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1. 发明申请

US20100145257A1 METHOD, APPARATUS, AND KIT FOR ONYCHOMYCOSIS TREATMENT 审中-公开
标题翻译：方法，装置和药盒治疗骨质疏松症
公开(公告)号：US20100145257A1
公开(公告)日：2010-06-10
申请号：US12632277
申请日：2009-12-07
申请人： Zvi NITZAN , Dov TAMARKIN , Daniela MAVOR , Nurit HAREL , Noam EMANUEL
发明人： Zvi NITZAN , Dov TAMARKIN , Daniela MAVOR , Nurit HAREL , Noam EMANUEL
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： Methods, apparatus, and kits for onychomycosis treatment are presented. In one embodiment, a kit for treatment includes an anti-fungal agent, in a composition, and an electrically powered patch. Exemplary embodiments of the patch include a first electrode, a power source having a first and second terminal, a second electrode coupled to the second terminal of the power source, and a base member supporting the first electrode, the second electrode, and the power source. Embodiments include those where the first and second electrode and power source are printed on the base member. Anti-fungal agents may be unionized while the composition includes an ionizing agent. Home use may be practiced, as embodiments include those in which the voltage or current of the power source cannot be adjusted by a user. Exemplary methods include the selection of a nail or diseased area to which treatment is desired and administering the kit as described.
摘要翻译：提出了用于甲真菌病治疗的方法，仪器和试剂盒。在一个实施方案中，用于治疗的试剂盒包括组合物中的抗真菌剂和电动贴剂。贴片的示例性实施例包括第一电极，具有第一和第二端子的电源，耦合到电源的第二端子的第二电极和支撑第一电极，第二电极和电源的基座部件。实施例包括将第一和第二电极和电源印刷在基底构件上的那些。抗真菌剂可以结合，而组合物包含电离剂。可以实施家庭使用，因为实施例包括其中电源的电压或电流不能由用户调整的实施例。示例性方法包括选择需要治疗的指甲或患病区域，并如所述施用试剂盒。

2. 发明申请

US20090130029A1 GLYCEROL ETHERS VEHICLE AND PHARMACEUTICAL COMPOSITIONS THEREOF 审中-公开
标题翻译： GLYCEROL ETHERS车辆及其药物组合物
公开(公告)号：US20090130029A1
公开(公告)日：2009-05-21
申请号：US12275532
申请日：2008-11-21
申请人： Dov TAMARKIN , Alex Besonov
发明人： Dov TAMARKIN , Alex Besonov
IPC分类号： A61K9/12
CPC分类号： A61K9/12 , A61K8/046 , A61K8/345 , A61K8/67 , A61K47/08 , A61Q19/00 , Y02A50/409
摘要： The present disclosure teaches unique foamable vehicles or carriers comprising at least one glycerol ether, a stabilizer, and water; pharmaceutical and cosmetic compositions with potentially enhanced skin delivery and their uses.
摘要翻译：本发明公开了包含至少一种甘油醚，稳定剂和水的独特的可发泡载体或载体; 具有潜在增强的皮肤递送及其用途的药物和化妆品组合物。

3. 发明申请

US20100137198A1 PHARMACEUTICAL COMPOSITION FOR TOPICAL APPLICATION 有权
标题翻译：用于局部应用的药物组合物
公开(公告)号：US20100137198A1
公开(公告)日：2010-06-03
申请号：US12705219
申请日：2010-02-12
申请人： Meir EINI , Dov TAMARKIN
发明人： Meir EINI , Dov TAMARKIN
IPC分类号： A61K38/13 , A61K47/12 , A61K31/16 , A61K31/65 , A61K31/43 , A61K31/4353 , A61K38/02 , A61K31/7048 , A61P17/00
CPC分类号： A61K9/0014 , A21D2/14 , A21D2/16 , A23C9/1315 , A23C11/04 , A23C13/12 , A23C15/16 , A23C19/055 , A23C19/093 , A23D7/0053 , A23D7/0056 , A23D7/011 , A23D7/013 , A23D9/007 , A23G1/305 , A23G1/36 , A23G1/38 , A23G3/346 , A23G2200/08 , A23J3/227 , A23L7/109 , A23L7/122 , A23L7/183 , A23L13/43 , A23L19/18 , A23L23/10 , A23L33/115 , A23P20/11 , A61K8/342 , A61K8/922 , A61K9/0048 , A61K31/225 , A61K31/351 , A61K31/43 , A61K31/496 , A61K31/545 , A61K31/573 , A61K31/65 , A61K36/738 , A61K36/899 , A61K45/06 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/44 , A61K47/46 , A61Q19/00 , A61K2300/00
摘要： A pharmaceutical or cosmetic carrier or composition for topical application characterized by rheological properties which render the carrier or composition semi-solid at rest and a liquid upon application of shear forces thereto. The composition or carrier are prepared by mixing 1-25 percent of a solidifying agent and 75-99 percent of a hydrophobic solvent, by weight, wherein at least one of them has therapeutic or cosmetic benefits, in the presence or absence of a biologically active substance.
摘要翻译：用于局部施用的药物或化妆品载体或组合物，其特征在于使得载体或组合物半固体静止时具有流变性质，并且在施加剪切力时使液体成为液体。组合物或载体通过混合1-25％的固化剂和75-99％的疏水性溶剂（按重量计），其中至少一种在存在或不存在生物活性的情况下具有治疗或美容益处物质。

