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1. 发明授权

US07586033B2 Metal-doped semiconductor nanoparticles and methods of synthesis thereof 失效
标题翻译：金属掺杂半导体纳米颗粒及其合成方法
公开(公告)号：US07586033B2
公开(公告)日：2009-09-08
申请号：US11120729
申请日：2005-05-03
申请人： Zhifeng Ren , Gang Chen , Bed Poudel , Shankar Kumar , Wenzhong Wang , Mildred Dresselhaus
发明人： Zhifeng Ren , Gang Chen , Bed Poudel , Shankar Kumar , Wenzhong Wang , Mildred Dresselhaus
IPC分类号： C01B25/14 , C01B19/00 , H01L35/16 , H01L35/22 , H01L35/14
CPC分类号： H01L35/26 , B82Y30/00 , C01B19/002 , C01B19/007 , C01P2002/52 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/30 , C01P2004/38 , C01P2004/62 , C01P2004/64 , C01P2006/40 , Y10S977/813
摘要： The present invention generally relates to binary or higher order semiconductor nanoparticles doped with a metallic element, and thermoelectric compositions incorporating such nanoparticles. In one aspect, the present invention provides a thermoelectric composition comprising a plurality of nanoparticles each of which includes an alloy matrix formed of a Group IV element and Group VI element and a metallic dopant distributed within the matrix.
摘要翻译：本发明一般涉及掺杂有金属元素的二元或更高阶半导体纳米颗粒，以及掺入这种纳米颗粒的热电组合物。一方面，本发明提供一种包含多个纳米颗粒的热电组合物，每个纳米颗粒包括由IV族元素和第VI族元素形成的合金基质和分布在基质内的金属掺杂剂。

2. 发明授权

US07255846B2 Methods for synthesis of semiconductor nanocrystals and thermoelectric compositions 失效
标题翻译：半导体纳米晶体和热电组合物的合成方法
公开(公告)号：US07255846B2
公开(公告)日：2007-08-14
申请号：US11120725
申请日：2005-05-03
申请人： Zhifeng Ren , Gang Chen , Bed Poudel , Shankar Kumar , Wenzhong Wang , Mildred Dresselhaus
发明人： Zhifeng Ren , Gang Chen , Bed Poudel , Shankar Kumar , Wenzhong Wang , Mildred Dresselhaus
IPC分类号： C01B19/04 , C01G19/02 , H01L21/02 , H01L35/34
CPC分类号： C01B19/007 , B82Y30/00 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/30 , C01P2004/38 , C01P2004/62 , C01P2004/64 , C04B35/547 , C04B35/632 , C04B35/63488 , C04B35/645 , C04B2235/32 , C04B2235/3201 , C04B2235/3281 , C04B2235/3291 , C04B2235/3293 , C04B2235/3296 , C04B2235/50 , C04B2235/5454 , C04B2235/549 , C04B2235/77 , C04B2235/781 , C04B2235/96 , C04B2235/9607 , H01M4/581 , Y10S977/773 , Y10S977/775 , Y10S977/813 , Y10S977/814
摘要： The present invention provides methods for synthesis of IV–VI nanostructures, and thermoelectric compositions formed of such structures. In one aspect, the method includes forming a solution of a Group IV reagent, a Group VI reagent and a surfactant. A reducing agent can be added to the solution, and the resultant solution can be maintained at an elevated temperature, e.g., in a range of about 20° C. to about 360° C., for a duration sufficient for generating nanoparticles as binary alloys of the IV–VI elements.
摘要翻译：本发明提供了合成IV-VI纳米结构的方法和由这种结构形成的热电组合物。一方面，该方法包括形成IV族试剂，VI族试剂和表面活性剂的溶液。可以向溶液中加入还原剂，并将所得溶液保持在高温下，例如在约20℃至约360℃的范围内，持续足够的时间以产生作为二元合金的纳米颗粒的IV-VI要素。

