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1. 发明授权

US09150530B2 Esters of 4, 9-dihydroxy-naphtho [2, 3-b] furans for disease therapies 有权
标题翻译：用于疾病治疗的4,9-二羟基 - 萘并[2,3-b]呋喃的酯
公开(公告)号：US09150530B2
公开(公告)日：2015-10-06
申请号：US14002986
申请日：2011-03-04
申请人： Zhiwei Jiang , Aijin Wang , Hongwei Hu , Jiali Xu , Yuesong Hu , Xian Li , Yan Ye , Jie Wang , Qinglong Li
发明人： Zhiwei Jiang , Aijin Wang , Hongwei Hu , Jiali Xu , Yuesong Hu , Xian Li , Yan Ye , Jie Wang , Qinglong Li
IPC分类号： A61K31/34 , C07D307/92 , A61K31/343 , A61K31/665 , A61K45/06 , C07F9/655
CPC分类号： C07D307/92 , A61K31/343 , A61K31/665 , A61K45/06 , C07F9/65517
摘要： The present invention discloses esters of 4,9-dihydroxy-naphtho[2,3-b]furans and methods of making and using the same. The present invention also discloses conversion of the esters into therapeutically active 4,9-dihydroxy-naphtho[2,3-b]furans in vivo. The present invention furthermore discloses pharmaceutical compositions comprising the esters of 4,9-dihydroxy-naphtho[2,3-b]furans for the treatment of various indications including proliferative diseases.
摘要翻译：本发明公开了4,9-二羟基 - 萘并[2,3-b]呋喃的酯及其制备和使用方法。本发明还公开了在体内将酯转化为治疗活性的4,9-二羟基 - 萘并[2,3-b]呋喃。本发明还公开了包含4,9-二羟基 - 萘并[2,3-b]呋喃的酯的药物组合物，用于治疗各种适应症，包括增殖性疾病。

2. 发明申请

US20130345176A1 NOVEL ESTERS OF 4, 9-DIHYDROXY-NAPHTHO [2, 3-b] FURANS FOR DISEASE THERAPIES 有权
标题翻译： 4,9-二羟基萘酚[2,3-b]用于疾病治疗的药物的新药
公开(公告)号：US20130345176A1
公开(公告)日：2013-12-26
申请号：US14002986
申请日：2011-03-04
申请人： Zhiwei Jiang , Aijin Wang , Hongwei Hu , Jiali Xu , Yuesong Hu , Xian Li , Yan Ye , Jie Wang , Qinglong Li
发明人： Zhiwei Jiang , Aijin Wang , Hongwei Hu , Jiali Xu , Yuesong Hu , Xian Li , Yan Ye , Jie Wang , Qinglong Li
IPC分类号： C07D307/92 , A61K45/06 , A61K31/665 , C07F9/655 , A61K31/343
CPC分类号： C07D307/92 , A61K31/343 , A61K31/665 , A61K45/06 , C07F9/65517
摘要： The present invention discloses esters of 4,9-dihydroxy-naphtho[2,3-b]furans and methods of making and using the same. The present invention also discloses conversion of the esters into therapeutically active 4,9-dihydroxy-naphtho[2,3-b]furans in vivo. The present invention furthermore discloses pharmaceutical compositions comprising the esters of 4,9-dihydroxy-naphtho[2,3-b]furans for the treatment of various indications including proliferative diseases.
摘要翻译：本发明公开了4,9-二羟基 - 萘并[2,3-b]呋喃的酯及其制备和使用方法。本发明还公开了在体内将酯转化为治疗活性的4,9-二羟基 - 萘并[2,3-b]呋喃。本发明还公开了包含4,9-二羟基 - 萘并[2,3-b]呋喃的酯的药物组合物，用于治疗各种适应症，包括增殖性疾病。

3. 发明授权

US08871802B2 Naphthoquinones for disease therapies 有权
标题翻译：用于疾病治疗的萘醌
公开(公告)号：US08871802B2
公开(公告)日：2014-10-28
申请号：US13818613
申请日：2010-08-24
申请人： Zhiwei Jiang , Aijin Wang , Xian Li , Qingrong Li , Hongwei Hu , Jiali Xu , Yuesong Hu , Yan Ye
发明人： Zhiwei Jiang , Aijin Wang , Xian Li , Qingrong Li , Hongwei Hu , Jiali Xu , Yuesong Hu , Yan Ye
IPC分类号： A61K31/343 , C07D307/92 , A61K45/06
CPC分类号： A61K31/343 , A61K45/06 , C07D307/92
摘要： The present invention discloses novel naphtho[2,3-b]furan-4,9-diones and naphtho[2,3-b]thiophene-4,9-diones and methods of making and using the same. The present invention also discloses pharmaceutical compositions comprising novel naphtho[2,3-b]furan-4,9-dione or naphtho[2,3-b]thiophene-4,9-diones for the treatment of various indications including proliferative diseases.
摘要翻译：本发明公开了新萘并[2,3-b]呋喃-4,9-二酮和萘并[2,3-b]噻吩-4,9-二酮及其制备和使用方法。本发明还公开了包含新型萘并[2,3-b]呋喃-4,9-二酮或萘并〔2,3-b〕噻吩-4,9-二氢discloses discloses discloses discloses discloses discloses discloses discloses discloses discloses discloses discloses discloses discloses。。。。。。。。。。

