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1. 发明申请

US20120145619A1 INTEGRATED DISPOSABLE SET FOR AN APHERESIS SYSTEM 审中-公开
标题翻译：一体化系统的集成替代设置
公开(公告)号：US20120145619A1
公开(公告)日：2012-06-14
申请号：US13400811
申请日：2012-02-21
申请人： Steven Gage URDAHL , Thomas J. FELT , Frank CORBIN, III
发明人： Steven Gage URDAHL , Thomas J. FELT , Frank CORBIN, III
IPC分类号： A61M1/38 , B01D21/26 , B01D63/02
CPC分类号： A61M1/36 , A61M1/3496 , A61M1/3696 , A61M1/38 , A61M2202/0415 , A61M2202/07 , A61M2205/12
摘要： An integrated pre-connected apheresis disposable set for separating plasma from blood in a separation vessel and further separating the separated plasma into desired plasma proteins in a plasma separator fluidly connected to the separation vessel to receive the separated plasma.
摘要翻译：一种用于在分离容器中分离等离子体与血液的集成的预连接的单采血浆置换组件，并且将分离的血浆进一步在流体连接到分离容器的等离子体分离器中分离成期望的血浆蛋白质以接收分离的血浆。

2. 发明授权

US08120760B2 Method and apparatus for separating a composite liquid into at least two components and for determining the yield of at least one component 有权
标题翻译：将复合液体分离成至少两种组分并确定至少一种组分的产率的方法和设备
公开(公告)号：US08120760B2
公开(公告)日：2012-02-21
申请号：US12494476
申请日：2009-06-30
申请人： Briden Ray Stanton , Geert Van Waeg
发明人： Briden Ray Stanton , Geert Van Waeg
IPC分类号： G01N33/48
CPC分类号： G01N33/491 , A61M1/0272 , A61M1/3696 , A61M2202/0427
摘要： Method and Apparatus for predicting the yield of a selected cellular component from a composite blood product by sensing the movement of the separated cellular component or another component during expression from a separation container to a collection container to produce a signal indicative of the movement, and predicting the yield of the separated cellular component from the signal.
摘要翻译：用于通过感测在从分离容器到收集容器的表达过程中分离的细胞组分或另一组分的移动以产生指示运动的信号并预测来自复合血液制品的选定细胞组分的产量的方法和装置从信号中分离的细胞成分的产率。

3. 发明授权

US08114003B2 Methods for hemolysis detection in centrifugal blood separator 有权
标题翻译：离心血液分离器溶血检测方法
公开(公告)号：US08114003B2
公开(公告)日：2012-02-14
申请号：US12423883
申请日：2009-04-15
申请人： Todd Curtis Green , Bruce W. Gibbs
发明人： Todd Curtis Green , Bruce W. Gibbs
IPC分类号： B04B15/00
CPC分类号： A61M1/3693 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3696 , A61M1/38 , A61M2205/18
摘要： A centrifugal blood processing apparatus comprising a centrifuge rotor, a separation chamber, a tubing set for conducting blood components and fluids and having an inlet line, and an outlet line. Apparatus tests flow conditions using a red light-green light sensor to detect non-recoverable hemolysis during priming by identifying a high R/G ratio, preferably a ratio of greater than or equal to fifty (50), prior to the beginning of the first return of blood components to a donor followed by identifying a R/G ratio at least as great as one and one tenth (1.1) together with a green signal less than a predetermined value, preferably less than or equal to one thousand (1000) reflectance units. If these conditions are detected, an alarm is given and the apheresis procedure is discontinued.
摘要翻译：一种离心血液处理设备，包括离心机转子，分离室，用于传导血液成分和流体的管道组件，并具有入口管线和出口管线。装置使用红色浅绿色光传感器测试流动条件，以通过在第一次开始之前识别高R / G比率，优选大于或等于五十（50）的比率来检测引发期间的不可恢复的溶血将血液成分返回到供体，然后将至少高达十分之一（1.1）的R / G比与绿色信号一起小于预定值，优选小于或等于一千（1000）反射率单位。如果检测到这些情况，则会发出警报，并停止血液分离程序。

4. 发明申请

US20120015795A1 CENTRIFUGE FOR PROCESSING BLOOD AND BLOOD COMPONENTS 有权
标题翻译：用于加工血液和血液成分的离心机
公开(公告)号：US20120015795A1
公开(公告)日：2012-01-19
申请号：US13185256
申请日：2011-07-18
申请人： Dennis J. HLAVINKA , John R. MERKLING
发明人： Dennis J. HLAVINKA , John R. MERKLING
IPC分类号： B04B5/04 , B01D21/26 , B04B7/12
CPC分类号： B04B5/0428 , A61M1/0209 , A61M1/3693 , A61M2202/0427 , B04B7/12
摘要： The present invention relates generally to the field of extracorporeal blood processing methods and apparatus which are particularly useful in blood component collection, and more specifically, the present invention relates to methods and apparatus for centrifugally separating buffy coat that reduce the surface available for separated buffy coat components to sediment on by varying the radius of the product collection bag.
摘要翻译：本发明一般涉及在血液成分收集中特别有用的体外血液加工方法和装置的领域，更具体地说，本发明涉及用于离心分离血沉棕黄层的方法和装置，其减少可用于分离的血沉棕黄层的表面通过改变产品收集袋的半径来沉淀的成分。

