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1. 发明申请

US20080178436A1 FASTENER WEBS WITH MICROSTRUCTURED PARTICLES AND METHODS OF MAKING SAME 审中-公开
标题翻译：具有微结构化颗粒的紧固件织物及其制备方法
公开(公告)号：US20080178436A1
公开(公告)日：2008-07-31
申请号：US11627065
申请日：2007-01-25
申请人： Zhiqun Zhang , Haiyan Zhang
发明人： Zhiqun Zhang , Haiyan Zhang
IPC分类号： A44B18/00
CPC分类号： A44B18/0061 , Y10T24/27
摘要： A hook fastener capable of engaging a suitable loop fabric, and a method of forming this hook fastener, are disclosed. The hook fastener comprises a base substrate with a surface having a multitude of engaging projections, the engaging projections having a top surface and an attached end which is joined to the surface of the base substrate at a bond juncture, wherein the top surfaces of at least some of the engaging projections comprise nonlinear microstructured features, such as intersecting peak and/or valley structures.
摘要翻译：公开了一种能够接合合适的环形织物的钩紧固件以及形成该钩紧固件的方法。钩紧固件包括具有多个接合突起的表面的基底，接合突起具有顶表面和附接端，该接合突起在接合处接合到基底基板的表面，其中至少一些接合突起包括非线性微结构特征，例如相交的峰和/或谷结构。

2. 发明授权

US06758884B2 Air filtration system using point ionization sources 有权
标题翻译：空气过滤系统采用点电离源
公开(公告)号：US06758884B2
公开(公告)日：2004-07-06
申请号：US10214052
申请日：2002-08-07
申请人： Zhiqun Zhang , Robert M. Swinehart
发明人： Zhiqun Zhang , Robert M. Swinehart
IPC分类号： B03C3155
CPC分类号： B03C3/80 , B03C3/12 , B03C3/32 , B03C3/41
摘要： A filtration system for filtering particulates from air. A plurality of point ionization sources are positioned in the proximity of the periphery of an air flow channel and being oriented to generate ions in the proximity of the air flow channel in a direction generally upstream from each respective one of the plurality of point ionization sources. A particulate collection surface is positioned within the air flow channel in a downstream direction from the plurality of point ionization sources. The particulate collection surface is electrostatically charged in an opposite direction with respect to ground than the electrical charge of the ions. An ion trap is positioned within the air flow channel between the plurality of ionization sources and the particulate collection surface. The ion trap is relatively electrically neutral as compared with the particulate collection surface and the ions.
摘要翻译：用于从空气中过滤颗粒物的过滤系统。多个点电离源被定位在空气流动通道的周边附近并且被定向成在大体上游于多个点电离源中的相应一个点电离源的上游方向上在空气流动通道附近产生离子。颗粒收集表面在多个点电离源的下游方向上位于空气流动通道内。颗粒收集表面相对于离子的电荷与地面相反的方向被静电充电。离子阱位于多个电离源和颗粒收集表面之间的空气流动通道内。与颗粒收集表面和离子相比，离子阱相对电中性。

3. 外观设计

USD484228S1 Air cleaner 失效
公开(公告)号：USD484228S1
公开(公告)日：2003-12-23
申请号：US29171315
申请日：2002-11-20
申请人： Zhiqun Zhang , Robert M. Swinehart
设计人： Zhiqun Zhang , Robert M. Swinehart

4. 发明授权

US06610494B2 Solid-phase activity assay for biologically active substance 失效
标题翻译：生物活性物质的固相活性测定
公开(公告)号：US06610494B2
公开(公告)日：2003-08-26
申请号：US09180819
申请日：1999-05-20
申请人： Ronald R. Marquardt , Xiao Hao , Guojie Wang , Zhiqun Zhang , Zhibo Gan
发明人： Ronald R. Marquardt , Xiao Hao , Guojie Wang , Zhiqun Zhang , Zhibo Gan
IPC分类号： G01N33533
CPC分类号： C12Q1/34 , G01N33/54306 , G01N2333/924 , G01N2333/948 , G01N2400/24
摘要： A method of detecting via a solid-phase assay the amount of biological activity, identity and/or the quantity of a biologically active substance is disclosed. The method utilizes the biological activity of the substance itself to provide the method of detection. The method provides competitive and noncompetitive assays.
摘要翻译：公开了通过固相测定法检测生物活性的量，生物活性物质的身份和/或数量的方法。该方法利用物质本身的生物活性提供检测方法。该方法提供竞争性和非竞争性测定。

