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1. 发明授权

US07985388B2 Process for making nano-sized and micro-sized precipitate particles 有权
标题翻译：制备纳米尺寸和微尺寸沉淀颗粒的方法
公开(公告)号：US07985388B2
公开(公告)日：2011-07-26
申请号：US12443942
申请日：2007-10-02
申请人： Zhigang Shen , Jiyao Zhang , Giawen Sim , Jimmy Sung Lai Yun , Jianfeng Chen
发明人： Zhigang Shen , Jiyao Zhang , Giawen Sim , Jimmy Sung Lai Yun , Jianfeng Chen
IPC分类号： B01J14/00 , C01B13/14 , C01B17/00 , C01B19/00
CPC分类号： C01B17/20 , B01F7/00558 , B01J8/10 , B01J19/1806 , B01J2219/00006 , B82Y30/00 , C01B19/007 , C01F17/0043 , C01G3/02 , C01G9/02 , C01G9/08 , C01G19/02 , C01G23/0536 , C01G25/02 , C01G49/06 , C01G49/08 , C01P2002/72 , C01P2004/04 , C01P2004/52 , C01P2004/64 , Y10S977/773
摘要： There is disclosed a process of making nano-sized or micro-sized precipitate particles. The process comprising the steps of mixing, in a reaction zone, a metal salt solution with a precipitant solution to form a precipitate, said precipitate being at least one of a metal chalcogenide, metal hydroxide and metal oxide; and applying a shear force to said mixing solutions in said reaction zone during said mixing step, wherein said shear force and the conditions within said reaction zone form said nano-sized or micro-sized precipitate particles.
摘要翻译：公开了制备纳米尺寸或微尺寸沉淀颗粒的方法。该方法包括在反应区中将金属盐溶液与沉淀剂溶液混合以形成沉淀物的步骤，所述沉淀物是金属硫族化物，金属氢氧化物和金属氧化物中的至少一种; 以及在所述混合步骤期间对所述反应区中的所述混合溶液施加剪切力，其中所述剪切力和所述反应区内的条件形成所述纳米尺寸或微尺寸的沉淀颗粒。

2. 发明申请

US20100028236A1 Process For Making Nano-Sized and Micro-Sized Precipitate Particles 有权
标题翻译：制备纳米尺寸和微尺寸沉淀颗粒的方法
公开(公告)号：US20100028236A1
公开(公告)日：2010-02-04
申请号：US12443942
申请日：2007-10-02
申请人： Zhigang Shen , Jiyao Zhang , Giawen Sim , Jimmy Sung Lai Yun , Jianfeng Chen
发明人： Zhigang Shen , Jiyao Zhang , Giawen Sim , Jimmy Sung Lai Yun , Jianfeng Chen
IPC分类号： C01F17/00 , C01G3/02 , C01G23/04 , C01G25/02 , C01G9/02 , C01G49/02 , C01G9/08 , B01J19/00
CPC分类号： C01B17/20 , B01F7/00558 , B01J8/10 , B01J19/1806 , B01J2219/00006 , B82Y30/00 , C01B19/007 , C01F17/0043 , C01G3/02 , C01G9/02 , C01G9/08 , C01G19/02 , C01G23/0536 , C01G25/02 , C01G49/06 , C01G49/08 , C01P2002/72 , C01P2004/04 , C01P2004/52 , C01P2004/64 , Y10S977/773
摘要： There is disclosed a process of making nano-sized or micro-sized precipitate particles. The process comprising the steps of mixing, in a reaction zone, a metal salt solution with a precipitant solution to form a precipitate, said precipitate being at least one of a metal chalcogenide, metal hydroxide and metal oxide; and applying a shear force to said mixing solutions in said reaction zone during said mixing step, wherein said shear force and the conditions within said reaction zone form said nano-sized or micro-sized precipitate particles.
摘要翻译：公开了制备纳米尺寸或微尺寸沉淀颗粒的方法。该方法包括在反应区中将金属盐溶液与沉淀剂溶液混合以形成沉淀物的步骤，所述沉淀物是金属硫族化物，金属氢氧化物和金属氧化物中的至少一种; 以及在所述混合步骤期间对所述反应区中的所述混合溶液施加剪切力，其中所述剪切力和所述反应区内的条件形成所述纳米尺寸或微尺寸的沉淀颗粒。

