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1. 发明申请

US20200061080A1 TRANSDERMAL CONTRACEPTIVE HORMONES DELIVERY 审中-公开
公开(公告)号：US20200061080A1
公开(公告)日：2020-02-27
申请号：US16436435
申请日：2019-06-10
申请人： Agile Therapeutics, Inc.
发明人： Thomas M. Rossi , Marie Foegh , Agis Kydonieus
IPC分类号： A61K31/567 , A61K9/70 , A61K31/535 , A61K31/56 , A61K31/565 , A61K9/00
摘要： Dosing regimens for transdermal delivery of hormones comprising a variable treatment cycle and a fixed rest interval are disclosed.

2. 发明申请

US20180104258A1 TRANSDERMAL CONTRACEPTIVE HORMONES DELIVERY 审中-公开
公开(公告)号：US20180104258A1
公开(公告)日：2018-04-19
申请号：US15705039
申请日：2017-09-14
申请人： Agile Therapeutics, Inc.
发明人： Thomas M. Rossi , Marie Foegh , Agis Kydonieus
IPC分类号： A61K31/57 , A61K9/70 , A61K31/565 , A61K31/566
CPC分类号： A61K31/57 , A61K9/7023 , A61K9/7038 , A61K9/7061 , A61K9/7084 , A61K31/565 , A61K31/566 , A61K2300/00
摘要： Dosing regimens for transdermal delivery of hormones comprising a 28 day treatment cycle with a fixed treatment interval and a fixed rest interval are disclosed.

3. 发明申请

US20180104193A1 Transdermal Delivery 审中-公开
公开(公告)号：US20180104193A1
公开(公告)日：2018-04-19
申请号：US15705093
申请日：2017-09-14
申请人： Agile Therapeutics, Inc.
发明人： Thomas M. Rossi , Marie Foegh , Agis Kydonieus
IPC分类号： A61K9/70 , A61K31/569 , A61K45/06 , A61K31/57 , A61K31/567
CPC分类号： A61K9/703 , A61K9/7038 , A61K9/7061 , A61K9/7084 , A61K31/567 , A61K31/569 , A61K31/57 , A61K45/06 , A61K2300/00
摘要： Dosing regimens for transdermal delivery of hormones comprising a five week treatment cycle with a fixed treatment interval and a fixed rest interval.

4. 发明授权

US09775848B2 Transdermal contraceptive hormones delivery 有权
公开(公告)号：US09775848B2
公开(公告)日：2017-10-03
申请号：US14925207
申请日：2015-10-28
申请人： Agile Therapeutics, Inc.
发明人： Thomas M. Rossi , Marie Foegh , Agis Kydonieus
IPC分类号： A61K31/57 , A61K31/565 , A61K31/566 , A61K9/70 , A61K47/12 , A61K47/14 , A61K47/24
CPC分类号： A61K31/57 , A61K9/7023 , A61K9/7038 , A61K9/7061 , A61K9/7084 , A61K31/565 , A61K31/566 , A61K47/12 , A61K47/14 , A61K47/24 , A61K2300/00
摘要： Dosing regimen for transdermal delivery of hormones comprising a monthly treatment cycle with a fixed treatment interval and a variable rest interval.

5. 发明申请

US20160045451A1 Transdermal Delivery 有权
标题翻译：透皮输送
公开(公告)号：US20160045451A1
公开(公告)日：2016-02-18
申请号：US14925239
申请日：2015-10-28
申请人： Agile Therapeutics, Inc.
发明人： Thomas M. ROSSI , Marie FOEGH , Agis KYDONIEUS
IPC分类号： A61K9/70 , A61K31/567
CPC分类号： A61K9/703 , A61K9/7038 , A61K9/7061 , A61K9/7084 , A61K31/567 , A61K31/569 , A61K31/57 , A61K45/06 , A61K2300/00
摘要： Dosing regimen for transdermal delivery of hormones comprising a 28 day treatment cycle with a fixed treatment interval and a fixed rest interval.
摘要翻译：用于经皮递送激素的给药方案，其包括具有固定治疗间隔和固定休息间隔的28天治疗周期。

6. 发明授权

US09198919B2 Contraceptive transdermal delivery of hormones 有权
标题翻译：激素的避孕透皮递送
公开(公告)号：US09198919B2
公开(公告)日：2015-12-01
申请号：US13123026
申请日：2009-10-07
申请人： Thomas M. Rossi , Marie Foegh , Agis Kydonieus
发明人： Thomas M. Rossi , Marie Foegh , Agis Kydonieus
IPC分类号： A61K31/565 , A61K31/57 , A61K9/70 , A61K31/56 , A61K31/535 , A61K31/567
CPC分类号： A61K31/567 , A61K9/0014 , A61K9/7038 , A61K9/7061 , A61K9/7084 , A61K31/535 , A61K31/56 , A61K31/565 , A61K2300/00
摘要： Dosing regimen for transdermal delivery of hormones comprising a variable treatment cycle and a variable rest interval.
摘要翻译：用于经皮递送激素的给药方案，包括可变治疗周期和可变休息间隔。

