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1. 发明授权

US08044177B2 Water-soluble keratin derivative and use thereof 有权
标题翻译：水溶性角蛋白衍生物及其用途
公开(公告)号：US08044177B2
公开(公告)日：2011-10-25
申请号：US12559949
申请日：2009-09-15
申请人： Keiji Umeda , Yositaka Nadachi , Katsunobu Sakai , Yukitaka Nogami , Masahiko Sudo
发明人： Keiji Umeda , Yositaka Nadachi , Katsunobu Sakai , Yukitaka Nogami , Masahiko Sudo
IPC分类号： C07K1/12 , C07K14/435 , C09K9/02 , C09K109/00
CPC分类号： C08H1/06 , A61K8/65 , A61Q17/04
摘要： The present invention provides a novel water-soluble keratin derivative and applications thereof. Water-soluble keratin produced by the alkali treatment of feathers, and modified keratin, gives the following useful materials: (1) a high energy wave absorber, (2) a luminescent substrate, (3) a material weatherproofness improver, (4) a water repellant, and (5) a foaming agent.
摘要翻译：本发明提供了一种新的水溶性角蛋白衍生物及其用途。通过碱处理羽毛产生的水溶性角蛋白和改性角蛋白，提供以下有用材料：（1）高能量波吸收剂，（2）发光基材，（3）材料耐候性改进剂，（4）防水剂，（5）发泡剂。

2. 发明申请

US20100069612A1 WATER-SOLUBLE KERATIN DERIVATIVE AND USE THEREOF 有权
标题翻译：水溶性可卡因衍生物及其用途
公开(公告)号：US20100069612A1
公开(公告)日：2010-03-18
申请号：US12559949
申请日：2009-09-15
申请人： Keiji UMEDA , Yositaka NADACHI , Katsunobu SAKAI , Yukitaka NOGAMI , Masahiko SUDO
发明人： Keiji UMEDA , Yositaka NADACHI , Katsunobu SAKAI , Yukitaka NOGAMI , Masahiko SUDO
IPC分类号： C07K14/78
CPC分类号： C08H1/06 , A61K8/65 , A61Q17/04
摘要： The present invention provides a novel water-soluble keratin derivative and applications thereof. Water-soluble keratin produced by the alkali treatment of feathers, and modified keratin, gives the following useful materials: (1) a high energy wave absorber, (2) a luminescent substrate, (3) a material weatherproofness improver, (4) a water repellant, and (5) a foaming agent.
摘要翻译：本发明提供了一种新的水溶性角蛋白衍生物及其用途。通过碱处理羽毛产生的水溶性角蛋白和改性角蛋白，提供以下有用材料：（1）高能量波吸收剂，（2）发光基材，（3）材料耐候性改进剂，（4）防水剂，（5）发泡剂。

3. 发明授权

US5352815A Agent for suppression and interception of mailard reaction 失效
标题翻译：抑制和拦截邮寄员反应的代理人
公开(公告)号：US5352815A
公开(公告)日：1994-10-04
申请号：US031997
申请日：1993-03-16
申请人： Norihiro Kakimoto , Kunie Nakamura
发明人： Norihiro Kakimoto , Kunie Nakamura
IPC分类号： A61K31/28 , A61P3/00 , A61P3/08 , A61P3/10 , A61P43/00 , C07B63/04 , C07F7/30 , C07K14/00
CPC分类号： C07F7/30 , A61K31/28
摘要： The present invention provides an agent for suppression or interception of the Mailard reaction, which comprises, as the active component, an organogermanium compound represented by formula (1): ##STR1## wherein R.sub.1 to R.sub.3 may be the same or different and each of them represents a hydrogen atom, a lower alkyl group, or a phenyl group; and X represents a hydroxyl group, an O-lower alkyl group, an amino group, or a salt represented by OY (Y is a metal or a basic group-containing compound).Said agent can effectively suppress or intercept the Mailard reaction and has high safety even when administered for a long period of time.
摘要翻译：本发明提供了用于抑制或拦截Mailard反应的试剂，其包含作为活性组分的由式（1）表示的有机锗化合物：其中R 1至R 3可以相同或不同，它们各自表示氢原子，低级烷基或苯基; X表示羟基，O-低级烷基，氨基或OY表示的盐（Y表示金属或含碱性化合物）。所述试剂可以有效地抑制或拦截Mailard反应，即使在长时间施用时也具有高安全性。

