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1. 发明授权

US5602104A Polycyclic aromatic derivatives, process for preparing the same and pharmaceutical and cosmetic compositions containing the same 失效
标题翻译：多环芳族衍生物，其制备方法和含有该多环芳族衍生物的药物和化妆品组合物
公开(公告)号：US5602104A
公开(公告)日：1997-02-11
申请号：US421235
申请日：1995-04-13
申请人： Braham Shroot , Jacques Eustache , Oliver Watts , Jean-Michel Bernardon , Philippe Nedoncelle
发明人： Braham Shroot , Jacques Eustache , Oliver Watts , Jean-Michel Bernardon , Philippe Nedoncelle
IPC分类号： C07C43/23 , A61K8/00 , A61K8/30 , A61K8/34 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/41 , A61K8/42 , A61K8/49 , A61K31/045 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/235 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/38 , A61K31/381 , A61P17/00 , A61P27/02 , A61P43/00 , A61Q5/02 , C07C27/00 , C07C29/147 , C07C33/18 , C07C33/34 , C07C41/30 , C07C43/303 , C07C45/00 , C07C47/52 , C07C51/00 , C07C63/331 , C07C63/49 , C07C65/24 , C07C65/26 , C07C67/00 , C07C69/76 , C07C69/94 , C07C233/65 , C07C233/68 , C07C235/42 , C07D307/42 , C07D307/68 , C07D311/92 , C07D319/06 , C07D333/38 , C07H13/08 , C07H13/10 , A01N43/08 , C07D307/02 , C07D333/16
CPC分类号： C07C65/24 , C07C63/331 , C07C63/49 , C07D307/68 , C07D311/92 , C07D333/38 , Y10S514/844 , Y10S514/859 , Y10S514/863 , Y10S514/864 , Y10S514/886
摘要： A polycyclic aromatic compound having the formula ##STR1## and its salts have useful therapeutic and cosmetic action particularly in psoriasis. In the formula,X represents --CH.dbd.CH--, O or S,R.sub.1 represents hydrogen, branched alkyl having 3-15 carbon atoms, alkoxy having 1-6 carbon atoms or 1-adamantyl, R.sub.2 represents hydroxy, hydrogen, linear or branched alkyl having 1-15 carbon atoms Or alkoxy having 1-6 carbon atoms, with the proviso that R.sub.1 and R.sub.2 are not simultaneously hydrogen, or R.sub.1 and R.sub.2 together with the adjacent carbon atoms of the naphthalene ring form a 5 or 6 chain ring optionally substituted by at least one lower alkyl radical, or interrupted by an oxygen atom,R.sub.3 represents --CH.sub.2 OH or --COR.sub.4, or --CH.sub.3 when R.sub.1 and R.sub.2 taken together form a 5 or 6 chain ring,R.sub.4 represents --OR.sub.5 or ##STR2## R.sub.5 represents hydrogen, alkyl having 1-20 carbon atoms, monohydroxyalkyl, polyhydroxyalkyl, aryl or aralkyl optionally substituted, or the residue of a sugar or the radical ##STR3## p is 1, 2 or 3, r' and r" represent hydrogen, lower alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl optionally substituted or the residue of an amino acid or the residue of an amino sugar, or taken together form a heterocycle.
摘要翻译：具有式（I）的多环芳族化合物及其盐具有有用的治疗和美容作用，特别是在牛皮癣中。在该式中，X表示-CH = CH-，O或S，R 1表示氢，具有3-15个碳原子的支链烷基，具有1-6个碳原子的烷氧基或1-金刚烷基，R2表示羟基，氢，直链或支链具有1-15个碳原子的烷基或具有1-6个碳原子的烷氧基，条件是R1和R2不同时为氢，或者R1和R2与萘环的相邻碳原子一起形成5或6个链环，被至少一个低级烷基取代或被氧原子中断时，R 3表示-CH 2 OH或-COR 4，或者当R 1和R 2一起形成5或6个环时为-CH 3，R 4表示-OR 5或R 5 表示氢，具有1-20个碳原子的烷基，单羟基烷基，多羟基烷基，任选取代的芳基或芳烷基，或糖或基团的残基p是1,2或3，r'和r“表示氢，低级烷基，单羟基烷基，多羟基烷基，任选取代的芳基或氨基酸的残基o r氨基糖的残基，或一起形成杂环。

