眼睛内部的透射照明。通过依次用红色，黄色和绿色光照射巩膜获得眼睛内部的彩色图像。然后这些图像由后处理单元处理为红色，绿色和蓝色图像，其组合它们以给出彩色图像。这对于观察或成像眼睛，视网膜或脉络膜的内部是有用的。通过应用所公开的照明方法来观察眼睛，视网膜或脉络膜内部的成像可以结合包括用于该目的的光学系统的任何系统来执行。

8. 发明授权

US06276798B1 Spectral bio-imaging of the eye 失效
标题翻译：眼睛的光谱生物成像
公开(公告)号：US06276798B1
公开(公告)日：2001-08-21
申请号：US09307569
申请日：1999-05-10
申请人： Tamir Gil , Dario Cabib , Mike Adel , Robert A. Buckwald , Eli Horn
发明人： Tamir Gil , Dario Cabib , Mike Adel , Robert A. Buckwald , Eli Horn
IPC分类号： A61B314
CPC分类号： A61B5/14546 , A61B3/10 , A61B5/0059 , A61B5/0066 , A61B5/0275 , A61B5/1455 , A61B5/14555 , A61B5/411 , A61B5/7257 , G01J3/2823 , G01J3/4406 , G01J3/462 , G01J3/502 , G01J3/51 , G01J2003/467
摘要： A spectral bio-imaging method for enhancing pathologic, physiologic, metabolic and health related spectral signatures of an eye tissue, the method comprising the steps of (a) providing an optical device for eye inspection being optically connected to a spectral imager; (b) illuminating the eye tissue with light via the iris, viewing the eye tissue through the optical device and spectral imager and obtaining a spectrum of light for each pixel of the eye tissue; and (c) attributing each of the pixels a color or intensity according to its spectral signature, thereby providing an image enhancing the spectral signatures of the eye tissue.
摘要翻译：一种用于增强眼组织的病理，生理，代谢和健康相关光谱特征的光谱生物成像方法，所述方法包括以下步骤：（a）提供用于眼睛检查的光学装置，光学连接到光谱成像器; （b）通过光圈照射眼组织，通过光学装置和光谱成像器观察眼组织，并为眼组织的每个像素获得光谱; 和（c）根据其光谱特征将每个像素归为颜色或强度，由此提供增强眼组织的光谱特征的图像。

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