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1. 发明申请

US20140023587A1 PHOSPHOLIPID ANALOGS AS DIAPEUTIC AGENTS AND METHODS THEREOF 有权
标题翻译：磷脂类似物作为自身药剂及其方法
公开(公告)号：US20140023587A1
公开(公告)日：2014-01-23
申请号：US13964315
申请日：2013-08-12
申请人： Cellectar, Inc.
发明人： Jamey P. Weichert , Marc Longino , Anatoly Pinchuk
IPC分类号： A61K51/04
CPC分类号： A61K51/0489 , A61K49/0017 , A61K51/04 , A61K51/0408 , C07F13/005 , C12Q1/34 , G01N33/57492
摘要： The present invention provides methods and uses of phospholipid ether analogs as diagnostic and therapeutic agents for numerous cancers.
摘要翻译：本发明提供磷脂醚类似物作为许多癌症的诊断和治疗剂的方法和用途。

2. 发明授权

US07893286B2 Method for the synthesis of phospholipid ethers 有权
标题翻译：磷脂醚合成方法
公开(公告)号：US07893286B2
公开(公告)日：2011-02-22
申请号：US12156287
申请日：2008-05-30
申请人： Anatoly Pinchuk , Jamey P. Weichert , Marc Longino
发明人： Anatoly Pinchuk , Jamey P. Weichert , Marc Longino
IPC分类号： C07F9/02
CPC分类号： C07F9/10
摘要： Disclosed are improved methods for the synthesis of phospholipid ether analogs and alkyl phosphocholine analogs. The methods allow greater versatility of the reactants used and greater ease in synthesizing alkyl chains of varying length while affording reaction temperatures at room temperature or below. The methods disclosed herein provide reactants and conditions using alkyl halides and organozinc reagents and do not utilize Gringard reactions thus, allowing greater ease of their separation and purity of products. The PLE compounds synthesized by the methods disclosed herein can also be used for synthesizing high specific activity phospholipid ether (PLE) analogs, for use in treatment and diagnosis of cancer.
摘要翻译：公开了用于合成磷脂醚类似物和烷基磷酸胆碱类似物的改进方法。所述方法允许所用反应物具有更大的通用性，并且更容易合成不同长度的烷基链，同时在室温或更低温度下提供反应温度。本文公开的方法提供使用烷基卤和有机锌试剂的反应物和条件，因此不利用Gringard反应，从而更容易地分离和纯化产物。通过本文公开的方法合成的PLE化合物也可用于合成高比活性磷脂醚（PLE）类似物，用于治疗和诊断癌症。

3. 发明授权

US09339564B2 Ether and alkyl phospholipid compounds for treating cancer and imaging and detection of cancer 有权
标题翻译：用于治疗癌症和成像和癌症检测的醚和烷基磷脂化合物
公开(公告)号：US09339564B2
公开(公告)日：2016-05-17
申请号：US13887981
申请日：2013-05-06
申请人： Cellectar, Inc.
发明人： Jamey P. Weichert , Anatoly Pinchuk , Irawati Kandela , Marc Longino , William R. Clarke
IPC分类号： A61K51/04 , A61K45/06
CPC分类号： A61K51/0489 , A61K31/661 , A61K45/06 , A61K51/0408 , C07B59/00
摘要： Methods and compositions utilizing ether and alkyl phospholipid ether analog compounds for treating cancer and imaging, monitoring, and detecting cancer stem cells in humans.
摘要翻译：使用醚和烷基磷脂醚类似物化合物治疗癌症并成像，监测和检测人类癌症干细胞的方法和组合物。

4. 发明申请

US20150093330A1 PHOSPHOLIPID ANALOGS AS DIAPEUTIC AGENTS AND METHODS THEREOF 有权
标题翻译：磷脂类似物作为自身药剂及其方法
公开(公告)号：US20150093330A1
公开(公告)日：2015-04-02
申请号：US14501373
申请日：2014-09-30
申请人： Cellectar, Inc.
发明人： Jamey P. Weichert , Marc Longino , Anatoly Pinchuk
IPC分类号： A61K51/04
CPC分类号： A61K51/0489 , A61K49/0017 , A61K51/04 , A61K51/0408 , C07F13/005 , C12Q1/34 , G01N33/57492
摘要： The present invention provides methods and uses of phospholipid ether analogs as diagnostic and therapeutic agents for numerous cancers.
摘要翻译：本发明提供磷脂醚类似物作为许多癌症的诊断和治疗剂的方法和用途。

