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1. 发明授权

US07008640B2 Pharmaceutical composition for oral use with improved absorption 失效
公开(公告)号：US07008640B2
公开(公告)日：2006-03-07
申请号：US09907557
申请日：2001-07-16
申请人： Shunsuke Watanabe , Shigeo Takemura , Yuuki Tsutsui , Hiromu Kondo , Kiyo Nakanishi , Kazuhiro Sako , Toyohiro Sawada
发明人： Shunsuke Watanabe , Shigeo Takemura , Yuuki Tsutsui , Hiromu Kondo , Kiyo Nakanishi , Kazuhiro Sako , Toyohiro Sawada
IPC分类号： A61K9/54 , A61K9/48 , A61K9/20 , A61K9/14 , A61K9/16
CPC分类号： A61K9/2027 , A61K9/2846 , A61K9/2853 , A61K9/2893 , A61K31/65 , A61K31/663 , A61K47/12 , A61K47/32
摘要： The present invention presents a pharmaceutical composition for oral use with improved absorption, which comprises drug, aminoalkyl methacrylate copolymer E, and acidic substance and is obtained by bringing said 3 components together and uniformly mixing at least this polymer and this acidic substance, and a method of improving oral absorption by using this pharmaceutical composition. Moreover, the present invention presents an agent for improving oral absorption that increases drug permeability of the digestive tract mucous membrane and/or mucous layer present on the surface of this membrane, whose active ingredient is aminoalkyl methacrylate copolymer E. In addition, the present invention presents an oral agent for improving absorption by increasing drug permeability of the digestive tract mucous membrane and/or the mucous layer distributed over this mucous membrane, whose effective component is aminoalkyl methacrylate copolymer E.

2. 发明授权

US07871644B2 Pharmaceutical composition for oral use with improved absorption 有权
标题翻译：用于口服使用的药物组合物具有改善的吸收
公开(公告)号：US07871644B2
公开(公告)日：2011-01-18
申请号：US10949114
申请日：2004-09-10
申请人： Shunsuke Watanabe , Shigeo Takemura , Yuuki Tsutsui , Himoru Kondo , Kiyo Nakanishi , Kazuhiro Sako , Toyohiro Sawada
发明人： Shunsuke Watanabe , Shigeo Takemura , Yuuki Tsutsui , Himoru Kondo , Kiyo Nakanishi , Kazuhiro Sako , Toyohiro Sawada
IPC分类号： A61K9/22 , A61K9/20 , A61K9/28 , A61K9/32 , A61K9/48
CPC分类号： A61K9/2027 , A61K9/2846 , A61K9/2853 , A61K9/2893 , A61K31/65 , A61K31/663 , A61K47/12 , A61K47/32
摘要： The present invention presents a pharmaceutical composition for oral use with improved absorption, which comprises drug, aminoalkyl methacrylate copolymer E, and acidic substance and is obtained by bringing said 3 components together and uniformly mixing at least this polymer and this acidic substance, and a method of improving oral absorption/by using this pharmaceutical composition. Moreover, the present invention presents an agent for improving oral absorption that increases drug permeability of the digestive tract mucous membrane and/or mucous layer present on the surface of this membrane, whose active ingredient is aminoalkyl methacrylate copolymer E. In addition, the present invention presents an oral agent for improving absorption by increasing drug permeability of the digestive tract mucous membrane and/or the mucous layer distributed over this mucous membrane, whose effective component is aminoalkyl methacrylate copolymer E.
摘要翻译：本发明提供了具有改善吸收性的口服用药物组合物，其包括药物，甲基丙烯酸氨基烷基酯共聚物E和酸性物质，并且通过使所述3种组分一起并将至少该聚合物与该酸性物质均匀混合而获得，通过使用该药物组合物改善口服吸收。此外，本发明提供了改善口服吸收的药剂，其增加存在于该膜的表面上的消化道粘膜和/或粘膜层的药物通透性，其活性成分是甲基丙烯酸氨基烷基酯共聚物E.另外，本发明提出了通过增加分泌在该粘膜上的消化道粘膜和/或粘膜层的药物通透性来改善吸收的口服剂，其有效成分是甲基丙烯酸氨基烷基酯共聚物E.