7. 发明申请

US20140256690A1 CONTRACEPTIVE METHOD 审中-公开
标题翻译：承办方式
公开(公告)号：US20140256690A1
公开(公告)日：2014-09-11
申请号：US14201153
申请日：2014-03-07
申请人： Arkady RUBIN , Maria FOEGH , Agis KYDONIEUS , Thomas M. ROSSI
发明人： Arkady RUBIN , Maria FOEGH , Agis KYDONIEUS , Thomas M. ROSSI
IPC分类号： A61K9/70 , A61K31/565 , A61K31/567
CPC分类号： A61K31/565 , A61K9/7061 , A61K31/567 , A61K2300/00
摘要： A transdermal drug delivery device for reducing the risk of pregnancy in overweight women is disclosed. Methods of using the device are also disclosed. When used in accordance with the disclosed methods, the probability that the device will be effective in overweight women is approximately equal to or greater than the probability that the device would be effective in the case of a woman who is not overweight.
摘要翻译：公开了一种用于降低超重女性怀孕风险的透皮给药装置。还公开了使用该装置的方法。当根据所公开的方法使用时，设备在超重女性中有效的可能性大约等于或大于在不超重的女性的情况下该装置有效的概率。

8. 发明申请

US20070065495A1 Transdermal hormone delivery system: compositions and methods 审中-公开
标题翻译：透皮激素递送系统：组合物和方法
公开(公告)号：US20070065495A1
公开(公告)日：2007-03-22
申请号：US11601954
申请日：2006-11-20
申请人： Te-Yen Chien
发明人： Te-Yen Chien
IPC分类号： A61K9/70 , A61K31/22
CPC分类号： A61K9/7038 , A61K9/0014 , A61K9/7061 , A61K31/565 , A61K31/57 , A61K47/12 , A61K47/14 , A61K47/20 , A61K2300/00
摘要： A transdermal hormone delivery system (THDS) is disclosed. The THDS is useful for control of fertility and as therapy for a variety of diseases and conditions treatable by robust delivery of progestin and estrogen hormones, particularly the progestin, levonorgestrel. The THDS comprises a backing layer, an adjoining adhesive polymer matrix comprising an effective amount of at least a progestin hormone, delivery of which is enhanced by one or more skin permeation enhancing agents present in pre-determined amounts. The THDS is capable of providing effective daily doses of progestin and estrogen hormones from a small surface area in contact with the skin, e.g., less than 20 square centimeters. Methods of fertility control and various types of hormone replacement therapy utilizing the THDS are also disclosed.
摘要翻译：公开透皮激素释放系统（THDS）。 THDS可用于控制生育力，并用于通过强力递送孕激素和雌激素激素，特别是孕激素左炔诺孕酮治疗的各种疾病和病症。 THDS包括背衬层，邻接的粘合剂聚合物基质，其包含有效量的至少一种孕激素，其输送通过以预定量存在的一种或多种皮肤渗透增强剂增强。 THDS能够从与皮肤接触的小表面积（例如小于20平方厘米）提供孕激素和雌激素的有效日剂量。还公开了生育控制方法和利用THDS的各种类型的激素替代疗法。

9. 发明申请

US20180325916A1 Dermal Delivery Compositions And Methods 审中-公开
公开(公告)号：US20180325916A1
公开(公告)日：2018-11-15
申请号：US16045338
申请日：2018-07-25
申请人： Agile Therapeutics, Inc.
发明人： Charles G. ARNOLD , Agis Kydonieus , Thomas M. Rossi , Alfred F. Altomari
IPC分类号： A61K31/567 , A61K47/20 , A61K47/32 , A61K31/57 , A61K47/12 , A61K9/00 , A61K9/70
CPC分类号： A61K31/567 , A61K9/0014 , A61K9/7053 , A61K9/7061 , A61K31/57 , A61K47/12 , A61K47/20 , A61K47/32
摘要： A composition for transdermal delivery of a progestin for progestin hormone therapy is disclosed. Also disclosed is a transdermal delivery device comprising the composition. For progestin-only hormone therapy, the composition contains an anti-oxidant and does not contain an estrogen. For therapy involving a progestin and an estrogen, the composition contains the progestin, the estrogen and an additional anti-oxidant. Methods of improving the stability of progestin-containing compositions comprising oxidative agents are also disclosed. The methods comprise including one or more anti-oxidants in the compositions.

10. 发明授权

US09782419B2 Transdermal contraceptive hormones delivery 有权
公开(公告)号：US09782419B2
公开(公告)日：2017-10-10
申请号：US14925223
申请日：2015-10-28
申请人： Agile Therapeutics, Inc.
发明人： Thomas M. Rossi , Marie Foegh , Agis Kydonieus
IPC分类号： A61K31/57 , A61K31/565 , A61K31/566 , A61K9/70 , A61K47/12 , A61K47/14 , A61K47/24 , A61K31/567 , A61K31/535 , A61K31/56 , A61K9/00
CPC分类号： A61K31/567 , A61K9/0014 , A61K9/7038 , A61K9/7061 , A61K9/7084 , A61K31/535 , A61K31/56 , A61K31/565 , A61K2300/00
摘要： Dosing regimen for transdermal delivery of hormones comprising a variable treatment cycle and a variable rest interval.

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