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1. 发明授权

US5581856A Process for the production of uncoated technical fabrics with low air permeability 失效
标题翻译：用于生产低透气性的未涂布技术织物的方法
公开(公告)号：US5581856A
公开(公告)日：1996-12-10
申请号：US455253
申请日：1995-05-31
申请人： Wolf Krummheuer , Hans A. Graefe , Volker Siejak
发明人： Wolf Krummheuer , Hans A. Graefe , Volker Siejak
IPC分类号： B60R21/16 , B60R21/235 , D03D1/02 , D06C21/00
CPC分类号： B60R21/235 , D03D1/02
摘要： Uncoated technical fabric is produced in a dense weave with low air permeability. The fabric contains polyamide filament yarns with a hot air shrinkage of 6 to 15% (determined at 160.degree. C.) and has an at least substantially symmetrical fabric construction. The fabric is adjusted to the required air permeability by a treatment in an aqueous bath at 60.degree. to 140.degree. C.
摘要翻译：无涂层的技术织物以低透气度的密集编织生产。该织物含有聚酰胺长丝纱线，其热空气收缩率为6至15％（在160℃下测定），并具有至少基本对称的织物结构。通过在60℃至140℃的水浴中进行处理将织物调节至所需的透气性。

2. 发明授权

US5514457A Textile structure for protective clothing 失效
标题翻译：防护服的纺织结构
公开(公告)号：US5514457A
公开(公告)日：1996-05-07
申请号：US203490
申请日：1994-02-28
申请人： Achim G. Fels , Georg K. Brustmann , Dieter H. P. Schuster
发明人： Achim G. Fels , Georg K. Brustmann , Dieter H. P. Schuster
IPC分类号： D02G3/44 , F41H1/02 , B32B5/02 , D02G3/00 , D03D3/00
CPC分类号： D02G3/442 , Y10S428/911 , Y10T428/2929 , Y10T428/2936 , Y10T442/3081 , Y10T442/3512 , Y10T442/3976 , Y10T442/438 , Y10T442/463 , Y10T442/608 , Y10T442/668 , Y10T442/696
摘要： Textile structures, such as fabrics, knits, warp-knitted fabrics, stitch-bonded fabrics, thread structures, etc. for use in clothing which protects against stabbing, cutting, fragments and bullets, are produced from wrapped yarns. These yarns have a core of penetration resistant fibers and an outer sheath of natural and/or manmade fibers that can easily be dyed, printed, or optically brightened.
摘要翻译：由包裹的纱线制造用于衣服中防止刺伤，切割，碎片和子弹的纺织结构，例如织物，针织物，经编织物，缝合织物，线结构等。这些纱线具有耐穿透纤维的芯和天然和/或人造纤维的外护套，其可以容易地染色，印刷或光学增亮。

3. 发明授权

US5464621A Canine corona virus vaccine 失效
标题翻译：犬冠状病毒疫苗
公开(公告)号：US5464621A
公开(公告)日：1995-11-07
申请号：US285611
申请日：1994-08-03
申请人： William Baxendale , William S. K. Chalmers
发明人： William Baxendale , William S. K. Chalmers
IPC分类号： C12N7/00 , A61K39/215 , A61P31/12 , C12R1/92 , C12N7/08
CPC分类号： A61K39/215 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , A61K2039/55577 , C12N2770/20034 , Y10S424/818 , Y10S435/948
摘要： A live or inactivated canine corona virus vaccine is provided which is derived from a virus of the novel antigenic type of the canine corona virus strain I-743 (CNCM, Institut Pasteur, Paris). A method for the preparation of this vaccine and the use of said vaccine in protecting susceptible animals against canine corona virus injection are also disclosed.
摘要翻译：提供活的或灭活的犬冠状病毒疫苗，其来源于犬冠状病毒株I-743的新型抗原型病毒（CNCM，Institut Pasteur，Paris）。还公开了制备该疫苗的方法和所述疫苗用于保护易感染动物免受犬冠状病毒注射的用途。

