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1. 发明授权

US08361524B2 Medicine to treat drug addiction and preparation method thereof 有权
标题翻译：药物治疗药物成瘾及其制备方法
公开(公告)号：US08361524B2
公开(公告)日：2013-01-29
申请号：US12940695
申请日：2010-11-05
申请人： Zheng Yang , Ming Fan , Jijun Chen , Guozhang Jin , Wuxian Ren , Wei Feng
发明人： Zheng Yang , Ming Fan , Jijun Chen , Guozhang Jin , Wuxian Ren , Wei Feng
IPC分类号： A61K36/00
CPC分类号： A61K36/481 , A61K36/232 , A61K36/258 , A61K36/59 , A61K36/8968 , A61K2300/00
摘要： The present invention declares a pharmaceutical extract, composition that has effect to treat drug addiction, and its preparation method and quality control method. This extract is extracted from Radix Stephaniae Epigaeae. Starting medicine material of said composition is Radix Ginseng, Radix Astragali, Rhizoma Corydalis, Radix Angelicae Sinensis and Radix Ophiopogonis; and said composition also can prepared by ethanol extract of Radix Ginseng, ethanol extract of Radix Angelicae Sinensis, total alkaloids of Radix Stephaniae Epigaeae, water extract of Radix Astragali and water extract of Radix Ophiopogonis. Quality control method of said pharmaceutical composition includes one of or several of identifications and content determinations. The present invention also declares the use of said pharmaceutical extract, composition in the preparation of a medicine to treat drug addiction.
摘要翻译：本发明公开了具有治疗药物成瘾作用的药物提取物组合物及其制备方法和质量控制方法。这种提取物是从西葫芦提取物。所述组合物的起始药物是人参，黄芪，延胡索，当归，白芍; 并且所述组合物还可以通过人参的乙醇提取物，当归的乙醇提取物，石菖蒲总生物碱，黄芪提取物和黄芪水提取物制备。所述药物组合物的质量控制方法包括鉴定和含量测定中的一种或几种。本发明还宣称所述药物提取物，组合物在制备药物中用于治疗药物成瘾的用途。

2. 发明申请

US20090123559A1 Medicine to Treat Drug Addiction and Preparation Method Thereof 审中-公开
标题翻译：药物治疗药物成瘾及其制备方法
公开(公告)号：US20090123559A1
公开(公告)日：2009-05-14
申请号：US11989520
申请日：2006-07-26
申请人： Zheng Yang , Ming Fan , Jijun Chen , Guozhang Jin , Wuxian Ren , Wei Feng
发明人： Zheng Yang , Ming Fan , Jijun Chen , Guozhang Jin , Wuxian Ren , Wei Feng
IPC分类号： A61K35/56 , A61P25/30
CPC分类号： A61K36/481 , A61K36/232 , A61K36/258 , A61K36/59 , A61K36/8968 , A61K2300/00
摘要： The present invention declares a pharmaceutical extract, composition that has effect to treat drug addiction, and its preparation method and quality control method. This extract is extracted from Radix Stephaniae Epigaeae. Starting medicine material of said composition is Radix Ginseng, Radix Astragali, Rhizoma Corydalis, Radix Angelicae Sinensis and Radix Ophiopogonis; and said composition also can prepared by ethanol extract of Radix Ginseng, ethanol extract of Radix Angelicae Sinensis, total alkaloids of Radix Stephaniae Epigaeae, water extract of Radix Astragali and water extract of Radix Ophiopogonis. Quality control method of said pharmaceutical composition includes one of or several of identifications and content determinations. The present invention also declares the use of said pharmaceutical extract, composition in the preparation of a medicine to treat drug addiction.
摘要翻译：本发明公开了具有治疗药物成瘾作用的药物提取物组合物及其制备方法和质量控制方法。这种提取物是从西葫芦提取物。所述组合物的起始药物是人参，黄芪，延胡索，当归，白芍; 并且所述组合物还可以通过人参的乙醇提取物，当归的乙醇提取物，石菖蒲总生物碱，黄芪提取物和黄芪水提取物制备。所述药物组合物的质量控制方法包括鉴定和含量测定中的一种或几种。本发明还宣称所述药物提取物，组合物在制备药物中用于治疗药物成瘾的用途。

3. 发明申请

US20110111074A1 MEDICINE TO TREAT DRUG ADDICTION AND PREPARATION METHOD THEREOF 有权
标题翻译：药物治疗药物治疗及其制备方法
公开(公告)号：US20110111074A1
公开(公告)日：2011-05-12
申请号：US12940695
申请日：2010-11-05
申请人： Zheng YANG , Ming Fan , Jijun Chen , Guozhang Jin , Wuxian Ren , Wei Feng
发明人： Zheng YANG , Ming Fan , Jijun Chen , Guozhang Jin , Wuxian Ren , Wei Feng
IPC分类号： A61K36/59 , A61P25/30
CPC分类号： A61K36/481 , A61K36/232 , A61K36/258 , A61K36/59 , A61K36/8968 , A61K2300/00
摘要： The present invention declares a pharmaceutical extract, composition that has effect to treat drug addiction, and its preparation method and quality control method. This extract is extracted from Radix Stephaniae Epigaeae. Starting medicine material of said composition is Radix Ginseng, Radix Astragali, Rhizoma Corydalis, Radix Angelicae Sinensis and Radix Ophiopogonis; and said composition also can prepared by ethanol extract of Radix Ginseng, ethanol extract of Radix Angelicae Sinensis, total alkaloids of Radix Stephaniae Epigaeae, water extract of Radix Astragali and water extract of Radix Ophiopogonis. Quality control method of said pharmaceutical composition includes one of or several of identifications and content determinations. The present invention also declares the use of said pharmaceutical extract, composition in the preparation of a medicine to treat drug addiction.
摘要翻译：本发明公开了具有治疗药物成瘾作用的药物提取物组合物及其制备方法和质量控制方法。这种提取物是从西葫芦提取物。所述组合物的起始药物是人参，黄芪，延胡索，当归，白芍; 并且所述组合物还可以通过人参的乙醇提取物，当归的乙醇提取物，石菖蒲总生物碱，黄芪提取物和黄芪水提取物制备。所述药物组合物的质量控制方法包括鉴定和含量测定中的一种或几种。本发明还宣称所述药物提取物，组合物在制备药物中用于治疗药物成瘾的用途。

