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1. 发明授权

US09133258B2 Myomegalin variant 8 有权
标题翻译：霉菌变体8
公开(公告)号：US09133258B2
公开(公告)日：2015-09-15
申请号：US13825945
申请日：2011-11-15
申请人： Zhe Wang , Robert Zhong Qi
发明人： Zhe Wang , Robert Zhong Qi
IPC分类号： C07H21/04 , A61K38/00 , A61K38/43 , C12P21/06 , C07K14/47 , G01N33/68 , C12Q1/68 , C07K16/18 , C12N15/113
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4716 , C07K16/18 , C12N15/113 , C12N2310/14 , C12Q1/6876 , G01N33/6887 , G01N33/6893 , G01N2500/00
摘要： The present invention provides a novel myomegalin isoform—myomegalin variant 8 (MMG8). The myomegalin variant 8 regulates microtubule organization at the Golgi apparatus, protein modification, secretion and trafficking, and cell proliferation. The present invention also provides nucleic acid molecules encoding the myomegalin isoforms, and vectors and host cells containing the nucleic acid molecules. Also provided are fusion constructs comprising the myomegalin isoform and antibodies that bind specifically to the myomegalin isoforms of the present invention. The present invention further provides uses of the myomegalin isoform as a diagnostic biomarker and as a target for screening for therapeutics for diseases such as cancer, diabetes, and lysosomal storage diseases.
摘要翻译：本发明提供了一种新型的大豆蛋白异构体 - 甲状腺球蛋白变体8（MMG8）。神经球蛋白变体8调节高尔基体上的微管组织，蛋白质修饰，分泌和运输以及细胞增殖。本发明还提供了编码大豆蛋白异构体的核酸分子以及含有核酸分子的载体和宿主细胞。还提供了包含myomegalin同种型和与本发明的myomegalin异构体特异性结合的抗体的融合构建体。本发明还提供了作为诊断性生物标志物的myomegalin同种型的用途以及用于筛选疾病如癌症，糖尿病和溶酶体贮积病的治疗剂的靶标。

2. 发明申请

US20130230532A1 MYOMEGALIN VARIANT 8 AND USES THEREOF 有权
标题翻译： MYOMEGALIN VARIANT 8及其用途
公开(公告)号：US20130230532A1
公开(公告)日：2013-09-05
申请号：US13825945
申请日：2011-11-15
申请人： Zhe Wang , Robert Zhong QI
发明人： Zhe Wang , Robert Zhong QI
IPC分类号： C07K14/47 , G01N33/68 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4716 , C07K16/18 , C12N15/113 , C12N2310/14 , C12Q1/6876 , G01N33/6887 , G01N33/6893 , G01N2500/00
摘要： The present invention provides a novel myomegalin isoform—myomegalin variant 8 (MMG8). The myomegalin variant 8 regulates microtubule organization at the Golgi apparatus, protein modification, secretion and trafficking, and cell proliferation. The present invention also provides nucleic acid molecules encoding the myomegalin isoforms, and vectors and host cells containing the nucleic acid molecules. Also provided are fusion constructs comprising the myomegalin isoform and antibodies that bind specifically to the myomegalin isoforms of the present invention. The present invention further provides uses of the myomegalin isoform as a diagnostic biomarker and as a target for screening for therapeutics for diseases such as cancer, diabetes, and lysosomal storage diseases.
摘要翻译：本发明提供了一种新型的大豆蛋白异构体 - 甲状腺球蛋白变体8（MMG8）。神经球蛋白变体8调节高尔基体上的微管组织，蛋白质修饰，分泌和运输以及细胞增殖。本发明还提供了编码大豆蛋白异构体的核酸分子以及含有核酸分子的载体和宿主细胞。还提供了包含myomegalin同种型和与本发明的myomegalin异构体特异性结合的抗体的融合构建体。本发明还提供了作为诊断性生物标志物的myomegalin同种型的用途，以及用于筛选疾病如癌症，糖尿病和溶酶体贮积病的治疗剂的靶标。