4. 发明授权

US5462959A 4-aryl-imidazole derivatives 失效
标题翻译： 4-芳基 - 咪唑衍生物
公开(公告)号：US5462959A
公开(公告)日：1995-10-31
申请号：US136530
申请日：1993-10-14
申请人： John H. Pick , Robert T. Logan
发明人： John H. Pick , Robert T. Logan
IPC分类号： A61K31/415 , A61K31/425 , A61K31/426 , A61P9/04 , A61P11/08 , A61P43/00 , C07D233/90 , C07D277/20 , C07D277/56
CPC分类号： C07D277/56 , C07D233/90
摘要： The invention concerns a 4-aryl-imidazole derivative having the formula I ##STR1## wherein X is 0 or NOH,Y is NR.sub.3,Ar is a group selected from phenyl, naphthyl, tetrahydronaphthyl, and biphenyl,R is one to four substituents independently selected from hydrogen, hydroxy, lower alkyl, lower alkoxy, lower thioalkyl, cycloalkyl, halogen, CF.sub.3, NO.sub.2, and O--ALK--NR.sub.1 R.sub.2, in which ALK is a saturated aliphatic hydrocarbon group having 2-6 carbon atoms, and R.sub.1 and R.sub.2 are independently hydrogen or lower alkyl, or form, together with the nitrogen atom to which they are bonded, a heterocyclic ring, andR.sub.3 is hydrogen or a lower alkyl; or a pharmaceutically acceptable salt thereof, with the proviso that 4-(4-chlorophenyl)-thiazole-2-carboxamide is excluded. The compounds according to the invention increase the sensitivity of cardiac myofibrils to calcium and possess phosphodiesterase inhibitory activity and bronchodilator activity, and are useful for the treatment of patients suffering from heart failure and asthma.
摘要翻译：本发明涉及具有式I的4-芳基 - 咪唑衍生物，其中X为0或NOH，Y为NR3，Ar为选自苯基，萘基，四氢萘基和联苯基的基团，R为1-4个取代基独立地选自氢，羟基，低级烷基，低级烷氧基，低级硫代烷基，环烷基，卤素，CF 3，NO 2和O-ALK-NR 1 R 2，其中ALK是具有2-6个碳原子的饱和脂族烃基， R2独立地为氢或低级烷基，或与它们所键合的氮原子一起形成杂环，并且R 3为氢或低级烷基; 或其药学上可接受的盐，条件是不包括4-（4-氯苯基） - 噻唑-2-甲酰胺。根据本发明的化合物增加心脏肌原纤维对钙的敏感性并具有磷酸二酯酶抑制活性和支气管扩张剂活性，并且可用于治疗患有心力衰竭和哮喘的患者。

5. 发明授权

US5433955A Site specific in vivo activation of therapeutic drugs 失效
标题翻译：治疗药物的体内活化位点特异性
公开(公告)号：US5433955A
公开(公告)日：1995-07-18
申请号：US134520
申请日：1993-10-08
申请人： Reinhard Bredehorst , Chong-Ho Kim , Richard McCabe , Nicholas Pomato , Carl-Wilhelm Vogel
发明人： Reinhard Bredehorst , Chong-Ho Kim , Richard McCabe , Nicholas Pomato , Carl-Wilhelm Vogel
IPC分类号： A61K31/715 , A61K47/48 , A61K38/52 , A61K31/70 , C07H15/252 , C12N11/06
CPC分类号： A61K31/70 , A61K31/715 , A61K47/48761 , B82Y5/00
摘要： A method for site-specific in-vivo activation of a prodrug in an animal using an activator-targeting moiety conjugate to localize an activator at a predetermined site of use and a prodrug compound that is converted to an active drug in the presence of the activator. In the preferred embodiment, the targeting moiety, the activator, and the prodrug demonstrate little or no immunogenicity in the animal being treated. The targeting moiety is relatively specific for binding to the target tissue than to non-target tissue. The activator is not found or present in only small amounts in circulation or in non-target tissue, does not have a substrate for its activity in circulation or in non-target tissue, can be linked to the targeting moiety, and is capable of converting the prodrug to an active drug. The prodrug is selected for its ability to exert a cytotoxic activity on the target tissue after conversion by the activator.
摘要翻译：使用活化剂 - 靶向部分缀合物在动物中进行体内前体药物的位点特异性体内活化的方法，以在预定的使用位点定位活化剂，以及在活化剂存在下转化为活性药物的前药化合物。在优选的实施方案中，靶向部分，活化剂和前药在所治疗的动物中表现出很少的或不具有免疫原性。靶向部分对于与非靶组织的结合相对于靶组织是相对特异的。活化剂在循环或非靶组织中没有发现或仅存在少量，不具有其在循环中或非靶组织中的活性的底物，可以连接到靶向部分，并且能够转化该前体药物为活性药物。选择前体药物是通过活化剂转化后在靶组织上发挥细胞毒活性的能力。

