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1. 发明授权

US5221673A Fodder compositions 失效
标题翻译： FODDER组合物
公开(公告)号：US5221673A
公开(公告)日：1993-06-22
申请号：US802235
申请日：1991-12-04
申请人： Zoltan Budai , Tibor Mezei , Klara Reiter nee Esses , Lajos Fekete , Karoly Magyar , Attila Nagy , Laszlo Puskas
发明人： Zoltan Budai , Tibor Mezei , Klara Reiter nee Esses , Lajos Fekete , Karoly Magyar , Attila Nagy , Laszlo Puskas
IPC分类号： A23K1/16 , A23K1/18 , C07D295/18
CPC分类号： A23K50/30 , A23K20/137
摘要： This invention relates to fodder compositions, particularly feed additives, premixes and ready-for-use fodders, and a method for increasing weight-gain and improving fodder utilization of dimestic animals.The compositions according to the invention comprise as active ingredient a compound of the general formula (I), ##STR1## wherein R.sup.1 represents methoxy or hydrogen andR stands for methyl; orR and R.sup.1 each denotes hydrogen; orR.sup.1 stands for hydrogen and R represents ethyl.The compounds of the general formula (I) known from the literature exhibit useful weight-gain increasing and fodder-utilization improving effects and can be used in animal husbandry.

2. 发明授权

US5254547A Thioacid amide derivatives and fodder compositions containing the same 失效
标题翻译：含硫酰胺衍生物和含有它们的饲料组合物
公开(公告)号：US5254547A
公开(公告)日：1993-10-19
申请号：US802236
申请日：1991-12-04
申请人： Zoltan Budai , Tibor Mezei , Klara Reiter nee Esses , Lajos Fekete , Karoly Magyar , Attila Nagy , Laszlo Puskas
发明人： Zoltan Budai , Tibor Mezei , Klara Reiter nee Esses , Lajos Fekete , Karoly Magyar , Attila Nagy , Laszlo Puskas
IPC分类号： A23K1/16 , C07D295/18 , C07D295/194 , A61K31/535
CPC分类号： C07D295/194 , Y10S426/807
摘要： The invention relates to new thioacid amide derivatives, a process for the preparation thereof, compositions, particularly feed additives, premixes and ready-for-use fodders, comprising the same, further to a method for increasing weight gain and improving fodder utilization of domestic animals.The new thioacid amide derivatives of the general formula (I), whereinR represents hydrogen, C.sub.1-18 alkyl, C.sub.2-6 alkenyl or C.sub.2-6 alkynyl andR.sup.1 stands for hydrogen, halogen or methoxy, with the provisos thata) at least one of R and R.sup.1 is other than hydrogen;b) if R represents ethyl, R.sup.1 is other than hydrogen; andc) if R stands for methyl, R.sup.1 is other than hydrogen or methoxy,exhibit useful weight-gain increasing and fodder-utilization improving effects and can be used in animal husbandry, particularly in pig.