2. 发明授权

US5468897A Bi-aromatic esters, a process for their preparation and their use in human or veterinary medicine and in cosmetic compositions 失效
标题翻译：双芳族酯，其制备方法及其在人或兽医学和化妆品组合物中的应用
公开(公告)号：US5468897A
公开(公告)日：1995-11-21
申请号：US237991
申请日：1994-05-04
申请人： Braham Shroot , Jean-Michel Bernardon , William R. Pilgrim
发明人： Braham Shroot , Jean-Michel Bernardon , William R. Pilgrim
IPC分类号： A61K31/235 , A61K8/00 , A61K8/30 , A61K8/33 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/46 , A61K8/49 , A61P11/00 , A61P17/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61Q5/00 , A61Q19/00 , C07C67/14 , C07C69/00 , C07C69/76 , C07C69/773 , C07C69/78 , C07C69/88 , C07C69/94 , C07C309/42 , C07C309/58 , C07C311/29 , C07C317/22 , C07C317/44 , C07C323/62 , C07C321/00
CPC分类号： C07C323/62 , C07C69/94 , C07C2103/74
摘要： Bi-aromatic esters have the formula ##STR1## wherein R.sub.1 represents H, OH, --CH.sub.3, --CH.sub.2 OH, --CH(OH)CH.sub.3, --COOR.sub.9, ##STR2## or SO.sub.2 R.sub.10 ; R.sub.9 represents H, C.sub.1 -C.sub.6 alkyl or mono or polyhydroxyalkyl; R.sub.10 represents OH, C.sub.1 -C.sub.6 alkyl or ##STR3## r' and r" represent H, C.sub.1 -C.sub.6 alkyl, aryl, aralkyl, mono or polyhydroxyalkyl, or r' and r" taken together form a heterocycle; R.sub.2 represents H, C.sub.1 -C.sub.6 alkyl, OR.sub.9, F or --CF.sub.3 ; R.sub.3, R.sub.4 and R.sub.5 represent H, F, OH, --CH.sub.3, --OCH.sub.3, --CF.sub.3, --COOH or --CH.sub.2 OH; R.sub.6 and R.sub.8 represent H, .alpha.-substituted C.sub.3 -C.sub.15 alkyl, .alpha., .alpha.'-disubstituted C.sub.4 -C.sub.12 alkyl, C.sub.3 -C.sub.12 cycloalkyl, C.sub.5 -C.sub.12 mono or polycyclic cycloalkyl whose linking carbon is trisubstituted, --SR.sub.11, --SO.sub.2 R.sub.11 or --SOR.sub.11 ; R.sub.11 represents C.sub.1 -C.sub.6 alkyl or cycloalkyl; R.sub.6 and R.sub.8 cannot simultaneously represent H; R.sub.7 represents H, C.sub.1 -C.sub.6 alkyl, alkenyl, alkenyloxy, OR.sub.12 or SR.sub.13 ; R.sub.12 represents H, C.sub.1 -C.sub.6 alkyl or alkenyl; R.sub.3 represents H, C1-C.sub.6 alkyl or aralkyl; with the proviso that when R.sub.1 represents ##STR4## and R.sub.2 represents H then: (i) either R.sub.3 and R.sub.4 are other than H or --CH.sub.3, (ii) or R.sub.7 is other than OR.sub.12 and R.sub.6 or R.sub.8 is cycloalkyl having more than 7 carbon atoms, (iii) or R.sub.7 is OR.sub.12 but R.sub.6 and R.sub.8 are other than H, (iv) or R.sub.7 is OR.sub.12 but R.sub.5 is other than H.The bi-aromatic esters are employed in human and veterinary medicine and in cosmetic compositions.
摘要翻译：双芳族酯具有式（I）其中R 1表示H，OH，-CH 3，-CH 2 OH，-CH（OH）CH 3，-COOR 9，或SO 2 R 10; R9表示H，C1-C6烷基或单或多羟基烷基; R 10表示OH，C 1 -C 6烷基或R 3'，R“表示H，C 1 -C 6烷基，芳基，芳烷基，单或多羟基烷基，或r'和r”一起形成杂环; R 2表示H，C 1 -C 6烷基，OR 9，F或-CF 3; R3，R4和R5表示H，F，OH，-CH3，-OCH3，-CF3，-COOH或-CH2OH; R 6和R 8表示H，α-取代的C 3 -C 15烷基，α，α'-二取代的C 4 -C 12烷基，C 3 -C 12环烷基，连接碳是三取代的C 5 -C 12单环或多环环烷基，-SR 11，-SO 2 R 11或 - SOR11; R11表示C1-C6烷基或环烷基; R6和R8不能同时代表H; R7表示H，C1-C6烷基，烯基，烯氧基，OR12或SR13; R12表示H，C1-C6烷基或烯基; R3表示H，C1-C6烷基或芳烷基; 条件是当R1表示且R2表示H时：（i）R3和R4不是H或-CH3，（ii）或R7不是OR12，R6或R8是大于7的环烷基碳原子，（iii）或R7是OR12，但R6和R8不是H，（iv）或R7是OR12，但R5不是H.双芳族酯用于人类和兽医学和化妆品组合物中。