4. 发明申请

US20120237453A1 SENSATION MODIFYING TOPICAL COMPOSITION FOAM 有权
标题翻译：传感器修改主题组合物泡沫
公开(公告)号：US20120237453A1
公开(公告)日：2012-09-20
申请号：US12350650
申请日：2009-01-08
申请人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , Ella ZLATKIS , David SCHUZ , Tal BERMAN
发明人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , Ella ZLATKIS , David SCHUZ , Tal BERMAN
IPC分类号： A61K9/12
CPC分类号： A61K9/0014 , A01N25/16 , A61K8/046 , A61K8/34 , A61K8/345 , A61K8/42 , A61K8/731 , A61K8/736 , A61K8/8152 , A61K8/8158 , A61K8/87 , A61K8/922 , A61K8/97 , A61K9/122 , A61K2800/24 , A61K2800/242 , A61K2800/244 , A61K2800/30 , A61Q17/02 , A61Q17/04 , A61Q19/00 , A61Q19/007 , A61Q19/02 , A61Q19/08
摘要： This invention relates to foamable compositions that are capable of producing a sensation or sensation modifying effect upon application on a body surface. More particularly the invention relates to foamable pharmaceutical, therapeutic and cosmetic compositions, comprising an active agent, having a sensation or sensation modifying affect on a body surface, upon application. More particularly, the invention relates to foamable compositions comprising: (a) a foamable carrier; (b) at least one sensation or sensation modifying agent, selected from the group of a cooling agent; a warming agent; a relaxing or soothing agent; stimulating or refreshing agent; or mixtures thereof and (c) a propellant at a concentration of about 3% to about 45% by weight of the total composition. The foamable carrier can be an emollient emulsion foamable vehicle, a foamable gel vehicle and can also be a substantially non aqueous foamable vehicle.
摘要翻译：本发明涉及能够在施用于身体表面时产生感觉或感觉改变作用的可发泡组合物。更具体地说，本发明涉及包含活性剂的可发泡药物，治疗和美容组合物，其在施用时具有对身体表面的感觉或感觉修饰作用。更具体地，本发明涉及可发泡组合物，其包含：（a）可发泡载体; （b）至少一种感觉或感觉改性剂，其选自冷却剂组; 加热剂; 一个放松或舒缓的代理; 刺激或清爽剂; 或其混合物和（c）浓度为总组合物重量的约3％至约45％的推进剂。可发泡载体可以是润肤乳液可发泡载体，可发泡凝胶载体，也可以是基本上非水性的可发泡载体。