3. 发明授权

US5523303A Trisubstituted cycloalkane derivatives and process for the preparation thereof 失效
标题翻译：三取代环烷烃衍生物及其制备方法
公开(公告)号：US5523303A
公开(公告)日：1996-06-04
申请号：US226051
申请日：1994-04-11
申请人： Judit Bajnogel , Gabor Blasko , Zoltan Budai , Andras Egyed , Marton Fekete , Erika Karaffa , Tibor Mezei , Klara Reiter nee Esses , Gyula Simig , Katalin Szemeredi , Eniko Szirt nee Kiszelly
发明人： Judit Bajnogel , Gabor Blasko , Zoltan Budai , Andras Egyed , Marton Fekete , Erika Karaffa , Tibor Mezei , Klara Reiter nee Esses , Gyula Simig , Katalin Szemeredi , Eniko Szirt nee Kiszelly
IPC分类号： A61K31/15 , A61K31/357 , A61K31/36 , A61K31/395 , A61K31/40 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/55 , A61P1/04 , C07C249/12 , C07C251/58 , C07D295/08 , C07D295/088 , C07D317/58
CPC分类号： C07D295/088 , C07C251/58 , C07C2101/08 , C07C2101/14 , C07C2101/18 , Y10S514/925 , Y10S514/926 , Y10S514/927 , Y10S514/928
摘要： The invention relates to novel, pharmaceutically active trisubstituted cycloalkane derivatives, a process for the preparation thereof and pharmaceutical compositions comprising the same. The invention also encompasses the use of the said cycloalkane derivatives for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases.The compounds according to the invention are characterized by the general formula (I), ##STR1## wherein R represents hydrogen, C.sub.1-4 alkyl or hydroxyl,R.sup.1 stands for C.sub.1-12 alkyl,R.sup.2 and R.sup.3 each represents hydrogen, C.sub.1-12 alkyl or C.sub.2-12 alkenyl, orR.sup.2 and R.sup.3 together with the adjacent nitrogen atom form a 4- to 7-membered ring optionally comprising an oxygen, sulfur or a further nitrogen atom, which latter may carry a phenyl, benzyl or C.sub.1-4 alkyl substituent,R.sup.4 and R.sup.5 each stands for hydrogen, halogen or C.sub.1-4 alkoxy, or together represent a 3,4-methylenedioxy group,n is an integer from 2 to 5,A represents a valency bond or a --CH.sub.2 -- group.The compounds exert a valuable antiulcer effect, so they can be used to advantage in the therapy.
摘要翻译：本发明涉及新颖的药学活性三取代环烷烃衍生物，其制备方法和包含其的药物组合物。本发明还包括所述环烷烃衍生物用于治疗疾病和制备适于治疗疾病的药物组合物的用途。根据本发明的化合物的特征在于通式（I），其中R表示氢，C 1-4烷基或羟基，R 1表示C 1-12烷基，R 2和R 3各自表示氢，C 1 -12烷基或C2-12烯基，或R2和R3与相邻的氮原子一起形成任选地包含氧，硫或另外的氮原子的4-至7-元环，后者可以携带苯基，苄基或C1 -4-烷基取代基，R4和R5各自代表氢，卤素或C1-4烷氧基，或一起代表3,4-亚甲二氧基，n是2至5的整数，A表示价键或-CH 2 - 组。这些化合物具有有价值的抗溃疡作用，因此可用于治疗。

4. 发明授权

US5130487A Aminopropanol derivatives, process for their preparation and pharmaceutical compositions comprising the same 失效
标题翻译：氨基壬酸衍生物，其制备方法和包含其的药物组合物
公开(公告)号：US5130487A
公开(公告)日：1992-07-14
申请号：US572641
申请日：1991-08-27
申请人： Zoltan Budai , Tibor Mezei , Klara Reiter nee Esses , Eniko Sziri neKiszelly , Gizella Zsila , Gabor Gigler , Lujza Petocz , Maria Szecsey nee Hegedus , Marton Fekete , Valeria Hoffmann , Laszlo Kapolnai
发明人： Zoltan Budai , Tibor Mezei , Klara Reiter nee Esses , Eniko Sziri neKiszelly , Gizella Zsila , Gabor Gigler , Lujza Petocz , Maria Szecsey nee Hegedus , Marton Fekete , Valeria Hoffmann , Laszlo Kapolnai
IPC分类号： A61K31/15 , A61K31/133 , A61K31/357 , A61K31/36 , A61K31/40 , A61K31/445 , A61K31/452 , A61K31/495 , A61K31/55 , A61P1/04 , A61P9/06 , A61P9/08 , A61P9/10 , A61P25/02 , A61P25/04 , A61P25/20 , A61P29/00 , C07C249/08 , C07C249/12 , C07C251/58 , C07D213/16 , C07D251/58 , C07D295/08 , C07D295/088 , C07D317/56
CPC分类号： C07D213/16 , C07C251/58 , C07D295/088 , C07C2101/02 , C07C2101/08 , C07C2101/14 , C07C2101/18
摘要： The invention relates to novel racemic or optically active aminopropanol derivatives of formula I ##STR1## wherein R and R.sup.1 are independently hydrogen atom, halogen atom, lower alkoxy, or together represent a methylene dioxy group,R.sup.2 and R.sup.3 together represent a chemical bond or independently stand for a hydrogen atom,R.sup.4 and R.sup.5 are independently hydrogen atom, C.sub.3-7 cycloalkyl group or straight or branched, saturated or unsaturated C.sub.1-12 alkyl group optionally substituted by one or more dialkylaminoalkyl, dimethoxyphenyl or phenyl groups, orR.sup.4 and R.sup.5 together with the adjacent nitrogen atom form a 4 to 7 membered ring optionally comprising an oxygen, sulfur or a further nitrogen atom, which ring is optionally substituted by a phenyl, benzyl or C.sub.1-3 alkyl group and the said substituents may carry a hydroxyl group, one or two methoxy groups, halogen atoms or trifluoromethyl groups, orR.sup.4 and R.sup.5 together with the adjacent nitrogen atom form a piperidine ring which is optionally substituted by a phenyl or benzyl group and, if desired, it comprises a double bond,R.sup.6 stands for hydrogen atom or benzoyl group, andn represents an integer from 3 to 6, acid-addition salts and quaternary ammonium derivatives thereof.Further the invention relates to processes for preparing these compounds.The compounds of the invention exert cardiac circulation controlling and/or improving, central nervous system tranquillizing and/or digestive system irregulations improving effects.
摘要翻译：本发明涉及式I的新型外消旋或光学活性氨基丙醇衍生物其中R和R 1独立地为氢原子，卤素原子，低级烷氧基或一起代表亚甲基二氧基，R2和R3一起表示化学键或独立地代表氢原子，R4和R5独立地是氢原子，C3-7环烷基或任选被一个或多个二烷基氨基烷基，二甲氧基苯基或苯基取代的直链或支链，饱和或不饱和的C1-12烷基，或R4和R5 与相邻的氮原子一起形成任选地包含氧，硫或另外的氮原子的4至7元环，该环任选被苯基，苄基或C 1-3烷基取代，所述取代基可以带有羟基，一个或两个甲氧基，卤素原子或三氟甲基，或R4和R5与相邻的氮原子一起形成哌啶环，其是任选取代的由苯基或苄基组成，如果需要，它包含双键，R6代表氢原子或苯甲酰基，n代表3-6的整数，其酸加成盐和季铵衍生物。本发明还涉及制备这些化合物的方法。本发明的化合物发挥心脏循环控制和/或改善，中枢神经系统镇定和/或消化系统不调节改善作用。

