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1. 发明申请

US20090068723A1 Isolated Fungal Promoters and Gene Transcription Terminators and Methods of Protein and Chemical Production in a Fungus 有权
标题翻译：分离的真菌启动子和基因转录终止子和真菌中蛋白质和化学生产的方法
公开(公告)号：US20090068723A1
公开(公告)日：2009-03-12
申请号：US12257261
申请日：2008-10-23
申请人： Ziyu Dai , Linda L. Lasure , Jon K. Magnuson
发明人： Ziyu Dai , Linda L. Lasure , Jon K. Magnuson
IPC分类号： C12N1/21 , C12N15/11 , C12N15/00
CPC分类号： C12P7/44 , C07K14/38 , C12N15/80 , C12P7/46 , C12P7/48 , C12P7/56 , C12P7/58 , C12P17/06 , C12P21/005 , C12P35/00 , C12P37/00
摘要： The present invention encompasses isolated gene regulatory elements and gene transcription terminators that are differentially expressed in a native fungus exhibiting a first morphology relative to the native fungus exhibiting a second morphology. The invention also encompasses a method of utilizing a fungus for protein or chemical production. A transformed fungus is produced by transforming a fungus with a recombinant polynucleotide molecule. The recombinant polynucleotide molecule contains an isolated polynucleotide sequence linked operably to another molecule comprising a coding region of a gene of interest. The gene regulatory element and gene transcription terminator may temporally and spatially regulate expression of particular genes for optimum production of compounds of interest in a transgenic fungus.
摘要翻译：本发明包括在天然真菌中差异表达的分离的基因调控元件和基因转录终止子，其表现出相对于表现出第二形态的天然真菌的第一形态。本发明还包括利用真菌进行蛋白质或化学生产的方法。通过用重组多核苷酸分子转化真菌产生转化的真菌。重组多核苷酸分子含有与包含感兴趣的基因的编码区的另一个分子可操作地连接的分离的多核苷酸序列。基因调控元件和基因转录终止子可以在时间上和空间上调节特定基因的表达，以在转基因真菌中最佳产生感兴趣的化合物。

2. 发明授权

US07449569B2 Isolated fungal promoters and gene transcription terminators and methods of protein and chemical production in a fungus 失效
标题翻译：分离的真菌启动子和基因转录终止子以及真菌中蛋白质和化学生产的方法
公开(公告)号：US07449569B2
公开(公告)日：2008-11-11
申请号：US10920625
申请日：2004-08-17
申请人： Ziyu Dai , Linda L. Lasure , Jon K. Magnuson
发明人： Ziyu Dai , Linda L. Lasure , Jon K. Magnuson
IPC分类号： C07H21/04 , C12Q1/68 , C12N15/00 , C12N15/63 , C12N1/00
CPC分类号： C12P7/44 , C07K14/38 , C12N15/80 , C12P7/46 , C12P7/48 , C12P7/56 , C12P7/58 , C12P17/06 , C12P21/005 , C12P35/00 , C12P37/00
摘要： The present invention encompasses isolated gene regulatory elements and gene transcription terminators that are differentially expressed in a native fungus exhibiting a first morphology relative to the native fungus exhibiting a second morphology. The invention also encompasses a method of utilizing a fungus for protein or chemical production. A transformed fungus is produced by transforming a fungus with a recombinant polynucleotide molecule. The recombinant polynucleotide molecule contains an isolated polynucleotide sequence linked operably to another molecule comprising a coding region of a gene of interest. The gene regulatory element and gene transcription terminator may temporally and spatially regulate expression of particular genes for optimum production of compounds of interest in a transgenic fungus.
摘要翻译：本发明包括在天然真菌中差异表达的分离的基因调控元件和基因转录终止子，其表现出相对于表现出第二形态的天然真菌的第一形态。本发明还包括利用真菌进行蛋白质或化学生产的方法。通过用重组多核苷酸分子转化真菌产生转化的真菌。重组多核苷酸分子含有与包含感兴趣的基因的编码区的另一个分子可操作地连接的分离的多核苷酸序列。基因调控元件和基因转录终止子可以在时间上和空间上调节特定基因的表达，以在转基因真菌中最佳产生感兴趣的化合物。