6. 发明授权

US5430187A Method for manufacturing dibenzylamine 失效
标题翻译：二苄胺的制备方法
公开(公告)号：US5430187A
公开(公告)日：1995-07-04
申请号：US244223
申请日：1994-05-17
申请人： Burkhard Weuste , Manfred Bergfeld
发明人： Burkhard Weuste , Manfred Bergfeld
IPC分类号： C07C209/26 , C07C209/24
CPC分类号： C07C209/26
摘要： The method for manufacturing dibenzylamine by reacting benzaldehyde and ammonia in the presence of hydrogen and a hydrogenation catalyst in an inert organic solvent is characterized by the fact that the reaction is conducted with an ammonia ratio of >0.5 mol per mol benzaldehyde and with a hydrogenation catalyst containing a platinum metal and/or a ferrous metal on a carrier. The method is performed at low temperatures, preferably 40.degree.-90.degree. C. In particular, a high selectivity for dibenzylamine of more than 90% is achieved with practically complete benzaldehyde conversion.
摘要翻译： PCT No.PCT / EP92 / 02918 Sec。 371日期：1994年5月17日 102（e）日期1994年5月17日PCT提交1992年12月16日PCT公布。公开号WO93 / 13047 日期：1993年7月8日。在惰性有机溶剂中，在氢气和氢化催化剂存在下，使苯甲醛和氨反应制备二苄基胺的方法的特征在于，反应是以氨比例> 0.5mol / 并与载体上含有铂金属和/或黑色金属的氢化催化剂反应。该方法在低温下进行，优选在40-90℃进行。特别地，通过几乎完全的苯甲醛转化，实现对二苄基胺的高选择性大于90％。

7. 发明授权

US5418044A Irreversibly stretchable laminate comprising layers of woven or knitted fabrics and water-vapor permeable films 失效
标题翻译：不可逆拉伸的层压材料包括机织或针织织物层和水蒸气透过膜
公开(公告)号：US5418044A
公开(公告)日：1995-05-23
申请号：US84436
申请日：1993-07-01
申请人： Rolf-Dirk Mahler
发明人： Rolf-Dirk Mahler
IPC分类号： A41D31/02 , B32B5/22 , D06N3/00 , D06N3/04 , D06N3/12 , D06N3/14 , B32B27/14 , B32B7/00
CPC分类号： B32B5/22 , A41D31/02 , D06N3/0009 , D06N3/045 , D06N3/121 , D06N3/14 , Y10T428/2481 , Y10T428/24826 , Y10T428/28 , Y10T428/2843 , Y10T442/3854 , Y10T442/3886 , Y10T442/40
摘要： In laminates composed of a woven or knitted fabric and a film impermeable to water and permeable to water vapor, the woven or knitted fabric is made of unstretched or partially stretched fibers. The laminates are highly extensible and retain the shape obtained by stretching. They are particularly useful as starting materials for intermediate layers in shoes and gloves and confer advantages over and above known laminates in respect to the manufacture and properties of the finished articles.
摘要翻译：在由编织物或针织织物组成的层压体和不透水的薄膜和水蒸气中，机织或针织织物由未拉伸或部分拉伸的纤维制成。层压板是高度可延伸的并且保持通过拉伸获得的形状。它们作为鞋子和手套中间层的起始材料是特别有用的，并且相对于成品的制造和性质而言，具有超过已知层压板的优点。

8. 发明授权

US5405324A Implantation device 失效
标题翻译：植入装置
公开(公告)号：US5405324A
公开(公告)日：1995-04-11
申请号：US38757
申请日：1993-03-30
申请人： Maarten A. H. M. Wiegerinck
发明人： Maarten A. H. M. Wiegerinck
IPC分类号： A61M5/158 , A61M20060101 , A61M1/12 , A61M5/00 , A61M25/00 , A61M31/00 , A61M37/00 , C07K20060101 , C12N20060101 , C12P20060101 , C12Q20060101 , G01N20060101
CPC分类号： A61M37/0069
摘要： The invention relates to an implantation device with which a medicinal implant can be introduced subcutaneously in humans or animals. The device comprises a hollow needle and a mandrel having a chamfered distal end, which precisely coincides with the plane of the chamfered distal end of the hollow needle. The invention also relates to a method for introducing an implant into subcutaneous tissue of humans or animals using the implantation device.
摘要翻译：本发明涉及一种植入装置，通过该植入装置可将医用植入物皮下注入人或动物。该装置包括中空针头和具有倒角远端的心轴，其精确地与中空针的倒角远端的平面重合。本发明还涉及使用植入装置将植入物引入人或动物的皮下组织的方法。

