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1. 发明授权

US07630750B2 Computer aided treatment planning 有权
标题翻译：计算机辅助治疗计划
公开(公告)号：US07630750B2
公开(公告)日：2009-12-08
申请号：US10182217
申请日：2001-02-05
申请人： Zhengrong Liang , Bin Li , Dongqing Chen , Eric E. Smouha , Clemente T. Roque , Arie E. Kaufman , Mark R. Wax , Kevin Kreeger
发明人： Zhengrong Liang , Bin Li , Dongqing Chen , Eric E. Smouha , Clemente T. Roque , Arie E. Kaufman , Mark R. Wax , Kevin Kreeger
IPC分类号： A61B5/05
CPC分类号： G06T19/003 , A61B34/10 , A61B90/36 , G06F19/00 , G06F19/321 , G06F19/3481 , G06T15/08 , G06T2210/41 , G16H50/50 , Y10S128/922
摘要： A method of computer aided treatment planning is performed by generating and manipulating a three dimensional (3D) image of a region which includes at least one anatomical structure for which treatment, such as surgery, biopsy, tissue component analysis, prosthesis implantation, radiation, chemotherapy and the like, is contemplated. A virtual intervention, which simulates at least a portion of the contemplated treatment, is performed in the 3D image. The user can then determine the effect of the intervention and interactively modify the intervention for improved treatment results. Preferably, a warning is automatically provided if the intervention poses a risk of detrimental effect. The user can navigate through the contemplated region in the 3D image and assess the results. The treatment plans can be saved for comparison and post treatment evaluation.
摘要翻译：计算机辅助治疗计划的方法通过生成和操纵包括至少一个解剖结构的区域的三维（3D）图像来进行，所述解剖结构例如手术，活组织检查，组织成分分析，假体植入，放射，化疗等等。在3D图像中执行模拟预期治疗的至少一部分的虚拟介入。然后，用户可以确定干预的效果并交互地修改干预以改善治疗结果。优选地，如果干预造成有害影响的风险，则自动提供警告。用户可以浏览3D图像中的预期区域并评估结果。治疗计划可以节省进行比较和治疗后评估。

2. 发明授权

US07356367B2 Computer aided treatment planning and visualization with image registration and fusion 失效
标题翻译：计算机辅助治疗计划和可视化与图像配准和融合
公开(公告)号：US07356367B2
公开(公告)日：2008-04-08
申请号：US10297349
申请日：2001-06-06
申请人： Zhengrong Liang , Dongqing Chen , Bin Li , Clemente T. Roque , Eric E. Smouha , Arie E. Kaufman , Mark R. Wax , Kevin Kreeger
发明人： Zhengrong Liang , Dongqing Chen , Bin Li , Clemente T. Roque , Eric E. Smouha , Arie E. Kaufman , Mark R. Wax , Kevin Kreeger
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/726 , A61B90/36 , A61B2090/364 , G06F19/00
摘要： A computer based system and method of visualizing a region using multiple image data sets is provided. The method includes acquiring first volumetric image data of a region and acquiring at least second volumetric image data of the region. The first image data is generally selected such that the structural features of the region are readily visualized. At least one control point is determined in the region using an identifiable structural characteristic discernable in the first volumetric image data. The at least one control point is also located in the at least second image data of the region such that the first image data and the at least second image data can be registered to one another using the at least one control point. Once the image data sets are registered, the registered first image data and at least second image data can be fused into a common display data set. The multiple image data sets have different and complimentary information to differentiate the structures and the functions in the region such that image segmentation algorithms and user interactive editing tools can be applied to obtain 3d spatial relations of the components in the region. Methods to correct spatial inhomogeneity in MR image data is also provided.
摘要翻译：提供了一种基于计算机的系统和使用多个图像数据集可视化区域的方法。该方法包括获取区域的第一体积图像数据并且获取该区域的至少第二体积图像数据。通常选择第一图像数据，使得该区域的结构特征容易可视化。使用在第一体积图像数据中可识别的可识别的结构特征在该区域中确定至少一个控制点。至少一个控制点也位于区域的至少第二图像数据中，使得可以使用至少一个控制点将第一图像数据和至少第二图像数据彼此对准。一旦注册了图像数据集，就可将注册的第一图像数据和至少第二图像数据融合到公共显示数据集中。多个图像数据集具有不同的和互补的信息以区分该区域中的结构和功能，使得可以应用图像分割算法和用户交互式编辑工具来获得该区域中的部件的3d空间关系。还提供了校正MR图像数据的空间不均匀性的方法。