5. 发明授权

US10165833B2 Mechanical fastener, fastening system, and disposable absorbent article 有权
公开(公告)号：US10165833B2
公开(公告)日：2019-01-01
申请号：US14344648
申请日：2012-09-13
申请人： Timothy P. Pariseau , Michael R. Gorman , Shin Katoh , Tadato Oritani , Zhiqun Zhang , Neelakandan Chandrasekaran
发明人： Timothy P. Pariseau , Michael R. Gorman , Shin Katoh , Tadato Oritani , Zhiqun Zhang , Neelakandan Chandrasekaran
IPC分类号： A44B18/00 , A61F13/496 , A61F13/62
摘要： A mechanical fastener is disclosed that includes a thermoplastic backing and multiple, upstanding fastening elements that have a post with a proximal end attached to the thermoplastic backing and a distal end comprising a cap larger in area than a cross-sectional area of the post. The basis weight of the mechanical fastener is in a range from 25 grams per square meter to 75 grams per square meter, and the height of the multiple, upstanding fastening elements is up to 300 micrometers. Fastening systems and disposable absorbent articles including the mechanical fastener are also disclosed.

6. 发明申请

US20130029362A1 MARKERS AND ASSAYS FOR DETECTION OF NEUROTOXICITY 审中-公开
标题翻译：用于检测神经毒性的标记和测定
公开(公告)号：US20130029362A1
公开(公告)日：2013-01-31
申请号：US13638611
申请日：2011-04-01
申请人： Andreas Jeromin , Oleana Glushakova , Kevin Ka-wang Wang , Zhiqun Zhang , Ronald L. Hayes
发明人： Andreas Jeromin , Oleana Glushakova , Kevin Ka-wang Wang , Zhiqun Zhang , Ronald L. Hayes
IPC分类号： G01N33/53 , G01N21/64
CPC分类号： C12Q1/6883 , C12Q2600/142 , C12Q2600/158 , G01N33/6896 , G01N2333/47 , G01N2333/91142 , G01N2333/96425 , G01N2500/10 , G01N2800/28
摘要： A process and assay for diagnosing neurotoxicity in a subject is provided. The extent of a neurotoxic insult to a subject is assessed through the measurement of one or more biomarkers in a biological fluid, such as CSF or serum. Other uses and advantages afforded include pre-market drug discovery, monitoring, drug neurotoxicity screening and post market assessment of safety and monitoring for drug of known potential neurotoxicity.
摘要翻译：提供了用于诊断受试者的神经毒性的方法和测定法。通过测量生物流体如CSF或血清中的一种或多种生物标志物来评估对受试者的神经毒性损伤的程度。提供的其他用途和优点包括市场前药物发现，监测，药物神经毒性筛选和市场后评估安全性和已知潜在神经毒性药物监测。

7. 发明授权

US08060633B2 Method and apparatus for identifying data content 有权
标题翻译：用于识别数据内容的方法和装置
公开(公告)号：US08060633B2
公开(公告)日：2011-11-15
申请号：US12347534
申请日：2008-12-31
申请人： Zhiqun Zhang , Huaqiang Hu
发明人： Zhiqun Zhang , Huaqiang Hu
IPC分类号： G06F15/16 , G06F15/173
CPC分类号： H04L69/18
摘要： A method for identifying data content comprises: establishing a character base which stores characters corresponding to various service applications and protocols; performing matching between contents of currently received data and the characters in the character base, and obtaining characters contained in the currently received data; identifying at least one of a service application and a protocol corresponding to the characters contained in the currently received data according to a mapping relation between characters and protocols as well as a mapping relation between characters and service applications. An apparatus for identifying data content is also disclosed. The technical scheme of the present invention can identify data content comprehensively and can be easily extended.
摘要翻译：一种用于识别数据内容的方法包括：建立一个字符库，其存储与各种服务应用和协议相对应的字符; 执行当前接收到的数据的内容与字符库中的字符之间的匹配，并且获得包含在当前接收的数据中的字符; 根据字符和协议之间的映射关系，以及字符和服务应用之间的映射关系，识别与当前接收到的数据中包含的字符相对应的服务应用和协议中的至少一个。还公开了一种用于识别数据内容的装置。本发明的技术方案可以全面地识别数据内容，并且可以容易地扩展。