3. 发明授权

US5446059A Benzimidazole-derived compounds, method for preparing the same, and therapeutical and cosmetic uses thereof 失效
标题翻译：衍生自苯并咪唑的化合物，其制备方法及其治疗和美容用途
公开(公告)号：US5446059A
公开(公告)日：1995-08-29
申请号：US142464
申请日：1994-01-10
申请人： Jean-Philippe Rocher , Daniel Cavey
发明人： Jean-Philippe Rocher , Daniel Cavey
IPC分类号： A61K8/49 , A61K8/00 , A61K8/11 , A61K31/415 , A61K31/4184 , A61P29/00 , A61P37/08 , A61Q17/00 , A61Q19/00 , A61Q19/10 , C07D235/12 , C07D235/18 , C07F9/6506
CPC分类号： C07F9/65068 , A61K8/4946 , A61Q19/00 , C07D235/18
摘要： Benzimidazole derivatives having general formula (I), wherein R.sub.1 and R.sub.2 are a hydrogen atom, a lower alkyl radical, an OR.sub.4 radical, a lower fluoroalkyl radical or a halogen atom; R.sub.3 is a hydrogen atom, a lower alkyl radical, a halogen, a hydroxyl or a lower alkoxy radical having 1-6 carbon atoms; R.sub.4 is a hydrogen atom, a lower alkyl radical, a benzyl radical or a (II) radical, PO.sub.3 H, SO.sub.3 H or an aminoacid residue; R.sub.7 is a lower alkyl radical, a lower alkoxy radical having 1-6 carbon atoms, a --(CH.sub.2).sub.n --COOH radical where n=1-6, or the radical (III), where r' and r" are a hydrogen atom or a lower alkyl radical, or form, together with the nitrogen atom, a 5 or 6-membered heterocyclic ring optionally interrupted by a heteroatom; R.sub.5 and R.sub.6 are different and represent the OR.sub.8 radical or a mono or polycyclic cycloalkyl radical having 5-12 carbon atoms bound to the phenyl core by a tertiary carbon; R.sub.8 is a hydrogen atom, a lower alkyl radical, an acyl radical having 2-7 carbon atoms, a benzyl radical optionally substituted by one or more halogen atoms, or a benzoyl radical; and salts of said compounds obtained by adding a pharmaceutically acceptable acid or base. Said compounds may be used therapeutically, in particular in relation to inflammatory and/or immunoallergic conditions, and cosmetically to provide body and hair care.
摘要翻译： PCT No.PCT / FR92 / 00482 Sec。 371日期1994年1月10日 102（e）日期1994年1月10日PCT提交1992年5月29日PCT公布。 WO92 / 21663 PCT出版物 1992年12月10日授权。具有通式（I）的苯并咪唑衍生物，其中R1和R2为氢原子，低级烷基，OR4基，低级氟代烷基或卤素原子。 R3是氢原子，低级烷基，卤素，羟基或具有1-6个碳原子的低级烷氧基; R4是氢原子，低级烷基，苄基或（Ⅱ）基，PO3H，SO3H或氨基酸残基; R7是低级烷基，具有1-6个碳原子的低级烷氧基，其中n = 1-6的 - （CH2）n-COOH基团或基团（III），其中r'和r“是氢原子或低级烷基，或与氮原子一起形成任选被杂原子间隔的5或6元杂环; R5和R6不同，代表OR8基团或具有5-12个碳原子的单或多环环烷基，其通过叔碳与苯基键合; R8是氢原子，低级烷基，具有2-7个碳原子的酰基，任选被一个或多个卤素原子取代的苄基或苯甲酰基; 和通过加入药学上可接受的酸或碱获得的所述化合物的盐。所述化合物可以在治疗上，特别是关于炎性和/或免疫过敏性病症，以及美容方面用于提供身体和头发护理。