5. 发明申请

US20110097279A1 STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES 审中-公开
标题翻译：稳定的非酒精泡沫药物组合物与联合动物及其用途
公开(公告)号：US20110097279A1
公开(公告)日：2011-04-28
申请号：US12974857
申请日：2010-12-21
申请人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , David SCHUZ , Tal BERMAN
发明人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , David SCHUZ , Tal BERMAN
IPC分类号： A61K9/12 , A61P17/00 , A61K8/06 , A61Q19/00
CPC分类号： A61K9/0014 , A61K8/046 , A61K8/39 , A61K8/731 , A61K8/86 , A61K9/1075 , A61K9/122 , A61Q7/00 , A61Q19/00
摘要： A stable non-alcoholic foamable pharmaceutical emulsion composition includes an unctuous emollient, at a concentration of about 0.5% to about 49% by weight; at least one multi-active agent; at a concentration of about 0.5% to about 15% by weight; water; an effective amount of an active pharmaceutical agent having a degree of solubility in the emulsion composition; and at least one liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the unctuous emollient comprises a petrolatum alone or in combination with other unctuous agents; wherein the multi active agent is selected from the group consisting of (a) two or more complex emulgators wherein there is a difference of about 4 or more units between the HLB values of two of the emulgators or there is a significant difference in the chemical nature or structure of two of the emulgators; (b) a surfactant and a foam adjuvant or co surfactant, wherein the surfactant has a HLB close to the required HLB of the oil phase; (c) a surfactant and a liquid wax, wherein the surfactant has a HLB close to the required HLB of the oil phase; (d) a surfactant and a polymeric agent other than starch or a modified starch ester, wherein the surfactant has a HLB close to the required HLB of the oil phase; (e) a polymeric agent and a foam adjuvant or co surfactant, which can cooperate to stabilize the emulsion; (f) a single surfactant without a long polymeric side chain that is composed of a mixture of esters having a HLB close to the required HLB of the oil phase; combinations of any of the above, and wherein the composition is substantially flowable is stored in an pressurized container and upon release expands to form a breakable foam.
摘要翻译：稳定的非醇可发泡药物乳液组合物包含浓度为约0.5％至约49％（重量）的单一润肤剂; 至少一种多活性剂; 浓度为约0.5％至约15％重量; 水; 有效量的在乳液组合物中具有溶解度的活性药剂; 和至少一种浓度为总组合物重量的约3％至约25％的液化或压缩气体推进剂; 其中所述柔性润肤剂单独包含凡士林或与其它浮游剂组合; 其中所述多活性剂选自（a）两种或更多种复合乳化剂，其中在两个所述乳化剂的HLB值之间存在约4个或更多个单元的差异，或者化学性质存在显着差异或结构的两个emulgators; （b）表面活性剂和泡沫助剂或助表面活性剂，其中表面活性剂具有接近油相所需HLB的HLB; （c）表面活性剂和液体蜡，其中所述表面活性剂具有接近所述油相所需HLB的HLB; （d）除淀粉或改性淀粉酯以外的表面活性剂和聚合物，其中所述表面活性剂具有接近油相所需HLB的HLB; （e）聚合剂和泡沫助剂或助表面活性剂，其可以配合以稳定乳液; （f）不含长聚合物侧链的单一表面活性剂，其由具有接近油相所需HLB的HLB的酯的混合物组成; 并且其中组合物基本可流动的组合物储存在加压容器中并且当释放时膨胀以形成可破裂的泡沫。

6. 发明申请

US20100111879A1 SACCHARIDE FOAMABLE COMPOSITIONS 审中-公开
标题翻译： SACCHARIDE可发泡组合物
公开(公告)号：US20100111879A1
公开(公告)日：2010-05-06
申请号：US12646322
申请日：2009-12-23
申请人： Dov TAMARKIN , Doron FRIEDMAN , Alex BESONOV
发明人： Dov TAMARKIN , Doron FRIEDMAN , Alex BESONOV
IPC分类号： A61K9/12 , A61P31/00 , A61P17/00 , A61P35/00
CPC分类号： A61K9/122 , A61K8/046 , A61K8/39 , A61K8/60 , A61K8/988 , A61K9/0014 , A61K9/7015 , A61K47/26 , A61K47/38 , A61Q19/00 , Y10S514/945
摘要： A foamable composition, containing a saccharide for use in the treatment of various disorders including: water, a saccharide, about 0.2% to about 5% by weight of a surface-active agent, about 0.01% to about 5% by weight of at least one polymeric agent selected from a bio-adhesive agent, a gelling agent, a film forming agent and a phase change agent, and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：一种可发泡组合物，其含有用于治疗各种疾病的糖类，包括水，糖类，约0.2％至约5％重量的表面活性剂，至少约0.01％至约5％一种选自生物粘合剂，胶凝剂，成膜剂和相变剂的聚合物，以及以总组合物重量计约3％至约25％浓度的液化或压缩气体推进剂。

