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1. 发明授权

US10259860B2 Fusion proteins binding to VEGF and angiopoietin 有权
公开(公告)号：US10259860B2
公开(公告)日：2019-04-16
申请号：US11932021
申请日：2007-10-31
申请人： Hak-Zoo Kim , Young Jun Koh , Ho-Min Kim , Keehoon Jung , Choonjoo Jeon , Gou Young Koh
发明人： Hak-Zoo Kim , Young Jun Koh , Ho-Min Kim , Keehoon Jung , Choonjoo Jeon , Gou Young Koh
IPC分类号： C07K14/71 , A61K38/18 , C12N15/62 , A61K38/00
摘要： The present application discloses an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding VEGF polypeptide and Angiopoietin polypeptide, which includes a nucleotide sequence encoding a Tie2 component and a VEGFR component.

2. 发明授权

US08268316B2 Monoclonal antibody specific to anthrax toxin 有权
标题翻译：对炭疽毒素特异性的单克隆抗体
公开(公告)号：US08268316B2
公开(公告)日：2012-09-18
申请号：US11908249
申请日：2006-03-10
申请人： Hyo Jeong Hong , Kyung Soo Inn , Nam Kyu Lim , Jung Whan Kim , Keun Soo Kim , Sang Yoon Lee , Se Yeon Kim , Hyun Jung Kang , Mee Sook Oh
发明人： Hyo Jeong Hong , Kyung Soo Inn , Nam Kyu Lim , Jung Whan Kim , Keun Soo Kim , Sang Yoon Lee , Se Yeon Kim , Hyun Jung Kang , Mee Sook Oh
IPC分类号： A61K39/40
CPC分类号： C07K16/1278 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/77
摘要： Disclosed is a monoclonal antibody having very high affinity to anthrax toxin and potent toxin-neutralizing activity. Also disclosed are a composition for neutralizing anthrax toxin comprising the antibody and a kit for detecting anthrax toxin.
摘要翻译：公开了对炭疽毒素具有非常高的亲和力和有效的毒素中和活性的单克隆抗体。还公开了用于中和包含抗体的炭疽毒素的组合物和用于检测炭疽毒素的试剂盒。

3. 发明授权

US08206698B2 Method of treating a cutaneous wound using a coiled coil chimeric molecule 有权
标题翻译：使用线圈嵌合分子治疗皮肤伤口的方法
公开(公告)号：US08206698B2
公开(公告)日：2012-06-26
申请号：US12728158
申请日：2010-03-19
申请人： Gou Young Koh , Chung-Hyun Cho
发明人： Gou Young Koh , Chung-Hyun Cho
IPC分类号： A61K38/18
CPC分类号： A61K38/18 , A61K38/00 , A61K38/39 , C07K14/515 , C07K2319/73 , C07K2319/74
摘要： The present application discloses a method of treating a disease that is treatable by therapeutic angiogenesis comprising administering to a needy subject an effective amount of a chimeric coiled coil molecule comprising a coiled-coil domain linked to a receptor binding domain of a ligand.
摘要翻译：本申请公开了一种治疗可通过治疗性血管发生治疗的疾病的方法，其包括向有需要的受试者施用有效量的嵌合螺旋线圈分子，其包含与配体的受体结合结构域连接的螺旋线圈结构域。

4. 发明申请

US20140073566A1 METHODS OF USING CHIMERIC COILED-COIL MOLECULE 审中-公开
标题翻译：使用二极管线圈分子的方法
公开(公告)号：US20140073566A1
公开(公告)日：2014-03-13
申请号：US13848015
申请日：2013-03-20
申请人： Aprogen, Inc.
发明人： Gou Young KOH , Chung-Hyun CHO
IPC分类号： A61K38/18 , A61K38/39
CPC分类号： A61K38/18 , A61K38/00 , A61K38/39 , C07K14/515 , C07K2319/73 , C07K2319/74
摘要： The present application discloses a method of treating a disease that is treatable by therapeutic angiogenesis comprising administering to a needy subject an effective amount of a chimeric coiled coil molecule comprising a coiled-coil domain linked to a receptor binding domain of a ligand.
摘要翻译：本申请公开了一种治疗可通过治疗性血管发生治疗的疾病的方法，其包括向有需要的受试者施用有效量的嵌合螺旋线圈分子，其包含与配体的受体结合结构域连接的螺旋线圈结构域。