4. 发明授权

US5118679A Agent for preventing and treating opacity of lens 失效
标题翻译：防止和处理镜片透明度的代理
公开(公告)号：US5118679A
公开(公告)日：1992-06-02
申请号：US554724
申请日：1990-07-19
申请人： Susumu Sato , Norihiro Kakimoto , Mikio Miyata , Shigezo Uga , Kunie Nakamura
发明人： Susumu Sato , Norihiro Kakimoto , Mikio Miyata , Shigezo Uga , Kunie Nakamura
IPC分类号： A61K31/28 , A61K31/535 , C07F7/30
CPC分类号： C07F7/30 , A61K31/28 , A61K31/535 , Y10S514/912
摘要： The present invention is to provide a highly effective agent for preventing and treating opacity of lens, containing the organic germanium compound represented by the fornula (1); ##STR1## (wherein R1 to R3 represent hydrogen atoms, lower alkyl groups each of which may be the same or different and selected from the group consisting of methyl group, ethyl group, etc., or phenyl groups substituted or unsubstituted; X represents a hydroxyl group, an O-lower alkyl group, an amino group or O.sup.- Y.sup.+ {Y represents a metal such as sodium, potassium, etc., or a compound having a basic group such as lysozyme and basic amino acid, etc.})or (2) a combination of the organic germanium compound and aminoguanidien, or (3) a combination of the organic germanium compound specifically defined above and the specific phenoxazine derivative.
摘要翻译：本发明提供一种防止和治疗透镜的不透明度的高效试剂，其含有由（1）所表示的有机锗化合物; （1）（其中R 1至R 3表示氢原子，各自可以相同或不同且选自甲基，乙基等的低级烷基或取代或未取代的苯基; X表示羟基，O-低级烷基，氨基或O-Y + {Y表示金属如钠，钾等，或具有碱性基团的化合物如溶菌酶和碱性氨基酸等））或（2）有机锗化合物和氨基胍二烯的组合，或（3）上述具体定义的有机锗化合物与特定吩恶嗪衍生物的组合。

5. 发明授权

US5006553A Agent for improving reduced functions of organs caused by inhibited blood circulation 失效
标题翻译：改善由血液循环受阻引起的器官功能降低的药剂
公开(公告)号：US5006553A
公开(公告)日：1991-04-09
申请号：US555829
申请日：1990-07-23
申请人： Norihiro Kakimoto , Kazuo Kumano , Kunie Nakamura
发明人： Norihiro Kakimoto , Kazuo Kumano , Kunie Nakamura
IPC分类号： C07F7/30
CPC分类号： C07F7/30
摘要： The present invention provides (1) an agent for improving the reduced functions of organs caused by inhibited blood circulation, characterized by containing, as an effective component, an organogermanium compound represented by the formula (I) ##STR1## wherein R.sub.1 to R.sub.3 are each a hydrogen atom, a lower alkyl group such as methyl, ethyl or the like which may be the same or different, or a substituted or unsubstituted phenyl group, and X is a hydroxyl group, an O-lower alkyl group, an amino group or O.sup.- Y.sup.+ (Y is a metal such as sodium, potassium or the like, or a basic group-containing compound such as lysozyme, basic amino acid or the like), and (2) a method for improving the reduced functions of organs caused by inhibited blood circulation, characterized by administering, in need of such treatment, an effective amount of an organogermanium compound represented by the above formula (I).
摘要翻译：本发明提供（1）一种用于改善由抑制血液循环引起的功能降低的药剂，其特征在于，含有式（I）表示的有机锗化合物作为有效成分，其中R1至 R3各自为氢原子，低级烷基如甲基，乙基等可以相同或不同，或取代或未取代的苯基，X为羟基，O-低级烷基，氨基或O-Y +（Y是金属如钠，钾等，或含碱性基团的化合物如溶菌酶，碱性氨基酸等），和（2）一种改善功能降低的方法其特征在于，在需要这种治疗的情况下施用有效量的由上述式（I）表示的有机锗化合物。

