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1. 发明授权

US10073019B2 Rapid quantitative element testing 有权
公开(公告)号：US10073019B2
公开(公告)日：2018-09-11
申请号：US14931263
申请日：2015-11-03
申请人： CEM Corporation
发明人： Cindy Moser , Michael Collins, Sr.
IPC分类号： G01N1/44 , G01N33/02 , G01N21/31 , G01N21/72 , G01N21/73
CPC分类号： G01N1/44 , G01N21/3103 , G01N21/72 , G01N21/73 , G01N33/02
摘要： A method of element testing is disclosed that includes the steps of weighing a sample, pressing the sample between pads, applying microwave radiation to the sample and pads in the presence of a microwave susceptor material and ashing the pressed sample, adding the pads and the ashed sample to an acid, and forwarding filtrate from the pad-sample-acid mixture to a spectrometer.

2. 发明申请

US20170312728A1 HIGH TEMPERATURE PRESSURE DIGESTION VESSEL SYSTEM WITH DUAL ACTION SEAL 审中-公开
公开(公告)号：US20170312728A1
公开(公告)日：2017-11-02
申请号：US15447250
申请日：2017-03-02
申请人： CEM Corporation
发明人： IAN GOLDSTEIN , WYATT P. HARGETT, III
IPC分类号： B01J19/02 , B01J19/12 , B01J19/24
CPC分类号： B01J19/02 , B01J3/03 , B01J3/042 , B01J19/126 , B01J19/24 , B01J2219/00141 , B01J2219/00162 , B01J2219/0295 , B01J2219/1218 , B01J2219/1224 , B01J2219/1227 , B01J2219/1233 , B01J2219/1236 , B01J2219/1943 , B01J2219/24
摘要： A vessel system for high-pressure reactions is disclosed. The system includes a plugged polymer cylinder reaction vessel with a pressure vent opening extending radially through the wall of the reaction vessel and a supporting frame into which the vessel is received. Complementing keying structure elements on the vessel and on the frame limit the orientation of the reaction vessel in the supporting frame and the radially extending vent opening to a defined single position.

3. 发明申请

US20170226152A1 SOLID PHASE PEPTIDE SYNTHESIS 审中-公开
公开(公告)号：US20170226152A1
公开(公告)日：2017-08-10
申请号：US15299931
申请日：2016-10-21
申请人： CEM Corporation
发明人： JONATHAN M. COLLINS
IPC分类号： C07K1/04 , C07K1/14 , C07K1/06 , C07K14/575 , C07K14/605 , C07K14/815 , C07K14/635 , C07K14/59 , C07K14/705 , C07K14/645 , C07K14/005 , C12N7/00 , C07K14/47 , C07K7/08 , C07K7/16 , C07K14/46 , B01J19/12 , C07K1/107
CPC分类号： C07K1/045 , B01J19/126 , B01J2204/005 , B01J2219/00058 , B01J2219/0879 , B01J2219/1248 , C07K1/04 , C07K1/063 , C07K1/1075 , C07K1/14 , C07K7/08 , C07K7/16 , C07K14/005 , C07K14/463 , C07K14/4701 , C07K14/4723 , C07K14/575 , C07K14/57572 , C07K14/59 , C07K14/605 , C07K14/635 , C07K14/645 , C07K14/705 , C07K14/815 , C12N7/00 , C12N2740/16322
摘要： An improved method of deprotection in solid phase peptide synthesis is disclosed. In particular the deprotecting composition is added in high concentration and small volume to the mixture of the coupling solution, the growing peptide chain, and any excess activated acid from the preceding coupling cycle, and without any draining step between the coupling step of the previous cycle and the addition of the deprotection composition for the successive cycle. Thereafter, the ambient pressure in the vessel is reduced with a vacuum pull to remove the deprotecting composition without any draining step and without otherwise adversely affecting the remaining materials in the vessel or causing problems in subsequent steps in the SPPS cycle.