8. 发明申请

US20100047817A1 Synaptotagmin and Collapsin Response Mediator Protein as Biomarkers for Traumatic Brain Injury 有权
标题翻译： Synaptotagmin和Collapsin Response Mediator Protein作为创伤性脑损伤的生物标志物
公开(公告)号：US20100047817A1
公开(公告)日：2010-02-25
申请号：US12535960
申请日：2009-08-05
申请人： Andrew K. Ottens , Firas H. Kobaissy , Ka-Wang (Kevin) Wang , Ronald L. Hayes , Zhiqun Zhang , Ming Chen Liu , Monika Oli
发明人： Andrew K. Ottens , Firas H. Kobaissy , Ka-Wang (Kevin) Wang , Ronald L. Hayes , Zhiqun Zhang , Ming Chen Liu , Monika Oli
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , G01N2800/28
摘要： Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological fluids after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain. Synaptotagmin breakdown products were also associated with TBI and could be detected along with intact protein in human cerebral spinal fluid (CSF). Both biomarkers were detected in human biofluid and related to recovery from traumatic brain injury.
摘要翻译：在创伤性脑损伤（TBI）神经损伤后，Collapsin反应介质蛋白（CRMPs）在组织中减少并且生物流体中增加。 CRMP1，CRMP2，CRMP4和CRMP5的显着降低伴随着由钙蛋白酶的蛋白水解切割引起的不同的58kDa（CRMP-2）或55kDa（CRMP-4）分解产物的出现。 Synaptotagmin分解产物也与TBI相关，并可与人脑脊髓液（CSF）中的完整蛋白一起检测。在人类生物流体中检测到两种生物标志物，并与创伤性脑损伤恢复相关。

9. 发明申请

US20120196307A1 SYNAPTOTAGMIN AND COLLAPSIN RESPONSE MEDIATOR PROTEIN AS BIOMARKERS FOR TRAUMATIC BRAIN INJURY 审中-公开
标题翻译： SYNAPTOTAGMIN和COLLAPSIN反应介质蛋白作为生物标志物治疗脑损伤
公开(公告)号：US20120196307A1
公开(公告)日：2012-08-02
申请号：US13337588
申请日：2011-12-27
申请人： ANDREW K. OTTENS , Firas H. Kobaissy , Ka-Wang (Kevin) Wang , Ronald L. Hayes , Zhiqun Zhang , Ming Chen Liu , Monika Oli
发明人： ANDREW K. OTTENS , Firas H. Kobaissy , Ka-Wang (Kevin) Wang , Ronald L. Hayes , Zhiqun Zhang , Ming Chen Liu , Monika Oli
IPC分类号： G01N33/566 , C07K2/00
CPC分类号： G01N33/6896 , G01N2800/28
摘要： Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological samples after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain. Synaptotagmin breakdown products were also associated with TBI and could be detected along with intact protein in human cerebral spinal fluid (biological samples). Both biomarkers were detected in human biofluid and related to recovery from traumatic brain injury.
摘要翻译：在创伤性脑损伤（TBI）神经损伤后，Collapsin反应介质蛋白（CRMPs）在组织中减少，生物样品中增加。 CRMP1，CRMP2，CRMP4和CRMP5的显着降低伴随着由钙蛋白酶的蛋白水解切割引起的不同的58kDa（CRMP-2）或55kDa（CRMP-4）分解产物的出现。 Synaptotagmin分解产物也与TBI相关，可与人脑脊髓液（生物样品）中的完整蛋白一起检测。在人类生物流体中检测到两种生物标志物，并与创伤性脑损伤恢复相关。

10. 发明申请

US20110143375A1 BIOMARKER DETECTION PROCESS AND ASSAY OF NEUROLOGICAL CONDITION 审中-公开
标题翻译：生物标志物检测过程和神经病学测定
公开(公告)号：US20110143375A1
公开(公告)日：2011-06-16
申请号：US13058748
申请日：2009-08-11
申请人： Kevin Ka-wang Wang , Ronald L. Hayes , Uwe R. Mueller , Zhiqun Zhang
发明人： Kevin Ka-wang Wang , Ronald L. Hayes , Uwe R. Mueller , Zhiqun Zhang
IPC分类号： G01N33/53 , G01N33/573 , C12M1/34 , B01J19/00
CPC分类号： G01N33/6896 , G01N2800/28 , G01N2800/2871 , G01N2800/60
摘要： The subject invention provides a robust, quantitative, and reproducible process and assay for diagnosis of a neurological condition in a subject. The invention provides measurement of two or more biomarkers in a biological fluid such as CSF or serum resulting in a synergistic mechanism for determining the extent of neurological damage in a subject with an abnormal neurological condition and for discerning subtypes thereof or tissue types subjected to damage.
摘要翻译：本发明提供用于诊断受试者神经病症的鲁棒，定量和可再现的方法和测定。本发明提供生物流体如CSF或血清中的两种或更多种生物标志物的测量，从而产生用于确定具有异常神经病症状况的受试者的神经损伤程度和受到损伤的辨别性亚型或组织类型的神经损伤程度的协同机制。

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