5. 发明授权

US08414877B2 Method for inducing angiogenesis in an infarcted heart by administering a coiled coil chimeric molecule 有权
标题翻译：通过施用螺旋线圈嵌合分子在梗死心脏中诱导血管生成的方法
公开(公告)号：US08414877B2
公开(公告)日：2013-04-09
申请号：US13474439
申请日：2012-05-17
申请人： Gou Young Koh , Chung-Hyun Cho
发明人： Gou Young Koh , Chung-Hyun Cho
IPC分类号： A61K38/18
CPC分类号： A61K38/18 , A61K38/00 , A61K38/39 , C07K14/515 , C07K2319/73 , C07K2319/74
摘要： The present application discloses a method of treating a disease that is treatable by therapeutic angiogenesis comprising administering to a needy subject an effective amount of a chimeric coiled coil molecule comprising a coiled-coil domain linked to a receptor binding domain of a ligand.
摘要翻译：本申请公开了一种治疗可通过治疗性血管发生治疗的疾病的方法，其包括向有需要的受试者施用有效量的嵌合螺旋线圈分子，其包含与配体的受体结合结构域连接的螺旋线圈结构域。

6. 发明授权

US07691366B2 Chimeric CMP-Ang1 molecule 有权
标题翻译：嵌合CMP-Ang1分子
公开(公告)号：US07691366B2
公开(公告)日：2010-04-06
申请号：US11956291
申请日：2007-12-13
申请人： Gou Young Koh
发明人： Gou Young Koh
IPC分类号： A61K38/18 , C07K14/515
CPC分类号： C07K14/515 , A61K38/00 , C07K2319/00
摘要： The present application describes a fusion molecule that includes coiled coil domain, which renders the molecule soluble and provides potent activity.
摘要翻译：本申请描述了包含卷曲螺旋结构域的融合分子，其使分子可溶并提供有效活性。

7. 发明授权

US08426570B2 Recombinant expression vector for animal cell 有权
标题翻译：动物细胞重组表达载体
公开(公告)号：US08426570B2
公开(公告)日：2013-04-23
申请号：US13002814
申请日：2009-07-07
申请人： Keun Soo Kim , Hye Kyung Ju , Choon Ju Jeon , Jae Seob Kim
发明人： Keun Soo Kim , Hye Kyung Ju , Choon Ju Jeon , Jae Seob Kim
IPC分类号： C07H21/02 , C07H21/04 , C12N5/00 , C12N5/02 , C12N15/00
CPC分类号： C12N15/85 , C12N9/003 , C12N15/8509 , C12N2800/107
摘要： The present invention relates to a recombinant expression vector for an animal cell containing a dihydrofolate reductase (DHFR) coding nucleotide sequence operatively linked to a DHFR promoter, to an animal cell line transformed by the vector, and to a method for preparing a target protein using the same. As compared with existing animal cell expression vectors, the vector of the present invention enables an effective screening of a cell line clone in which foreign genes are amplified together with DHFR genes even at a much lower methotrexate concentration. The present invention exhibits excellent effects in cell line preparation as high-productivity cell lines can be ensured in a short time through the use of a lower concentration of methotrexate in the process of protein production cell line establishment.
摘要翻译：本发明涉及用于动物细胞的重组表达载体，其含有编码与DHFR启动子有效连接的二氢叶酸还原酶（DHFR）的核苷酸序列，与载体转化的动物细胞系，以及使用一样。与现有的动物细胞表达载体相比，本发明的载体能够有效筛选外源基因与DHFR基因一起扩增的细胞系克隆，即使在低得多的甲氨蝶呤浓度下也是如此。本发明在蛋白质生产细胞系建立过程中通过使用较低浓度的甲氨蝶呤可以在短时间内确保高生产率细胞系，从而在细胞系制备中表现出优异的效果。

