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1. 发明授权

US08551944B2 Methods of treating glucose metabolism disorders 有权
公开(公告)号：US08551944B2
公开(公告)日：2013-10-08
申请号：US13640720
申请日：2011-04-15
申请人： Zhaodan Cao , Yarong Lu , Daniel David Kaplan , Peng Zhang
发明人： Zhaodan Cao , Yarong Lu , Daniel David Kaplan , Peng Zhang
IPC分类号： A61P5/50 , A61P3/10
CPC分类号： A61K38/1709 , A61K9/0019 , C07K2319/30 , C12N2750/14143
摘要： Methods of treating individuals with a glucose metabolism disorder, and compositions thereof, are provided.

2. 发明申请

US20130130975A1 Methods of Treating Glucose Metabolism Disorders 有权
公开(公告)号：US20130130975A1
公开(公告)日：2013-05-23
申请号：US13640720
申请日：2011-04-15
申请人： Zhaodan Cao , Yarong Lu , Daniel David Kaplan , Peng Zhang
发明人： Zhaodan Cao , Yarong Lu , Daniel David Kaplan , Peng Zhang
IPC分类号： A61K38/17
CPC分类号： A61K38/1709 , A61K9/0019 , C07K2319/30 , C12N2750/14143
摘要： Methods of treating individuals with a glucose metabolism disorder, and compositions thereof, are provided.

3. 发明申请

US20120315274A1 Methods of Treating Glucose Metabolism Disorders 审中-公开
标题翻译：治疗葡萄糖代谢紊乱的方法
公开(公告)号：US20120315274A1
公开(公告)日：2012-12-13
申请号：US13519557
申请日：2011-01-07
申请人： Zhaodan Cao , Yarong Lu , Peng Zhang , Daniel David Kaplan
发明人： Zhaodan Cao , Yarong Lu , Peng Zhang , Daniel David Kaplan
IPC分类号： A61K38/17 , A61P3/10 , A61K39/395 , A61P3/00
CPC分类号： A61K38/1709
摘要： Methods of treating individuals with a glucose metabolism disorder such as diabetes, hyperglycemia, hyperinsulinemia or obesity by administering human FAM3D (family with sequence similarity 3, member D) are provided. Specifically a method of treating hyperglycemia resulting in a reduction of plasma glucose is provided. Additionally, a method of treating hyperinsulinemia resulting in a reduction of plasma glucose is provided. In addition, a method of treating glucose intolerance resulting in an increased glucose tolerance is provided. Pharmaceutical compositions are provided.
摘要翻译：提供了通过施用人FAM3D（具有序列相似性3，成员D的家族）来治疗患有葡萄糖代谢紊乱例如糖尿病，高血糖症，高胰岛素血症或肥胖症的个体的方法。具体地说，提供了治疗导致血浆葡萄糖降低的高血糖症的方法。此外，提供了治疗导致血浆葡萄糖降低的高胰岛素血症的方法。此外，提供了治疗葡萄糖耐受不良的方法，其导致葡萄糖耐量增加。提供药物组合物。

4. 发明授权

US08609612B2 Methods of treating glucose metabolism disorders 有权
标题翻译：治疗葡萄糖代谢紊乱的方法
公开(公告)号：US08609612B2
公开(公告)日：2013-12-17
申请号：US13577641
申请日：2011-02-07
申请人： Zhaodan Cao , Yarong Lu , Daniel David Kaplan
发明人： Zhaodan Cao , Yarong Lu , Daniel David Kaplan
IPC分类号： A01N47/00
CPC分类号： A61K38/17 , A61K38/1709
摘要： Methods of treating individuals with a glucose metabolism disorder, and compositions thereof, are provided.
摘要翻译：提供了治疗患有葡萄糖代谢障碍的个体的方法及其组合物。

5. 发明申请

US20130136738A1 Methods of Treating Glucose Metabolism Disorders 审中-公开
标题翻译：治疗葡萄糖代谢紊乱的方法
公开(公告)号：US20130136738A1
公开(公告)日：2013-05-30
申请号：US13520781
申请日：2011-01-21
申请人： Zhaodan Cao , Yarong Lu , Daniel David Kaplan
发明人： Zhaodan Cao , Yarong Lu , Daniel David Kaplan
IPC分类号： A61K38/17
CPC分类号： A61K38/1709 , A61K38/17
摘要： Methods of treating individuals with a glucose metabolism disorder, and compositions thereof, are provided.
摘要翻译：提供了治疗患有葡萄糖代谢障碍的个体的方法及其组合物。

6. 发明申请

US20130071391A1 Methods of Treating Glucose Metabolism Disorders 审中-公开
公开(公告)号：US20130071391A1
公开(公告)日：2013-03-21
申请号：US13520782
申请日：2011-01-21
申请人： Zhaodan Cao , Yarong Lu , Daniel David Kaplan
发明人： Zhaodan Cao , Yarong Lu , Daniel David Kaplan
IPC分类号： A61K39/395 , A61K38/17
CPC分类号： A61K38/1709 , A61K38/465 , A61K39/395 , C12Y301/01004
摘要： Methods of treating individuals with a glucose metabolism disorder, and compositions thereof, are provided.