4. 发明申请

US20160131561A1 RAPID QUANTITATIVE ELEMENT TESTING 审中-公开
标题翻译：快速量化元素测试
公开(公告)号：US20160131561A1
公开(公告)日：2016-05-12
申请号：US14931263
申请日：2015-11-03
申请人： CEM Corporation
发明人： Cindy Moser , Michael Collins, SR.
IPC分类号： G01N1/44 , G01N21/27 , G01N33/02
CPC分类号： G01N1/44 , G01N21/3103 , G01N21/72 , G01N21/73 , G01N33/02
摘要： A method of element testing is disclosed that includes the steps of weighing a sample, pressing the sample between pads, applying microwave radiation to the sample and pads in the presence of a microwave susceptor material and ashing the pressed sample, adding the pads and the ashed sample to an acid, and forwarding filtrate from the pad-sample-acid mixture to a spectrometer.
摘要翻译：公开了一种元件测试方法，该方法包括以下步骤：对样品进行称重，将样品压在衬垫之间，在微波感受器材料存在下向样品和衬垫施加微波辐射并灰化受压样品，添加衬垫和灰化将样品加到酸中，并将滤液从垫样品酸混合物转移到光谱仪中。

5. 发明授权

US09211522B2 Microwave-assisted peptide synthesis 有权
标题翻译：微波辅助肽合成
公开(公告)号：US09211522B2
公开(公告)日：2015-12-15
申请号：US14493876
申请日：2014-09-23
申请人： CEM CORPORATION
发明人： Jonathan McKinnon Collins , Joseph Joshua Lambert , Michael John Collins
IPC分类号： A61K38/00 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , B01J19/12 , C07K1/04 , B01J19/08 , C07K5/08 , C07K7/06
CPC分类号： B01J19/126 , B01J19/087 , B01J2219/0871 , B01J2219/0879 , B01J2219/1206 , B01J2219/1209 , B01J2219/1215 , B01J2219/1218 , B01J2219/1221 , B01J2219/1254 , B01J2219/126 , B01J2219/1272 , B01J2219/1293 , C07K1/045 , C07K1/063 , C07K5/08 , C07K7/06
摘要： An instrument and method for accelerating the solid phase synthesis of peptides are disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase resin by admixing the protected linked acid with a deprotecting solution in a microwave transparent vessel while irradiating the admixed acid and solution with microwaves, activating a second amino acid, coupling the second amino acid to the first acid while irradiating the composition in the same vessel with microwaves, and cleaving the linked peptide from the solid phase resin by admixing the linked peptide with a cleaving composition in the same vessel while irradiating the composition with microwaves.
摘要翻译：公开了用于促进肽的固相合成的仪器和方法。该方法包括以下步骤：通过将受保护的连接酸与去保护溶液混合在微波透明容器中，同时用微波照射混合的酸和溶液，活化第二个氨基酸，偶联同时用微波在相同的容器中照射组合物的第二个氨基酸，并且通过将相连的肽与裂解组合物在相同的容器中混合同时用微波照射组合物来从固相树脂中切割连接的肽。

6. 发明授权

US09091632B2 Automated protein analyzer 有权
标题翻译：自动蛋白分析仪
公开(公告)号：US09091632B2
公开(公告)日：2015-07-28
申请号：US14038900
申请日：2013-09-27
申请人： CEM Corp.
发明人： Michael J Collins, Sr. , Joseph J Lambert , Timothy A Zawatsky , David L Herman
IPC分类号： G01N33/00 , G01N1/00 , G01N21/17 , G01N33/68 , G01N21/25 , G01N1/28 , G01N35/10 , G01N33/12 , G01N1/40
CPC分类号： G01N33/6839 , G01N1/286 , G01N21/17 , G01N21/251 , G01N33/12 , G01N33/6803 , G01N35/1095 , G01N2001/4088 , Y10T436/10 , Y10T436/105831 , Y10T436/25
摘要： A dye binding method for protein analysis is disclosed. The method includes the steps of preparing an initial reference dye solution of unknown concentration from an initial reference dye concentrate and creating an electronic signal based upon the absorbance of the initial reference dye solution. Thereafter, an electronic signal is created based upon the absorbance of a dye filtrate solution prepared from the initial reference dye solution and an initial protein sample. The absorbance signals from the reference dye solution and the dye filtrate solution are sent to a processor that compares the respective absorbances and calculates the protein content of the protein sample based upon the difference between the absorbances. An electronic signal is created based upon the absorbance of a successive dye filtrate solution prepared from the reference dye solution and a successive protein sample, and the absorbance signal from the successive sample dye filtrate solution is sent to the processor to calculate the protein content of the successive sample based upon the difference between the absorbance of the initial reference dye solution and the absorbance of the successive dye filtrate solution.
摘要翻译：公开了用于蛋白质分析的染料结合方法。该方法包括以下步骤：从初始参考染料浓缩物制备未知浓度的初始参考染料溶液，并基于初始参考染料溶液的吸光度产生电子信号。此后，基于由初始参考染料溶液和初始蛋白质样品制备的染料滤液的吸光度，产生电子信号。将来自参考染料溶液和染料滤液的吸光度信号送至处理器，该处理器根据吸光度之差来比较各吸光度，并计算蛋白质样品的蛋白质含量。基于由参考染料溶液和连续蛋白质样品制备的连续染料滤液的吸光度产生电子信号，并将来自连续样品染料滤液的溶液的吸光度信号发送到处理器，以计算蛋白质含量基于初始参考染料溶液的吸光度与连续的染料滤液的吸光度之间的差异的连续样品。