3. 发明授权

US08835376B2 Process for making particles for delivery of drug nanoparticles 有权
标题翻译：用于制备用于递送药物纳米颗粒的颗粒的方法
公开(公告)号：US08835376B2
公开(公告)日：2014-09-16
申请号：US13120146
申请日：2009-09-24
申请人： Zhigang Shen , Jimmy Sung Lai Yun , Jun Hu , Nital Arvind Jugade , Jiyao Zhang , Wenhao Chen , Zhe Wang , Lingyan Gao , William Glover , Jian Feng Chen
发明人： Zhigang Shen , Jimmy Sung Lai Yun , Jun Hu , Nital Arvind Jugade , Jiyao Zhang , Wenhao Chen , Zhe Wang , Lingyan Gao , William Glover , Jian Feng Chen
IPC分类号： A61K38/02 , A61K31/216 , A61K31/513 , A61K31/546 , A61K38/13 , A61K31/357 , A61K31/57 , A61K31/7052 , A61K31/277 , A61K31/197 , A61K47/38 , A61K47/24 , B01J2/06 , A61K9/16 , A61K9/20 , A61K9/14 , B01J19/00
CPC分类号： A61K9/14 , A61K9/1623 , A61K9/1652 , A61K9/1694 , A61K9/2077 , B01J2/06 , B01J19/0093 , B01J2219/00788 , B01J2219/00889
摘要： A process for making particles for delivery of drug nanoparticles is disclosed herein. The process comprises the steps of (a) forming a suspension of drug nanoparticles by mixing a precipitant solution with an anti-solvent solution under micro-mixing environment, where the formed nanoparticles have a narrow particle size distribution; (b) providing an excipient to at least one of the precipitant solution, the anti-solvent solution and the suspension of drug nanoparticles, the excipient being selected to maintain said drug nanoparticles in a dispersed state when in liquid form; and (c) drying the suspension of drug nanoparticles containing the excipient therein to remove solvent therefrom, wherein removal of the solvent causes the excipient to solidify and thereby form micro-sized matrix particles, each micro-sized particle being comprised of drug nanoparticles dispersed in a solid matrix of the excipient.
摘要翻译：本文公开了用于制备用于递送药物纳米颗粒的颗粒的方法。该方法包括以下步骤：（a）通过在微混合环境下将沉淀剂溶液与抗溶剂溶液混合形成药物纳米颗粒的悬浮液，其中所形成的纳米颗粒具有窄的粒度分布; （b）向沉淀剂溶液，抗溶剂溶液和药物纳米颗粒的悬浮液中的至少一种提供赋形剂，所述赋形剂被选择为当液体形式时将所述药物纳米颗粒维持在分散状态; 和（c）干燥其中含有赋形剂的药物纳米颗粒的悬浮液以从其中除去溶剂，其中去除溶剂导致赋形剂固化，从而形成微尺寸的基质颗粒，每个微尺寸颗粒由分散在赋形剂的固体基质。

4. 发明申请

US20110306539A1 PROCESS FOR MAKING PARTICLES FOR DELIVERY OF DRUG NANOPARTICLES 有权
标题翻译：制备用于输送药物纳米颗粒的颗粒的方法
公开(公告)号：US20110306539A1
公开(公告)日：2011-12-15
申请号：US13120146
申请日：2009-09-24
申请人： Zhigang Shen , Jimmy Sung Lai Yun , Jun Hu , Arvind Jugade , Jiyao Zhang , Wenhao Chen , Zhe Wang , Lingyan Gao , Jian Feng Chen
发明人： Zhigang Shen , Jimmy Sung Lai Yun , Jun Hu , Arvind Jugade , Jiyao Zhang , Wenhao Chen , Zhe Wang , Lingyan Gao , Jian Feng Chen
IPC分类号： A61K38/02 , A61K31/216 , A61K31/513 , A61K31/546 , A61K38/13 , A61K31/357 , A61K31/57 , A61K31/7052 , A61K31/277 , A61K31/197 , A61K47/38 , A61K47/24 , A61K47/26 , A61K47/10 , A61P29/00 , A61K47/32 , A61P31/04 , A61P33/02 , A61P7/02 , A61P3/10 , A61P25/24 , A61P25/08 , A61P31/10 , A61P9/12 , A61P35/00 , A61P25/06 , A61P33/00 , A61P25/16 , A61P25/18 , A61P25/20 , A61P11/14 , A61P31/12 , A61P17/00 , A61P1/00 , A61P23/00 , A61P7/04 , A61P23/02 , A61P9/08 , A61K31/56
CPC分类号： A61K9/14 , A61K9/1623 , A61K9/1652 , A61K9/1694 , A61K9/2077 , B01J2/06 , B01J19/0093 , B01J2219/00788 , B01J2219/00889
摘要： A process for making particles for delivery of drug nanoparticles is disclosed herein. The process comprises the steps of (a) forming a suspension of drug nanoparticles by mixing a precipitant solution with an anti-solvent solution under micro-mixing environment, where the formed nanoparticles have a narrow particle size distribution; (b) providing an excipient to at least one of the precipitant solution, the anti-solvent solution and the suspension of drug nanoparticles, the excipient being selected to maintain said drug nanoparticles in a dispersed state when in liquid form; and (c) drying the suspension of drug nanoparticles containing the excipient therein to remove solvent therefrom, wherein removal of the solvent causes the excipient to solidify and thereby form micro-sized matrix particles, each micro-sized particle being comprised of drug nanoparticles dispersed in a solid matrix of the excipient.
摘要翻译：本文公开了用于制备用于递送药物纳米颗粒的颗粒的方法。该方法包括以下步骤：（a）通过在微混合环境下将沉淀剂溶液与抗溶剂溶液混合形成药物纳米颗粒的悬浮液，其中所形成的纳米颗粒具有窄的粒度分布; （b）向沉淀剂溶液，抗溶剂溶液和药物纳米颗粒的悬浮液中的至少一种提供赋形剂，所述赋形剂被选择为当液体形式时将所述药物纳米颗粒维持在分散状态; 和（c）干燥其中含有赋形剂的药物纳米颗粒的悬浮液以从其中除去溶剂，其中去除溶剂导致赋形剂固化，从而形成微尺寸的基质颗粒，每个微尺寸颗粒由分散在赋形剂的固体基质。