4. 发明申请

US20090305975A1 Use of Trap Protein Per se as an Active Ingredient for the Manufacture of a Medicament for the Treatment of Staphylococcus Aureus Infection 审中-公开
标题翻译： Trap蛋白质本身作为生产用于治疗金黄色葡萄球菌感染药物的活性成分的应用
公开(公告)号：US20090305975A1
公开(公告)日：2009-12-10
申请号：US12226491
申请日：2007-04-16
申请人： Guang Yang , Ningsheng Shao , Yaping Gao , Yu Liu , Jie Dong , Shaohua Li , Chuan Liu , Beifen Shen , Ming Fan
发明人： Guang Yang , Ningsheng Shao , Yaping Gao , Yu Liu , Jie Dong , Shaohua Li , Chuan Liu , Beifen Shen , Ming Fan
IPC分类号： A61K38/16 , C07K14/31
CPC分类号： A61K38/164
摘要： Disclosed herein is the use of TRAP per se as an active ingredient for the manufacture of a medicament for the treatment of Staphylococcus aureus infection. An exogenous TRAP (native TRAP or recombinant TRAP) per se can effectively inhibit the production of Staphylococcus aureus exotoxins, thereby reducing the pathogenicity of Staphylococcus aureus. In addition, a medicament including TRAP also stimulates the production of corresponding antibodies in human body at the time when it is used to treat Staphylococcus aureus infections, and these antibodies can further inhibit the production of Staphylococcus aureus exotoxins. Such double actions increase the effects of medicament and provide a novel medicament action mode. Moreover, since TRAP functions merely to the toxicity of bacteria but does not affect the growth of bacteria, it cannot make bacteria readily develop drug resistance, and also effective to drug resistant Staphylococcus aureus. Moreover, no homologous sequence of the TRAP proteins is found in human genome, so that the medicaments of TRAP cannot cause human immunologic diseases.
摘要翻译：本文公开了TRAP本身作为生产用于治疗金黄色葡萄球菌感染的药物的活性成分的用途。外源TRAP（天然TRAP或重组TRAP）本身可以有效抑制金黄色葡萄球菌外毒素的产生，从而降低金黄色葡萄球菌的致病性。此外，包含TRAP的药物在用于治疗金黄色葡萄球菌感染时也刺激人体中相应抗体的产生，并且这些抗体可以进一步抑制金黄色葡萄球菌外毒素的产生。这种双重作用增加了药物的作用并提供了新的药物作用模式。此外，由于TRAP仅仅对细菌的毒性起作用，而不影响细菌的生长，所以不能使细菌容易产生耐药性，并且对耐金黄色葡萄球菌也是有效的。此外，在人类基因组中没有发现TRAP蛋白的同源序列，因此TRAP的药物不能引起人类免疫学疾病。

5. 发明授权

US06139856A Composition useful for providing one-step surgical preparation and drape 失效
标题翻译：用于提供一步手术准备和悬垂的组合物
公开(公告)号：US06139856A
公开(公告)日：2000-10-31
申请号：US988729
申请日：1997-12-11
申请人： Grazyna Kaminska , Nancy Girard , Ming Fan , H. Ralph Rawls
发明人： Grazyna Kaminska , Nancy Girard , Ming Fan , H. Ralph Rawls
IPC分类号： A61L29/00 , A01N25/24 , A01N25/34 , A61K31/155 , A61K31/573 , A61K31/7135 , A61K33/38 , A61K38/22 , A61K45/00 , A61L26/00 , A61L31/00 , A61L31/04 , A61P7/02 , A61P7/04 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61K31/00
CPC分类号： A61L31/041 , A01N25/24
摘要： This invention relates to an improved polyvinylidene fluoride-based composition useful for forming a flexible, tack-free, nonflammable, substantially fluid resistant barrier film with substantially improved durability and skin-adhesion properties. The composition providing a long-lasting protective barrier film capable of disinfecting the skin surface of normally present microorganisms upon initial application, and said film imparting continuous and prolonged antimicrobial properties to the skin surface through sustained release of an encapsulated antimicrobial agent. The barrier film is further capable of remaining substantially adherent to the skin surface after prolonged exposure to biological fluids. A kit and methods of use for the composition are disclosed.
摘要翻译：本发明涉及一种改进的基于聚偏二氟乙烯的组合物，其可用于形成具有显着改善的耐久性和表皮粘合性能的柔性，无粘性，不可燃，基本上耐流体的阻隔膜。所述组合物提供能够在初次使用时消毒正常存在的微生物的皮肤表面的长效保护性屏障膜，并且所述膜通过包封的抗微生物剂的持续释放赋予皮肤表面持续和延长的抗微生物性能。阻隔膜还能够在长时间暴露于生物流体之后保持基本上粘附于皮肤表面。公开了用于组合物的试剂盒和使用方法。

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