5. 发明申请

US20120010062A1 BLOOD PROCESSING APPARATUS AND METHOD WITH AUTOMATICALLY ADJUSTED COLLECTION TARGETS 审中-公开
标题翻译：自动调节收集目标的血液加工装置和方法
公开(公告)号：US20120010062A1
公开(公告)日：2012-01-12
申请号：US13164586
申请日：2011-06-20
申请人： Christopher FLETCHER , John PITTINGER
发明人： Christopher FLETCHER , John PITTINGER
IPC分类号： B04B11/06 , B04B15/00 , B01D21/26
CPC分类号： A61M1/38 , A61M1/0209 , A61M1/3693 , A61M1/3696 , A61M2202/0427
摘要： A method and apparatus for collecting a maximum amount of platelets for a selected blood separation procedure without collecting excess platelets above those required for a selected platelet product, whether that product was one unit of platelets, two units of platelets (a double platelet), or more. The method and apparatus will continue to adjust the platelet yield target for platelet collection throughout the procedure without operator intervention, unless the selected procedure cannot be completed successfully, and the operator is required to select another allowed procedure.
摘要翻译：用于收集用于所选血液分离程序的最大量血小板的方法和装置，而不收集超过所选血小板产品所需血小板以上的血小板，无论该产物是血小板的一个单位，两个单位的血小板（双血小板），还是更多。除非所选择的程序不能成功完成，否则该方法和装置将继续调整血小板收集在整个过程中的血小板产生目标，而不需要操作员干预，并且操作者需要选择另一个允许的程序。

6. 发明申请

US20110275056A1 Method and Apparatus for Controlling a Cell Expansion Apparatus 审中-公开
标题翻译：用于控制细胞扩增装置的方法和装置
公开(公告)号：US20110275056A1
公开(公告)日：2011-11-10
申请号：US13098705
申请日：2011-05-02
申请人： Glen Delbert ANTWILER
发明人： Glen Delbert ANTWILER
IPC分类号： C12Q3/00 , C12M1/36 , C12M1/34
CPC分类号： C12M41/32
摘要： A method for controlling cell expansion comprising conducting a fluid containing cellular matter into a cellular growth area; providing oxygenated fluid to said cellular growth area to maintain conditions conducive for cell growth in said cellular growth area; monitoring inflow and outflow conditions; determining rates of change (first derivative) for selected conditions and calculating cell numbers therefrom; determining a rate of change of a rate of change (second derivative) for the selected conditions and calculating a predicted process time; and terminating the growth process when adequate cell numbers have been produced and an apparatus for performing the method.
摘要翻译：一种用于控制细胞扩增的方法，包括将含有细胞物质的流体导入细胞生长区域; 向所述细胞生长区域提供氧化流体以保持有助于所述细胞生长区域中的细胞生长的条件; 监测流入和流出状况; 确定所选条件的变化率（一阶导数），并从中计算细胞数; 确定所选条件的变化率（二阶导数）的变化率并计算预测的处理时间; 并且当生产足够的细胞编号时终止生长过程和用于执行该方法的装置。

7. 发明申请

US20110201487A1 Blood Processing Apparatus with Optical Reference Control 有权
标题翻译：具有光学参考控制的血液处理设备
公开(公告)号：US20110201487A1
公开(公告)日：2011-08-18
申请号：US13092639
申请日：2011-04-22
申请人： William SWEAT
发明人： William SWEAT
IPC分类号： B04B13/00
CPC分类号： G01N15/042 , G01N15/05 , G01N2015/045
摘要： A density centrifuge blood processing system with automatic two-dimensional optical control of fluid separation by observing fluid characteristics in observation regions. The location of the regions is determined by monitoring an optical reference. Points representing edges of an optical reference are measured and lines are computed through the points. An error measurement is calculated for each line. If the error is too large, the image is abandoned. One of the lines is selected as a referent line. A new line is calculated orthogonal to the referent line. The error function is again computed for the dependant line. If the error exceeds a selected maximum, the frame is discarded. A transformation function translates data points from an (r, s) domain derived from measurements of the edges into an (x, y) domain used to identify pixels in the observation areas.
摘要翻译：密度离心机血液处理系统，通过观察观察区域的流体特性，自动进行二维光学控制流体分离。通过监视光学参考来确定区域的位置。测量表示光学基准的边缘的点，并通过点计算线条。计算每行的误差测量。如果错误太大，图像被放弃。选择其中一行作为指示行。计算与指示线正交的新线。对依赖线再次计算误差函数。如果错误超过选定的最大值，则丢弃该帧。变换函数将来自（r，s）域的数据点从边缘的测量转换成用于识别观察区域中的像素的（x，y）域。