3. 发明授权

US07574024B2 Centerline and tree branch skeleton determination for virtual objects 有权
标题翻译：虚拟对象的中心线和树枝骨架确定
公开(公告)号：US07574024B2
公开(公告)日：2009-08-11
申请号：US10380211
申请日：2001-10-02
申请人： Ingmar Bitter , Ming Wan , Arie E. Kaufman , Frank Dachille , Kevin Kreeger , Zhengrong Liang , Mark R. Wax
发明人： Ingmar Bitter , Ming Wan , Arie E. Kaufman , Frank Dachille , Kevin Kreeger , Zhengrong Liang , Mark R. Wax
IPC分类号： G06K9/00
CPC分类号： G06T19/20 , G06T7/12 , G06T7/62 , G06T7/64 , G06T15/08 , G06T15/10 , G06T2200/04 , G06T2207/10072 , G06T2207/20044 , G06T2207/20132 , G06T2207/30028 , G06T2207/30061 , G06T2207/30172 , G06T2210/41 , G06T2219/028 , G06T2219/2012
摘要： In accordance with the present invention, a method for determining a centerline through a region of interest in a 3D image dataset is provided. The method includes identifying the boundaries of the region of interest and identifying the endpoints of the region of interest. For those points within the boundaries, a penalty value which is a function of the proximity of the point to a boundary is determined. A centerline is then identified by the path connecting the endpoints which has the minimum penalized distance wherein the penalized distance reflects the actual accumulated pathlength and the penalties associated with the points along the path. From the centerline, branches of a complete skeleton can be established by determining branch endpoints and then finding the minimum penalized distance from each endpoint the centerline or another intersecting branch.
摘要翻译：根据本发明，提供了一种通过3D图像数据集中的感兴趣区域确定中心线的方法。该方法包括识别感兴趣区域的边界并识别感兴趣区域的端点。对于边界内的那些点，确定作为点到边界的接近度的函数的惩罚值。然后通过连接具有最小惩罚距离的端点的路径来识别中心线，其中惩罚距离反映实际累积路径长度和与沿着路径的点相关联的惩罚。从中心线，可以通过确定分支端点，然后从中心线或另一个相交分支的每个端点找到最小惩罚距离来建立完整骨架的分支。

4. 发明授权

US07706600B2 Enhanced virtual navigation and examination 有权
标题翻译：增强虚拟导航和检查
公开(公告)号：US07706600B2
公开(公告)日：2010-04-27
申请号：US10380210
申请日：2001-10-02
申请人： Kevin Kreeger , Sarang Lakare , Zhenrong Liang , Mark R. Wax , Ingmar Bitter , Frank Dachille , Dongqing Chen , Arie E. Kaufman
发明人： Kevin Kreeger , Sarang Lakare , Zhenrong Liang , Mark R. Wax , Ingmar Bitter , Frank Dachille , Dongqing Chen , Arie E. Kaufman
IPC分类号： G06K9/00 , G06K9/36 , A61B5/05 , G06T15/00
CPC分类号： G06T19/20 , G06T7/12 , G06T7/62 , G06T7/64 , G06T15/08 , G06T15/10 , G06T2200/04 , G06T2207/10072 , G06T2207/20044 , G06T2207/20132 , G06T2207/30028 , G06T2207/30061 , G06T2207/30172 , G06T2210/41 , G06T2219/028 , G06T2219/2012
摘要： Virtual navigation (2255) and examination of virtual objects are enhanced using methods of insuring that an entire surface to be examined has been properly viewed. A user interface (FIG. 23) identifies regions which have not been subject to examination and provides a mechanism (2250) to route the user to these regions in the 3D display. Virtual examination is further improved by the use of measuring disks (905) to enhance quantitative measurements such as diameter, distance, volume and angle. Yet another enhancement to the virtual examination of objects is a method of electronic segmentation, or cleaning, which corrects for partial volume effects occurring in an object.
摘要翻译：虚拟导航（2255）和虚拟对象的检查是通过确保正确观察整个被检查表面的方法得到增强。用户界面（图23）识别未经检查的区域，并且提供将用户定向到3D显示中的这些区域的机构（2250）。通过使用测量盘（905）进一步提高虚拟检查以增强诸如直径，距离，体积和角度的定量测量。对物体的虚拟检查的另一个增强是电子分割或清洁的方法，其校正在对象中发生的部分体积效应。