3. 发明申请

US20060251569A1 Methods for synthesis of semiconductor nanocrystals and thermoelectric compositions 失效
标题翻译：半导体纳米晶体和热电组合物的合成方法
公开(公告)号：US20060251569A1
公开(公告)日：2006-11-09
申请号：US11120725
申请日：2005-05-03
申请人： Zhifeng Ren , Gang Chen , Bed Poudel , Shankar Kumar , Wenzhong Wang , Mildred Dresselhaus
发明人： Zhifeng Ren , Gang Chen , Bed Poudel , Shankar Kumar , Wenzhong Wang , Mildred Dresselhaus
IPC分类号： C01B19/02 , H01M4/58
CPC分类号： C01B19/007 , B82Y30/00 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/30 , C01P2004/38 , C01P2004/62 , C01P2004/64 , C04B35/547 , C04B35/632 , C04B35/63488 , C04B35/645 , C04B2235/32 , C04B2235/3201 , C04B2235/3281 , C04B2235/3291 , C04B2235/3293 , C04B2235/3296 , C04B2235/50 , C04B2235/5454 , C04B2235/549 , C04B2235/77 , C04B2235/781 , C04B2235/96 , C04B2235/9607 , H01M4/581 , Y10S977/773 , Y10S977/775 , Y10S977/813 , Y10S977/814
摘要： The present invention provides methods for synthesis of IV-VI nanostructures, and thermoelectric compositions formed of such structures. In one aspect, the method includes forming a solution of a Group IV reagent, a Group VI reagent and a surfactant. A reducing agent can be added to the solution, and the resultant solution can be maintained at an elevated temperature, e.g., in a range of about 20° C. to about 360° C., for a duration sufficient for generating nanoparticles as binary alloys of the IV-VI elements.
摘要翻译：本发明提供了合成IV-VI纳米结构的方法和由这种结构形成的热电组合物。一方面，该方法包括形成IV族试剂，VI族试剂和表面活性剂的溶液。可以向溶液中加入还原剂，并将所得溶液保持在高温下，例如在约20℃至约360℃的范围内，持续足够的时间以产生作为二元合金的纳米颗粒的IV-VI要素。

4. 发明申请

US20060249704A1 Metal-doped semiconductor nanoparticles and methods of synthesis thereof 失效
公开(公告)号：US20060249704A1
公开(公告)日：2006-11-09
申请号：US11120729
申请日：2005-05-03
申请人： Zhifeng Ren , Gang Chen , Bed Poudel , Shankar Kumar , Wenzhong Wang , Mildred Dresselhaus
发明人： Zhifeng Ren , Gang Chen , Bed Poudel , Shankar Kumar , Wenzhong Wang , Mildred Dresselhaus
IPC分类号： H01L35/14
CPC分类号： H01L35/26 , B82Y30/00 , C01B19/002 , C01B19/007 , C01P2002/52 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/30 , C01P2004/38 , C01P2004/62 , C01P2004/64 , C01P2006/40 , Y10S977/813
摘要： The present invention generally relates to binary or higher order semiconductor nanoparticles doped with a metallic element, and thermoelectric compositions incorporating such nanoparticles. In one aspect, the present invention provides a thermoelectric composition comprising a plurality of nanoparticles each of which includes an alloy matrix formed of a Group IV element and Group VI element and a metallic dopant distributed within the matrix.