4. 发明授权

US5597839A Di(aromatic) compounds and their use in human and veterinary medicine and in cosmetics 失效
标题翻译：二（芳香族）化合物及其在人兽药和化妆品中的应用
公开(公告)号：US5597839A
公开(公告)日：1997-01-28
申请号：US430615
申请日：1995-04-28
申请人： Jean-Michel Bernardon , William R. Pilgrim
发明人： Jean-Michel Bernardon , William R. Pilgrim
IPC分类号： A61K8/30 , A61K8/00 , A61K8/33 , A61K8/35 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/67 , A61K31/135 , A61K31/165 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/235 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61P11/00 , A61P17/00 , A61P27/02 , A61P29/00 , A61Q5/00 , A61Q19/00 , C07C49/788 , C07C49/84 , C07C69/00 , C07C69/614 , C07C69/732 , C07C69/738 , C07C69/76 , C07C69/767 , C07C69/773 , C07C69/78 , C07C69/80 , C07C69/84 , C07C69/86 , C07C69/88 , C07C69/92 , C07C69/94 , C07C69/96 , C07C233/55 , C07C233/65 , C07C233/75 , C07C233/76 , C07C233/77 , C07C233/87 , C07C235/38 , C07C235/42 , C07C235/52 , C07C235/60 , C07C235/78 , C07C271/56 , C07C271/58 , C07C275/42 , C07C327/20 , C07C327/26 , C07C327/32 , C07D295/192 , C07D307/68 , C07D333/38 , C07D333/40
CPC分类号： C07D333/38 , A61K8/368 , A61K8/37 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/4913 , A61K8/4986 , A61K8/671 , A61Q19/00 , A61Q5/00 , C07C233/55 , C07C233/87 , C07C235/38 , C07C235/42 , C07C235/60 , C07C235/78 , C07C271/58 , C07C275/42 , C07C327/26 , C07C327/32 , C07C69/76 , C07C69/86 , C07C69/88 , C07C69/92 , C07C69/96 , C07D295/192 , C07C2102/10 , C07C2103/74 , Y10S514/859 , Y10S514/861 , Y10S514/863
摘要： Di(aromatic) compounds corresponding to the following formula: ##STR1## in which: Ar represents either ##STR2## X represents a divalent radical, Z represents O, S or a divalent radical,and R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 represent a hydrogen atom or various organic radicals, and the salts of the compounds of formula (I) when R.sub.1 is a carboxylic acid function.Use in human and veterinary medicine and in cosmetics.
摘要翻译：对应于下式的二（芳香族）化合物：其中：Ar表示二价基团，Z表示O，S或二价基，R 1，R 2，R 3，R 4和R 5表示氢原子或各种有机基团，R 1为羧酸官能团时，式（I）化合物的盐。用于人兽药和化妆品。