5. 发明申请

US20060020130A1 Amorphous cefuroxime axetil and preparation process therefore 有权
公开(公告)号：US20060020130A1
公开(公告)日：2006-01-26
申请号：US11187555
申请日：2005-07-22
申请人： Jianfeng Chen , Jie Zhong , Zhigang Shen , Jiyao Zhang
发明人： Jianfeng Chen , Jie Zhong , Zhigang Shen , Jiyao Zhang
IPC分类号： C07D501/00 , A61K9/14
CPC分类号： C07D501/00
摘要： A novel process for the preparation of amorphous cefuroxime axetil particles and the amorphous cefuroxime axetil particles therefrom are disclosed in the invention. Specifically, the invention is implemented by means of antisolvent recrystallization to prepare the cefuroxime axetil in an amorphous form; particularly, the amorphous ultrafine or even nanosized cefuroxime axetil with a controllable particle size and a narrow particle size distribution. The cefuroxime axetil according to the invention can used to enhance bioavailability, since it is in an amorphous form and has a controllable particle size and a narrow particle size distribution.

6. 发明授权

US07507813B2 Amorphous cefuroxime axetil and preparation process therefore 有权
标题翻译：无定形头孢呋辛酯及其制备方法
公开(公告)号：US07507813B2
公开(公告)日：2009-03-24
申请号：US11187555
申请日：2005-07-22
申请人： Jianfeng Chen , Jie Zhong , Zhigang Shen , Jiyao Zhang
发明人： Jianfeng Chen , Jie Zhong , Zhigang Shen , Jiyao Zhang
IPC分类号： C07D501/34
CPC分类号： C07D501/00
摘要： A novel process for the preparation of amorphous cefuroxime axetil particles and the amorphous cefuroxime axetil particles therefrom are disclosed in the invention. Specifically, the invention is implemented by means of antisolvent recrystallization to prepare the cefuroxime axetil in an amorphous form; particularly, the amorphous ultrafine or even nanosized cefuroxime axetil with a controllable particle size and a narrow particle size distribution. The cefuroxime axetil according to the invention can used to enhance bioavailability, since it is in an amorphous form and has a controllable particle size and a narrow particle size distribution.
摘要翻译：在本发明中公开了一种用于制备无定形头孢呋辛酯颗粒和无定形头孢呋辛酯颗粒的新方法。具体地说，本发明是通过抗溶剂重结晶实现的，以制备无定形形式的头孢呋辛酯; 特别是具有可控粒度和窄粒度分布的无定形超细或甚至纳米尺寸的头孢呋辛酯。根据本发明的头孢呋辛酯可用于提高生物利用度，因为其为无定形形式并且具有可控的粒度和窄的粒度分布。