7. 发明授权

US08852948B2 Colorimetric protein analysis method 有权
标题翻译：比色蛋白分析法
公开(公告)号：US08852948B2
公开(公告)日：2014-10-07
申请号：US12185575
申请日：2008-08-04
申请人： Michael J. Collins, Sr. , Joseph J. Lambert , Timothy A. Zawatsky , David L. Herman
发明人： Michael J. Collins, Sr. , Joseph J. Lambert , Timothy A. Zawatsky , David L. Herman
IPC分类号： G01N33/00 , G01N21/00 , G01N33/68 , G01N33/52
CPC分类号： G01N33/6803 , G01N33/52
摘要： A protein analysis instrument and method are disclosed. The method includes mixing a binding dye composition and a protein sample using a homogenizer, measuring a parameter selected from the group consisting of the speed of the homogenizer and the resistance of the mixture to the homogenizer, adjusting the speed of the homogenizer based upon the measured parameter, pumping unreacted dye composition from the mixture and to a calorimeter, and measuring the absorbance of the dye composition in the calorimeter. Aspects of the invention also include inserting a spout into a sample cup at a position where the spout opening is positioned to avoid foam and precipitate generated by the mixing step and above the bottom of the sample cup and thereafter pumping the dye composition from the mixture in the sample cup through the spout and to a colorimeter.
摘要翻译：公开了一种蛋白质分析仪器和方法。该方法包括使用均化器混合结合染料组合物和蛋白质样品，测量选自均化器的速度和混合物对均化器的电阻的参数，基于测量的调节匀浆器的速度参数，从混合物和比色计中抽出未反应的染料组合物，并测量色度计中染料组合物的吸光度。本发明的方面还包括将喷口插入样品杯中，在出口开口的位置处，以避免由混合步骤产生的泡沫和沉淀，并且在样品杯的底部之上，然后从混合物中抽出染料组合物样品杯通过喷口和色度计。

8. 发明申请

US20130228449A1 MICROWAVE-ASSISTED PEPTIDE SYNTHESIS 有权
公开(公告)号：US20130228449A1
公开(公告)日：2013-09-05
申请号：US13866063
申请日：2013-04-19
申请人： CEM CORPORATION
发明人： JONATHAN MCKINNON COLLINS , JOSEPH JOSHUA LAMBERT , MICHAEL JOHN COLLINS
IPC分类号： B01J19/12
CPC分类号： B01J19/126 , B01J19/087 , B01J2219/0871 , B01J2219/0879 , B01J2219/1206 , B01J2219/1209 , B01J2219/1215 , B01J2219/1218 , B01J2219/1221 , B01J2219/1254 , B01J2219/126 , B01J2219/1272 , B01J2219/1293 , C07K1/045 , C07K1/063 , C07K5/08 , C07K7/06
摘要： An instrument and method for accelerating the solid phase synthesis of peptides are disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase resin by admixing the protected linked acid with a deprotecting solution in a microwave transparent vessel while irradiating the admixed acid and solution with microwaves, activating a second amino acid, coupling the second amino acid to the first acid while irradiating the composition in the same vessel with microwaves, and cleaving the linked peptide from the solid phase resin by admixing the linked peptide with a cleaving composition in the same vessel while irradiating the composition with microwaves.