5. 发明授权

US5587367A Pharmaceutical or cosmetic composition containing a combination of a retinoid and a sterol 失效
标题翻译：含有类视色素和甾醇的组合的药物或化妆品组合物
公开(公告)号：US5587367A
公开(公告)日：1996-12-24
申请号：US447776
申请日：1995-05-23
申请人： Uwe Reichert , Rainer Schmidt , Braham Shroot
发明人： Uwe Reichert , Rainer Schmidt , Braham Shroot
IPC分类号： A61K8/30 , A61K8/00 , A61K8/33 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/41 , A61K8/42 , A61K8/43 , A61K8/46 , A61K8/49 , A61K8/63 , A61K8/67 , A61K31/19 , A61K31/20 , A61K31/56 , A61K31/575 , A61P3/06 , A61P17/00 , A61P17/02 , A61P17/08 , A61P43/00 , A61Q11/00 , A61Q19/00 , A61Q19/08 , A61K31/44 , A61K31/38 , A61K31/415
CPC分类号： A61Q19/08 , A61K31/575 , A61K8/63 , A61K8/671 , A61Q19/00 , A61K2800/59
摘要： A pharmaceutical or cosmetic composition is disclosed comprising in combination a retinoid and a sterol capable of inhibiting the biosynthesis of cholesterol resulting in a synergistic effect in the treatment of disorders of epidermic keratinization, proliferation and/or sebaceous function.
摘要翻译：公开了药物或化妆品组合物，其组合包含能够抑制胆固醇生物合成的类视色素和固醇，从而在治疗表皮角质化，增殖和/或皮脂腺功能紊乱方面具有协同效应。

6. 发明授权

US5556844A Pharmaceutical or cosmetic composition containing a combination of a retinoid and a sterol 失效
标题翻译：含有类视色素和甾醇的组合的药物或化妆品组合物
公开(公告)号：US5556844A
公开(公告)日：1996-09-17
申请号：US962596
申请日：1993-03-02
申请人： Uwe Reichert , Rainer Schmidt , Braham Shroot
发明人： Uwe Reichert , Rainer Schmidt , Braham Shroot
IPC分类号： A61K8/30 , A61K8/00 , A61K8/33 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/41 , A61K8/42 , A61K8/43 , A61K8/46 , A61K8/49 , A61K8/63 , A61K8/67 , A61K31/19 , A61K31/20 , A61K31/56 , A61K31/575 , A61P3/06 , A61P17/00 , A61P17/02 , A61P17/08 , A61P43/00 , A61Q11/00 , A61Q19/00 , A61Q19/08 , A61K31/07 , A61K31/235
CPC分类号： A61Q19/08 , A61K31/575 , A61K8/63 , A61K8/671 , A61Q19/00 , A61K2800/59
摘要： A pharmaceutical or cosmetic composition comprising in combination, a retinoid and a sterol inhibits the biosynthesis of cholesterol, is disclosed wherein a synergistic effect, principally in the treatment of disorders of epidermic keratinization, disorders of epidermic or epithelial proliferation and/or disorders of sebaceous function, is exhibited.
摘要翻译： PCT No.PCT / FR91 / 00526 Sec。 371日期1993年3月2日 102（e）1993年3月2日PCT PCT 1991年7月2日PCT公布。第WO92 / 00076号公报日期1992年1月9日公开了包含组合类视黄醇和固醇的药物或化妆品组合物抑制胆固醇的生物合成，其中主要用于治疗表皮角质化疾病，表皮或上皮增殖紊乱和/ 或皮脂腺功能障碍。