5. 发明授权

US07591913B2 Thermoelectric properties by high temperature annealing 失效
标题翻译：高温退火的热电性能
公开(公告)号：US07591913B2
公开(公告)日：2009-09-22
申请号：US11100950
申请日：2005-04-06
申请人： Zhifeng Ren , Gang Chen , Shankar Kumar , Hohyun Lee
发明人： Zhifeng Ren , Gang Chen , Shankar Kumar , Hohyun Lee
IPC分类号： C22C1/00 , H01L21/00
CPC分类号： H01L35/22 , C22C1/005 , C22C11/00 , C22C12/00 , C22C28/00 , C22F1/00 , H01L35/16
摘要： The present invention generally provides methods of improving thermoelectric properties of alloys by subjecting them to one or more high temperature annealing steps, performed at temperatures at which the alloys exhibit a mixed solid/liquid phase, followed by cooling steps. For example, in one aspect, such a method of the invention can include subjecting an alloy sample to a temperature that is sufficiently elevated to cause partial melting of at least some of the grains. The sample can then be cooled so as to solidify the melted grain portions such that each solidified grain portion exhibits an average chemical composition, characterized by a relative concentration of elements forming the alloy, that is different than that of the remainder of the grain.
摘要翻译：本发明通常提供了通过使合金呈现出一种或多种高温退火步骤来提高合金的热电性能的方法，所述高温退火步骤在合金呈现混合的固相/液相的温度下进行，然后进行冷却步骤。例如，在一个方面，本发明的这种方法可以包括使合金样品经受足够升高的温度以引起至少一些晶粒的部分熔融。然后可以将样品冷却以固化熔融的颗粒部分，使得每个固化的颗粒部分显示平均化学组成，其特征在于形成合金的元素的相对浓度，其不同于其余颗粒的元素的相对浓度。

6. 发明申请

US20050252582A1 Thermoelectric properties by high temperature annealing 失效
标题翻译：高温退火的热电性能
公开(公告)号：US20050252582A1
公开(公告)日：2005-11-17
申请号：US11100950
申请日：2005-04-06
申请人： Zhifeng Ren , Gang Chen , Shankar Kumar , Hohyun Lee
发明人： Zhifeng Ren , Gang Chen , Shankar Kumar , Hohyun Lee
IPC分类号： C22C1/00 , C22C11/00 , C22C12/00 , C22C28/00 , C22F1/00 , H01L35/14 , H01L35/16 , H01L35/22
CPC分类号： H01L35/22 , C22C1/005 , C22C11/00 , C22C12/00 , C22C28/00 , C22F1/00 , H01L35/16
摘要： The present invention generally provides methods of improving thermoelectric properties of alloys by subjecting them to one or more high temperature annealing steps, performed at temperatures at which the alloys exhibit a mixed solid/liquid phase, followed by cooling steps. For example, in one aspect, such a method of the invention can include subjecting an alloy sample to a temperature that is sufficiently elevated to cause partial melting of at least some of the grains. The sample can then be cooled so as to solidify the melted grain portions such that each solidified grain portion exhibits an average chemical composition, characterized by a relative concentration of elements forming the alloy, that is different than that of the remainder of the grain.
摘要翻译：本发明通常提供了通过使合金呈现出一种或多种高温退火步骤来提高合金的热电性能的方法，所述高温退火步骤在合金呈现混合的固相/液相的温度下进行，然后进行冷却步骤。例如，在一个方面，本发明的这种方法可以包括使合金样品经受足够升高的温度以引起至少一些晶粒的部分熔融。然后可以将样品冷却以固化熔融的颗粒部分，使得每个固化的颗粒部分显示平均化学组成，其特征在于形成合金的元素的相对浓度，其不同于其余颗粒的元素的相对浓度。

7. 发明授权

US09028830B2 Antibodies to CD122 有权
标题翻译：抗CD122抗体
公开(公告)号：US09028830B2
公开(公告)日：2015-05-12
申请号：US13082352
申请日：2011-04-07
申请人： J. Yun Tso , Naoya Tsurushita , Nicholas F. Landolfi , Shankar Kumar
发明人： J. Yun Tso , Naoya Tsurushita , Nicholas F. Landolfi , Shankar Kumar
IPC分类号： A61K39/395 , C07K16/00 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2317/76
摘要： The invention provides monoclonal antibodies that specifically bind to CD122, which is one component of receptors for IL-2 and IL-15. The monoclonal antibodies have the capacity for substantial inhibition of both IL-2 and IL-15 mediated functions by inhibiting binding of these cytokines to their receptors. The monoclonal antibodies can be used for inhibiting undesired immune responses or treatment of cancer, among other applications.
摘要翻译：本发明提供了特异性结合CD122的单克隆抗体，CD122是IL-2和IL-15受体的一个组分。通过抑制这些细胞因子与其受体的结合，单克隆抗体具有对IL-2和IL-15介导的功能的显着抑制的能力。除了其它应用之外，单克隆抗体可用于抑制不期望的免疫应答或癌症的治疗。