5. 发明授权

US4939142A Substituted styrene derivatives 失效
标题翻译：取代苯乙烯衍生物
公开(公告)号：US4939142A
公开(公告)日：1990-07-03
申请号：US301944
申请日：1989-01-26
申请人： Zoltan Budai , Lujza Petocz , Tibor Mezei , Eniko Szirt nee Kiszelly , Maria Szecsey nee Hegedus , Gabor Gigler , Klara Reiter nee Esses , Aranka Lay nee Konya , Eva Furdyga , Istvan Gertyan , Istvan Gacsalyi
发明人： Zoltan Budai , Lujza Petocz , Tibor Mezei , Eniko Szirt nee Kiszelly , Maria Szecsey nee Hegedus , Gabor Gigler , Klara Reiter nee Esses , Aranka Lay nee Konya , Eva Furdyga , Istvan Gertyan , Istvan Gacsalyi
IPC分类号： A61K31/15 , A61K31/357 , A61K31/36 , A61K31/40 , A61P1/04 , A61P9/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/20 , A61P25/24 , A61P25/26 , C07C249/04 , C07C249/08 , C07C251/44 , C07C251/58 , C07D295/08 , C07D295/088 , C07D317/58
CPC分类号： C07D295/088 , C07C251/44 , C07C2101/16
摘要： The new compounds of the general Formula I ##STR1## (wherein A stands for a C.sub.2-4 straight or branched chain alkylene group;R.sup.1 and R.sup.2 may be same or different and each stands for hydrogen, halogen, lower alkyl or lower alkoxy; orR.sup.1 and R.sup.2 together form a methylenedioxy group;R.sup.3 and R.sup.4 may be the same or different and each stands for C.sub.1.ident. alkyl or C.sub.3.notident. cycloalkyl orR.sup.3 and R.sup.4 together with the nitrogen atom, they are attached to, form a 4-7 membered ring which may contain as additional ring member an oxygen or sulfur atom or a further nitrogen atom and the latter nitrogen atom may optionally bear a C.sub.1-3 alkyl or benzyl substituent)and pharmaceutically acceptable acid addition salts and quaternary ammonium salts thereof possess valuable therapeutical properties and exert particularly useful transquillant-sedative, antidepressant, antiepileptic, antiparkinson, analgesic, local anaesthetic, gastric acid secretion inhibiting and/or antianginal effect.The new compounds of the general Formula I may be prepared by methods known per se.
摘要翻译：通式I的新化合物（I）（其中A代表C2-4直链或支链亚烷基; R1和R2可以相同或不同，代表氢，卤素，低级烷基或低级）烷氧基;或R 1和R 2一起形成亚甲二氧基; R 3和R 4可以相同或不同，并且各自代表C 1 =烷基或C 3或C 6的环烷基或R 3和R 4与氮原子一起形成4个 -7元环，其可以含有氧或硫原子或另外的氮原子作为附加的环成员，后一个氮原子可以任选地带有C 1-3烷基或苄基取代基）及其药学上可接受的酸加成盐和季铵盐具有有价值的治疗性质，并且发挥特别有用的抗惊孕药，抗抑郁药，抗癫痫药，抗帕金森，止痛剂，局部麻醉剂，胃酸分泌抑制和/或抗心绞痛作用。通式I的新化合物可以通过本身已知的方法制备。