5. 发明授权

US07133041B2 Apparatus and method for volume processing and rendering 失效
标题翻译：用于体积处理和渲染的装置和方法
公开(公告)号：US07133041B2
公开(公告)日：2006-11-07
申请号：US10204685
申请日：2001-02-26
申请人： Arie E. Kaufman , Ingmar Bitter , Frank Dachille , Kevin Kreeger , Baoquan Chen
发明人： Arie E. Kaufman , Ingmar Bitter , Frank Dachille , Kevin Kreeger , Baoquan Chen
IPC分类号： G06T15/00
CPC分类号： G06T15/08 , G06T15/06 , G06T15/40
摘要： An apparatus and method for real-time volume processing and universal three-dimensional rendering. The apparatus includes a plurality of three-dimensional (3D) memory units; at least one pixel bus for providing global horizontal communication; a plurality of rendering pipelines; at least one geometry bus; and a control unit. The apparatus includes a block processor having a circular ray integration pipeline for processing voxel data and ray data. Rays are generally processed in image order thus permitting great flexibility (e.g., perspective projection, global illumination). The block processor includes a splatting unit and a scattering unit. A method for casting shadows and performing global illumination in relation to light sources includes sweeping a two dimensional array of rays through the volume can also be implemented with the apparatus. A method for approximating a perspective projection includes using parallel projection.
摘要翻译：用于实时卷处理和通用三维渲染的装置和方法。该装置包括多个三维（3D）存储器单元; 用于提供全局水平通信的至少一个像素总线; 多个渲染管线; 至少一个几何总线; 和控制单元。该装置包括具有用于处理体素数据和射线数据的圆形射线集成管线的块处理器。通常以图像顺序处理光线，从而允许很大的灵活性（例如，透视投影，全局照明）。块处理器包括分散单元和散射单元。用于投射阴影和执行与光源相关的全局照明的方法包括扫描通过该体积的二维阵列的射线也可以用该装置来实现。用于近似透视投影的方法包括使用平行投影。

6. 发明授权

US07471291B2 Apparatus and method for real-time volume processing and universal three-dimensional rendering 失效
标题翻译：用于实时体积处理和通用三维渲染的装置和方法
公开(公告)号：US07471291B2
公开(公告)日：2008-12-30
申请号：US11556993
申请日：2006-11-06
申请人： Arie E. Kaufman , Ingmar Bitter , Frank Dachille , Kevin Kreeger , Baoquan Chen
发明人： Arie E. Kaufman , Ingmar Bitter , Frank Dachille , Kevin Kreeger , Baoquan Chen
IPC分类号： G06T17/00
CPC分类号： G06T15/08 , G06T15/06 , G06T15/40
摘要： An apparatus and method for real-time volume processing and universal three-dimensional rendering. The apparatus includes a plurality of three-dimensional (3D) memory units; at least one pixel bus for providing global horizontal communication; a plurality of rendering pipelines; at least one geometry bus; and a control unit. The apparatus includes a block processor having a circular ray integration pipeline for processing voxel data and ray data. Rays are generally processed in image order thus permitting great flexibility (e.g., perspective projection, global illumination). The block processor includes a splatting unit and a scattering unit. A method for casting shadows and performing global illumination in relation to light sources includes sweeping a two dimensional array of rays through the volume can also be implemented with the apparatus. A method for approximating a perspective projection includes using parallel projection.
摘要翻译：用于实时卷处理和通用三维渲染的装置和方法。该装置包括多个三维（3D）存储器单元; 用于提供全局水平通信的至少一个像素总线; 多个渲染管线; 至少一个几何总线; 和控制单元。该装置包括具有用于处理体素数据和射线数据的圆形射线集成管线的块处理器。通常以图像顺序处理光线，从而允许很大的灵活性（例如，透视投影，全局照明）。块处理器包括分散单元和散射单元。用于投射阴影和执行与光源相关的全局照明的方法包括扫描通过该体积的二维阵列的射线也可以用该装置来实现。用于近似透视投影的方法包括使用平行投影。

