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1. 发明授权

US07994293B2 Antibodies specific for Dkk-1 有权
标题翻译： Dkk-1特异性抗体
公开(公告)号：US07994293B2
公开(公告)日：2011-08-09
申请号：US12012885
申请日：2008-02-06
申请人： Zhiqiang An , Fang Chen , John E. Fisher , Helmut Glantschnig , Donald B. Kimmel , Alfred A. Reszka , Fubao Wang
发明人： Zhiqiang An , Fang Chen , John E. Fisher , Helmut Glantschnig , Donald B. Kimmel , Alfred A. Reszka , Fubao Wang
IPC分类号： C07K16/24 , C07K16/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/622 , C07K2317/76 , C12N2799/026
摘要： Antibodies specific for Dkk-1, an inhibitor of the osteoanabolic Wnt/LRP5 signaling pathway, are described. The antibodies, which inhibit binding of Dkk-1 to LRP5, are useful in compositions for stimulating bone growth, in particular, compositions for treating bone disorders which result in a loss in bone, for example, osteoporosis.
摘要翻译：描述了针对骨代谢Wnt / LRP5信号通路的抑制剂Dkk-1特异的抗体。抑制Dkk-1与LRP5结合的抗体可用于刺激骨生长的组合物，特别是用于治疗导致骨丢失的骨病症的组合物，例如骨质疏松症。

2. 发明申请

US20080193449A1 Antibodies specific for DKK-1 有权
标题翻译：特异于DKK-1的抗体
公开(公告)号：US20080193449A1
公开(公告)日：2008-08-14
申请号：US12012885
申请日：2008-02-06
申请人： Zhiqiang An , Fang Chen , John E. Fisher , Helmut Glantschnig , Donald B. Kimmel , Alfred A. Reszka , Fubao Wang
发明人： Zhiqiang An , Fang Chen , John E. Fisher , Helmut Glantschnig , Donald B. Kimmel , Alfred A. Reszka , Fubao Wang
IPC分类号： A61K39/00 , C07K16/00 , C07H21/04 , C12N15/00 , C12N5/00 , C12P21/04
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/622 , C07K2317/76 , C12N2799/026
摘要： Antibodies specific for Dkk-1, an inhibitor of the osteoanabolic Wnt/LRP5 signaling pathway, are described. The antibodies, which inhibit binding of Dkk-1 to LRP5, are useful in compositions for stimulating bone growth, in particular, compositions for treating bone disorders which result in a loss in bone, for example, osteoporosis.
摘要翻译：描述了针对骨代谢Wnt / LRP5信号通路的抑制剂Dkk-1特异的抗体。抑制Dkk-1与LRP5结合的抗体可用于刺激骨生长的组合物，特别是用于治疗导致骨丢失的骨病症的组合物，例如骨质疏松症。

3. 发明申请

US20120201835A1 ANTIBODIES SPECIFIC FOR DKK-1 审中-公开
标题翻译： DKK-1特异性抗体
公开(公告)号：US20120201835A1
公开(公告)日：2012-08-09
申请号：US13169523
申请日：2011-06-27
申请人： Zhiqiang An , Fang Chen , John E. Fisher , Helmut Glantschnig , Donald B. Kimmel , Alfred A. Reszka , Fubao Wang
发明人： Zhiqiang An , Fang Chen , John E. Fisher , Helmut Glantschnig , Donald B. Kimmel , Alfred A. Reszka , Fubao Wang
IPC分类号： A61K39/395 , C07K16/18 , C12N15/13 , A61P19/10 , C12N1/19 , C12N1/15 , C12N5/10 , A61P19/02 , C12N15/63 , C12P21/02
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/622 , C07K2317/76 , C12N2799/026
摘要： Antibodies specific for Dkk-1, an inhibitor of the osteoanabolic Wnt/LRP5 signaling pathway, are described. The antibodies, which inhibit binding of Dkk-1 to LRP5, are useful in compositions for stimulating bone growth, in particular, compositions for treating bone disorders which result in a loss in bone, for example, osteoporosis.
摘要翻译：描述了针对骨代谢Wnt / LRP5信号通路的抑制剂Dkk-1特异的抗体。抑制Dkk-1与LRP5结合的抗体可用于刺激骨生长的组合物，特别是用于治疗导致骨丢失的骨病症的组合物，例如骨质疏松症。

4. 外观设计

USD1034348S1 Fender 有权
公开(公告)号：USD1034348S1
公开(公告)日：2024-07-09
申请号：US29908068
申请日：2024-01-11
申请人： Fang Chen
设计人： Fang Chen
摘要： FIG. 1 is a first perspective view of a fender showing my new design;
FIG. 2 is a second perspective view thereof;
FIG. 3 is a front view thereof;
FIG. 4 is a back view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a right side view thereof;
FIG. 7 is a top view thereof;
FIG. 8 is a bottom view thereof; and,
FIG. 9 is an enlarged view of the selected portion 9 in FIG. 1.
The dash-dash broken lines shown in the drawings depict portions of the fender that form no part of the claimed design. The dot-dash broken lines illustrate the periphery of the enlarged views of the fender and form no part of the claimed design.