6. 发明授权

US5597822A Pharmaceutical compositions for the prevention and/or treatment a gastrointestinal diseases 失效
标题翻译：用于预防和/或治疗胃肠道疾病的药物组合物
公开(公告)号：US5597822A
公开(公告)日：1997-01-28
申请号：US443487
申请日：1995-05-18
申请人： Eniko Szirt nee Kislelly , Zoltan Budai , Tibor Mezei , Gabor Blasko , Klara Kazo nee Daroczi , Andras Egyed , Gabor Gigler , Marton Fekete , Klara Reiter nee Esses , Gyula Simig , Katalin Szemeredi
发明人： Eniko Szirt nee Kislelly , Zoltan Budai , Tibor Mezei , Gabor Blasko , Klara Kazo nee Daroczi , Andras Egyed , Gabor Gigler , Marton Fekete , Klara Reiter nee Esses , Gyula Simig , Katalin Szemeredi
IPC分类号： A61K31/15 , A61K31/495 , A61K31/50 , A61K31/505
CPC分类号： A61K31/15 , A61K31/495
摘要： The invention refers to pharmaceutical compositions for the prevention and/or treatment of gastrointestinal diseases connected with infections caused by Helicobacter pylori and a method for the treatment of such diseases.The pharmaceutical composition of the invention comprises as active ingredient a cyclic ketone derivative of the formula I ##STR1## wherein and R.sup.1 mean independently hydrogen or halo;R.sup.0 stands for hydrogen or a C.sub.1-4 alkoxy group;R.sup.2 and R.sup.3 independently represent hydrogen; a straight or branched chain C.sub.1-8 alkyl optionally substituted by a dimethylamino group; a C.sub.2-6 alkenyl or a C.sub.3-7 cycloalkyl group; orR.sup.2 and R.sup.3 together with the adjacent nitrogen atom form a 6-membered heterocyclic group containing an additional nitrogen atom that may bear a phenyl group optionally substituted by a C.sub.1-4 alkoxy group;or its stereoisomer or optical isomer or a possible mixture thereof, or a pharmaceutically acceptable acid addition salt or quaternary ammonium salt thereof in admixture with carrier(s) commonly used in pharmaceutical compositions.
摘要翻译：本发明涉及用于预防和/或治疗与由幽门螺杆菌引起的感染有关的胃肠道疾病的药物组合物和治疗这些疾病的方法。本发明的药物组合物包含作为活性成分的式I（I）的环酮衍生物，其中R 1独立地表示氢或卤素; R0表示氢或C1-4烷氧基; R2和R3独立地表示氢; 任选被二甲基氨基取代的直链或支链C 1-8烷基; C 2-6烯基或C 3-7环烷基; 或者R 2和R 3与相邻的氮原子一起形成含有另外的氮原子的6元杂环基，其可以具有任选被C 1-4烷氧基取代的苯基; 或其立体异构体或光学异构体或其可能的混合物，或其药学上可接受的酸加成盐或季铵盐与药物组合物中通常使用的载体混合。

