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1. 发明授权

US06972122B2 Contrast enhancement agent for magnetic resonance imaging 失效
标题翻译：磁共振成像对比增强剂
公开(公告)号：US06972122B2
公开(公告)日：2005-12-06
申请号：US10025698
申请日：2001-12-18
申请人： Zishan Haroon , Mark W. Dewhirst , Charles S. Greenberg , Michal Neeman
发明人： Zishan Haroon , Mark W. Dewhirst , Charles S. Greenberg , Michal Neeman
IPC分类号： A61K49/08 , A61K49/14 , G01N33/49 , A61K49/00
CPC分类号： A61K49/14 , A61K49/085 , G01N33/4905
摘要： Imaging agents for magnetic resonance imaging are disclosed. Methods of monitoring angiogenesis and the growth and remission of tumor tissue are also disclosed. Methods of monitoring blood clot formation and dissolution are additionally disclosed. Methods of monitoring wound healing are further disclosed. A kit for obtaining an image of a biological structure is further disclosed.
摘要翻译：公开了用于磁共振成像的成像剂。还公开了监测血管生成和肿瘤组织生长和缓解的方法。还公开了监测血块形成和溶解的方法。进一步公开了监测伤口愈合的方法。还公开了一种用于获得生物结构图像的套件。

2. 发明授权

US07208138B2 Contrast enhancement agent for magnetic resonance imaging 失效
标题翻译：磁共振成像对比增强剂
公开(公告)号：US07208138B2
公开(公告)日：2007-04-24
申请号：US11294625
申请日：2005-12-05
申请人： Zishan Haroon , Mark W. Dewhirst , Charles S. Greenberg , Michal Neeman
发明人： Zishan Haroon , Mark W. Dewhirst , Charles S. Greenberg , Michal Neeman
IPC分类号： A61K49/00 , A61B5/055
CPC分类号： A61K49/14 , A61K49/085 , G01N33/4905
摘要： Imaging agents for magnetic resonance imaging are disclosed. Methods of monitoring angiogenesis and the growth and remission of tumor tissue are also disclosed. Methods of monitoring blood clot formation and dissolution are additionally disclosed. Methods of monitoring wound healing are further disclosed. A kit for obtaining an image of a biological structure is further disclosed.
摘要翻译：公开了用于磁共振成像的成像剂。还公开了监测血管生成和肿瘤组织生长和缓解的方法。还公开了监测血块形成和溶解的方法。进一步公开了监测伤口愈合的方法。还公开了一种用于获得生物结构图像的套件。

3. 发明授权

US5328898A Factor XIIIA fibrin binding fragments 失效
标题翻译：因子XIIIA纤维蛋白结合片段
公开(公告)号：US5328898A
公开(公告)日：1994-07-12
申请号：US543116
申请日：1990-06-22
申请人： Charles S. Greenberg
发明人： Charles S. Greenberg
IPC分类号： A61K38/00 , C07K14/745 , C12N15/54 , A61K37/00 , A61K37/52 , C07K13/00
CPC分类号： C07K14/745 , A61K38/00 , C07K2319/00 , Y10S930/10
摘要： Fibrin binding peptides disclosed include (a) peptides having the amino acid sequence of a human Blood Coagulation Factor XIIIA fragment (i.e., NKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPVPIVSELQSGKWGAKIVMREDR SVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETDTYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQF-R', where R, is --CONH.sub.2 or --NH.sub.2); (b) peptides which are fragments of the foregoing Factor XIIIA fragment and which retain the capability thereof of binding to fibrin; and (c) peptides which bind to fibrin, which have the amino acid sequence of any of the foregoing peptides, and which have additional amino acid residues attached to the N-terminal end and/or the C-terminal end thereof.The peptides are useful for localizing blood clots in vivo, inhibiting fibrin stabilization, and promoting thrombolysis.
摘要翻译：公开的血纤维蛋白结合肽包括（a）具有人血液凝固因子XIIIA片段的氨基酸序列（即，NKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPVPIVSELQSGKWGAKIVMREDR SVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETDTYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQF-R”，其中R是-CONH 2或-NH 2）的肽; （b）作为上述因子XIIIA片段的片段并且保留其结合纤维蛋白的能力的肽; 和（c）结合纤维蛋白的肽，其具有任何前述肽的氨基酸序列，并且具有连接到N-末端和/或其C-末端的另外的氨基酸残基。这些肽可用于体内定位血块，抑制纤维蛋白稳定化和促进溶栓。

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