9. 发明授权

US08153761B2 Microwave-assisted peptide synthesis 有权
标题翻译：微波辅助肽合成
公开(公告)号：US08153761B2
公开(公告)日：2012-04-10
申请号：US12433145
申请日：2009-04-30
申请人： Jonathan McKinnon Collins , Joseph Joshua Lambert , Michael John Collins
发明人： Jonathan McKinnon Collins , Joseph Joshua Lambert , Michael John Collins
IPC分类号： A61K38/00 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： B01J19/126 , B01J19/087 , B01J2219/0871 , B01J2219/0879 , B01J2219/1206 , B01J2219/1209 , B01J2219/1215 , B01J2219/1218 , B01J2219/1221 , B01J2219/1254 , B01J2219/126 , B01J2219/1272 , B01J2219/1293 , C07K1/045 , C07K1/063 , C07K5/08 , C07K7/06
摘要： An instrument and associated method are disclosed for the accelerated synthesis of peptides by the solid phase method. The instrument includes a microwave cavity, a microwave source in communication with the cavity, a column in the cavity formed of a material that is transparent to microwave radiation, a solid phase peptide support resin in the column, respective filters for maintaining the solid phase support resin in the column, a first passageway for adding starting compositions to the column, a second passageway for removing compositions from the column, and a third passageway for circulating compositions from the column into the third passageway and back to the column.
摘要翻译：公开了通过固相法加速合成肽的仪器和相关方法。仪器包括微波腔，与空腔连通的微波源，空腔中的柱，由对微波辐射透明的材料形成，柱中的固相肽支撑树脂，用于保持固相载体的相应过滤器柱中的树脂，用于将起始组合物添加到塔的第一通道，用于从塔中除去组合物的第二通道和用于将组合物从塔进入第三通道并返回塔的第三通道。

10. 发明授权

US07997790B2 Dual energy source loss-on-drying instrument 有权
标题翻译：双能量损耗干燥仪
公开(公告)号：US07997790B2
公开(公告)日：2011-08-16
申请号：US12508648
申请日：2009-07-24
申请人： Robert N. Revesz , Michael J. Collins, Sr.
发明人： Robert N. Revesz , Michael J. Collins, Sr.
IPC分类号： G01N25/00 , G01J5/00
CPC分类号： G01N5/045 , G01N1/44
摘要： An instrument and associated method are disclosed for the loss-on-drying determination of the volatile content of a wide variety of samples. The instrument includes a cavity in which a sample for which the volatile content is to be determined can be placed, a first source for introducing microwaves into the cavity that have frequencies substantially other than infrared frequencies, a second source for introducing radiant heat into the cavity at frequencies different from the frequencies introduced by the first source, an analytical balance for measuring the weight of a sample while the sample is in the cavity and on the balance, a temperature sensor capable of measuring and positioned to measure the temperature of a sample in the cavity and on the balance, and a processor in communication with the temperature sensor and each of the first and second sources for controlling the introduction of the frequencies of microwave and radiant energy into the cavity in response to the temperatures measured by the temperature sensor to control the sample temperature until the microwaves from the first source and the radiant heat from the second source dry the sample sufficiently for the processor to determine the volatile content of the sample based on the weight change of the sample on the balance.
摘要翻译：公开了用于各种样品的挥发物含量的干燥损失测定的仪器和相关方法。该仪器包括其中可以放置要确定挥发物含量的样品的空腔，用于将微波引入具有基本上不同于红外频率的频率的空腔的第一源，用于将辐射热引入腔中的第二源在与第一源引入的频率不同的频率处，用于测量样品在腔中和平衡时的重量的分析天平，能够测量和定位以测量样品的温度的温度传感器空腔和平衡部，以及与温度传感器和第一和第二源中的每一个通信的处理器，用于响应于由温度传感器测量的温度而将微波和辐射能的频率引入空腔中控制样品温度，直到来自第一个来源的微波和来自th的辐射热第二来源充分干燥样品以使处理器基于样品在天平上的重量变化来确定样品的挥发性含量。

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