8. 发明授权

US08617829B2 Humanized antibodies specific for amino acid sequence RGD of an extracellular matrix protein and the uses thereof 有权
公开(公告)号：US08617829B2
公开(公告)日：2013-12-31
申请号：US13497692
申请日：2010-09-22
申请人： Shankar Kumar , J. Yun Tso , Naoya Tsurushita
发明人： Shankar Kumar , J. Yun Tso , Naoya Tsurushita
IPC分类号： C12Q1/68 , C07K16/00 , C07K16/46 , C07K16/24
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/76
摘要： The present invention provides humanized antibodies that immunospecifically recognize the RGD sequence. Some of these antibodies inhibit the biological functions of the RGD proteins, thereby exhibiting therapeutic effects on various disorders or diseases that are associated with RGD proteins, including cancer, e.g., the growth and metastasis of a cancer cell, and inflammatory diseases, e.g., rheumatoid arthritis, osteoarthritis, hepatitis, endometriosis, bronchial asthma, fibrosis, diabetes, arteriosclerosis, multiple sclerosis, granuloma, an inflammatory bowel disease (ulcerative colitis and Crohn's disease), an autoimmune disease, and so forth.

9. 发明授权

US08017118B2 Anti-hDlk-1 antibody having an antitumor activity in vivo 有权
标题翻译：具有体内抗肿瘤活性的抗hDlk-1抗体
公开(公告)号：US08017118B2
公开(公告)日：2011-09-13
申请号：US12404419
申请日：2009-03-16
申请人： Koji Nakamura , Rie Tajima , Shankar Kumar , J. Yun Tso , Naoya Tsurushita
发明人： Koji Nakamura , Rie Tajima , Shankar Kumar , J. Yun Tso , Naoya Tsurushita
IPC分类号： C07K16/18
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92 , G01N2800/00
摘要： The present invention provides antibodies specifically against hDlk-1 and having anti-tumor activity in vivo (anti-hDlk-1 antibodies), a fragments of the antibodies, hybridomas that produce the antibodies, a complex of the antibody or antibody fragment and an agent, a pharmaceutical composition comprising the antibody and the like, a tumor therapeutic agent, a tumor angiogenesis inhibitor, a tumor diagnostic agent, a method for detecting tumor, a kit for detecting and/or diagnosing tumor, etc.
摘要翻译：本发明提供抗体特异性抗体，并具有体内抗肿瘤活性（抗hDlk-1抗体），抗体片段，产生抗体的杂交瘤，抗体或抗体片段的复合物和药剂，包含抗体等的药物组合物，肿瘤治疗剂，肿瘤血管生成抑制剂，肿瘤诊断剂，肿瘤检测方法，肿瘤检测和/或诊断用试剂盒等。

10. 发明授权

US09163085B2 Anti-OX40 antibodies and methods of treating cancer 有权
标题翻译：抗OX40抗体及其治疗方法
公开(公告)号：US09163085B2
公开(公告)日：2015-10-20
申请号：US14240535
申请日：2012-02-09
申请人： Yong-Jun Liu , Kui Shin Voo , Laura Bover , Naoya Tsurushita , J. Yun Tso , Shankar Kumar
发明人： Yong-Jun Liu , Kui Shin Voo , Laura Bover , Naoya Tsurushita , J. Yun Tso , Shankar Kumar
IPC分类号： C07K16/28 , A61K39/00
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/75
摘要： Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided.
摘要翻译：公开了与人OX40特异性结合的人抗体，优选重组人抗体，人源化和嵌合。优选的抗体对OX40受体具有高亲和力，并在体外和体内激活受体。抗体可以是全长抗体或其抗原结合部分。抗体或抗体部分可用于调节受体活性，例如在患有OX40活性有害的病症的人类受试者中。提供用于表达重组人抗体的核酸，载体和宿主细胞，并提供合成重组人抗体的方法。

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