6. 发明授权

US5877311A Process for isomerization of compound of aldose structure into compound of ketose structure, and isomerization agent or accelerator used therin 失效
标题翻译：醛糖结构化合物异构化为酮糖结构化合物的方法，异构化剂或促进剂
公开(公告)号：US5877311A
公开(公告)日：1999-03-02
申请号：US888285
申请日：1997-07-03
申请人： Keiji Umeda , Norihiro Kakimoto , Takafumi Kasumi
发明人： Keiji Umeda , Norihiro Kakimoto , Takafumi Kasumi
IPC分类号： C07H1/00 , C01G17/00
CPC分类号： C07H1/00
摘要： A process is provided which comprises isomerizing a compound having a ketose structure by the use of or in the presence of an organogermanium compound having a structural portion represented by formula (I): ##STR1## Due to the use or presence of the organogermanium compound, the process is free from the problems of the prior art, and is capable of isomerizing a compound having an aldose structure into a compound having a ketose structure at a high isomerization ratio without requiring any special apparatus or any complicated operation.
摘要翻译：提供了一种方法，其包括通过使用或在具有由式（I）表示的结构部分的有机锗化合物的存在下异构化具有酮糖结构的化合物：（I）由于使用或存在有机锗化合物，该方法没有现有技术的问题，并且能够将具有醛糖结构的化合物异构化成具有高异构化比例的酮糖结构的化合物，而不需要任何特殊的装置或任何复杂的操作。

7. 发明授权

US11981693B2 Organogermanium compound 有权
公开(公告)号：US11981693B2
公开(公告)日：2024-05-14
申请号：US17442450
申请日：2020-10-26
申请人： ASAI Germanium Research Institute Co., Ltd.
发明人： Takashi Nakamura , Katsuyuki Sato , Yasuhiro Shimada
IPC分类号： C07F7/30
CPC分类号： C07F7/30
摘要： The present invention relates to a compound of general formula (I) (wherein R1, R2, and R3 are each independently a hydrogen atom or a lower alkyl and X is an alkali metal cation, ammonium cation, or quaternary ammonium cation). This compound is highly soluble in water, and solutions thereof need not be neutralized when administered to the living body. The compound is useful as a medicine, etc.

8. 发明授权

US5041577A Organogermanium compounds, processes for producing the same, and agent for inhibiting the activity of opioid peptide-degrading enzyme 失效
标题翻译：有机锗化合物，其制备方法和抑制阿片样肽降解酶活性的试剂
公开(公告)号：US5041577A
公开(公告)日：1991-08-20
申请号：US468670
申请日：1990-01-23
申请人： Norihiro Kakimoto , Toru Yoshihara
发明人： Norihiro Kakimoto , Toru Yoshihara
IPC分类号： C07F7/30
CPC分类号： C07F7/30
摘要： The present invention relates to (a) novel organogermanium compounds represented by the general formula (1) ##STR1## (R.sub.1 to R.sub.6 are independently a hydrogen atom or a lower alkyl group; X is a halogen atom; and Y.sub.1 and Y.sub.2 are independently a hydroxyl group or a group chemically equivalent thereto) or by the general formula (2) ##STR2## (R.sub.1 to R.sub.6 are independently a hydrogen atom or a lower alkyl group, and Z is an oxygen atom or a sulfur atom), (b) processes for producing the above organogermanium compounds, and (c) an agent for inhibiting the activity of opioid peptide-degrading enzyme, containing the above organogermanium compounds as an active ingredient.
摘要翻译：本发明涉及（a）由通式（1）表示的新型有机锗化合物（R1至R6独立地为氢原子或低级烷基; X为卤素原子; Y1和Y2独立地为羟基或与其化学等价的基团）或通式（2）的化合物（R 2 -R 6独立地为氢原子或低级烷基，Z为氧原子或硫原子），（b）制备上述有机锗化合物的方法，和（c）含有上述有机锗化合物作为活性成分的用于抑制阿片样肽降解酶活性的试剂。