5. 发明申请

US20150030538A1 PHOSPHOLIPID ETHER ANALOGS AS AGENTS FOR DETECTING AND LOCATING CANCER, AND METHODS THEREOF 有权
标题翻译：作为用于检测和定位癌症的试剂的磷脂醚类似物及其方法
公开(公告)号：US20150030538A1
公开(公告)日：2015-01-29
申请号：US14501473
申请日：2014-09-30
申请人： Cellectar, Inc.
发明人： Jamey P. Weichert , Marc Longino , Anatoly Pinchuk
IPC分类号： A61K51/04
CPC分类号： A61K51/0408 , A61K49/0017 , A61K51/04 , C07F13/005 , G01N33/57492
摘要： The present invention provides methods for treating, detecting and locating recurrence of cancer, radiation and chemo insensitive cancer or metastasis of cancer selected from the group consisting of Lung cancer, Adrenal cancer, Melanoma, Colon cancer, Colorectal cancer, Ovarian cancer, Prostate cancer, Liver cancer, Subcutaneous cancer, Squamous cell cancer, Intestinal cancer, Hepatocellular carcinoma, Retinoblastoma, Cervical cancer, Glioma, Breast cancer and Pancreatic cancer in subject using phospholipid ether analogs.
摘要翻译：本发明提供了治疗，检测和定位癌症，辐射和化学不敏感性癌症或癌症转移的复发的方法，其选自肺癌，肾上腺癌，黑色素瘤，结肠癌，结肠直肠癌，卵巢癌，前列腺癌，肝癌，皮下癌，鳞状细胞癌，肠癌，肝细胞癌，视网膜母细胞瘤，宫颈癌，胶质瘤，乳腺癌和胰腺癌患者使用磷脂醚类似物。

6. 发明授权

US08540968B2 Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof 有权
标题翻译：磷脂醚类似物作为检测和定位癌症的药剂及其方法
公开(公告)号：US08540968B2
公开(公告)日：2013-09-24
申请号：US11316620
申请日：2005-12-20
申请人： Jamey Weichert , Marc Longino , Anatoly Pinchuk
发明人： Jamey Weichert , Marc Longino , Anatoly Pinchuk
IPC分类号： A61K49/00
CPC分类号： A61K51/0408 , A61K49/0017 , A61K51/04 , C07F13/005 , G01N33/57492
摘要： The present invention provides methods for treating, detecting and locating recurrence of cancer, radiation and chemo insensitive cancer or metastasis of cancer selected from the group consisting of Lung cancer, Adrenal cancer, Melanoma, Colon cancer, Colorectal cancer, Ovarian cancer, Prostate cancer, Liver cancer, Subcutaneous cancer, Squamous cell cancer, Intestinal cancer, Hepatocellular carcinoma, Retinoblastoma, Cervical cancer, Glioma, Breast cancer and Pancreatic cancer in subject using phospholipid ether analogs.
摘要翻译：本发明提供了治疗，检测和定位癌症，辐射和化学不敏感性癌症或癌症转移的复发的方法，其选自肺癌，肾上腺癌，黑色素瘤，结肠癌，结肠直肠癌，卵巢癌，前列腺癌，肝癌，皮下癌，鳞状细胞癌，肠癌，肝细胞癌，视网膜母细胞瘤，宫颈癌，胶质瘤，乳腺癌和胰腺癌患者使用磷脂醚类似物。