7. 发明申请

US20130017994A1 Methods of Treating Glucose Metabolism Disorders 有权
公开(公告)号：US20130017994A1
公开(公告)日：2013-01-17
申请号：US13577641
申请日：2011-02-07
申请人： Zhaodan Cao , Yarong Lu , Daniel David Kaplan
发明人： Zhaodan Cao , Yarong Lu , Daniel David Kaplan
IPC分类号： A61K38/17 , A61P3/08 , A61P5/48 , A61P3/10
CPC分类号： A61K38/17 , A61K38/1709
摘要： Methods of treating individuals with a glucose metabolism disorder, and compositions thereof, are provided.

8. 发明授权

US06235513B1 IKK-&agr; proteins, nucleic acids and methods 失效
公开(公告)号：US06235513B1
公开(公告)日：2001-05-22
申请号：US09023324
申请日：1998-02-13
申请人： Mike Rothe , Zhaodan Cao , Catherine Régnier
发明人： Mike Rothe , Zhaodan Cao , Catherine Régnier
IPC分类号： C12N912
CPC分类号： G01N33/6842 , C12N9/1205 , G01N33/5008 , G01N33/502 , G01N33/68 , G01N2333/9121
摘要： The invention provides methods and compositions relating to an I&kgr;B kinase, IKK-&agr;, and related nucleic acids. The polypeptides may be produced recombinantly from transformed host cells from the disclosed IKK-&agr; encoding nucleic acids or purified from human cells. The invention provides isolated IKK-&agr; hybridization probes and primers capable of specifically hybridizing with the disclosed IKK-&agr; genes, IKK-&agr;-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

9. 发明申请

US20080153778A1 N-aryl pyrazole compounds, compositions, and methods for their use 有权
标题翻译： N-芳基吡唑化合物，组合物及其使用方法
公开(公告)号：US20080153778A1
公开(公告)日：2008-06-26
申请号：US11973900
申请日：2007-10-09
申请人： Yasuyuki Ogawa , Ryo Okuyama , Satoshi Shibuya , Narihiro Toda , Zhaodan Cao , Zice Fu , Xiaolin Hao , Yong-Jae Kim , Leping Li , Sarah E. Lively , Mike Lizarzaburu , Hui Tian , Ming Yu
发明人： Yasuyuki Ogawa , Ryo Okuyama , Satoshi Shibuya , Narihiro Toda , Zhaodan Cao , Zice Fu , Xiaolin Hao , Yong-Jae Kim , Leping Li , Sarah E. Lively , Mike Lizarzaburu , Hui Tian , Ming Yu
IPC分类号： A61K31/715 , A61K31/155 , A61K31/4439 , A61P3/10 , C07D401/04 , A61K31/44
CPC分类号： C07D409/14 , C07D401/14 , C07D403/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Compounds having formula I: where A1, A2, L, V, W, R1, R2, R3, R4 and R5 are as described herein, compositions thereof, and their use for the treatment or prevention of type 2 diabetes and type 2 diabetes-related conditions are provided herein.
摘要翻译：具有式I的化合物：其中A 1，A 2，L，V，W，R 1，R 2， >，R 3，R 4和R 5如本文所述，其组合物及其用于治疗或预防2型的用途本文提供糖尿病和2型糖尿病相关病症。

10. 发明授权

US06576444B2 IRAK3 polynucleotides 失效
标题翻译： IRAK3多核苷酸
公开(公告)号：US06576444B2
公开(公告)日：2003-06-10
申请号：US09863549
申请日：2001-05-22
申请人： Zhaodan Cao
发明人： Zhaodan Cao
IPC分类号： C12P2106
CPC分类号： C07K14/7056 , A61K38/00
摘要： The invention provides methods and compositions relating to a novel kinase, IRAK3. The polypeptides may be produced recombinantly from transformed host cells from the disclosed IRAK3 encoding nucleic acids or purified from human cells. The invention provides isolated IRAK3 hybridization probes and primers capable of specifically hybridizing with the disclosed IRAK3 genes, IRAK3-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
摘要翻译：本发明提供了与新型激酶IRAK3有关的方法和组合物。可以从所公开的编码IRAK3的核酸转化的宿主细胞重组产生多肽或从人细胞纯化。本发明提供能够与所公开的IRAK3基因IRAK3特异性结合剂如特异性抗体特异性杂交的分离的IRAK3杂交探针和引物，以及在诊断，治疗和生物制药工业中制备和使用受试者组合物的方法。

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