3. 发明申请

US20200094842A1 CRANK VELOCITY DRIVELINE FILTERING FOR CONSECUTIVE MISFIRE DETECTION 审中-公开
公开(公告)号：US20200094842A1
公开(公告)日：2020-03-26
申请号：US16142502
申请日：2018-09-26
申请人： Jaeyeong Chang , Richard K. Moote , Arthur J. Varady , Ilias Anagnostopoulos-Politis , Zhe Wang , Yan Zhang
发明人： Jaeyeong Chang , Richard K. Moote , Arthur J. Varady , Ilias Anagnostopoulos-Politis , Zhe Wang , Yan Zhang
IPC分类号： B60W30/20 , B60W20/17 , F16F15/00
摘要： A misfire detection system and method for a vehicle utilize a controller to obtain a crankshaft speed signal indicative of a rotational speed of an engine crankshaft connected to a device that mitigates vibrational disturbances at the crankshaft caused by misfires of the engine, detect that a first firing event of the engine is a first misfire based on the crankshaft speed signal, monitor a vibrational response of the crankshaft, detect that a consecutive second firing event of the engine is a second misfire based on a first modified crankshaft speed signal and the first set of thresholds, and in response to detecting the second misfire, reset the monitoring of the vibrational response of the crankshaft including modifying the amplitude of the crankshaft speed signal to obtain a second modified crankshaft speed signal and comparing the second modified crankshaft speed signal to a set of thresholds.

4. 发明授权

US10108314B2 Method and system for displaying and processing high dynamic range video and images 有权
公开(公告)号：US10108314B2
公开(公告)日：2018-10-23
申请号：US13805185
申请日：2011-06-23
申请人： Jiefu Zhai , Joan Llach , Zhe Wang
发明人： Jiefu Zhai , Joan Llach , Zhe Wang
IPC分类号： G06F3/048 , G06F3/00 , G06K9/00 , G06F3/0484 , G06T5/00 , G06T5/40
摘要： A tone mapping graphical user interface (GUI) is provided that allows a video engineer to process a video using a set of tools for changing high dynamic range data into lower dynamic range data. The tone mapping GUI includes a video player region that includes the current video output section for a region-based method of performing HDR conversion, and a current video output section for a reference method that performs HDR conversion using, for example, a global process.

5. 发明授权

US08860154B2 CMOS compatible silicon differential condenser microphone and method for manufacturing the same 有权
标题翻译： CMOS兼容硅差动电容麦克风及其制造方法
公开(公告)号：US08860154B2
公开(公告)日：2014-10-14
申请号：US13581882
申请日：2011-03-11
申请人： Zhe Wang
发明人： Zhe Wang
IPC分类号： H01L29/84 , G01P15/08 , H04R23/00 , G01L9/00 , B81B3/00 , H04R19/04 , B81C1/00
CPC分类号： B81B3/0078 , B81B2207/015 , B81C1/00246 , H04R19/005 , H04R19/04
摘要： The present invention provides a CMOS compatible silicon differential condenser microphone and a method of manufacturing the same. Said microphone comprises a silicon substrate, wherein a CMOS circuitry is accommodated thereon; a first rigid conductive perforated backplate supported on the silicon substrate with an insulating layer inserted therebetween; a second rigid perforated backplate formed above the first backplate, including CMOS passivation layers and a metal layer sandwiched between the CMOS passivation layers as an electrode plate of the second plate, wherein an air gap, with a spacer forming its boundary, is provided between the opposite perforated areas of the first backplate and the second backplate; a compliant diaphragm provided between the first backplate and the second backplate, wherein a back hole is formed to be open in the silicon substrate underneath the first backplate so as to allow sound pass through, and the diaphragm and the first backplate form a first variable condenser, the diaphragm and the second backplate form a second variable condenser, and the first variable condenser and the second variable condenser form differential condensers.
摘要翻译：本发明提供一种CMOS兼容的硅差分电容麦克风及其制造方法。所述麦克风包括硅衬底，其中容纳CMOS电路; 支撑在硅衬底上的第一刚性导电多孔背板，绝缘层插入其间; 形成在第一背板上方的第二刚性多孔背板，包括CMOS钝化层和夹在CMOS钝化层之间的金属层作为第二板的电极板，其中具有形成其边界的间隔件的气隙设置在第一背板和第二背板的相对穿孔区域; 设置在所述第一背板和所述第二背板之间的柔性隔膜，其中形成在所述第一背板下方的所述硅基板中开口的后孔，以允许声音通过，并且所述隔膜和所述第一背板形成第一可变冷凝器，隔膜和第二背板形成第二可变冷凝器，第一可变冷凝器和第二可变冷凝器形成差动冷凝器。