7. 发明申请

US20080184914A1 Process for Forming Dispersant-Coated Carbon Particles 审中-公开
标题翻译：形成分散剂涂覆的碳颗粒的方法
公开(公告)号：US20080184914A1
公开(公告)日：2008-08-07
申请号：US11914812
申请日：2006-06-05
申请人： Zhigang Shen , Jimmy Sung Lai Yun , Jiangfeng Chen
发明人： Zhigang Shen , Jimmy Sung Lai Yun , Jiangfeng Chen
IPC分类号： C09C1/48 , C08K9/08
CPC分类号： C09C1/56 , B82Y30/00 , C01P2004/03 , C01P2004/04 , C01P2004/51 , C01P2004/64 , C08K9/04 , C08K9/08
摘要： A process of making dispersant-coated carbon particles comprising the steps of providing a liquid mixture comprising carbon particles and a dispersant, and imparting a shear force to the liquid mixture to thereby form said dispersant-coated carbon particles.
摘要翻译：制备分散剂涂覆的碳颗粒的方法，包括以下步骤：提供包含碳颗粒和分散剂的液体混合物，并向液体混合物赋予剪切力，从而形成分散剂涂覆的碳颗粒。

8. 发明申请

US20050019248A1 High-gravity reactive precipitation process for the preparation of barium titanate powders 有权
标题翻译：用于制备钛酸钡粉末的高重力反应沉淀法
公开(公告)号：US20050019248A1
公开(公告)日：2005-01-27
申请号：US10624944
申请日：2003-07-21
申请人： Jianfeng Chen , Xiaolin Liu , Zhigang Shen , Guangwen Chu
发明人： Jianfeng Chen , Xiaolin Liu , Zhigang Shen , Guangwen Chu
IPC分类号： B01J8/10 , C01G23/00 , C01G23/04
CPC分类号： B82Y30/00 , B01J8/10 , B01J2219/00006 , C01G23/006 , C01P2002/72 , C01P2004/04 , C01P2004/62 , C01P2004/64 , C01P2006/40
摘要： The invention relates to a process for the preparation of fine barium titanate (BaTiO3) powders. The process comprises introducing an aqueous solution (I) containing salts of barium and titanium, and an aqueous basic solution (II) containing an inorganic or organic base separately and simultaneously into a high-gravity reactor with the high-gravity level of 1.25G to 12,500G and performing the reaction of the solution (I) with the solution (II) at a temperature of from 60 to 100° C. The solution (I) is preheated to a temperature ranging from 60° C. to 65° C. and the solution (II) is preheated to a temperature ranging from 60° C. to 100° C. respectively prior to the reaction, in which the Ba/Ti molar ratio in the solution (I) is more than 1 and the concentration of the base in the solution (II) is such that the reaction mixture is maintained at a constant OH− concentration, preferably a pH value of about 14. The reaction product is separated by filtering and washed with deionized water to remove the impurity ions and excessive barium ions, and then dried to obtain BaTiO3 powders. Said powders consist essentially of crystalline, primary particles having a uniform particle size ranging from 5 to 200 nm, an approximately spherical morphology and a high sintering activity.
摘要翻译：本发明涉及一种制备精细钛酸钡（BaTiO3）粉末的方法。该方法包括将含有钡和钛的盐的水溶液（I）和含有无机或有机碱的碱性水溶液（II）分别并入同时进入高重力水平为1.25G的高重力反应器中 12,500G，并在60〜100℃的温度下进行溶液（I）与溶液（II）的反应。将溶液（I）预热至60℃至65℃的温度。并且溶液（II）分别在反应之前预热至60℃至100℃的温度，其中溶液（I）中的Ba / Ti摩尔比大于1，浓度溶液（II）中的碱使得反应混合物保持恒定的OH - 浓度，优选pH值为约14.反应产物通过过滤分离并用去离子水洗涤以除去杂质离子和过量的钡离子，然后干燥得到BaTiO3粉末呃所述粉末基本上由具有5至200nm的均匀粒度的晶体初级粒子，近似球形的形态和高烧结活性组成。

