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1. 发明申请

US20090180996A1 Epigenetic modification of cell phenotype, fate and/or function by RNA transfer 审中-公开
标题翻译：通过RNA转移对细胞表型，命运和/或功能的表观遗传修饰
公开(公告)号：US20090180996A1
公开(公告)日：2009-07-16
申请号：US12268095
申请日：2008-11-10
申请人： Zeki Beyhan , Arif Kocabas , Jose Bernardo Cibelli , Steven T. Suhr
发明人： Zeki Beyhan , Arif Kocabas , Jose Bernardo Cibelli , Steven T. Suhr
IPC分类号： A61K35/12 , C12N15/87 , C12N15/89 , C12N15/88 , A61P35/00 , A61P37/00 , A61P31/00 , A61P29/00 , A61P37/08
CPC分类号： C12N15/1079 , C12N2506/00 , C12N2799/027
摘要： The invention relates to methods for altering the fate or differentiation status of somatic cells by RNA transfer. These methods can be used to transdifferentiate or dedifferentiate somatic cells of one phenotype or lineage into pluripotent cells or into somatic cells of a different lineage or phenotype.
摘要翻译：本发明涉及通过RNA转移来改变体细胞的命运或分化状态的方法。这些方法可用于将一种表型或谱系的体细胞分化或去分化成多能细胞或不同谱系或表型的体细胞。

2. 发明申请

US20090028835A1 HUMAN TRANSCRIPTOME CORRESPONDING TO HUMAN OOCYTES AND USE OF SAID GENES OR THE CORRESPONDING POLYPEPTIDES TO TRANS-DIFFERENTIATE SOMATIC CELLS 审中-公开
标题翻译：人类代谢物与人类卵巢癌相关的转录因子和相关基因的多态性与转移性差异化细胞的相关性
公开(公告)号：US20090028835A1
公开(公告)日：2009-01-29
申请号：US11852677
申请日：2007-09-10
申请人： Jose Bernardo Cibelli , Arif Murat Kocabas , Bing Lim , Hasan H. Otu
发明人： Jose Bernardo Cibelli , Arif Murat Kocabas , Bing Lim , Hasan H. Otu
IPC分类号： A61K48/00 , C12N15/11 , C12N5/10 , A61P35/00 , A61P37/00 , A61P31/00 , C12Q1/68
CPC分类号： C12N15/8509 , C12N2510/00 , C12Q1/6883 , C12Q1/6886 , C12Q2600/158
摘要： The identification of 101 genes upregulated or differentially expressed by mature human oocytes is provided herein. These genes and the corresponding gene products will facilitate a greater understanding of oogenesis, folliculogenesis, fertilization, and embryonic development. In addition these genes and the corresponding gene products can be used to effect dedifferentiation and/or transdifferentiation of desired somatic cells. The resultant dedifferentiated cells and somatic cells derived therefrom can be used in cell therapies such as in the treatment of cancer, autoimmunity, and other diseases wherein specific types of cells such as hematopoietic cells may be depleted because of the underlying disease or the treatment of the disease.Also, a core group of 66 transcripts was identified by intersecting significantly up-regulated genes of the human oocyte with those from the mouse oocyte and from human and mouse embryonic stem cells. Within the up-regulated probe sets, the top overrepresented categories were related to RNA and protein metabolism, followed by DNA metabolism and chromatin modification. This invention therefore provides a comprehensive expression baseline of genes expressed in in vivo matured human oocytes. Further understanding of the biological role of these genes will also expand knowledge on meiotic cell cycle, fertilization, chromatin remodeling, lineage commitment, pluripotency, tissue regeneration, and morphogenesis.
摘要翻译：本文提供了由成熟人卵母细胞上调或差异表达的101种基因的鉴定。这些基因和相应的基因产物将有助于更好地了解卵子发生，卵泡发生，受精和胚胎发育。此外，这些基因和相应的基因产物可用于实现所需体细胞的去分化和/或转分化。由此产生的去分化细胞和体细胞细胞可以用于细胞治疗，例如治疗癌症，自身免疫和其它疾病，其中特定类型的细胞例如造血细胞可能由于潜在的疾病而被消耗或治疗疾病。此外，通过将人类卵母细胞的显着上调基因与来自小鼠卵母细胞和来自人和小鼠胚胎干细胞的上调基因相交，鉴定了66个转录物的核心组。在上调的探针组中，顶部超表现类别与RNA和蛋白质代谢相关，其次是DNA代谢和染色质修饰。因此，本发明提供在体内成熟的人卵母细胞中表达的基因的综合表达基线。进一步了解这些基因的生物学作用还将扩大减数分裂细胞周期，受精，染色质重塑，谱系承诺，多能性，组织再生和形态发生的知识。

3. 发明申请

US20080175827A1 PHOSPHOLIPASE C ZETA MEDIATED OOCYTE ACTIVATION, COMPOSITIONS FOR USE THEREIN, AND ASSAYS FOR DETECTING AND IDENTIFYING AGENTS FOR TREATING MALE INFERTILITY 审中-公开
标题翻译：磷脂酶C ZETA介导的OOCYTE激活，其使用的组合物和用于检测和鉴定用于治疗男性感染的药剂的测定
公开(公告)号：US20080175827A1
公开(公告)日：2008-07-24
申请号：US11942406
申请日：2007-11-19
申请人： Rafael A. Fissore , Pablo Visconti , Manabu Kurokawa , Sook-Young Yoon , Daniel R. Grow , Teru J. Jellerette , Jose Bernardo Cibelli , Pablo Juan Ross
发明人： Rafael A. Fissore , Pablo Visconti , Manabu Kurokawa , Sook-Young Yoon , Daniel R. Grow , Teru J. Jellerette , Jose Bernardo Cibelli , Pablo Juan Ross
IPC分类号： A61K48/00 , C12N5/00 , C12N15/00 , C12Q1/68 , A01N1/02 , C12Q1/42
CPC分类号： C12N5/0609 , C12N15/8771 , C12N2501/70 , C12N2517/10
摘要： The invention relates to the use of phospholipase C zeta in inducing or promoting the activation of oocytes, preferably human oocytes, nuclear transfer embryos, parthenogenic embryos, cross species embryos and during in vitro fertilization.The invention further relates to methods of detecting levels of expression of phospholipase c zeta in sperm as a means of detecting male infertility.The invention also relates to the use of phospholipase C zeta to treat male infertility. Still further the invention relates to the recombinant cells that are engineered to express phospholipase C zeta, preferably under inducible conditions.Also, the invention relates to antibodies specific to phospholipase C zeta, preferably human phospholipase C zeta.
摘要翻译：本发明涉及磷脂酶C zeta在诱导或促进卵母细胞，优选人卵母细胞，核转移胚，单性胚胎，交叉种胚胎和体外受精期间的活化中的用途。本发明还涉及检测精子中磷脂酶ζ的表达水平的方法，作为检测男性不育症的手段。本发明还涉及磷脂酶C zeta用于治疗男性不育症的用途。本发明还涉及优选在可诱导条件下工程化以表达磷脂酶C zeta的重组细胞。此外，本发明涉及对磷脂酶C zeta，优选人磷脂酶C zeta特异性的抗体。

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