6. 发明申请

US20140299948A1 SILICON BASED MEMS MICROPHONE, A SYSTEM AND A PACKAGE WITH THE SAME 有权
标题翻译：基于硅的MEMS麦克风，一个系统和一个包装
公开(公告)号：US20140299948A1
公开(公告)日：2014-10-09
申请号：US13582141
申请日：2011-12-29
申请人： Zhe Wang , Mengjin Cai
发明人： Zhe Wang , Mengjin Cai
IPC分类号： H04R1/02 , H04R7/04
CPC分类号： H04R1/02 , B81B7/0061 , B81B2201/0257 , H01L2924/1461 , H04R1/086 , H04R7/04 , H04R19/005 , H04R19/04 , H04R2201/003 , H04R2201/02 , H04R2207/00
摘要： The present invention relates to a silicon based MEMS microphone, comprising a silicon substrate and an acoustic sensing part supported on the silicon substrate, wherein a mesh-structured back hole is formed in the substrate and aligned with the acoustic sensing part, the mesh-structured back hole includes a plurality of mesh beams which are interconnected with each other and supported on the side wall of the mesh-structure back hole, the plurality of mesh beams and the side wall define a plurality of mesh holes which all have a tapered profile and merge into one hole in the vicinity of the acoustic sensing part at the top side of the silicon substrate. The mesh-structured back hole can help to streamline the air pressure pulse caused, for example, in a drop test and thus reduce the impact on the acoustic sensing part of the microphone, and also serve as a protection filter to prevent alien substances such as particles entering the microphone.
摘要翻译：本发明涉及一种基于硅的MEMS麦克风，其包括硅衬底和支撑在硅衬底上的声学感测部件，其中在衬底中形成网格结构的后孔并与声学感测部件对准，网状结构后孔包括彼此互连并支撑在网状结构后孔的侧壁上的多个网眼梁，多个网状梁和侧壁限定多个网孔，其全部具有锥形轮廓，合并到硅衬底顶部的声学传感部分附近的一个孔中。网格结构的后孔可以帮助简化例如在跌落测试中引起的空气压力脉冲，从而减少对麦克风的声学传感部分的影响，并且还用作保护过滤器以防止外来物质例如颗粒进入麦克风。

7. 发明申请

US20140061058A1 AEROBIC OXIDATION OF ALKANES 有权
标题翻译：碱的氧化性氧化
公开(公告)号：US20140061058A1
公开(公告)日：2014-03-06
申请号：US13597071
申请日：2012-08-28
申请人： Xiangqun Zeng , Zhe Wang
发明人： Xiangqun Zeng , Zhe Wang
IPC分类号： C25B3/02
CPC分类号： C25B3/02 , C25B3/00 , C25B9/08
摘要： An aerobic method for oxidizing an alkane is disclosed herein. At least a portion of a surface of a platinum working electrode is activated at an interface between the platinum working electrode and an ionic liquid electrolyte (i.e., 1-ethyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide, 1-propyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide, 1-butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide, 1-pentyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide, 1-hexyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide, 1-heptyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide, 1-octyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide, 1-nonyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide, and 1-decyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imidem, and combinations thereof). An interface complex is formed at the interface. An alkane gas is supplied to the interface. The alkane adsorbs at or near the interface complex. The alkane gas in the presence of oxygen is supplied to the interface. While the alkane gas in the presence of oxygen is supplied to the interface, a positive electrode potential is applied to the platinum working electrode, which causes a reactive oxygen species formed at the interface to catalyze oxidation of the adsorbed alkane to form a reaction product.
摘要翻译：本文公开了一种用于氧化烷烃的好氧方法。铂工作电极的至少一部分表面在铂工作电极和离子液体电解质（即，1-乙基-1-甲基吡咯烷鎓双（三氟甲基磺酰基）酰亚胺，1-丙基-1-甲基吡咯烷鎓（三氟甲基磺酰基）酰亚胺，双（三氟甲基磺酰基）酰亚胺，1-戊基-1-甲基吡咯烷鎓双（三氟甲基磺酰基）酰亚胺，1-己基-1-甲基吡咯烷鎓双（三氟甲基磺酰基）酰亚胺，1-庚基-1 （三氟甲基磺酰基）酰亚胺，1-辛基-1-甲基吡咯烷鎓双（三氟甲基磺酰基）酰亚胺，1-壬基-1-甲基吡咯烷鎓双（三氟甲基磺酰基）酰亚胺和1-癸基-1-甲基吡咯烷鎓双（三氟甲磺酰基）亚胺，以及组合）。在接口上形成接口复合体。烷烃气体被供应到界面。烷烃在界面络合物处或附近吸附。在存在氧气的情况下将烷烃气体供应给界面。当在存在氧气的情况下将烷烃气体供应到界面时，将正极电位施加到铂工作电极，这导致在界面处形成的活性氧物质催化吸附的烷烃的氧化以形成反应产物。