7. 发明授权

US08877160B2 Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof 有权
标题翻译：磷脂醚类似物作为检测和定位癌症的药剂及其方法
公开(公告)号：US08877160B2
公开(公告)日：2014-11-04
申请号：US13964380
申请日：2013-08-12
申请人： Cellectar, Inc.
发明人： Jamey P. Weichert , Marc Longino , Anatoly Pinchuk
IPC分类号： A61K51/00 , A61M36/14 , A61K51/04 , G01N33/574 , C07F13/00 , A61K49/00
CPC分类号： A61K51/0408 , A61K49/0017 , A61K51/04 , C07F13/005 , G01N33/57492
摘要： The present invention provides methods for treating, detecting and locating recurrence of cancer, radiation and chemo insensitive cancer or metastasis of cancer selected from the group consisting of Lung cancer, Adrenal cancer, Melanoma, Colon cancer, Colorectal cancer, Ovarian cancer, Prostate cancer, Liver cancer, Subcutaneous cancer, Squamous cell cancer, Intestinal cancer, Hepatocellular carcinoma, Retinoblastoma, Cervical cancer, Glioma, Breast cancer and Pancreatic cancer in subject using phospholipid ether analogs.
摘要翻译：本发明提供了治疗，检测和定位癌症，辐射和化学不敏感性癌症或癌症转移的复发的方法，其选自肺癌，肾上腺癌，黑色素瘤，结肠癌，结肠直肠癌，卵巢癌，前列腺癌，肝癌，皮下癌，鳞状细胞癌，肠癌，肝细胞癌，视网膜母细胞瘤，宫颈癌，胶质瘤，乳腺癌和胰腺癌患者使用磷脂醚类似物。

8. 发明授权

US08535641B2 Phospholipid analogs as diapeutic* agents and methods thereof 有权
标题翻译：磷脂类似物作为治疗剂及其方法
公开(公告)号：US08535641B2
公开(公告)日：2013-09-17
申请号：US10906687
申请日：2005-03-02
申请人： Jamey Weichert , Marc Longino , Anatoly Pinchuk
发明人： Jamey Weichert , Marc Longino , Anatoly Pinchuk
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K51/0489 , A61K49/0017 , A61K51/04 , A61K51/0408 , C07F13/005 , C12Q1/34 , G01N33/57492
摘要： The present invention provides methods and uses of phospholipid ether analogs as diagnostic and therapeutic agents for numerous cancers.
摘要翻译：本发明提供磷脂醚类似物作为许多癌症的诊断和治疗剂的方法和用途。

9. 发明申请

US20120156133A1 NON-RADIOACTIVE PHOSPHOLIPID COMPOUNDS, COMPOSITIONS, AND METHODS OF USE 审中-公开
标题翻译：非放射性磷脂化合物，组合物和使用方法
公开(公告)号：US20120156133A1
公开(公告)日：2012-06-21
申请号：US13403445
申请日：2012-02-23
申请人： Anatoly Pinchuk , Marc Longino , Jamey P. Weichert , William R. Clarke , Abram M. Vaccaro , Irawati Kandela
发明人： Anatoly Pinchuk , Marc Longino , Jamey P. Weichert , William R. Clarke , Abram M. Vaccaro , Irawati Kandela
IPC分类号： A61K51/04 , A61P35/00 , A61K31/685
CPC分类号： A61K51/0408 , A61K31/685 , A61K31/688
摘要： The present invention provides phospholipid ether and alkyl phospholipid compounds and their combinations with other cancer therapy agents. More specifically, the invention relates to the use of phospholipid ether compounds comprising a “cold” isotope of iodine, e.g. 127I, or H, for treating cancer and combinations of phospholipid compounds comprising radioactive (i.e., “hot”) and non-radioactive (i.e., “cold”) isotopes of iodine.
摘要翻译：本发明提供磷脂醚和烷基磷脂化合物及其与其它癌症治疗剂的组合。更具体地，本发明涉及包含碘的“冷”同位素的磷脂醚化合物的用途，例如， 127I或H，用于治疗癌症和包含放射性（即“热”）和非放射性（即“冷”）碘同位素的磷脂化合物的组合。

10. 发明授权

US07811548B1 Fluorescent phospholipid ether compounds and compositions 有权
标题翻译：荧光磷脂醚化合物和组合物
公开(公告)号：US07811548B1
公开(公告)日：2010-10-12
申请号：US12463970
申请日：2009-05-11
申请人： Anatoly Pinchuk , Jamey P. Weichert , Marc Longino , Irawati Kandela , William R. Clarke
发明人： Anatoly Pinchuk , Jamey P. Weichert , Marc Longino , Irawati Kandela , William R. Clarke
IPC分类号： A61K51/00
CPC分类号： A61K49/0021 , C07F9/094 , C07F9/5728 , C07F9/59 , C07F9/65583 , C07F9/6561
摘要： The invention generally relates to novel fluorescent phospholipid compounds and compositions comprising these compounds. A preferred compound of the present invention has the following structural formula:
摘要翻译：本发明一般涉及新型荧光磷脂化合物和包含这些化合物的组合物。本发明优选的化合物具有以下结构式：

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