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1. 发明授权

US5980941A Self-binding shearform compositions 失效
标题翻译：自结合剪切组合物
公开(公告)号：US5980941A
公开(公告)日：1999-11-09
申请号：US99847
申请日：1998-06-19
申请人： Michael G. Raiden , Pradeepkumar P. Sanghvi , Tushar K. Misra , Jeffrey W. Currington , Satish V. Kamath
发明人： Michael G. Raiden , Pradeepkumar P. Sanghvi , Tushar K. Misra , Jeffrey W. Currington , Satish V. Kamath
IPC分类号： A61K9/14 , A61K9/00 , A61K9/20 , A61K31/167 , A61K31/192 , A61K31/60 , A61K47/10 , A61K47/26
CPC分类号： A61K9/2077 , A61K9/2018 , A61K9/0056
摘要： A self-binding, glycerine-free tablettable composition has a saccharide carrier and the sugar alcohols sorbitol and xylitol.
摘要翻译：自结合的，不含甘油的可食用组合物具有糖载体和糖醇山梨糖醇和木糖醇。

2. 发明授权

US5976603A Fiber and vitamin-fortified drink composition and beverage and method of making 失效
标题翻译：纤维和维生素强化饮料组合物和饮料及其制作方法
公开(公告)号：US5976603A
公开(公告)日：1999-11-02
申请号：US140380
申请日：1998-08-26
申请人： Suresh B. Kota , Bei Zhang , Tommy Chau , Robert K. Yang , Subraman R. Cherukuri , Abhijit Banerjee
发明人： Suresh B. Kota , Bei Zhang , Tommy Chau , Robert K. Yang , Subraman R. Cherukuri , Abhijit Banerjee
IPC分类号： A23L1/308 , A23L2/395 , A23L2/52 , A23L2/00
CPC分类号： A23L2/52 , A23L2/395 , A23L33/21
摘要： A beverage composition has a source of fiber, as well as one or more additional nutrients. The composition is in the form of a shearform matrix as a result of flash-flow processing. The beverage composition is highly storage stable.
摘要翻译：饮料组合物具有纤维源，以及一种或多种另外的营养物质。作为闪蒸流程处理的结果，组合物为剪切形式的形式。饮料组合物高度贮存稳定。

3. 发明授权

US5891845A Drug delivery systems utilizing liquid crystal structures 失效
标题翻译：使用液晶结构的药物输送系统
公开(公告)号：US5891845A
公开(公告)日：1999-04-06
申请号：US975827
申请日：1997-11-21
申请人： Garry Myers
发明人： Garry Myers
IPC分类号： A61K47/34 , A61K9/00 , A61K9/127 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/355 , A61K31/455 , A61K31/554 , A61K38/00 , A61K38/13 , A61K31/44 , A61K31/55
CPC分类号： A61K9/146 , A61K31/355 , A61K38/13 , A61K9/1274 , A61K9/0092 , A61K9/2013 , A61K9/2072 , A61K9/4858
摘要： Vitamin E TPGS/drug compositions and methods are provided which obviate the need for surfactants or non-evaporated co-solvents because the active drug component is dissolved directly into Vitamin E TPGS to form a true molecular solution--not an emulsion or a micro-emulsion. The invention provides a slowly dissolving TPGS/Drug matrix that absorbs gastrointestinal fluid into the matrix at the dosage form/fluid interface, where a gel-like liquid crystal is formed. This gel front forms a liquid crystal boundary where drug dissolution is highest. At this liquid crystal/GI fluid boundary, a synchronization takes place in which the rate of formation of liquid crystals equals the dissolution rate of liquid crystals at the water interface, thereby giving controlled order release of the drug into the GI tract. The rate of dissolution is also controlled by the geometry of the dosage form. The solid Vitamin E TPGS/drug matrices of the invention can be solidified and compressed into tablets or filled into capsules, with other excipients, binders and/or fillers. The solid TPGS/drug solution of the invention also can be made into an immediate release liquid formulation upon addition of water, or into a controlled release system solid tablet by the use of impermeable or semi-permeable barriers or coatings surrounding portions of the tablet.
摘要翻译：提供维生素E TPGS /药物组合物和方法，其消除了对表面活性剂或非蒸发共溶剂的需要，因为活性药物组分直接溶解于维生素E TPGS中以形成真正的分子溶液 - 而不是乳液或微乳液。本发明提供了缓慢溶解的TPGS /药物基质，其在形成凝胶状液晶的剂型/流体界面处将胃肠液吸收到基质中。该凝胶前体形成药物溶出度最高的液晶边界。在该液晶/ GI液体边界处，发生液晶的形成速率等于水界面处的液晶的溶解速率的同步，从而将药物控制释放到GI道中。溶解速率也可以通过剂型的几何形状来控制。本发明的固体维生素E TPGS /药物基质可以固化并压制成片剂或者与其它赋形剂，粘合剂和/或填充剂一起填充到胶囊中。本发明的固体TPGS /药物溶液还可以通过加入水制成立即释放的液体制剂，或通过使用围绕片剂部分的不渗透的或半渗透的屏障或涂层，进入控释系统的固体片剂。