3. 发明授权

US08735562B2 Isolated fungal promoters and gene transcription terminators and methods of protein and chemical production in a fungus 有权
标题翻译：分离的真菌启动子和基因转录终止子以及真菌中蛋白质和化学生产的方法
公开(公告)号：US08735562B2
公开(公告)日：2014-05-27
申请号：US12257261
申请日：2008-10-23
申请人： Ziyu Dai , Linda L. Lasure , Jon K. Magnuson
发明人： Ziyu Dai , Linda L. Lasure , Jon K. Magnuson
IPC分类号： C07H21/04 , C12N15/63
CPC分类号： C12P7/44 , C07K14/38 , C12N15/80 , C12P7/46 , C12P7/48 , C12P7/56 , C12P7/58 , C12P17/06 , C12P21/005 , C12P35/00 , C12P37/00
摘要： The present invention encompasses isolated gene regulatory elements and gene transcription terminators that are differentially expressed in a native fungus exhibiting a first morphology relative to the native fungus exhibiting a second morphology. The invention also encompasses a method of utilizing a fungus for protein or chemical production. A transformed fungus is produced by transforming a fungus with a recombinant polynucleotide molecule. The recombinant polynucleotide molecule contains an isolated polynucleotide sequence linked operably to another molecule comprising a coding region of a gene of interest. The gene regulatory element and gene transcription terminator may temporally and spatially regulate expression of particular genes for optimum production of compounds of interest in a transgenic fungus.
摘要翻译：本发明包括在天然真菌中差异表达的分离的基因调控元件和基因转录终止子，其表现出相对于表现出第二形态的天然真菌的第一形态。本发明还包括利用真菌进行蛋白质或化学生产的方法。通过用重组多核苷酸分子转化真菌产生转化的真菌。重组多核苷酸分子含有与包含感兴趣的基因的编码区的另一个分子可操作地连接的分离的多核苷酸序列。基因调控元件和基因转录终止子可以在时间上和空间上调节特定基因的表达，以在转基因真菌中最佳产生感兴趣的化合物。

4. 发明申请

US20090042302A1 Isolated Polynucleotides and Methods of Promoting a Morphology in a Fungus 审中-公开
标题翻译：分离的多核苷酸和促进真菌形态学的方法
公开(公告)号：US20090042302A1
公开(公告)日：2009-02-12
申请号：US12237292
申请日：2008-09-24
申请人： Linda L. Lasure , Ziyu Dai
发明人： Linda L. Lasure , Ziyu Dai
IPC分类号： C12N15/74
CPC分类号： C07H21/04 , C07K14/38 , C12N1/14
摘要： The invention includes isolated polynucleotide molecules that are differentially expressed in a native fungus exhibiting a first morphology relative to the native fungus exhibiting a second morphology. The invention includes a method of enhancing a bioprocess utilizing a fungus. A transformed fungus is produced by transforming a fungus with a recombinant polynucleotide molecule. The recombinant polynucleotide molecule contains an isolated polynucleotide sequence linked operably to a promoter. The polynucleotide sequence is expressed to promote a first morphology. The first morphology of the transformed fungus enhances a bioprocess relative to the bioprocess utilizing a second morphology.
摘要翻译：本发明包括在表现出具有第二形态的天然真菌的第一形态的天然真菌中差异表达的分离的多核苷酸分子。本发明包括利用真菌增强生物过程的方法。通过用重组多核苷酸分子转化真菌产生转化的真菌。重组多核苷酸分子含有与启动子可操作地连接的分离的多核苷酸序列。表达多核苷酸序列以促进第一形态。转化真菌的第一种形态使用第二种形态增强了相对于生物过程的生物过程。

5. 发明授权

US07439067B2 Isolated polynucleotides and methods of promoting a morphology in a fungus 失效
标题翻译：分离的多核苷酸和促进真菌形态的方法
公开(公告)号：US07439067B2
公开(公告)日：2008-10-21
申请号：US10442017
申请日：2003-05-19
申请人： Linda L. Lasure , Ziyu Dai
发明人： Linda L. Lasure , Ziyu Dai
IPC分类号： C12N15/80 , C12P7/48
CPC分类号： C07H21/04 , C07K14/38 , C12N1/14
摘要： The invention includes isolated polynucleotide molecules that are differentially expressed in a native fungus exhibiting a first morphology relative to the native fungus exhibiting a second morphology. The invention includes a method of enhancing a bioprocess utilizing a fungus. A transformed fungus is produced by transforming a fungus with a recombinant polynucleotide molecule. The recombinant polynucleotide molecule contains an isolated polynucleotide sequence linked operably to a promoter. The polynucleotide sequence is expressed to promote a first morphology. The first morphology of the transformed fungus enhances a bioprocess relative to the bioprocess utilizing a second morphology.
摘要翻译：本发明包括在表现出具有第二形态的天然真菌的第一形态的天然真菌中差异表达的分离的多核苷酸分子。本发明包括利用真菌增强生物过程的方法。通过用重组多核苷酸分子转化真菌产生转化的真菌。重组多核苷酸分子含有与启动子可操作地连接的分离的多核苷酸序列。表达多核苷酸序列以促进第一形态。转化真菌的第一种形态使用第二种形态增强了相对于生物过程的生物过程。

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