7. 发明授权

US5473072A Process for the preparation of high purity buspiron and the hydrochloride thereof 失效
标题翻译：制备高纯度buspiron及其盐酸盐的方法
公开(公告)号：US5473072A
公开(公告)日：1995-12-05
申请号：US274848
申请日：1994-07-14
申请人： Tibor Mezei , Gabor Blasko , Zoltan Budai , Margit Csorgo , Eva Furdyga , Imre Klebovich , Laszlo Koncz , Ilona Sztruhar , Attila Mandi , Kalman Nagy , Klara Reiter nee Esses , Gyula Simig , Judit Szego , Gyongyi Vereczkey nee Donath
发明人： Tibor Mezei , Gabor Blasko , Zoltan Budai , Margit Csorgo , Eva Furdyga , Imre Klebovich , Laszlo Koncz , Ilona Sztruhar , Attila Mandi , Kalman Nagy , Klara Reiter nee Esses , Gyula Simig , Judit Szego , Gyongyi Vereczkey nee Donath
IPC分类号： C07D401/14 , A61K31/445 , A61K31/505 , A61P25/20 , B01J23/44 , B01J25/02 , C07B61/00 , C07D221/20 , C07D239/00 , C07D241/00 , C07D295/00 , C07D401/12 , C07D403/04
CPC分类号： C07D401/12
摘要： Process for the preparation of 8 -[4 -[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-dione (buspiron) of the Formula I ##STR1## and the hydrochlorides thereof having high purity by continuously adding a solution of 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-but-2 -inyl]-8-aza-spiro[4.5]decane-7,9-dione of the formula II ##STR2## formed with an inert organic solvent having a concentration of at least 40% by weight to a suspension of a hydrogenation catalyst in an inert organic solvent and optionally converting the 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-dione thus obtained into the hydrochloride thereof.
摘要翻译：制备8- [4- [嘧啶-2-基] - 哌嗪-1-基] - 丁基] -8-氮杂 - 螺[4.5]癸烷-7,9-二酮（buspiron）的方法通过连续加入8- [4- [4-（嘧啶-2-基） - 哌嗪-1-基] - 丁-2-炔基的溶液，使式I（I）化合物及其盐酸盐具有高纯度 ] -8-氮杂 - 螺[4.5]癸烷-7,9-二酮，其具有浓度为至少40重量％的惰性有机溶剂与氢化催化剂的悬浮液形成的式II（II）在惰性有机溶剂中并任选地将8- [4- [4-（嘧啶-2-基） - 哌嗪-1-基] - 丁基] -8-氮杂 - 螺[4.5]癸烷-7,9-二酮从而得到其盐酸盐。

8. 发明授权

US5652270A Pharmaceutical compositions containing bicycloheptane ether amines and a process for the preparation thereof 失效
标题翻译：含有双环庚烷醚胺的药物组合物及其制备方法
公开(公告)号：US5652270A
公开(公告)日：1997-07-29
申请号：US664804
申请日：1996-06-17
申请人： Zoltan Budai , Istvan Gacsalyi , Gabor Szenasi , Tibor Mezei , Aniko Kovacs , Gabor Blasko , Katalin Szemeredi , Gyula Simig , Lujza Petocz , Klara Reiter nee Esses
发明人： Zoltan Budai , Istvan Gacsalyi , Gabor Szenasi , Tibor Mezei , Aniko Kovacs , Gabor Blasko , Katalin Szemeredi , Gyula Simig , Lujza Petocz , Klara Reiter nee Esses
IPC分类号： A61K31/135 , A61K31/54 , A61K31/445 , A61K31/495
CPC分类号： A61K31/135
摘要： The invention refers to a pharmaceutical composition, a process for the preparation thereof and a novel medical use of bicycloheptane derivatives. The pharmaceutical compositions of the invention comprise a bicycloheptane derivative of the formula I ##STR1## wherein said derivative is as defined in the specification herein. The pharmaceutical compositions of the invention are suitable for the treatment of diseases and disorders that are connected with the influence on the cholecystokinin system, especially for preventing the spastic contraction of the gallbladder.
摘要翻译：本发明涉及药物组合物，其制备方法和双环庚烷衍生物的新型医疗用途。本发明的药物组合物包含本说明书中所述的式I的双环庚烷衍生物。本发明的药物组合物适用于治疗与缩胆囊素系统的影响相关的疾病和病症，特别是用于防止胆囊的痉挛性收缩。

