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1. 发明申请

US20140256690A1 CONTRACEPTIVE METHOD 审中-公开
标题翻译：承办方式
公开(公告)号：US20140256690A1
公开(公告)日：2014-09-11
申请号：US14201153
申请日：2014-03-07
申请人： Arkady RUBIN , Maria FOEGH , Agis KYDONIEUS , Thomas M. ROSSI
发明人： Arkady RUBIN , Maria FOEGH , Agis KYDONIEUS , Thomas M. ROSSI
IPC分类号： A61K9/70 , A61K31/565 , A61K31/567
CPC分类号： A61K31/565 , A61K9/7061 , A61K31/567 , A61K2300/00
摘要： A transdermal drug delivery device for reducing the risk of pregnancy in overweight women is disclosed. Methods of using the device are also disclosed. When used in accordance with the disclosed methods, the probability that the device will be effective in overweight women is approximately equal to or greater than the probability that the device would be effective in the case of a woman who is not overweight.
摘要翻译：公开了一种用于降低超重女性怀孕风险的透皮给药装置。还公开了使用该装置的方法。当根据所公开的方法使用时，设备在超重女性中有效的可能性大约等于或大于在不超重的女性的情况下该装置有效的概率。

2. 发明申请

US20220218716A1 TREATMENT OF INFANTILE HEMANGIOMA 有权
公开(公告)号：US20220218716A1
公开(公告)日：2022-07-14
申请号：US17595746
申请日：2020-05-22
申请人： Thomas M. ROSSI , Beth DROLET , Agis KYDONIEUS , PEDIATRIC DERM DEVELOPEMENT LLC
发明人： Thomas M. ROSSI , Beth DROLET , Agis KYDONIEUS
IPC分类号： A61K31/5377 , A61K31/222 , A61K9/00 , A61K47/10 , A61K47/38
摘要： Transdermal delivery of beta blockers to treat Infantile Hemangiomas.

3. 发明申请

US20130116222A1 Dermal Delivery Compositions and Methods 有权
标题翻译：皮肤输送成分和方法
公开(公告)号：US20130116222A1
公开(公告)日：2013-05-09
申请号：US13667632
申请日：2012-11-02
申请人： Charles G. ARNOLD , Agis KYDONIEUS , Thomas M. ROSSI , Alfred F. ALTOMARI
发明人： Charles G. ARNOLD , Agis KYDONIEUS , Thomas M. ROSSI , Alfred F. ALTOMARI
IPC分类号： A61K31/567
CPC分类号： A61K31/567 , A61K9/0014 , A61K9/7053 , A61K9/7061 , A61K31/57 , A61K47/12 , A61K47/20 , A61K47/32
摘要： A composition for transdermal delivery of a progestin for progestin hormone therapy is disclosed. Also disclosed is a transdermal delivery device comprising the composition. For progestin-only hormone therapy, the composition contains an anti-oxidant and does not contain an estrogen. For therapy involving a progestin and an estrogen, the composition contains the progestin, the estrogen and an additional anti-oxidant. Methods of improving the stability of progestin-containing compositions comprising oxidative agents are also disclosed. The methods comprise including one or more anti-oxidants in the compositions.
摘要翻译：公开了用于孕激素治疗孕激素透皮递送的组合物。还公开了包含该组合物的透皮递送装置。对于仅孕激素治疗，该组合物含有抗氧化剂并且不含有雌激素。对于涉及孕激素和雌激素的治疗，组合物含有孕激素，雌激素和另外的抗氧化剂。还公开了改善含有孕激素的组合物包含氧化剂的稳定性的方法。所述方法包括在组合物中包含一种或多种抗氧化剂。

