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1. 发明申请

US20070292487A1 Anti-Inflammatory Dissolvable Film 有权
标题翻译：抗炎溶解膜
公开(公告)号：US20070292487A1
公开(公告)日：2007-12-20
申请号：US11765587
申请日：2007-06-20
申请人： Zvi Loewy , William Levine , Aron Saffer
发明人： Zvi Loewy , William Levine , Aron Saffer
IPC分类号： A61K36/185 , A61K9/70
CPC分类号： A61K36/23 , A61K9/006 , A61K31/00 , A61K36/00 , A61K36/09 , A61K36/185 , A61K36/236 , A61K36/28 , A61K36/328 , A61K36/38 , A61K36/45 , A61K36/53 , A61K36/74 , A61K36/76 , A61K36/82 , A61K2300/00
摘要： Provided, among other things, is a slowly dissolvable film comprising: herbal bioactive agent(s); and polymer(s), dissolvable in the aggregate, wherein the film becomes adhesive as it is placed against a mucosal surface and begins to absorb moisture therefrom.
摘要翻译：提供了一种缓慢溶解的膜，其包含：草药生物活性剂; 和可溶于聚集体的聚合物，其中当其抵靠粘膜表面放置并开始吸收水分时，该膜变得粘合。

2. 发明申请

US20060266715A1 Separation and accumulation of subcellular components, and proteins derived therefrom 审中-公开
标题翻译：亚细胞组分的分离和积累以及由此衍生的蛋白质
公开(公告)号：US20060266715A1
公开(公告)日：2006-11-30
申请号：US11266921
申请日：2005-11-04
申请人： Zvi Loewy
发明人： Zvi Loewy
IPC分类号： C02F1/38
CPC分类号： C07K1/36 , Y10T436/25375
摘要： The present invention provides for proteome fractionation through the separation and accumulation of subcellar organelles from a biological sample such that the subcellular organelles are highly enriched, substantially pure, and whose structural integrity and functions are well-preserved. The methods of the invention provide a manner by which to reduce the complexity of the proteome and facilitate the detection and isolation of difficult-to-study proteins, such as low-abundance proteins. The methods of the present invention for pre-fractioning proteomes of biological samples by parallel separation and isolation of subcellular organelles from the biological samples using continuous-flow ultracentrifugation are also easily and effectively scalable through adjustment to ultracentrifugation parameters, such as, for example, rotor speed, rotor size, rotor geometry.
摘要翻译：本发明提供了通过从生物样品中分离和积聚亚细胞器的蛋白质组分离，使得亚细胞细胞器被高度富集，基本上纯，并且其结构完整性和功能得到良好保存。本发明的方法提供了一种降低蛋白质组学复杂性并促进难以研究的蛋白质如低丰度蛋白质的检测和分离的方式。通过使用连续流超速离心从生物样品中平行分离和分离亚细胞细胞器，本发明的用于预分离生物样品的蛋白质组学的方法也可以通过调节超离心参数（例如转子速度，转子尺寸，转子几何形状。

3. 发明授权

US06287595B1 Biomedical assay device 失效
标题翻译：生物医学测定装置
公开(公告)号：US06287595B1
公开(公告)日：2001-09-11
申请号：US09535522
申请日：2000-03-24
申请人： Zvi Loewy , Dennis Lee Matthies
发明人： Zvi Loewy , Dennis Lee Matthies
IPC分类号： A61K952
CPC分类号： A61J3/00 , A61J1/035 , A61K9/70 , B05B5/08 , B65B1/04 , B65B1/30 , B65B11/50 , G01N33/521 , G01N33/54386
摘要： The present invention provides an integrated structural unit that includes a diagnostic form that includes at least one active ingredient that is present in an amount that advantageously does not vary by more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate, a deposit that is disposed on the substrate, and a spreading layer that overlies the deposit and is used to retain and spread a sample of liquid which is to be assayed. The deposit comprises a powder, including the active ingredient(s). The diagnostic form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.
摘要翻译：本发明提供了一种综合结构单元，其包括诊断形式，其包括至少一种活性成分，所述活性成分的存在量有利地不超过预定目标量的约5％。在一个实施例中，单元形式包括衬底，设置在衬底上的沉积物和覆盖在沉积物上并用于保留和铺展待测定的液体样品的铺展层。沉积物包含包含活性成分的粉末。通过使用静电卡盘和带电粉末输送装置将粉末静电沉积在基底上的干粉沉积装置产生诊断形式。