7. 发明授权

US07372988B2 Registration of scanning data acquired from different patient positions 有权
标题翻译：注册从不同病人位置获得的扫描数据
公开(公告)号：US07372988B2
公开(公告)日：2008-05-13
申请号：US11273430
申请日：2005-11-14
申请人： Suzanne Yoakum-Stover , Arie E. Kaufman , Kevin Kreeger
发明人： Suzanne Yoakum-Stover , Arie E. Kaufman , Kevin Kreeger
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T7/33 , G06T7/38 , G06T7/60 , G06T15/08 , G06T2200/04 , G06T2207/10081 , G06T2207/10088 , G06T2207/20044 , G06T2207/30004 , G06T2207/30028 , Y10S128/92
摘要： A system and method are provided for generating a three-dimensional visualization image of an object such as an organ using volume visualization techniques and exploring the image using a guided navigation system that allows the operator to travel along a flight path and to adjust the view to a particular portion of the image of interest in order, for example, to identify polyps, cysts or other abnormal features in the visualized organ; where imaging data sets are acquired using conventional two-dimensional scans of the object in both a supine and prone orientation, and correspondence between the respective data sets is determined to permit jumping from one visualization orientation to the other while remaining at the same virtual location within the organ.
摘要翻译：提供了一种用于使用体积可视化技术来生成诸如器官的对象的三维可视化图像的系统和方法，并且使用允许操作者沿着飞行路径行进并且将视图调整到的视图来引导图像感兴趣的图像的特定部分，以便例如识别可视化器官中的息肉，囊肿或其他异常特征; 其中成像数据集是使用在仰卧位和倾向取向的对象的常规二维扫描来获取的，并且各个数据集之间的对应被确定为允许从一个可视化方向跳到另一个，同时保持在相同的虚拟位置器官。

8. 发明申请

US20050169507A1 Registration of scanning data acquired from different patient positions 审中-公开
标题翻译：注册从不同病人位置获得的扫描数据
公开(公告)号：US20050169507A1
公开(公告)日：2005-08-04
申请号：US10496430
申请日：2002-11-21
申请人： Kevin Kreeger , Suzanne Stover , Anna Ceteno , Bin Li , Frank Dachille , Jeffrey Meade
发明人： Kevin Kreeger , Suzanne Stover , Anna Ceteno , Bin Li , Frank Dachille , Jeffrey Meade
IPC分类号： G06K9/00 , G06T7/00 , G06T15/08 , G06T17/00
CPC分类号： G06T7/0012 , G06T7/33 , G06T7/38 , G06T7/60 , G06T15/08 , G06T2200/04 , G06T2207/10081 , G06T2207/10088 , G06T2207/20044 , G06T2207/30004 , G06T2207/30028 , Y10S128/92
摘要： A system and method are provided for generating a three-dimensional visualization image of an object such as an organ using volume visualization techniques and exploring the image using a guided navigation system that allows the operator to travel along a flight path and to adjust the view to a particular portion of the image of interest in order, for example, to identify polyps, cysts or other abnormal features in the visualized organ; where imaging data sets are acquired using conventional two-dimensional scans of the object in both a supine and prone orientation, and correspondence between the respective data sets is determined to permit jumping from one visualization orientation to the other while remaining at the same virtual location within the organ.
摘要翻译：提供了一种用于使用体积可视化技术来生成诸如器官的对象的三维可视化图像的系统和方法，并且使用允许操作者沿着飞行路径行进并且将视图调整到的视图来引导图像感兴趣的图像的特定部分，以便例如识别可视化器官中的息肉，囊肿或其他异常特征; 其中成像数据集是使用在仰卧位和倾向取向的对象的常规二维扫描来获取的，并且各个数据集之间的对应被确定为允许从一个可视化方向跳到另一个，同时保持在相同的虚拟位置器官。