7. 发明申请

US20090068118A1 DEVICE FOR DELIVERY OF A FOAMABLE COMPOSITION 有权
标题翻译：用于输送可发泡组合物的装置
公开(公告)号：US20090068118A1
公开(公告)日：2009-03-12
申请号：US12204771
申请日：2008-09-04
申请人： Meir EINI , David SCHUZ , Helen SHIFRIN , Yohan HAZOT , Dov TAMARKIN
发明人： Meir EINI , David SCHUZ , Helen SHIFRIN , Yohan HAZOT , Dov TAMARKIN
IPC分类号： A61K9/12 , A61M31/00
CPC分类号： A61M31/00
摘要： A device for delivery of a foamable composition to a body cavity includes a pressurized composition reservoir; a hollow body having a longitudinally extending wall and having at least one aperture provided through a wall of said body, the proximal end in fluid communication with the reservoir for receiving a foamable composition from said composition reservoir; and an actuator operatively connected to the composition reservoir for effecting release of a foamable composition from said composition reservoir into a body cavity through said hollow body; wherein said body has a length less than about 125 mm and internal diameter in the range of about 1.5 mm to about 3.5 mm, wherein said length and internal diameter are selected to provide a delivery of at least about 70% of the foamable composition during operation. The foam delivery device can have multiple apertures.
摘要翻译：用于将可发泡组合物递送到体腔的装置包括加压组合物储存器; 具有纵向延伸的壁并具有通过所述主体的壁设置的至少一个孔的空心体，所述近端与所述储存器流体连通以从所述组合物储存器接收可发泡组合物; 以及致动器，其可操作地连接到所述组合物储存器，用于通过所述中空体从所述组合物储存器中释放可发泡组合物到体腔中; 其中所述主体具有小于约125mm的长度，并且内径在约1.5mm至约3.5mm的范围内，其中所述长度和内径被选择为在操作期间提供至少约70％的可发泡组合物的输送。泡沫输送装置可以具有多个孔。

8. 发明申请

US20080317679A1 FOAMABLE COMPOSITIONS AND KITS COMPRISING ONE OR MORE OF A CHANNEL AGENT, A CHOLINERGIC AGENT, A NITRIC OXIDE DONOR, AND RELATED AGENTS AND THEIR USES 审中-公开
标题翻译：包含一个或多个通道代理，化学试剂，氮氧化物和相关试剂及其用途的可燃组合物和试剂盒
公开(公告)号：US20080317679A1
公开(公告)日：2008-12-25
申请号：US11767442
申请日：2007-06-22
申请人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , Tal BERMAN , Alex BESONOV
发明人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , Tal BERMAN , Alex BESONOV
IPC分类号： A61K9/00 , A61P17/14 , A61P17/02 , A61P17/06
CPC分类号： A61K31/554 , A01N25/16 , A61K9/1075 , A61K9/12 , A61K31/4422 , A61K31/505 , A61K47/10
摘要： The present invention relates to a foamable therapeutic composition comprising: (a) a therapeutically effective concentration of at least one active agent selected from the group consisting of a channel agent, a cholinergic agent, and a nitric oxide donor; and (b) a foamable carrier comprising: i. about 50% to about 98% of a solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, and mixtures thereof; ii. 0% to about 48% of a secondary solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, a co-solvent, a penetration enhancer and mixtures thereof; iii. a surface-active agent; iv. about 0% to about 5% by weight of at least one polymeric agent; and v. a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the composition is housed in a container and is substantially flowable, and which upon release expands to form a breakable foam; and wherein the foamable carrier is selected to generate a foam of good to excellent quality. The invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering such a composition to an afflicted target site.
摘要翻译：本发明涉及可发泡治疗组合物，其包含：（a）治疗有效浓度的至少一种选自通道剂，胆碱能药和一氧化氮供体的活性剂; 和（b）可发泡载体，包括：i。约50％至约98％的选自水的溶剂; 亲水性溶剂; 疏水溶剂; 有效溶剂; 极性溶剂，硅氧烷，软化剂及其混合物; ii。 0％至约48％的选自水的第二溶剂; 亲水性溶剂; 疏水溶剂; 有效溶剂; 极性溶剂，硅氧烷，软化剂，助溶剂，渗透增强剂及其混合物; iii。表面活性剂; iv。约0重量％至约5重量％的至少一种聚合物; 和v。浓度为总组合物重量的约3％至约25％的液化或压缩气体推进剂; 其中所述组合物容纳在容器中并且基本上是可流动的，并且其在释放时膨胀以形成可破坏的泡沫; 并且其中所述可发泡载体被选择以产生良好至优异质量的泡沫。本发明进一步提供治疗，减轻或预防哺乳动物受试者病症的方法，包括将所述组合物施用于受影响的靶位点。