4. 发明授权

US5851555A Controlled release dosage forms containing water soluble drugs 失效
标题翻译：含有水溶性药物的控释剂型
公开(公告)号：US5851555A
公开(公告)日：1998-12-22
申请号：US914339
申请日：1997-08-15
申请人： Pradeepkumar P. Sanghvi , Tushar K. Misra , David V. Prior
发明人： Pradeepkumar P. Sanghvi , Tushar K. Misra , David V. Prior
IPC分类号： A61K9/16 , A61K9/20 , A61K9/22 , A61K9/26 , A61K31/34
CPC分类号： A61K9/2077 , A61K9/1617 , A61K9/1652
摘要： Controlled release dosage units containing water soluble active agents can be made using an active agent, an optional inert carrier, a cellulosic polymer and a lipophilic ingredient.
摘要翻译：可以使用活性剂，任选的惰性载体，纤维素聚合物和亲脂性成分制备含有水溶性活性剂的控释剂量单位。

5. 发明授权

US5851553A Process and apparatus for making rapidly dissolving dosage units and product therefrom 失效
公开(公告)号：US5851553A
公开(公告)日：1998-12-22
申请号：US772024
申请日：1996-12-19
申请人： Garry L. Myers , Gerald E. Battist , Richard C. Fuisz
发明人： Garry L. Myers , Gerald E. Battist , Richard C. Fuisz
IPC分类号： A23G3/00 , A23G3/10 , A23G3/34 , A23G3/36 , A61K9/00 , A61K9/20 , A61K9/70 , C13B30/02 , A61K9/22
CPC分类号： A23G3/10 , A23G3/346 , A23G3/368 , A61K9/0056 , A61K9/2018 , A61K9/2095 , A61K9/70 , C13B30/021 , C13B50/00 , A23G2200/06 , A61F2013/0296 , Y10S514/96
摘要： The present invention is a method of preparing rapidly dissolving comestible units such as tablets. The present invention also includes an apparatus for making the comestible units and the units themselves. The product prepared in accordance with the present invention can include active ingredients and is capable of dissolving in the mouth of the consumer within several seconds. The unit dosage forms prepared in accordance with the present invention are particularly useful as antacids and as a delivery vehicle for biologically active ingredients, especially those which are ideally combined with antacid ingredients in order to ameliorate the effects of antacid environment.

6. 发明授权

US5840334A Self-binding shearform compositions 失效
标题翻译：自结合剪切组合物
公开(公告)号：US5840334A
公开(公告)日：1998-11-24
申请号：US915068
申请日：1997-08-20
申请人： Michael G. Raiden , Pradeepkumar P. Sanghvi , Tushar K. Misra , Jeffery W. Currington , Satish V. Kamath , Mahendra Govind Pankhania
发明人： Michael G. Raiden , Pradeepkumar P. Sanghvi , Tushar K. Misra , Jeffery W. Currington , Satish V. Kamath , Mahendra Govind Pankhania
IPC分类号： A61K9/00 , A61K9/20
CPC分类号： A61K9/2077 , A61K9/2018 , A61K9/0056
摘要： Shearform compositions made without added glycerine are disclosed. The compositions are self-binding and exhibit excellent cohesivity when used in tableting compositions. Typically, xylitol is incorporated into a feedstock which is flash-flow processed to form a self-binding shearform matrix.
摘要翻译：公开了没有添加甘油制备的纱布组合物。当用于压片组合物时，组合物是自粘结的并且表现出优异的粘结性。通常，将木糖醇并入进料中，其被快速流动加工以形成自结合剪切形式的基质。

7. 发明授权

US5833071A Puncturable entry-resistant package for low density tablets 失效
标题翻译：针对低密度片剂的可穿刺入口包装
公开(公告)号：US5833071A
公开(公告)日：1998-11-10
申请号：US887429
申请日：1997-07-02
申请人： Thomas O. Ray
发明人： Thomas O. Ray
IPC分类号： B65D75/32 , B65D75/34 , B65D83/04
CPC分类号： B65D75/327 , B65D2575/3218 , B65D2575/3245
摘要： A child resistant tablet package accommodates low density pharmaceutical tablets. The package includes a blister tray having a planar surface and a plurality of spaced apart open ended tablet accommodating first blister depressions formed therein. A plurality of entry facilitating second blister depressions are provided on the planar surface spaced adjacent each first blister depression. A planar lid is removably sealed over the planar surface of the blister tray and includes portions overlying disposed over the first and second blister depressions. The lid is puncturable through the plane of the lid at a location over the second blister depressions so as to facilitate removal of portions of the lid overlying the first blister depressions so as to expose the tablets for dispensing.
摘要翻译：抗小孩片剂包装适合低密度药物片剂。该包装包括具有平坦表面的泡罩托盘和容纳形成在其中的第一泡罩凹部的多个间隔开口的片剂。在与每个第一泡罩凹陷相邻的平面上设有多个促进第二泡泡凹陷的入口。平面盖可移除地密封在泡罩托盘的平坦表面上，并且包括覆盖在第一和第二泡罩凹陷上的部分。盖子可以穿过盖子的平面穿过第二泡罩凹陷处的位置，从而有助于移除覆盖在第一泡罩凹部上的盖子的部分，以便露出用于分配的片剂。

