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1. 发明授权

US11624747B2 Biomarkers for the early detection of breast cancer 有权
公开(公告)号：US11624747B2
公开(公告)日：2023-04-11
申请号：US17015702
申请日：2020-09-09
申请人： ARIZONA BOARD OF REGENTS, a body corporate acting for and on behalf of Arizona State University , DANA-FARBER CANCER INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： Joshua Labaer , Karen Sue Anderson , Garrick Wallstrom , Sahar Sibani , Niroshan Ramachandran
IPC分类号： G01N33/574 , C07K14/47 , C07K17/00 , C12Q1/6886 , C40B40/10
摘要： The present invention provides reagents and methods for breast cancer detection.

2. 发明授权

US09589793B2 Laterally varying II-VI alloys and uses thereof 有权
标题翻译：二次变化的II-VI合金及其用途
公开(公告)号：US09589793B2
公开(公告)日：2017-03-07
申请号：US13126864
申请日：2009-11-06
申请人： Cun-Zheng Ning , Anlian Pan
发明人： Cun-Zheng Ning , Anlian Pan
IPC分类号： H01L31/06 , H01L21/02 , H01L31/0296 , H01L31/0352 , H01L33/02 , H01L33/28 , H01S5/10 , H01S5/327
CPC分类号： H01L21/02557 , H01L21/02422 , H01L21/02491 , H01L21/0256 , H01L21/02562 , H01L21/02568 , H01L21/0262 , H01L21/02636 , H01L31/0296 , H01L31/0352 , H01L33/02 , H01L33/28 , H01L2924/0002 , H01S5/1042 , H01S5/327 , H01L2924/00
摘要： Described herein are semiconductor structures comprising laterally varying II-VI alloy layer formed over a surface of a substrate. Further, methods are provided for preparing laterally varying II-VI alloy layers over at least a portion of a surface of a substrate comprising contacting at least a portion of a surface of a substrate within a reaction zone with a chemical vapor under suitable reaction conditions to form a laterally varying II-VI alloy layer over the portion of the surface of the substrate, wherein the chemical vapor is generated by heating at least two II-VI binary compounds; and the reaction zone has a temperature gradient of at least 50-100° C. along an extent of the reaction zone. Also described here are devices such as lasers, light emitting diodes, detectors, or solar cells that can use such semiconductor structures. In the case of lasers, spatially varying wavelength can be realized while in the case of solar cells and detectors multiple solar cells can be achieved laterally where each cell absorbs solar energy of a given wavelength range such that entire solar spectrum can be covered by the said solar cell structure. For LED applications, spatial variation of alloy composition can be used to engineer colors of light emission.
摘要翻译：这里描述的是包括在衬底的表面上形成的横向变化的II-VI合金层的半导体结构。此外，提供了用于在衬底的表面的至少一部分上制备横向变化的II-VI合金层的方法，包括使反应区内的衬底的至少一部分表面与合适的反应条件下的化学蒸气接触，在衬底的表面的部分上形成横向变化的II-VI合金层，其中通过加热至少两种II-VI二元化合物产生化学蒸气; 并且反应区沿着反应区的程度具有至少50-100℃的温度梯度。这里还描述了可以使用这种半导体结构的诸如激光器，发光二极管，检测器或太阳能电池的装置。在激光器的情况下，可以实现空间变化的波长，而在太阳能电池和检测器的情况下，可以横向实现多个太阳能电池，其中每个电池吸收给定波长范围的太阳能，使得整个太阳能光谱可被所述太阳能电池结构。对于LED应用，合金成分的空间变化可用于工程发光的颜色。

3. 发明授权

US08440811B2 DNA nanostructures that promote cell-cell interaction and use thereof 有权
标题翻译：促进细胞相互作用和使用的DNA纳米结构
公开(公告)号：US08440811B2
公开(公告)日：2013-05-14
申请号：US13122482
申请日：2009-10-02
申请人： Yung Chang , Hao Yan
发明人： Yung Chang , Hao Yan
IPC分类号： C07H21/04 , C07H21/02
CPC分类号： C12N15/115 , A61K31/711 , B82Y5/00 , C12N15/10 , C12N15/111 , C12N2310/16 , C12N2310/51 , C12N2320/13 , Y10T428/2982
摘要： The present invention provides a ligand-nucleic acid nanostructure that promotes cell-cell interaction. Specially, the invention provides a ligand-nucleic acid nanostructure for treating tumor in a mammal. The methods of using and making the composition comprising a ligand-nucleic acid nanostructure are also provided.
摘要翻译：本发明提供了促进细胞 - 细胞相互作用的配体 - 核酸纳米结构。特别地，本发明提供了用于治疗哺乳动物肿瘤的配体 - 核酸纳米结构。还提供了使用和制备包含配体 - 核酸纳米结构的组合物的方法。