9. 发明申请

US20080206155A1 STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES 审中-公开
标题翻译：稳定的非酒精泡沫药物组合物与联合动物及其用途
公开(公告)号：US20080206155A1
公开(公告)日：2008-08-28
申请号：US11940290
申请日：2007-11-14
申请人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , David SCHUZ , Tal BERMAN
发明人： Dov TAMARKIN , Meir EINI , Doron FRIEDMAN , David SCHUZ , Tal BERMAN
IPC分类号： A61K9/12
CPC分类号： A61K9/0014 , A61K8/046 , A61K8/39 , A61K8/731 , A61K8/86 , A61K9/1075 , A61K9/122 , A61Q7/00 , A61Q19/00
摘要： A stable non-alcoholic foamable pharmaceutical emulsion composition includes an unctuous emollient, at a concentration of about 0.5% to about 49% by weight; at least one multi-active agent; at a concentration of about 0.5% to about 15% by weight; water; an effective amount of an active pharmaceutical agent having a degree of solubility in the emulsion composition; and at least one liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the unctuous emollient comprises a petrolatum alone or in combination with other unctuous agents; wherein the multi active agent is selected from the group consisting of (a) two or more complex emulgators wherein there is a difference of about 4 or more units between the HLB values of two of the emulgators or there is a significant difference in the chemical nature or structure of two of the emulgators; (b) a surfactant and a foam adjuvant or co surfactant, wherein the surfactant has a HLB close to the required HLB of the oil phase; (c) a surfactant and a liquid wax, wherein the surfactant has a HLB close to the required HLB of the oil phase; (d) a surfactant and a polymeric agent other than starch or a modified starch ester, wherein the surfactant has a HLB close to the required HLB of the oil phase; (e) a polymeric agent and a foam adjuvant or co surfactant, which can cooperate to stabilize the emulsion; (f) a single surfactant without a long polymeric side chain that is composed of a mixture of esters having a HLB close to the required HLB of the oil phase; combinations of any of the above, and wherein the composition is substantially flowable is stored in an pressurized container and upon release expands to form a breakable foam.
摘要翻译：稳定的非醇可发泡药物乳液组合物包含浓度为约0.5％至约49％（重量）的单一润肤剂; 至少一种多活性剂; 浓度为约0.5％至约15％重量; 水; 有效量的在乳液组合物中具有溶解度的活性药剂; 和至少一种浓度为总组合物重量的约3％至约25％的液化或压缩气体推进剂; 其中所述柔性润肤剂单独包含凡士林或与其它浮游剂组合; 其中所述多活性剂选自（a）两种或更多种复合乳化剂，其中在两个所述乳化剂的HLB值之间存在约4个或更多个单元的差异，或者化学性质存在显着差异或结构的两个emulgators; （b）表面活性剂和泡沫助剂或助表面活性剂，其中表面活性剂具有接近油相所需HLB的HLB; （c）表面活性剂和液体蜡，其中所述表面活性剂具有接近所述油相所需HLB的HLB; （d）除淀粉或改性淀粉酯以外的表面活性剂和聚合物，其中所述表面活性剂具有接近油相所需HLB的HLB; （e）聚合剂和泡沫助剂或助表面活性剂，其可以配合以稳定乳液; （f）不含长聚合物侧链的单一表面活性剂，其由具有接近所述油相所需HLB的HLB的酯的混合物组成; 并且其中组合物基本可流动的组合物储存在加压容器中并且当释放时膨胀以形成可破裂的泡沫。

10. 发明申请

US20110281827A1 COMPOSITIONS, GELS AND FOAMS WITH RHEOLOGY MODULATORS AND USES THEREOF 有权
标题翻译：组成，凝胶和流变学调节剂及其用途
公开(公告)号：US20110281827A1
公开(公告)日：2011-11-17
申请号：US13100724
申请日：2011-05-04
申请人： Dov TAMARKIN , Elana GAZAL , Yohan HAZOT , David SCHUZ , Irakliy PAPIASHVILI
发明人： Dov TAMARKIN , Elana GAZAL , Yohan HAZOT , David SCHUZ , Irakliy PAPIASHVILI
IPC分类号： A61K31/65 , A61K31/575 , A61P17/10 , A61K31/58 , A61P31/04 , A61P29/00 , A61K31/60 , A61K31/327
CPC分类号： A61K47/44 , A61K8/31 , A61K8/342 , A61K8/361 , A61K9/0014 , A61K9/0048 , A61K9/12 , A61K9/122 , A61K9/124 , A61K31/137 , A61K31/192 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K31/65 , A61K45/06 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K2800/31 , A61K2800/33 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： The present disclosure relates generally to compositions for cosmetic or pharmaceutical application. The compositions include a carrier and rheology modulators.
摘要翻译：本公开一般涉及用于化妆品或药物应用的组合物。组合物包括载体和流变学调节剂。

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