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    • 3. 发明授权
    • Process for the controlled production of organic particles
    • 控制生产有机颗粒的方法
    • US07875295B2
    • 2011-01-25
    • US10477386
    • 2002-04-15
    • Sung Lai Jimmy YunJian Feng Chen
    • Sung Lai Jimmy YunJian Feng Chen
    • A61K9/14A61K9/00B29B9/00
    • B01J13/04A61K9/14B01J13/10
    • A process for the production of a microparticle or a nanoparticle of a chemical compound comprising the steps of providing a solution of said chemical compound in a first liquid; providing a second liquid in which said chemical compound is insoluble or substantially insoluble; combining said liquids in a region of high shear thereby causing formation of said particles; and isolating said particles of said compound. The processing time of a coacervation style process can be reduced and the yield can be substantially increased both by control of the precipitation step which allows for desolvation step to be dispensed with leading to significant process time reduction. The invention also provides a molecular mixing unit comprising an outer body defining a mixing zone; a shear means to provide shear liquid in said mixing zone; at least one fluid inlet means for a first liquid; at least one fluid inlet means for a second liquid and a fluid outlet means.
    • 一种制备化合物的微粒或纳米颗粒的方法,包括以下步骤:将所述化合物溶液提供在第一液体中; 提供其中所述化合物不溶或基本不溶的第二液体; 在高剪切区域中组合所述液体,从而形成所述颗粒; 并分离所述化合物的所述颗粒。 凝聚过程的处理时间可以降低,并且可以通过控制沉淀步骤来显着地提高产量,所述沉淀步骤允许去除去溶剂化步骤,导致显着的处理时间减少。 本发明还提供了一种分子混合单元,其包括限定混合区的外体; 剪切装置,用于在所述混合区中提供剪切液体; 用于第一液体的至少一个流体入口装置; 用于第二液体和流体出口装置的至少一个流体入口装置。
    • 4. 发明申请
    • Process for the controlled production of organic particles
    • 控制生产有机颗粒的方法
    • US20080212402A1
    • 2008-09-04
    • US12082178
    • 2008-04-08
    • Sung Lai Jimmy YunJian Feng Chen
    • Sung Lai Jimmy YunJian Feng Chen
    • G05D11/02B01F15/02
    • B01J13/06A61K9/14B01F7/16
    • A process for the production of a microparticle or a nanoparticle of a chemical compound comprising the steps of providing a solution of said chemical compound in a first liquid; providing a second liquid in which said chemical compound is insoluble or substantially insoluble; combining said liquids in a region of high shear thereby causing formation of said particles; and isolating said particles of said compound. The processing time of a coacervation style process can be reduced and the yield can be substantially increased both by control of the precipitation step which allows for the desolvation step to be dispensed with leading to significant process time reduction. The invention also provides a molecular mixing unit comprising an outer body defining a mixing zone; a shear means to provide shear liquid in said mixing zone; at least one fluid inlet means for a first liquid; at least one fluid inlet means for a second liquid and a fluid outlet means.
    • 一种制备化合物的微粒或纳米颗粒的方法,包括以下步骤:将所述化合物溶液提供在第一液体中; 提供其中所述化合物不溶或基本不溶的第二液体; 在高剪切区域中组合所述液体,从而形成所述颗粒; 并分离所述化合物的所述颗粒。 凝聚过程的处理时间可以降低,并且可以通过控制沉淀步骤来显着增加产量,这允许去溶剂化步骤被排除,导致显着的处理时间减少。 本发明还提供了一种分子混合单元,其包括限定混合区的外体; 剪切装置,用于在所述混合区中提供剪切液体; 用于第一液体的至少一个流体入口装置; 用于第二液体和流体出口装置的至少一个流体入口装置。