7. 发明授权

US5869067A Bi-aromatic compounds and pharmaceutical and cosmetic compositions 失效
标题翻译：双芳族化合物和药物和化妆品组合物
公开(公告)号：US5869067A
公开(公告)日：1999-02-09
申请号：US311790
申请日：1994-09-26
申请人： Jean-Phillippe Rocher , Jean-Michel Bernardon
发明人： Jean-Phillippe Rocher , Jean-Michel Bernardon
IPC分类号： A61K31/136 , A61K31/137 , A61K31/166 , A61K31/195 , A61K31/196 , A61K31/245 , C07C251/24 , C07C257/08 , C07C257/18 , C07C327/58 , A61K9/00 , A61K31/04 , A61K31/045 , A61K31/085 , A61K31/095 , A61K31/33
CPC分类号： A61K31/136 , A61K31/137 , A61K31/166 , A61K31/195 , A61K31/196 , A61K31/245 , C07C251/24 , C07C257/08 , C07C257/18 , C07C327/58 , C07C2102/10 , C07C2103/74
摘要： The present invention relates to new aromatic compounds, to their preparation and to their use in human and veterinary medicine and in cosmetic compositions.
摘要翻译：本发明涉及新的芳族化合物，其制备方法及其在人和兽医学和化妆品组合物中的用途。

8. 发明授权

US5434180A Polycyclic aromatic derivatives, process for preparing the same and pharmaceutical and cosmetic compositions containing the same 失效
标题翻译：多环芳族衍生物，其制备方法和含有该多环芳族衍生物的药物和化妆品组合物
公开(公告)号：US5434180A
公开(公告)日：1995-07-18
申请号：US859046
申请日：1992-03-27
申请人： Braham Shroot , Jacques Eustache , Oliver Watts , Jean-Michel Bernardon , Philippe Nedoncelle
发明人： Braham Shroot , Jacques Eustache , Oliver Watts , Jean-Michel Bernardon , Philippe Nedoncelle
IPC分类号： C07C43/23 , A61K8/00 , A61K8/30 , A61K8/34 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/41 , A61K8/42 , A61K8/49 , A61K31/045 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/235 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/38 , A61K31/381 , A61P17/00 , A61P27/02 , A61P43/00 , A61Q5/02 , C07C27/00 , C07C29/147 , C07C33/18 , C07C33/34 , C07C41/30 , C07C43/303 , C07C45/00 , C07C47/52 , C07C51/00 , C07C63/331 , C07C63/49 , C07C65/24 , C07C65/26 , C07C67/00 , C07C69/76 , C07C69/94 , C07C233/65 , C07C233/68 , C07C235/42 , C07D307/42 , C07D307/68 , C07D311/92 , C07D319/06 , C07D333/38 , C07H13/08 , C07H13/10 , A61K31/195 , A61K31/075
CPC分类号： C07C65/24 , C07C63/331 , C07C63/49 , C07D307/68 , C07D311/92 , C07D333/38 , Y10S514/844 , Y10S514/859 , Y10S514/863 , Y10S514/864 , Y10S514/886
摘要： The present invention relates to new polycyclic aromatic derivatives, to processes for their preparation and to their use in therapeutic and cosmetic formulations.
摘要翻译：本发明涉及新的多环芳族衍生物，其制备方法及其在治疗和美容制剂中的应用。