8. 发明申请

US20110152740A1 METHODS AND APPARATUS FOR COLLECTION OF FILTERED BLOOD COMPONENTS 审中-公开
标题翻译：用于收集过滤血液组分的方法和装置
公开(公告)号：US20110152740A1
公开(公告)日：2011-06-23
申请号：US12962784
申请日：2010-12-08
申请人： Bruce W. GIBBS
发明人： Bruce W. GIBBS
IPC分类号： A61M1/38 , B01D36/00 , B01D37/00
CPC分类号： A61M1/3693 , A61M1/0218 , A61M1/0231 , A61M1/3696
摘要： A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell separation and collection procedure. After red blood cells have been collected, an unwanted blood component, e.g., buffy coat, is diverted into the red blood cell collect line. Operation of a peristaltic pump engaging pump loop allows insertion of a pre-determined quantity of buffy coat into the collect line. The buffy coat can therefore push red blood cells out of the filter and into a collect bag without diluting the collected red blood cells. Alternatively, gravitational force may be used to allow the unwanted blood component to displace red blood cells out of the filter.
摘要翻译：提供了一种用于红血液收集和过滤的方法和装置，其中红细胞收集组件与红血细胞分离和收集程序同时或之后提供白细胞减少过滤。在收集红细胞之后，将不需要的血液成分例如血沉棕黄层转入红细胞收集线。蠕动泵接合泵回路的操作允许将预定数量的血沉棕黄层插入收集线。因此，血沉棕黄层可以将红细胞从过滤器中推出并收集到收集袋中，而不会稀释收集的红细胞。或者，可以使用重力来使不需要的血液成分将红细胞置换出过滤器。

9. 发明授权

US07951059B2 Blood processing apparatus with optical reference control 有权
公开(公告)号：US07951059B2
公开(公告)日：2011-05-31
申请号：US12233185
申请日：2008-09-18
申请人： William Sweat
发明人： William Sweat
IPC分类号： B04B15/00
CPC分类号： G01N15/042 , G01N15/05 , G01N2015/045
摘要： A density centrifuge blood processing system with automatic two-dimensional optical control of fluid separation by observing fluid characteristics in observation regions. The location of the regions is determined by monitoring an optical reference. Points representing edges of an optical reference are measured and lines are computed through the points. An error measurement is calculated for each line. If the error is too large, the image is abandoned. One of the lines is selected as a referent line. A new line is calculated orthogonal to the referent line. The error function is again computed for the dependant line. If the error exceeds a selected maximum, the frame is discarded. A transformation function translates data points from an (r, s) domain derived from measurements of the edges into an (x, y) domain used to identify pixels in the observation areas.

10. 发明申请

US20100273627A1 Method for Separating Discrete Volumes of A Composite Liquid 有权
标题翻译：分离复合液体体积的方法
公开(公告)号：US20100273627A1
公开(公告)日：2010-10-28
申请号：US12832101
申请日：2010-07-08
申请人： Darryl HUDOCK , Daniel A. JOSEPH , Victor DOLECEK
发明人： Darryl HUDOCK , Daniel A. JOSEPH , Victor DOLECEK
IPC分类号： B01D17/038
CPC分类号： A61M1/3693 , A61M1/0218 , A61M1/3696 , A61M1/3698 , A61M2202/0429 , A61M2202/0439 , A61M2205/3365 , B04B5/0428 , B04B9/14 , B04B2009/143 , B04B2013/006
摘要： A method for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising centrifuging at least two separation bags containing two discrete volumes of a composite liquid respectively, so as to separate therein the first and second components; transferring at least one fraction of a first separated component from the separation bags into satellite bags connected thereto respectively; detecting a characteristic of a component at determined location in each separation bag; and stopping transferring the at least one fraction of the first component from each separation bag into the first satellite bag connected thereto, upon detection of the characteristic of a component at the determined location.
摘要翻译：一种用于将至少两个离散体积的复合液体分离成至少第一组分和第二组分的方法，包括分别离心分离含有两个离散体积的复合液体的至少两个分离袋，以便在其中分离第一和第二组分组件; 将来自分离袋的至少一部分第一分离组分转移到分别与其连接的卫星袋中; 检测每个分离袋中的确定位置处的部件的特性; 并且在检测到所确定的位置处的部件的特性时，停止将来自每个分离袋的第一部件的至少一部分转移到与其连接的第一卫星袋中。

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