9. 发明授权

US4621101A Pharmaceutical compositions with antianginal activity 失效
标题翻译：具有抗心绞痛活性的药物组合物
公开(公告)号：US4621101A
公开(公告)日：1986-11-04
申请号：US751623
申请日：1985-07-02
申请人： Zoltan Budai , Tibor Mezei , Aranka Lay nee Konya , Lujza Petocz , Katalin Grasser , Zsuzsanna Orr
发明人： Zoltan Budai , Tibor Mezei , Aranka Lay nee Konya , Lujza Petocz , Katalin Grasser , Zsuzsanna Orr
IPC分类号： A61K31/15 , A61P43/00 , C07C251/38
CPC分类号： C07C251/58 , C07C2101/14 , C07C2101/18
摘要： The invention relates to pharmaceutical compositions possessing valuable antianginal activity. These compositions show higher activity and more favorable therapeutic indices than the reference compound Prenylamine. Preparation of different kinds of pharmaceutical compositions, such as tablets, dragees, capsules and injectable solutions, containing compounds of general formula (I) ##STR1## or their acid addition salts as active ingredients, is disclosed, wherein in formula (I)R is phenyl or 4-chlorophenyl;R.sup.1 and R.sup.2 each represent hydrogen, methyl or isopropyl;R.sup.3 and R.sup.4 are hydrogen, or together form a chemical bond;n is an integer from 4 to 6;A means trimethylene, if n is 4 or 6; or ethylene, if n is 5.
摘要翻译：本发明涉及具有有价值的抗心绞痛活性的药物组合物。这些组合物显示比参考化合物Prenylamine更高的活性和更有利的治疗指数。公开了含有通式（I）化合物或其酸加成盐作为活性成分的不同种类的药物组合物如片剂，硫化物，胶囊和可注射溶液的制备，其中在式（I）中R是苯基或4-氯苯基; R1和R2各自表示氢，甲基或异丙基; R3和R4是氢，或一起形成化学键; n为4-6的整数; 如果n为4或6，则表示三亚甲基; 或乙烯，如果n为5。

10. 发明授权

US4425158A Bicyclo(2.2.1)heptane oximes used for plant growth regulating 失效
标题翻译：用于植物生长调节的双环（2.2.1）庚烷肟
公开(公告)号：US4425158A
公开(公告)日：1984-01-10
申请号：US322675
申请日：1981-11-18
申请人： Zoltan Budai , Attila Kis-Tamas , Tibor Mezei , Aranka Lay nee Konya , Zoltan Vigh , Agnes Sokorai nee Janki
发明人： Zoltan Budai , Attila Kis-Tamas , Tibor Mezei , Aranka Lay nee Konya , Zoltan Vigh , Agnes Sokorai nee Janki
IPC分类号： A01N33/24 , A01N33/04 , A01N35/10 , A01P21/00 , C07C251/44 , C07C251/50
CPC分类号： A01N35/10
摘要： The invention relates to new bicyclo(2.2.1)heptane derivatives of the general formula I ##STR1## wherein R represents a C.sub.1-12 alkyl group optionally substituted by a lower alkoxy group, a C.sub.2-4 alkenyl group or a phenyl-(lower alkyl) group optionally substituted on the phenyl ring by one or more lower alkoxy groups or halogen atoms.The invention relates further to plant growth regulating compositions comprising as active agent 0.001 to 95% by weight of a racemic and/or optically active compound of the general formula I, wherein R has the above defined meanings, along with a conventional organic or inorganic, solid and/or liquid carrier and/or filler and/or diluent and/or surfactant.The invention encompasses also the preparation of the compounds of the general formula I which comprises reacting a racemic or optically active compound of the general formula II ##STR2## wherein Y is an oxygen or sulfur atom or an oxim group, with a compund of the general formula IIIR - XwhereinR is as defined above, andX represents a leaving group, preferably a halogen atom, a sulfonyloxy or an aminooxy group, with the proviso that when using a compound of the general formula II, in which Y is an oxim group, X is other than aminooxy group,in the presence of a basic condensing agent, and optionally resolving the racemic compound of the general formula I obtained into its optically active antipodes.
摘要翻译：本发明涉及通式I的新的双环（2.2.1）庚烷衍生物，其中R表示任选被低级烷氧基，C 2-4链烯基或苯基 - （低级烷基）基团，其任选在苯环上被一个或多个低级烷氧基或卤素原子取代。本发明进一步涉及植物生长调节组合物，其包含作为活性剂0.001至95重量％的通式I的外消旋和/或旋光活性化合物，其中R具有上述定义的含义，以及常规的有机或无机，固体和/或液体载体和/或填料和/或稀释剂和/或表面活性剂。本发明还包括通式I的化合物的制备，其包括使通式II的外消旋或旋光活性化合物其中Y是氧或硫原子或肟基，与下列化合物反应：通式III R-X其中R如上定义，X表示离去基团，优选卤素原子，磺酰氧基或氨基氧基，条件是当使用通式II的化合物时，其中Y为肟基，X不是氨基氧基，在碱性缩合剂的存在下，并且任选地将所得通式I的外消旋化合物拆分成其光学活性对映体。

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