8. 发明授权

US08420353B2 Humanized antibody and process for preparing same 有权
标题翻译：人源化抗体及其制备方法
公开(公告)号：US08420353B2
公开(公告)日：2013-04-16
申请号：US10508759
申请日：2003-03-22
申请人： Hyo Jeong Hong , Cheol-Young Maeng , Gi-Hyeok Yang , Meong Hee Jang , Mee Sook Oh , Jin-Soo Song , Young Kug Jang
发明人： Hyo Jeong Hong , Cheol-Young Maeng , Gi-Hyeok Yang , Meong Hee Jang , Mee Sook Oh , Jin-Soo Song , Young Kug Jang
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/464 , A61K2039/505 , C07K16/082 , C07K16/461 , C07K2317/565 , C07K2317/92
摘要： A humanized antibody is produced by process comprising the steps of: (a) selecting a specificity determining residue (SDR) of the complementarity determining region (CDR) of murine monoclonal antibody heavy chain and light chain variable regions; and (b) grafting said SDR to at least one of the corresponding amino acid sequences in human antibody variable regions.
摘要翻译：通过包括以下步骤的方法制备人源化抗体：（a）选择鼠单克隆抗体重链和轻链可变区的互补决定区（CDR）的特异性测定残基（SDR）; 和（b）将所述SDR移植到人抗体可变区中的至少一个相应的氨基酸序列。

9. 发明授权

US07691365B2 Methods of using chimeric coiled coil molecule to treat ischemic disease 有权
标题翻译：使用嵌合卷曲螺旋分子治疗缺血性疾病的方法
公开(公告)号：US07691365B2
公开(公告)日：2010-04-06
申请号：US11576146
申请日：2005-09-28
申请人： Gou Young Koh , Chung-Hyun Cho
发明人： Gou Young Koh , Chung-Hyun Cho
IPC分类号： A61K38/18
CPC分类号： A61K38/18 , A61K38/00 , A61K38/39 , C07K14/515 , C07K2319/73 , C07K2319/74
摘要： The present application discloses a method of treating a disease that is treatable by therapeutic angiogenesis comprising administering to a needy subject an effective amount of a chimeric coiled coil molecule comprising a coiled-coil domain linked to a receptor binding domain of a ligand.
摘要翻译：本申请公开了一种治疗可通过治疗性血管发生治疗的疾病的方法，其包括向有需要的受试者施用有效量的嵌合螺旋线圈分子，其包含与配体的受体结合结构域连接的螺旋线圈结构域。

10. 发明授权

US11820831B2 Antibody binding to carbonic anhydrase and use thereof 有权
公开(公告)号：US11820831B2
公开(公告)日：2023-11-21
申请号：US17489885
申请日：2021-09-30
申请人： APROGEN INC.
发明人： Yoo Ri Moon , Sangsoon Yoon , Jeong Won Hong , Eun Jung Kim , Da Bin Choi
IPC分类号： C07K16/40 , A61K47/68 , A61P35/00 , C12N5/16 , C12N15/85 , G01N33/532 , G01N33/574 , A61K39/395
CPC分类号： C07K16/40 , A61K39/395 , A61K47/68 , A61P35/00 , C12N5/16 , C12N15/85 , G01N33/532 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57438
摘要： Provided is an antibody that recognizes and binds to carbonic anhydrase or antigen-binding fragment, a nucleic acid molecule coding for the antibody or antigen-binding fragment, a vector carrying the nucleic acid molecule, a host cell including the nucleic acid molecule or the vector, and use of the antibody or antigen-binding fragment thereof in the alleviation, prevention, treatment or diagnosis of solid cancers.

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