9. 发明申请

US20120037232A1 MICROCHANNEL DOUBLE PIPE DEVICE AND USAGE THEREOF 有权
标题翻译：微通道双管设备及其使用
公开(公告)号：US20120037232A1
公开(公告)日：2012-02-16
申请号：US13263833
申请日：2010-04-09
申请人： Zhigang Shen , Jimmy Sunglai Yun , Jianfeng Chen , Guangwen Chu
发明人： Zhigang Shen , Jimmy Sunglai Yun , Jianfeng Chen , Guangwen Chu
IPC分类号： F15D1/00 , F16L9/18
CPC分类号： B01F15/065 , B01F11/0266 , B01F13/0067 , B01F13/1027 , B01J19/0093 , B01J2219/00788 , B01J2219/00889 , B22F2998/00 , Y10T137/0318
摘要： A microchannel double pipe device comprises a channel for inner nozzle (4), a channel for outer nozzle (5) and a mechanical probe (8). The channel for outer nozzle (5) concentrically surrounds the channel for inner nozzle (4), and the channel for inner nozzle (4) concentrically surrounds the mechanical probe (8). Constricted at the outlet of the channel for inner nozzle (4), the channel for inner nozzle (4) extends to form an inner nozzle core (9). Constricted at the outlet of the channel for outer nozzle (5), the channel for outer nozzle (5) extends to form an outer nozzle core (10). The outer nozzle core (10) essentially concentrically surrounds the inner nozzle core (9), and the outlets of the inner nozzle core (9) and the outer nozzle core (10) are at the same level essentially. The mechanical probe (8) is configured to intermittently empty the inner nozzle core (9). The device can be used for microcosmic mixing and reaction, especially suitable for continuous preparation of inorganic, organic or medicine particles with nanostructure or micron-structure using liquid-liquid precipitation method.
摘要翻译：微通道双管装置包括用于内部喷嘴（4）的通道，用于外部喷嘴（5）的通道和机械探针（8）。外喷嘴（5）的通道同心地围绕用于内喷嘴（4）的通道，内喷嘴（4）的通道同心地围绕机械探头（8）。在内喷嘴（4）的通道的出口处被限制，内喷嘴（4）的通道延伸以形成内喷嘴芯（9）。在外喷嘴（5）的通道的出口处受限，外喷嘴（5）的通道延伸以形成外喷嘴芯（10）。外喷嘴芯（10）基本上同心地围绕内喷嘴芯（9），并且内喷嘴芯（9）和外喷嘴芯（10）的出口基本上处于相同的水平。机械探针（8）构造成间歇地排空内部喷嘴芯（9）。该装置可用于微观混合和反应，特别适用于使用液 - 液沉淀法连续制备具有纳米结构或微米结构的无机，有机或药物颗粒。

10. 发明申请

US20060045840A1 Process for preparing perovskite-type crystalline compound powders 审中-公开
标题翻译：制备钙钛矿型结晶化合物粉末的方法
公开(公告)号：US20060045840A1
公开(公告)日：2006-03-02
申请号：US11214145
申请日：2005-08-29
申请人： Jianfeng Chen , Zhigang Shen , Yun Jimmy
发明人： Jianfeng Chen , Zhigang Shen , Yun Jimmy
IPC分类号： C01F17/00
CPC分类号： C04B35/4682 , B82Y30/00 , C01G1/02 , C01G23/002 , C01G23/006 , C01G25/006 , C01P2002/34 , C01P2002/72 , C01P2004/04 , C04B35/49 , C04B2235/3213 , C04B2235/3215 , C04B2235/3293 , C04B2235/444 , C04B2235/528 , C04B2235/5454 , C04B2235/768
摘要： A process for preparing perovskite-type compound Ax(BO3)y powders involving reacting a solution containing A and a solution containing B, or a combined solution comprising A and B, with an alkaline solution in a high-gravity reactor at a temperature ranging from about 60° C. to about 100° C. A is one or more metal elements selected from the group consisting of Li, Na, K, Mg, Ca, Sr, Ba, Pb, Sm, La, Nd, Bi, and other rare-earth metal elements. B is one or more metal elements selected from the group consisting of Ti, Zr, Sn, Hf, Nb, Ce, Al, Zn, Mn, Co, Ni, Fe, Cr, Y, Sc, W, Ta, and the like. The resulting mixture is then filtered, rinsed and dried to obtain the desired powders. The obtained perovskite-type compound Ax(BO3)y powders have a small average particle size with a narrow particle size distribution, a perfect crystal form and a uniform particle shape, and is suitable for use as raw material for making dielectric, piezoelectric, anti-ferroelectric, pyroelectric, pressure-resisting, sensing, microwave media, and other ceramics.
摘要翻译：一种制备钙钛矿型化合物A的方法，包括使含有A的溶液和含有B的溶液或（B 3）包含A和B的组合溶液，在约60℃至约100℃的温度范围内，在高重力反应器中具有碱性溶液.A是一种或多种选自Li，Na ，K，Mg，Ca，Sr，Ba，Pb，Sm，La，Nd，Bi等稀土金属元素。 B是选自Ti，Zr，Sn，Hf，Nb，Ce，Al，Zn，Mn，Co，Ni，Fe，Cr，Y，Sc，W，Ta等中的一种或多种金属元素。然后将所得混合物过滤，漂洗并干燥，得到所需粉末。得到的钙钛矿型化合物A SUB（BO 3/3）y粉末的平均粒径小，粒径分布窄，晶体形状均匀，粒子形状均匀，适用于制造电介质，压电，反铁电，热电，耐压，感应，微波介质等陶瓷的原料。

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