8. 发明申请

US20140008740A1 MEMS MICROPHONE AND METHOD FOR PACKAGING THE SAME 有权
标题翻译： MEMS麦克风及其包装方法
公开(公告)号：US20140008740A1
公开(公告)日：2014-01-09
申请号：US13581823
申请日：2010-12-30
申请人： Zhe Wang , Qinglin Song , Shengli Pang , Fanghui Gu
发明人： Zhe Wang , Qinglin Song , Shengli Pang , Fanghui Gu
IPC分类号： B81B3/00 , B81C1/00
CPC分类号： B81B3/0018 , B81B2201/0257 , B81B2207/015 , B81C1/00158 , B81C1/00246 , H04R1/021 , H04R19/005 , H04R31/00 , H04R2201/003
摘要： The present invention relates to a MEMS microphone and a method of manufacturing the same, the MEMS microphone comprising: a monolithic silicon chip incorporating an acoustic sensing element and one or more conditioning CMOS integrated circuits; a silicon-based carrier chip having an acoustic cavity; a substrate for surface mounting the assembly of the monolithic chip and the silicon-based carrier chip thereon; a conductive cover attached and electrically connected to the substrate to accommodates the assembly of the monolithic chip and the silicon-based carrier chip; and an acoustic port formed on either the conductive cover or the substrate for an external acoustic wave to reach the acoustic sensing element, wherein the monolithic silicon chip, the silicon-based carrier chip and the acoustic port are configured in such a way that the diaphragm of the acoustic sensing element can be vibrated by the external sound wave from one side thereof.
摘要翻译： MEMS麦克风及其制造方法技术领域本发明涉及一种MEMS麦克风及其制造方法，该MEMS麦克风包括：包含声学感测元件和一个或多个调节CMOS集成电路的单片硅芯片; 具有声腔的硅基载体芯片; 用于将单片芯片和硅基载体芯片的组件表面安装在其上的基板; 导电盖，其附接并电连接到所述基板以容纳所述单片芯片和所述硅基载体芯片的组装; 以及形成在导电盖或用于外部声波的基板上的声波端口到达声学感测元件，其中单片硅芯片，硅基载体芯片和声学端口被构造成使得隔膜的声学传感元件可以通过外部声波从其一侧振动。

9. 发明申请

US20130258067A1 SYSTEM AND METHOD FOR TRINOCULAR DEPTH ACQUISITION WITH TRIANGULAR SENSOR 审中-公开
标题翻译：用三角波传感器进行三角波深度采集的系统和方法
公开(公告)号：US20130258067A1
公开(公告)日：2013-10-03
申请号：US13991636
申请日：2010-12-08
申请人： Dong-Qing Zhang , Jiefu Zhai , Zhe Wang
发明人： Dong-Qing Zhang , Jiefu Zhai , Zhe Wang
IPC分类号： H04N13/02
CPC分类号： H04N13/25 , G06T7/55 , G06T2207/20088 , H04N13/243
摘要： A depth acquisition system utilizes at least three sensors with at least one sensor in a non-colinear configuration to increase depth information. This configuration provides both vertical and horizontal depth information to be combined to enhance image quality, especially in three-dimensional image gathering. Vertical sensor pairs aid in determining disparities for horizontal edges and make depth estimations for horizontal edges more accurate.
摘要翻译：深度采集系统利用至少三个具有非共线配置中的至少一个传感器的传感器来增加深度信息。该配置提供要组合的垂直和水平深度信息以增强图像质量，特别是在三维图像采集中。垂直传感器对有助于确定水平边缘的差异，并使水平边缘的深度估计更准确。

10. 发明授权

US08361958B2 Oximyl HCV serine protease inhibitors 有权
标题翻译： Oximyl HCV丝氨酸蛋白酶抑制剂
公开(公告)号：US08361958B2
公开(公告)日：2013-01-29
申请号：US12328433
申请日：2008-12-04
申请人： Yonghua Gai , Yat Sun Or , Zhe Wang
发明人： Yonghua Gai , Yat Sun Or , Zhe Wang
IPC分类号： A61K38/00
CPC分类号： A61K38/21 , C07D207/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention discloses compounds of formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

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