4. 发明授权

US5939261A Method for capturing a nucleic acid 失效
标题翻译：捕获核酸的方法
公开(公告)号：US5939261A
公开(公告)日：1999-08-17
申请号：US881282
申请日：1997-06-24
申请人： Zvi Loewy , Rajan Kumar
发明人： Zvi Loewy , Rajan Kumar
IPC分类号： C12N15/10 , C12Q1/68 , C07H21/02 , C07H21/04 , C12N15/00
CPC分类号： C12N15/1013 , C12N15/1006 , C12Q1/6834
摘要： The present invention relates to a method for capturing a class of nucleic acids comprising (a) providing a population of nucleic acids, wherein the population comprises the class; (b) binding a probe moiety to nucleic acids of the class, thereby forming one or more complexes, wherein the probe moiety is attached to a substrate; and (c) capturing the complex. The method can be implemented in certain embodiments in a structure comprised of one or more reservoirs, preferably wherein the reservoirs include one or more second chambers that are in communication with a first chamber. Preferably, the present invention is used to capture the class of nucleic acids that comprise regulatory elements included in a population of nucleic acids isolated from a cell, tissue, or organism. An alternative preferred embodiment of the present invention involves the capture of the class of nucleic acids that comprises certain repetitive elements included in a population of nucleic acids derived from an organism.
摘要翻译：本发明涉及一种用于捕获一类核酸的方法，包括（a）提供核酸群体，其中群体包括该类; （b）将探针部分与该类核酸结合，从而形成一种或多种复合物，其中探针部分连接到底物上; 和（c）捕获复合物。该方法可以在由一个或多个储存器构成的结构中的某些实施例中实施，优选地，其中储存器包括与第一室连通的一个或多个第二室。优选地，本发明用于捕获包含从细胞，组织或生物分离的核酸群体中包含的调节元件的核酸类。本发明的替代优选实施方案涉及捕获包含在衍生自生物体的核酸群体中的某些重复元件的核酸类。

5. 发明授权

US5939291A Microfluidic method for nucleic acid amplification 失效
标题翻译：用于核酸扩增的微流控法
公开(公告)号：US5939291A
公开(公告)日：1999-08-17
申请号：US665209
申请日：1996-06-14
申请人： Zvi Loewy , Rajan Kumar
发明人： Zvi Loewy , Rajan Kumar
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6844 , B01L3/5027
摘要： The nucleic acid amplification reactions of the present invention are conducted isothermally, using non-thermal denaturation procedures, such as occurs in chemical- or electrostatic-based denaturation. Embodiments are set forth for automated forms of the claimed procedures.
摘要翻译：本发明的核酸扩增反应是等温进行的，使用非热变性方法，例如在基于化学或静电的变性中发生。为所要求保护的程序的自动化形式阐述了实施例。

6. 发明授权

US5914229A Method for amplifying a polynucleotide 失效
标题翻译：扩增多核苷酸的方法
公开(公告)号：US5914229A
公开(公告)日：1999-06-22
申请号：US663688
申请日：1996-06-14
申请人： Zvi Loewy
发明人： Zvi Loewy
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6865
摘要： In one aspect, the present invention relates to methods of amplifying a target nucleic acid, the methods involving the production of a double-stranded promoter to provide for transcription of the target sequence, and the provision of a poly-A tail in the transcription product. In another aspect, the present invention relates to methods of detecting a target nucleic acid in a sample.
摘要翻译：一方面，本发明涉及扩增靶核酸的方法，涉及产生双链启动子以提供靶序列转录的方法，以及在转录产物中提供多聚A尾。另一方面，本发明涉及检测样品中靶核酸的方法。

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