3. 发明申请

US20100221223A1 IMMUNE RESPONSE INDUCTION METHOD 审中-公开
标题翻译：免疫应答诱导方法
公开(公告)号：US20100221223A1
公开(公告)日：2010-09-02
申请号：US12777202
申请日：2010-05-10
申请人： Yuuki Tsutsui , Kiyo Nakanishi , Shunsuke Watanabe , Shigeo Takemura
发明人： Yuuki Tsutsui , Kiyo Nakanishi , Shunsuke Watanabe , Shigeo Takemura
IPC分类号： A61K38/21
CPC分类号： A61K39/39 , A61K38/212 , A61K2039/543 , A61K2039/55522 , A61K2300/00
摘要： The present invention proposes a method of inducing both vaccine antigen-specific antibody in blood and vaccine antigen-specific antibody secreted at the mucosal surface using vaccine antigen and adjuvant of said vaccine antigen.
摘要翻译：本发明提出了使用疫苗抗原和所述疫苗抗原的佐剂诱导血液中的疫苗抗原特异性抗体和分泌在粘膜表面的疫苗抗原特异性抗体的方法。

4. 发明申请

US20050031587A1 Immune response induction method 审中-公开
标题翻译：免疫反应诱导方法
公开(公告)号：US20050031587A1
公开(公告)日：2005-02-10
申请号：US10674581
申请日：2003-09-29
申请人： Yuuki Tsutsui , Kiyo Nakanishi , Shunsuke Watanabe , Shigeo Takemura
发明人： Yuuki Tsutsui , Kiyo Nakanishi , Shunsuke Watanabe , Shigeo Takemura
IPC分类号： A61K38/21 , A61K39/00
CPC分类号： A61K39/39 , A61K38/212 , A61K2039/543 , A61K2039/55522 , A61K2300/00
摘要： The present invention proposes a method of inducing both vaccine antigen-specific antibody in blood and vaccine antigen-specific antibody secreted at the mucosal surface using vaccine antigen and adjuvant of said vaccine antigen.
摘要翻译：本发明提出了使用疫苗抗原和所述疫苗抗原的佐剂诱导血液中的疫苗抗原特异性抗体和分泌在粘膜表面的疫苗抗原特异性抗体的方法。

5. 发明授权

US07923025B2 Pharmaceutical composition for oral use with improved absorption 有权
标题翻译：用于口服使用的药物组合物具有改善的吸收
公开(公告)号：US07923025B2
公开(公告)日：2011-04-12
申请号：US10345051
申请日：2003-01-15
申请人： Shunsuke Watanabe , Kiyo Nakanishi , Shigeo Takemura , Yuuki Tsutsui
发明人： Shunsuke Watanabe , Kiyo Nakanishi , Shigeo Takemura , Yuuki Tsutsui
IPC分类号： A61K9/46 , A61K9/20
CPC分类号： A61K9/0095 , A61K9/2027 , A61K9/2031 , A61K9/2853 , A61K9/4866 , A61K31/785 , A61K38/11 , A61K38/23 , A61K38/28 , A61K47/32 , A61K2300/00
摘要： The present invention relates to an agent for inhibiting decomposition of a biologically active peptide by a digestive enzyme, which is aminoalkyl methacrylate copolymer E as an effective ingredient, and an agent for reducing viscosity of the gastrointestinal mucosa and mucous layers distributed over this mucosa. The present invention relates to a method for inhibiting decomposition of a biologically active peptide by a digestive enzyme, or a method for reducing viscosity of the gastrointestinal mucosa and/or mucous layers distributed over the mucosa, by administration of aminoalkyl methacrylate copolymer E. Furthermore, the present invention relates to a pharmaceutical composition for oral use with improved absorption, which comprises a biologically active peptide and aminoalkyl methacrylate copolymer E. Excellent oral absorption of a biologically active peptide that were considered difficult to absorb by oral administration in the past, can be realized based on the ability to inhibit decomposition of a biologically active peptide, the ability to reduce viscosity of the gastrointestinal mucosa and/or mucous layers distributed over this mucosa, and the ability to improve permeability of a biologically active peptide in the gastrointestinal mucosa and/or mucous layers of the pharmaceutical composition of the present invention.
摘要翻译：本发明涉及通过消化酶抑制生物活性肽分解的试剂，其为甲基丙烯酸氨基烷基酯共聚物E作为有效成分，以及用于降低分布在该粘膜上的胃肠粘膜和粘液层的粘度的试剂。本发明涉及通过使用氨基烷基甲基丙烯酸酯共聚物E来抑制由消化酶分解生物活性肽的方法或降低分布在粘膜上的胃肠粘膜和/或粘膜层粘度的方法。此外，本发明涉及具有改善吸收性的口服用药物组合物，其包含生物活性肽和甲基丙烯酸氨基烷基酯共聚物E.过去通过口服给药难以吸收的生物活性肽的良好口服吸收可以是基于抑制生物活性肽分解的能力实现，降低分布在该粘膜上的胃肠粘膜和/或粘液层的粘度的能力，以及提高生物活性肽在胃肠粘膜和/ 或药物组合物的粘液层本发明的范围。