4. 发明申请

US20130071590A1 MOLECULAR FILMS FOR HYDROPHOBIC IMPLANT SURFACES 审中-公开
标题翻译：用于疏水植入表面的分子膜
公开(公告)号：US20130071590A1
公开(公告)日：2013-03-21
申请号：US13674307
申请日：2012-11-12
申请人： Arizona Board of Regents, a body corporate acting
发明人： Nicole Herbots , James Doug Bradley , Murdock Hart , David Sell , Shawn D. Whaley , Qian Xing Bradley
IPC分类号： H01B1/12 , A61F2/16 , B65D25/08
CPC分类号： H01B1/122 , A61L27/34 , A61L27/50 , A61L27/52 , A61L2400/10 , A61L2420/02 , A61L2430/16 , B65D25/08 , C08L1/28 , C09D101/28 , Y10T428/1352 , Y10T428/139 , Y10T428/31507 , Y10T428/31663 , Y10T428/3188 , Y10T428/31971
摘要： Compositions are disclosed containing a solvated viscoelastic polymeric gel diluted into an ionically conductive aqueous solution which can be usefully applied to any surface that is hydrophobic to act, for example, as an antifogging coating with minimal optical distortion and excellent transparency. The compositions can also be used as lubricious agents on medical implants, shunts, and surgical supplies to minimize tissue trauma, to maximize bio-compatibility, and to increase healing by enhancing better irrigation and flow in adjacent tissue.
摘要翻译：公开了包含稀释成离子导电水溶液的溶剂化粘弹性聚合物凝胶的组合物，其可有效地施加到任何疏水性表面上，例如作为具有最小光学变形和优异透明度的防雾涂层。组合物还可以用作医疗植入物，分流器和手术用品上的润滑剂，以最小化组织创伤，最大化生物相容性，并通过增强相邻组织中更好的灌注和流动来增加愈合。

5. 发明授权

US08369956B2 Neurostimulator 失效
标题翻译：神经刺激器
公开(公告)号：US08369956B2
公开(公告)日：2013-02-05
申请号：US13214077
申请日：2011-08-19
申请人： Bruce C. Towe , William E. Crisp
发明人： Bruce C. Towe , William E. Crisp
IPC分类号： A61N1/00
CPC分类号： A61N1/3787 , A61N1/05 , A61N1/32 , A61N1/36071 , A61N1/36125 , A61N1/37205 , A61N7/00
摘要： Methods and devices for stimulating nerves are disclosed. In one embodiment adapted for stimulating excitable tissue, the invention includes drive circuitry, an acoustic transducer and a pair of electrodes.
摘要翻译：公开了刺激神经的方法和装置。在适于刺激可兴奋组织的一个实施例中，本发明包括驱动电路，声换能器和一对电极。

6. 发明授权

US08272576B2 Gas dynamic virtual nozzle for generation of microscopic droplet streams 有权
标题翻译：用于产生微小液滴流的气体动态虚拟喷嘴
公开(公告)号：US08272576B2
公开(公告)日：2012-09-25
申请号：US12664437
申请日：2008-06-20
申请人： Robert Bruce Doak , John C. H. Spence , Uwe Weierstall , Daniel DePonte , Dmitri Starodub , Jared Scott Warner
发明人： Robert Bruce Doak , John C. H. Spence , Uwe Weierstall , Daniel DePonte , Dmitri Starodub , Jared Scott Warner
IPC分类号： A62C5/02
CPC分类号： B05B7/0475 , B05B1/02
摘要： A nozzle for producing a single-file stream of droplets of a fluid, methods using the nozzle, and an injector, comprising the nozzle of the invention, for providing the single-file stream of droplets of a fluid to a high-vacuum system are described. The nozzle comprises two concentric tubes wherein the outer tube comprises a smoothly converging-diverging exit channel and the outlet end of the first tube is positioned within the converging section of the exit channel.
摘要翻译：用于产生流体液滴单液流的喷嘴，使用喷嘴的方法和喷射器，其包括本发明的喷嘴，用于向高真空系统提供流体的单液滴流。描述。喷嘴包括两个同心管，其中外管包括平稳会聚的发散出口通道，并且第一管的出口端位于出口通道的会聚部分内。