9. 发明授权

US06674430B1 Apparatus and method for real-time volume processing and universal 3D rendering 失效
标题翻译：用于实时音量处理和通用3D渲染的装置和方法
公开(公告)号：US06674430B1
公开(公告)日：2004-01-06
申请号：US09354876
申请日：1999-07-16
申请人： Arie Kaufman , Ingmar Bitter , Baoquan Chen , Frank Dachille , Kevin Kreeger
发明人： Arie Kaufman , Ingmar Bitter , Baoquan Chen , Frank Dachille , Kevin Kreeger
IPC分类号： G06T1700
CPC分类号： G06T15/005 , G06T15/08
摘要： An apparatus and method for real-time volume processing and universal three-dimensional rendering. The apparatus includes a plurality of three-dimensional (3D) memory units; at least one pixel bus for providing global horizontal communication; a plurality of rendering pipelines; at least one geometry bus; and a control unit. The plurality of rendering pipelines each preferably include hardware for interpolation, shading, FIFO buffering, communication and table lookups. The apparatus of the present invention may be coupled to a geometry pipeline for mixing surfaces, images and volumes together in a single image. A method for performing volumetric ray casting of a 3D volume includes the steps of calculating a distance along a major projection axis from a predefined viewpoint; dividing the volume into a plurality of consecutive regions having exponentially increasing bounds; casting a plurality of rays from the viewpoint through the volume; either merging two or more rays or splitting one or more rays at the region boundaries; and repeating the ray casting and merging/splitting steps until the entire volume has been processed. The apparatus and methods of the present invention achieve true real-time performance for high-resolution volume rendering, mixing surfaces and volumes in a single image, and accelerating other imaging operations, including texture mapping and image-based rendering.
摘要翻译：用于实时卷处理和通用三维渲染的装置和方法。该装置包括多个三维（3D）存储器单元; 用于提供全局水平通信的至少一个像素总线; 多个渲染管线; 至少一个几何总线; 和控制单元。多个渲染管线各自优选地包括用于内插，着色，FIFO缓冲，通信和表查找的硬件。本发明的装置可以耦合到几何管线，用于将表面，图像和体积一起在单个图像中混合。用于执行3D体积的体积射线投射的方法包括以下步骤：从预定视点计算沿主投影轴的距离; 将体积分成具有指数增加界限的多个连续区域; 从视点投射多个光线通过该体积; 合并两个或更多个射线或在区域边界处分裂一个或多个射线; 并重复射线投射和合并/分割步骤直到整个体积被处理。本发明的装置和方法实现了用于高分辨率体绘制，单个图像中的混合曲面和体积的真实实时性能，并且加速了包括纹理映射和基于图像的渲染的其他成像操作。

10. 发明申请

US20110206247A1 Imaging system and methods for cardiac analysis 审中-公开
标题翻译：成像系统和心脏分析方法
公开(公告)号：US20110206247A1
公开(公告)日：2011-08-25
申请号：US10496438
申请日：2002-11-21
申请人： Frank C. Dachille , Kevin Kreeger , Jenny Hizver , Wenli Cai , George Economos
发明人： Frank C. Dachille , Kevin Kreeger , Jenny Hizver , Wenli Cai , George Economos
IPC分类号： G06K9/00
CPC分类号： G06T11/001 , G06T7/11 , G06T7/187 , G06T2207/30048 , G06T2207/30101
摘要： Imaging systems and methods for viewing medical images of human anatomy and, in particular, to a 3-dimensional imaging system that allows a user to efficiently and accurately detect and view coronary artery calcification as displayed graphically on a computer screen. In one aspect, a method for displaying medical images comprises obtaining an image dataset comprising anatomical image data (step 50), automatically grouping connected components in the image data to form groups of connected components (steps 50-57), and displaying the groups of connected components are distinguishable in the displayed image (58-59). The image dataset may comprise a volume data set and the groups of connected components comprise regions of neighboring voxels that share a similar property. The image dataset may comprise a 2-dimensional data set and the groups of connected components comprise regions of neighboring pixels that share a similar property. Different groups of connected components may be displayed in different colors and/or different opacities or certain groups may not be displayed at all.
摘要翻译：用于观察人体解剖结构的医学图像的成像系统和方法，特别是用于允许用户有效和准确地检测和观察冠状动脉钙化的三维成像系统，如图形显示在计算机屏幕上。一方面，一种用于显示医学图像的方法包括获得包括解剖图像数据的图像数据集（步骤50），自动对图像数据中的连通分量进行分组以形成连接分量组（步骤50-57），并显示组连接的组件在显示的图像中是可区分的（58-59）。图像数据集可以包括体数据集，并且连接的组件的组包括共享相似属性的相邻体元的区域。图像数据集可以包括2维数据集，并且连接的分量组包括共享相似属性的相邻像素的区域。可以以不同的颜色和/或不同的不透明度显示不同组的连接的组件，或者根本不显示某些组。

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