4. 发明申请

US20130150437A1 NAPHTHOQUINONES FOR DISEASE THERAPIES 有权
标题翻译：用于疾病治疗的石墨烯
公开(公告)号：US20130150437A1
公开(公告)日：2013-06-13
申请号：US13818613
申请日：2010-08-24
申请人： Zhiwei Jiang , Aijin Wang , Xian Li , Qingrong Li , Hongwei Hu , Jiali Xu , Yuesong Hu , Yan Ye
发明人： Zhiwei Jiang , Aijin Wang , Xian Li , Qingrong Li , Hongwei Hu , Jiali Xu , Yuesong Hu , Yan Ye
IPC分类号： A61K31/343 , A61K45/06 , C07D307/92
CPC分类号： A61K31/343 , A61K45/06 , C07D307/92
摘要： The present invention discloses novel naphtho[2,3-b]furan-4,9-diones and naphtho[2,3-b]thiophene-4,9-diones and methods of making and using the same. The present invention also discloses pharmaceutical compositions comprising novel naphtho[2,3-b]furan-4,9-dione or naphtho[2,3-b]thiophene-4,9-diones for the treatment of various indications including proliferative diseases.
摘要翻译：本发明公开了新萘并[2,3-b]呋喃-4,9-二酮和萘并[2,3-b]噻吩-4,9-二酮及其制备和使用方法。本发明还公开了包含新型萘并[2,3-b]呋喃-4,9-二酮或萘并〔2,3-b〕噻吩-4,9-二氢discloses discloses discloses discloses discloses discloses discloses discloses discloses discloses discloses discloses discloses discloses。。。。。。。。。。

5. 发明申请

US20150164794A1 METHOD FOR PREPARING AQUEOUS NANOPARTICLE SUSPENSIONS OF DERIVATIVES OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURAN ALIPHATIC ACID ESTERS 审中-公开
标题翻译：制备4,9-二羟基萘并[2,3-b]呋喃糖酸酯衍生物的水性纳米颗粒悬浮液的方法
公开(公告)号：US20150164794A1
公开(公告)日：2015-06-18
申请号：US14379247
申请日：2012-02-17
申请人： Zhiwei Jianh , Xian Li , Hairong Xu , Yan Ye , Hongwei Hu , Huanhuan Yang
发明人： Zhiwei Jianh , Xian Li , Hairong Xu , Yan Ye , Hongwei Hu , Huanhuan Yang
IPC分类号： A61K9/10 , A61K31/343
CPC分类号： A61K9/10 , A61K9/1075 , A61K9/5146 , A61K31/343 , C07D307/92
摘要： Disclosed is a method for preparing aqueous nanoparticle suspensions of derivatives of 4,9-dihydroxy-naphtho[2,3-b]furan aliphatic acid esters. The compositions and the uses of the aqueous nanoparticle suspensions prepared according to the method as described herein are also disclosed.
摘要翻译：公开了一种制备4,9-二羟基 - 萘并[2,3-b]呋喃脂肪酸酯衍生物的水性纳米颗粒悬浮液的方法。还公开了根据本文所述的方法制备的纳米颗粒水悬浮液的组合物和用途。

6. 发明申请

US20130304835A1 TRANSMITTING AND DISPLAYING OFFLINE DATA 审中-公开
标题翻译：发送和显示离线数据
公开(公告)号：US20130304835A1
公开(公告)日：2013-11-14
申请号：US13891678
申请日：2013-05-10
申请人： Hongwei Hu
发明人： Hongwei Hu
IPC分类号： H04L12/58
CPC分类号： H04L51/24 , H04L51/38
摘要： The present disclosure discloses a method, an apparatus, and a system for transmitting and displaying offline data. When communication application software on a client terminal is under an offline state, a background service corresponding to the communication application software at the client terminal is started so that the client terminal establishes a communication connection between the client terminal and a message server via the background service. The client terminal receives offline data from the message server via the background service. The background service also analyzes the offline data to generate a prompt message for displaying, and displays the prompt message at a pre-determined display area. The present techniques enable a user to obtain updated messages in real-time and improve an efficiency of the user for acquiring data and user experiences.
摘要翻译：本公开公开了一种用于发送和显示离线数据的方法，装置和系统。当客户终端上的通信应用软件处于脱机状态时，开始与客户终端处的通信应用软件相对应的后台服务，使得客户终端经由后台服务建立客户终端与消息服务器之间的通信连接。客户终端经由后台服务从消息服务器接收离线数据。后台服务还分析离线数据，生成提示信息进行显示，并在预先确定的显示区域显示提示信息。本技术使得用户能够实时获得更新的消息，并提高用户获取数据和用户体验的效率。

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