5. 发明申请

US20190080012A1 METHOD AND SYSTEM FOR PROVIDING A HIGHLY-PERSONALIZED RECOMMENDATION ENGINE 审中-公开
公开(公告)号：US20190080012A1
公开(公告)日：2019-03-14
申请号：US16129453
申请日：2018-09-12
申请人： Yu Huang , Fang Chen
发明人： Yu Huang , Fang Chen
IPC分类号： G06F17/30 , G06K9/00 , G06N3/08
摘要： Various embodiments of a deep learning (DL)-based face perception engine for constructing, providing, and applying a highly-personalized face perception model for an individual through a deep learning process are disclosed. In some embodiments, a disclosed face perception engine includes a deep neural network configured for training a personalized face perception model for a unique individual based on a standard set of training images and a corresponding set of decisions on the set of training images provided by the unique individual. When sufficiently trained using the standard set of training images and the corresponding set of decisions, the personalized face perception model for the unique individual perceives a new face photo/image as if through the eyes of that unique individual. Hence, the trained face perception model can be used an “agent” or “representative” of the associated person in making very personal decisions, such as to decide if a given face photo/image includes a desirable face in the eyes of that person.

6. 发明授权

US09309528B2 Biofuel production methods and compositions 有权
标题翻译：生物燃料生产方法和组成
公开(公告)号：US09309528B2
公开(公告)日：2016-04-12
申请号：US11944217
申请日：2007-11-21
申请人： Richard A. Dixon , Fang Chen , Zengyu Wang
发明人： Richard A. Dixon , Fang Chen , Zengyu Wang
IPC分类号： A01H5/00 , A01H5/10 , C12N15/82 , C12P7/06
CPC分类号： C12N15/8245 , C12N15/8255 , Y02E50/17
摘要： The invention provides methods for increasing the level of fermentable carbohydrates in a biofuel crop plant such as alfalfa or switchgrass, by modification of the lignin biosynthetic pathway. Also provided are plants prepared by the methods of the invention. Methods for processing plant tissue and for producing ethanol by utilizing such plants are also provided.
摘要翻译：本发明提供了通过修饰木质素生物合成途径来增加生物燃料作物植物如苜蓿或柳枝稷中可发酵碳水化合物的水平的方法。还提供了通过本发明的方法制备的植物。还提供了利用这些植物处理植物组织和生产乙醇的方法。

7. 发明申请

US20140249038A1 Method of detecting a pre-determined event in a nucleic acid sample and system thereof 审中-公开
标题翻译：检测核酸样品中的预定事件的方法及其系统
公开(公告)号：US20140249038A1
公开(公告)日：2014-09-04
申请号：US14351468
申请日：2011-12-21
申请人： Hui Jiang , Fang Chen , Huijuan Ge , Peipei Li , Xuchao Li , Jian Wang , Jun Wang , Huanming Yang , Xiuqing Zhang
发明人： Hui Jiang , Fang Chen , Huijuan Ge , Peipei Li , Xuchao Li , Jian Wang , Jun Wang , Huanming Yang , Xiuqing Zhang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6869 , C12Q1/6883 , C12Q2600/156
摘要： Disclosed are a method of detecting a pre-determined event in a nucleic acid sample and a system thereof. The method of detecting the pre-determined event in the nucleic acid sample comprises the following steps: constructing a sequencing-library for the nucleic acid sample; sequencing the sequencing-library to obtain a sequencing result consisting of a plurality of sequencing data; determining the sequencing data from a pre-determined region; and determining an occurrence of the pre-determined event in the nucleic acid sample based on a composition of the sequencing data from the pre-determined region.
摘要翻译：公开了一种在核酸样品及其系统中检测预定事件的方法。检测核酸样品中预先确定事件的方法包括以下步骤：构建核酸样品的测序文库; 测序序列库以获得由多个测序数据组成的测序结果; 确定来自预定区域的测序数据; 以及基于来自预定区域的测序数据的组成确定核酸样品中预定事件的发生。