9. 发明授权

US5073361A Compound marked with tritium, its preparation and its use in the location of nuclear receptors of retinoids 失效
标题翻译：化合物标记的三氯乙烯，其制备及其在核酸受体的位置使用
公开(公告)号：US5073361A
公开(公告)日：1991-12-17
申请号：US553812
申请日：1990-07-19
申请人： Braham Shroot , Michel Darmon
发明人： Braham Shroot , Michel Darmon
IPC分类号： G01N33/60 , A61K51/00 , A61K51/04 , C07B59/00 , C07C27/02 , C07C65/26 , G01N33/534
CPC分类号： G01N33/534 , A61K51/0402 , C07C65/26 , A61K2123/00
摘要： 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid marked with tritium; its preparation; and its use as a radioactive marker, in the titration of nuclear receptors of retinoids in the presence of contaminating CRABP, or in the measurement of the affinity of retinoids for these nuclear receptors.
摘要翻译：用氚标记的6- [3-（1-金刚烷基）-4-甲氧基苯基] -2-萘甲酸; 其准备; 以及其作为放射性标记物的用途，在存在污染性CRABP时滴定类视黄醇的核受体，或用于测定类视黄醇对这些核受体的亲和力。

10. 发明授权

US5668156A Di (aromatic) compounds and their use in human and veterinary medicine and in cosmetics 失效
标题翻译：二（芳香族）化合物及其在人兽药和化妆品中的应用
公开(公告)号：US5668156A
公开(公告)日：1997-09-16
申请号：US430613
申请日：1995-04-28
申请人： Jean-Michel Bernardon , William Robert Pilgrim
发明人： Jean-Michel Bernardon , William Robert Pilgrim
IPC分类号： A61K8/30 , A61K8/00 , A61K8/33 , A61K8/35 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/67 , A61K31/135 , A61K31/165 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/235 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61P11/00 , A61P17/00 , A61P27/02 , A61P29/00 , A61Q5/00 , A61Q19/00 , C07C49/788 , C07C49/84 , C07C69/00 , C07C69/614 , C07C69/732 , C07C69/738 , C07C69/76 , C07C69/767 , C07C69/773 , C07C69/78 , C07C69/80 , C07C69/84 , C07C69/86 , C07C69/88 , C07C69/92 , C07C69/94 , C07C69/96 , C07C233/55 , C07C233/65 , C07C233/75 , C07C233/76 , C07C233/77 , C07C233/87 , C07C235/38 , C07C235/42 , C07C235/52 , C07C235/60 , C07C235/78 , C07C271/56 , C07C271/58 , C07C275/42 , C07C327/20 , C07C327/26 , C07C327/32 , C07D295/192 , C07D307/68 , C07D333/38 , C07D333/40 , A61K31/12 , A61K31/44
CPC分类号： C07D333/38 , A61K8/368 , A61K8/37 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/4913 , A61K8/4986 , A61K8/671 , A61Q19/00 , A61Q5/00 , C07C233/55 , C07C233/87 , C07C235/38 , C07C235/42 , C07C235/60 , C07C235/78 , C07C271/58 , C07C275/42 , C07C327/26 , C07C327/32 , C07C69/76 , C07C69/86 , C07C69/88 , C07C69/92 , C07C69/96 , C07D295/192 , C07C2102/10 , C07C2103/74 , Y10S514/859 , Y10S514/861 , Y10S514/863
摘要： Di(aromatic) compounds corresponding to the following formula: ##STR1## in which: Ar represents either ##STR2## n=1 or 2 or: ##STR3## X represents a divalent radical, Z represents O, S or a divalent radical, and R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 represent a hydrogen atom or various organic radicals, and the salts of the compounds of formula (I) when R.sub.1 is a carboxylic acid function.Use in human and veterinary medicine and in cosmetics.
摘要翻译：对应于下式的二（芳香族）化合物：其中：Ar表示n = 1或2或者：（III）X表示二价基，Z表示 O，S或二价基团，R 1，R 2，R 3，R 4和R 5表示氢原子或各种有机基团，R 1为羧酸官能团时，式（I）化合物的盐。用于人兽药和化妆品。

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