4. 发明申请

US20130195956A1 Transdermal Hormone Delivery 审中-公开
标题翻译：透皮激素递送
公开(公告)号：US20130195956A1
公开(公告)日：2013-08-01
申请号：US13749976
申请日：2013-01-25
申请人： Agis KYDONIEUS , Thomas M. ROSSI , Charles G. ARNOLD , Ajay K. BANGA , Vishal SACHDEVA
发明人： Agis KYDONIEUS , Thomas M. ROSSI , Charles G. ARNOLD , Ajay K. BANGA , Vishal SACHDEVA
IPC分类号： A61K9/00
CPC分类号： A61K9/0014 , A61K9/7053 , A61K31/565 , A61K31/567 , A61K2300/00
摘要： Compositions and devices for transdermal hormone delivery are disclosed. The compositions and devices include desogestrel and enable delivery of effective amounts of progestin without the use of skin permeation enhancers.
摘要翻译：公开了用于透皮激素递送的组合物和装置。组合物和装置包括去氧孕烯并且能够递送有效量的孕激素而不使用皮肤渗透促进剂。

5. 发明申请

US20130018337A1 DERMAL DELIVERY DEVICE WITH IN SITU SEAL 有权
标题翻译：带密封件的DERMAL DELIVERY设备
公开(公告)号：US20130018337A1
公开(公告)日：2013-01-17
申请号：US13553362
申请日：2012-07-19
申请人： Agis KYDONIEUS , Robert G. CONWAY , Thomas M. ROSSI
发明人： Agis KYDONIEUS , Robert G. CONWAY , Thomas M. ROSSI
IPC分类号： A61M35/00
CPC分类号： A61K9/7061 , A61F2013/00646 , A61K9/7084 , A61K31/566 , A61K31/567 , A61K31/568 , A61K31/573 , A61K47/14 , A61K47/20
摘要： This invention relates to a transdermal drug delivery device that comprises an active ingredient (AI) layer, having a skin contacting surface and a non-skin contacting surface and comprising a volatile component, a release liner impermeable to the volatile component adjacent the skin contacting surface of the Al layer having a perimeter that extends beyond the perimeter of the AI layer in all directions, and an overlay comprising a pressure sensitive adhesive (PSA) that does not absorb the volatile component adjacent the non-skin contacting surface of the Al layer having a perimeter of which extends beyond the perimeter of the Al layer in all directions, wherein the release liner and the PSA of the overlay are in contact with and adhered to each other around the perimeter of the Al layer to form a seal that reduces or prevents volatile component loss.
摘要翻译：本发明涉及一种透皮药物递送装置，其包含活性成分（AI）层，其具有皮肤接触表面和非皮肤接触表面，并且包含挥发性成分，不透过皮肤接触表面的挥发性组分的剥离衬垫的Al层具有在所有方向上延伸超过AI层的周边的周边，以及覆盖层，其包含不吸收与Al层的非皮肤接触表面相邻的挥发性组分的压敏粘合剂（PSA），所述粘合剂其周边在所有方向上延伸超出Al层的周边，其中覆盖层的剥离衬垫和PSA与Al层的周边彼此接触并彼此粘附以形成密封，以减少或防止挥发性成分损失。

6. 发明申请

US20150216989A1 MULTI-DAY DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES 审中-公开
标题翻译：生物活性物质的多日交付
公开(公告)号：US20150216989A1
公开(公告)日：2015-08-06
申请号：US14670780
申请日：2015-03-27
申请人： Agis KYDONIEUS
发明人： Agis KYDONIEUS
IPC分类号： A61K47/48
CPC分类号： A61K47/481 , A61K9/0009 , A61K9/0019 , A61K9/0021 , A61K9/0043 , A61K47/55 , A61K47/554
摘要： Compositions and methods for modifying biologically active substances to achieve multi-day delivery of such substances, particularly through oral or parenteral administration, are disclosed. The compositions include the biologically active substance conjugated to a carrier having a suitably long half life, typically more than one day, wherein the conjugate optionally contains a spacer linking the carrier to the biologically active substance. Pharmaceutical formulations of the conjugates are also disclosed, as are methods of extending delivery of a single dose of a biologically active substance for more than one day.
摘要翻译：公开了用于改变生物活性物质以实现这种物质的多日输送的组合物和方法，特别是通过口服或肠胃外给药。所述组合物包括缀合至具有合适的半衰期（通常超过一天）的载体的生物活性物质，其中缀合物任选地含有将载体与生物活性物质连接的间隔基。还公开了缀合物的药物制剂，以及将单剂量的生物活性物质的递送延长超过一天的方法。

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