9. 发明授权

US5403485A Dialysis membrane made of cellulose acetate 失效
标题翻译：由醋酸纤维素制成的透析膜
公开(公告)号：US5403485A
公开(公告)日：1995-04-04
申请号：US63321
申请日：1993-05-19
申请人： Gustav Dunweg , Lother Steinfeld , Wolfgang Ansorge
发明人： Gustav Dunweg , Lother Steinfeld , Wolfgang Ansorge
IPC分类号： B01D61/24 , A61M1/18 , B01D63/02 , B01D67/00 , B01D69/08 , B01D71/16 , D01D5/24 , D01F2/28 , B01D33/21
CPC分类号： B01D71/16 , B01D69/08 , D01D5/24 , D01F2/28 , Y10T428/2975
摘要： A dialysis membrane in the form of a hollow fiber with a continuous internal cavity is made of cellulose acetate or a cellulose acetate derivative. The hollow fiber is made by using a gas to form the internal hollow cavity. A dialysis membrane in the form of a hollow fiber with a continuous hollow cavity may be made in a process using a spinning solution containing an organic carboxylic acid. Modification agents can be added to the solution and the solution extruded through a spinneret suitable for manufacturing hollow fibers, while an internal medium is introduced simultaneously into the internal cavity of the forming hollow fiber. The precipitation of the dialysis membrane thus formed and an ordinary further aftertreatment take place subsequently in a precipitation bath. The hollow fiber is made by using a gas as the internal medium to form the internal cavity.
摘要翻译：具有连续内腔的中空纤维形式的透析膜由乙酸纤维素或醋酸纤维素衍生物制成。通过使用气体形成中空纤维以形成内部中空腔。可以使用含有有机羧酸的纺丝溶液的方法制造具有连续中空腔的中空纤维形式的透析膜。可以向溶液中加入改性剂，并将溶液通过适于制造中空纤维的喷丝头挤出，同时将内部介质同时引入成型中空纤维的内腔中。这样形成的透析膜的沉淀和普通的进一步的后处理随后在沉淀浴中进行。中空纤维通过使用气体作为内部介质来形成内部空腔。

10. 发明授权

US5367082A Process for the preparation of 2-mercaptobenzothiazole 失效
标题翻译： 2-巯基苯并噻唑的制备方法
公开(公告)号：US5367082A
公开(公告)日：1994-11-22
申请号：US11767
申请日：1993-02-01
申请人： Manfred J. Bergfeld , Norbert Gutlein , Klaus Wohlfahrt , Eberhard Aust
发明人： Manfred J. Bergfeld , Norbert Gutlein , Klaus Wohlfahrt , Eberhard Aust
IPC分类号： C07D277/72
CPC分类号： C07D277/72 , Y02P20/582
摘要： In a process for the preparation of 2-mercaptobenzothiazole from aniline, sulfur and carbon disulfide under pressure and for separation of the 2-mercaptobenzothiazole from the crude reaction product by cooling and recycling the desirable intermediates and by-products into the reactor together with aniline, sulfur and carbon disulfide, the reaction is carried out using a residence time in the reactor of at least one hour to a time before the 2-mercaptobenzothiazole product thus-formed begins to decompose into undesirable intermediate products. A maximum hydrogen sulfide pressure is maintained on quenching to a temperature ranging between 220 and 280.degree. C. by mixing the crude reaction product with carbon disulfide at a temperature sufficient to obtain a homogeneous quenched mixture. The hydrogen sulfide is removed completely only after crystallization of the 2-mercaptobenzothiazole.
摘要翻译：在压力下从苯胺，硫和二硫化碳制备2-巯基苯并噻唑的方法中，通过与苯胺一起冷却和再循环所需的中间体和副产物，将2-巯基苯并噻唑与粗反应产物分离，硫和二硫化碳，反应在反应器中停留时间至少1小时至此后由此形成的2-巯基苯并噻唑产物开始分解成不期望的中间产物。通过在足以获得均匀淬火的混合物的温度下将粗反应产物与二硫化碳混合，将淬火后的最大硫化氢压力维持在220-280℃的温度。仅在2-巯基苯并噻唑结晶后才完全除去硫化氢。

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