7. 发明申请

US20110254052A1 Hybrid Group IV/III-V Semiconductor Structures 审中-公开
标题翻译：混合组IV / III-V半导体结构
公开(公告)号：US20110254052A1
公开(公告)日：2011-10-20
申请号：US13062304
申请日：2009-09-16
申请人： John Kouvetakis , Jose Menendez
发明人： John Kouvetakis , Jose Menendez
IPC分类号： H01L29/12 , H01L21/20
CPC分类号： H01L21/02381 , H01L21/0245 , H01L21/02452 , H01L21/02543 , H01L21/02546 , H01L21/02549 , H01L21/0262 , H01L31/0324 , H01L31/0687 , H01L31/076 , H01L31/105 , H01L31/1804 , H01L31/1844 , H01L31/1852 , Y02E10/544 , Y02E10/547 , Y02E10/548 , Y02P70/521
摘要： Described herein are semiconductor structures comprising (i) a Si substrate; (ii) a buffer region formed directly over the Si substrate, wherein the buffer region comprises (a) a Ge layer having a threading dislocation density below about 105 cm−2; or (b) a Ge1-xSnx layer formed directly over the Si substrate and a Ge1-x-ySixSny layer formed over the Ge1-xSnx layer; and (iii) a plurality of III-V active blocks formed over the buffer region, wherein the first III-V active block formed over the buffer region is lattice matched or pseudomorphically strained to the buffer region. Further, methods for forming the semiconductor structures are provided and novel Ge1-x-ySixSny, alloys are provided that are lattice matched or pseudomorphically strained to Ge and have tunable band gaps ranging from about 0.80 eV to about 1.4O eV.
摘要翻译：本文描述的是包括（i）Si衬底的半导体结构; （ii）直接形成在所述Si衬底上的缓冲区，其中所述缓冲区包括（a）穿透位错密度低于约105cm -2的Ge层; 或（b）直接形成在Si衬底上的Ge1-xSnx层和形成在Ge1-xSnx层上的Ge1-x-ySixSny层; 和（iii）形成在所述缓冲区上的多个III-V有源块，其中形成在所述缓冲区上的所述第一III-V有源块与所述缓冲区是晶格匹配的或伪形变应变的。此外，提供了用于形成半导体结构的方法，并且提供新颖的Ge1-x-ySixSny合金，它们是与Ge晶格匹配或伪晶变应变的，并具有约0.80eV至约140eV的可调带隙。

8. 发明申请

US20110077722A1 NEUROSTIMULATOR 有权
标题翻译：神经细胞
公开(公告)号：US20110077722A1
公开(公告)日：2011-03-31
申请号：US12908792
申请日：2010-10-20
申请人： Bruce Towe , William E. Crisp
发明人： Bruce Towe , William E. Crisp
IPC分类号： A61N1/36
CPC分类号： A61N1/3787 , A61N1/05 , A61N1/32 , A61N1/36071 , A61N1/36125 , A61N1/37205 , A61N7/00
摘要： Methods and devices of stimulating nerves are disclosed. In one embodiment adapted for stimulating excitable tissue, the invention includes drive circuitry (12), an acoustic transducer (14) and a pair of electrodes (28).
摘要翻译：公开了刺激神经的方法和装置。在适于刺激可兴奋组织的一个实施例中，本发明包括驱动电路（12），声换能器（14）和一对电极（28）。

9. 发明申请

US20100179628A1 Neurostimulator 有权
公开(公告)号：US20100179628A1
公开(公告)日：2010-07-15
申请号：US12732001
申请日：2010-03-25
申请人： Bruce Towe , William E. Crisp
发明人： Bruce Towe , William E. Crisp
IPC分类号： A61N1/05
CPC分类号： A61N1/3787 , A61N1/05 , A61N1/32 , A61N1/36071 , A61N1/36125 , A61N1/37205 , A61N7/00
摘要： Methods and devices of stimulating nerves are disclosed. In one embodiment adapted for stimulating excitable tissue, the invention includes drive circuitry (12), an acoustic transducer (14) and a pair of electrodes (28).

10. 发明申请

US20090041793A1 Immunostimulatory Compositions and Uses Thereof 有权
标题翻译：免疫刺激成分及其用途
公开(公告)号：US20090041793A1
公开(公告)日：2009-02-12
申请号：US10588627
申请日：2005-02-04
申请人： Laura L. Eggink , Valerie Jacobs , Kenneth Hoober
发明人： Laura L. Eggink , Valerie Jacobs , Kenneth Hoober
IPC分类号： A61K39/00 , C07K7/00 , A61K38/03 , C07H21/04 , A61P35/00 , A61P29/00 , A61P37/00 , A61P19/00 , G01N33/566 , C12N15/63 , C12N5/00
CPC分类号： C07K14/57
摘要： The present invention provides novel immuno-stimulatory polypeptides, and methods for their use and identification.
摘要翻译：本发明提供了新的免疫刺激多肽及其使用和鉴定方法。

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