8. 发明申请

US20140099642A1 NONINVASIVE DETECTION OF FETAL GENETIC ABNORMALITY 有权
标题翻译：非遗传性检测基因遗传异常
公开(公告)号：US20140099642A1
公开(公告)日：2014-04-10
申请号：US13641080
申请日：2011-06-29
申请人： Fuman Jiang , Huifei Chen , Xianghua Chai , Yuying Yuan , Xiuqing Zhang , Fang Chen
发明人： Fuman Jiang , Huifei Chen , Xianghua Chai , Yuying Yuan , Xiuqing Zhang , Fang Chen
IPC分类号： G06F19/18
CPC分类号： G06F19/18 , C12Q1/6883 , C12Q2600/156 , G06F19/22
摘要： The current invention is directed to methods for noninvasive detection of fetal genetic abnormalities by large-scale sequencing of nucleotides from maternal biological sample. Further provided are methods to remove GC bias from the sequencing results according to the difference in GC content of a chromosome. The current invention not only makes the detection much more accurate but also represents a comprehensive method for fetal aneuploidy detection including sex chromosome disorders such as XO, XXX, XXY, and XYY, etc.
摘要翻译：本发明涉及通过来自母体生物样品的核苷酸的大规模测序来非侵入性检测胎儿遗传异常的方法。还提供了根据染色体GC含量差异从测序结果中除去GC偏差的方法。本发明不仅使检测更准确，而且代表了包括性染色体异常如XO，XXX，XXY和XYY等胎儿非整倍体检测的综合方法。

9. 发明申请

US20130033989A1 ENHANCED DOWNLINK RATE ADAPTATION FOR LTE HETEROGENEOUS NETWORK BASE STATIONS 有权
标题翻译： LTE异步网络基站的增强下行速率适配
公开(公告)号：US20130033989A1
公开(公告)日：2013-02-07
申请号：US13197412
申请日：2011-08-03
申请人： Alan Barbieri , Vikas Jain , Muruganandam Jayabalan , Tao Luo , Saikiran Nudurupati , Fang Chen
发明人： Alan Barbieri , Vikas Jain , Muruganandam Jayabalan , Tao Luo , Saikiran Nudurupati , Fang Chen
IPC分类号： H04W72/04 , H04W24/00
CPC分类号： H04W72/048 , H04L1/0003 , H04L1/0009 , H04L1/0015 , H04L1/0026 , H04L1/0031 , H04L1/0086 , H04L1/1812 , H04L1/203 , H04L5/0053 , H04L2001/0092
摘要： Downlink rate adaptation in wireless communication systems are disclosed in which a UE reports RIs for both interference-free and interference-limited subframes. In general, the RI for the interference-free subframes will be higher than the RI reported for the interference-limited subframes. However, an eNB selects an RI and a transmission rate for interference-limited subframes based on what the UE can sustain instead of based only on the RI reported by the UE.
摘要翻译：公开了无线通信系统中的下行链路速率适配，其中UE报告无干扰和受干扰限制的子帧的RI。通常，无干扰子帧的RI将高于针对干扰受限子帧报告的RI。然而，eNB基于UE可以维持什么来选择RI和传输速率用于干扰限制子帧，而不是仅基于UE报告的RI。

10. 发明申请

US20130021422A1 INKLESS PRINTING METHOD WITH HEATING PROCESS AND PRINTING HEAD UNIT THEREFOR 审中-公开
标题翻译：具有加热过程的无缝印刷方法和印刷头单元
公开(公告)号：US20130021422A1
公开(公告)日：2013-01-24
申请号：US13639828
申请日：2011-06-28
申请人： Jinxiang Chen , Zhishen Wu , Gang Wu , Juan Xie , Fang Chen
发明人： Jinxiang Chen , Zhishen Wu , Gang Wu , Juan Xie , Fang Chen
IPC分类号： B41J2/32
CPC分类号： B41J2/32 , B44C1/02
摘要： An inkless printing method with heating process is disclosed. In the method, a conventional printing paper (15) is used, and a printing head (4,27) contacts the printing paper directly or indirectly. A heating element (13,22) is placed in the printing head(4,27), which provides heat energy to cause a color change in a surface layer of the paper, thereby producing a character or an image. When the printing head (4,27) contacts the printing paper directly, a temperature of the printing head (4,27) is set to 100-1000° C.; and a stagnation time of the printing head (4,27) is set to 0.1-100 ms; when the printing head (4,27) contacts the printing paper indirectly, a temperature of the printing head (4,27) is set to 200-1000° C. The method does not need to use toner, ink or paint, and only needs conventional printing paper (15) and said heating process to achieve printing effect. A printing head unit to be used in said printing method is also disclosed.
摘要翻译：公开了一种具有加热工艺的无油印刷方法。在该方法中，使用传统的打印纸（15），并且打印头（4,27）直接或间接接触打印纸。加热元件（13,22）放置在打印头（4,27）中，其提供热能以引起纸张的表面层中的颜色变化，从而产生字符或图像。当打印头（4,27）直接接触打印纸时，打印头（4,27）的温度设定为100-1000℃; 并且打印头（4,27）的停滞时间设定为0.1-100ms; 当打印头（4,27）间接接触打印纸时，打印头（4,27）的温度设定为200-1000℃。该方法不需要使用调色剂，油墨或油漆，只能使用需要常规打印纸（15）和所述加热过程来实现打印效果。还公开了用于所述打印方法的打印头单元。

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