8. 发明授权

US5811123A Method of treating mucosal tissue 失效
标题翻译：治疗粘膜组织的方法
公开(公告)号：US5811123A
公开(公告)日：1998-09-22
申请号：US465974
申请日：1995-06-06
申请人： Richard C. Fuisz
发明人： Richard C. Fuisz
IPC分类号： A61K9/00 , A61K9/16 , A61K9/22 , A61K9/70 , A61K31/192 , A61K31/341 , A61K31/415 , A61K31/4164 , A61K31/426 , A61K31/4439 , A61K31/70 , A61K47/36 , A61P1/04 , A61K9/10 , A61K9/14
CPC分类号： A61K31/616 , A61K31/192 , A61K31/341 , A61K31/415 , A61K31/4164 , A61K31/426 , A61K31/4439 , A61K31/70 , A61K31/7135 , A61K9/1652 , A61K9/70 , Y10S514/925
摘要： Anti-ulcer compositions are disclosed having therapeutic agents dispersed in a soluble matrix formed by melt spinning the therapeutic agent with a carrier and hydrogel. Methods of treating mucosal ulcer-bearing tissue and preparing the matrix are also disclosed. One embodiment includes use of gastric irritating bio-affecting agents in which case the composition is preventative as well as therapeutic.
摘要翻译：公开了抗溃疡组合物，其具有分散在通过用载体和水凝胶熔化纺丝治疗剂而形成的可溶性基质中的治疗剂。还公开了治疗粘膜溃疡组织和制备基质的方法。一个实施方案包括使用胃刺激性生物影响剂，在这种情况下，组合物是预防性和治疗性的。

9. 发明授权

US5726161A Porous particle aggregate and method therefor 失效
标题翻译：多孔粒子聚集体及其方法
公开(公告)号：US5726161A
公开(公告)日：1998-03-10
申请号：US416741
申请日：1996-07-12
申请人： Roy L. Whistler
发明人： Roy L. Whistler
IPC分类号： A23G4/00 , A01N25/12 , A23L1/00 , A23L1/0522 , A23L1/0526 , A23L1/0528 , A23L1/0534 , A23L1/0562 , A61K8/04 , A61K8/92 , A61K9/16 , A61K9/50 , A61K47/36 , A61Q11/00 , B29C67/20 , C08B31/00 , C08B37/02 , C08B37/16 , C08J9/35 , C08L1/26 , C08L3/02 , C08L5/04 , C08L5/14 , C08L89/06 , A61K31/715 , A01N43/04 , C07H1/00 , C08B30/00
CPC分类号： C08J9/35 , A01N25/12 , A23L29/212 , A23L29/238 , A23L29/244 , A23L29/262 , A23L29/284 , A23P10/20 , A23P10/22 , A61K8/0275 , A61K8/922 , A61K9/1652 , A61K9/5047 , A61Q11/00 , B29C67/202 , B29C67/205 , C08L3/02 , A61K2800/56 , C08J2303/02 , C08L1/26 , C08L5/04 , C08L5/14 , C08L89/06
摘要： The invention deals with porous aggregates and a process for making same. The aggregates generally comprise discrete particles which are bound together, the aggregates having intra-aggregate volumes which may contain drug substances or other functional substances.
摘要翻译： PCT No.PCT / US95 / 00707 Sec。 371日期：1996年7月12日 102（e）日期1996年7月12日PCT提交1995年1月17日PCT公布。公开号WO95 / 19376 日期1995年7月20日本发明涉及多孔骨料及其制造方法。聚集体通常包含结合在一起的离散颗粒，所述聚集体具有可能含有药物物质或其它功能性物质的总体积。

10. 发明授权

US5582855A Flash flow formed solloid delivery systems 失效
公开(公告)号：US5582855A
公开(公告)日：1996-12-10
申请号：US269679
申请日：1994-07-01
申请人： Subraman R. Cherukuri , Gerald E. Battist , James H. Perkins
发明人： Subraman R. Cherukuri , Gerald E. Battist , James H. Perkins
IPC分类号： A23G4/00 , A23G4/20 , A23L1/00 , A23L1/0534 , A23L1/22 , A23L1/221 , A23P1/00 , A23P1/06 , A61K8/04 , A61K9/16 , A61Q11/00 , A23G3/30
CPC分类号： A23G4/20 , A23L27/70 , A23L27/80 , A23L29/262 , A23P10/25 , A61K8/025 , A61K9/1617 , A61K9/1652 , A61K9/1694 , A61Q11/00
摘要： Discrete entities of a solid suspension are made from a solid fat matrix and a non-fat solid substrate having an active associated with said substrate. These entities are spheroidal in shape, have uniform size and substantially the same active content due to the flash flow process used to make them. They are especially useful as delivery systems for comestibles, pharmaceuticals and personal products.

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