9. 发明授权

US5002968A Activator for osteoblasts 失效
标题翻译：成骨细胞激活剂
公开(公告)号：US5002968A
公开(公告)日：1991-03-26
申请号：US276666
申请日：1988-11-28
申请人： Hajime Orimo , Hiroshi Satoh , Kohei Miyao , Norihiro Kakimoto
发明人： Hajime Orimo , Hiroshi Satoh , Kohei Miyao , Norihiro Kakimoto
IPC分类号： A61K31/80 , A61K31/28 , A61P3/00 , A61P19/10 , A61P43/00 , C07F7/30
CPC分类号： C07F7/30
摘要： The present invention provides (a) an activator for osteoblast comprising, as an active ingredient, a salt between (1) an organogermanium compound represented by the formula (I) ##STR1## [in the above formula (I), R.sub.1, R.sub.2 and R.sub.3 which may be the same or different, are independently a hydrogen atom, a lower alkyl group such as methyl, ethyl or the like, or an aryl group] and (2) a basic group-containing compound, and (b) a method for activating osteoblasts, which comprises administering in need of such treatment an effective amount of a salt between an organogermanium compound represented by the above formula (I) and a basic group-containing compound.
摘要翻译：本发明提供（a）成骨细胞活化剂，其包含作为活性成分的（1）由式（I）表示的有机锗化合物（I）[在上述式（I）中的R 1 ，R2和R3可以相同或不同，独立地为氢原子，低级烷基如甲基，乙基等或芳基]和（2）含碱性基团的化合物，和（b ）一种激活成骨细胞的方法，其包括在上述式（I）表示的有机锗化合物和含碱性基团的化合物之间施用有效量的盐。

10. 发明授权

US4956272A Organogermanium containing solution for washing and storing separated organs 失效
标题翻译：含有机硅的溶液用于洗涤和储存分离的器官
公开(公告)号：US4956272A
公开(公告)日：1990-09-11
申请号：US261628
申请日：1988-10-24
申请人： Norihiro Kakimoto , Kazuo Kumano , Kunie Nakamura
发明人： Norihiro Kakimoto , Kazuo Kumano , Kunie Nakamura
IPC分类号： A01N1/02 , A01N55/02
CPC分类号： A01N55/02 , A01N1/02 , A01N1/0226
摘要： The present invention provides (1) a solution for washing and storing separated organs, characterized by containing, as an effective component, an organogermanium compound represented by the formula (I) ##STR1## wherein R.sub.1 to R.sub.3 are each a hydrogen atom, a lower alkyl group such as methyl, ethyl or the like which may be the same or different, or a substituted or unsubstituted phenyl group, and X is a hydroxyl group, an O-lower alkyl group, an amino group or O.sup.- Y.sup.+ (Y is a metal such as sodium, potassium or the like, or a basic group-containing compound such as lysozyme, basic amino acid or the like), and (2) a method for washing and storing separated organs with a solution containing, as an effective component, an organogermanium compound represented by the formula (I).
摘要翻译：本发明提供（1）洗涤和储存分离的器官的溶液，其特征在于含有式（I）表示的有机锗化合物作为有效成分，其中R1至R3各自为氢原子，可以相同或不同的甲基，乙基等的低级烷基或取代或未取代的苯基，X是羟基，O-低级烷基，氨基或O-Y + （Y是钠，钾等金属或溶菌酶，碱性氨基酸等含碱性化合物的化合物），和（2）将分离的器官与含有作为有效成分，由式（I）表示的有机锗化合物。

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