6. 发明申请

US20050112206A1 Pharmaceutical composition for oral use with improved absorption 有权
标题翻译：用于口服使用的药物组合物具有改善的吸收
公开(公告)号：US20050112206A1
公开(公告)日：2005-05-26
申请号：US10949114
申请日：2004-09-10
申请人： Shunsuke Watanabe , Shigeo Takemura , Yuuki Tsutsui , Himoru Kondo , Kiyo Nakanishi , Kazuhiro Sako , Toyohiro Sawada
发明人： Shunsuke Watanabe , Shigeo Takemura , Yuuki Tsutsui , Himoru Kondo , Kiyo Nakanishi , Kazuhiro Sako , Toyohiro Sawada
IPC分类号： A61K31/663 , A61K45/00 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/22 , A61K47/32 , A61P1/00 , A61P1/04 , A61P1/10 , A61P1/12 , A61P1/14 , A61P1/16 , A61P3/02 , A61P3/06 , A61P3/10 , A61P5/00 , A61P5/38 , A61P7/04 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/08 , A61P11/10 , A61P11/14 , A61P13/00 , A61P13/02 , A61P19/06 , A61P19/10 , A61P21/02 , A61P23/00 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , A61K9/70 , A61K9/14
CPC分类号： A61K9/2027 , A61K9/2846 , A61K9/2853 , A61K9/2893 , A61K31/65 , A61K31/663 , A61K47/12 , A61K47/32
摘要： The present invention presents a pharmaceutical composition for oral use with improved absorption, which comprises drug, aminoalkyl methacrylate copolymer E, and acidic substance and is obtained by bringing said 3 components together and uniformly mixing at least this polymer and this acidic substance, and a method of improving oral absorption/by using this pharmaceutical composition. Moreover, the present invention presents an agent for improving oral absorption that increases drug permeability of the digestive tract mucous membrane and/or mucous layer present on the surface of this membrane, whose active ingredient is aminoalkyl methacrylate copolymer E. In addition, the present invention presents an oral agent for improving absorption by increasing drug permeability of the digestive tract mucous membrane and/or the mucous layer distributed over this mucous membrane, whose effective component is aminoalkyl methacrylate copolymer E.
摘要翻译：本发明提供了具有改善吸收性的口服用药物组合物，其包括药物，甲基丙烯酸氨基烷基酯共聚物E和酸性物质，并且通过使所述3种组分一起并将至少该聚合物与该酸性物质均匀混合而获得，通过使用该药物组合物改善口服吸收。此外，本发明提供了改善口服吸收的药剂，其增加存在于该膜的表面上的消化道粘膜和/或粘膜层的药物通透性，其活性成分是甲基丙烯酸氨基烷基酯共聚物E.另外，本发明提出了通过增加分泌在该粘膜上的消化道粘膜和/或粘膜层的药物通透性来改善吸收的口服剂，其有效成分是甲基丙烯酸氨基烷基酯共聚物E.

7. 发明授权

US08870353B2 Liquid ejecting head, liquid ejecting head unit and liquid ejecting apparatus 有权
标题翻译：液体喷射头，液体喷射头单元和液体喷射装置
公开(公告)号：US08870353B2
公开(公告)日：2014-10-28
申请号：US13075146
申请日：2011-03-29
申请人： Shunsuke Watanabe
发明人： Shunsuke Watanabe
IPC分类号： B41J2/045 , B41J2/015 , B41J2/15 , B41J2/145 , B41J2/04 , B41J2/05 , B41J2/17 , B41J2/175 , B41J2/14
CPC分类号： B41J2/14274 , B41J2002/14419 , B41J2202/08
摘要： A liquid ejecting head includes a pressure generation chamber which fluidly communicates with a nozzle opening through which liquid is discharged, a pressure generation unit which causes pressure change on liquid in the pressure generation chamber, a manifold which serves as a liquid chamber common to a plurality of the pressure generation chambers, a flexible film which is configured to cover the manifold so as to absorb a pressure change generated in the manifold, and a heat generation unit which is formed on the flexible film at a region opposed to the manifold and is made of a pattered metal.
摘要翻译：液体喷射头包括压力产生室，该压力产生室与被喷射出液体的喷嘴开口流体连通;压力产生单元，其对压力发生室中的液体产生压力变化，用作多个共同的液体室的歧管压力产生室的柔性膜，构造成覆盖歧管以吸收在歧管中产生的压力变化的柔性膜，以及在与歧管相对的区域上形成在柔性膜上的发热单元，并被制成一个图案金属。

8. 发明授权

US08636335B2 Liquid ejecting head and liquid ejecting apparatus 有权
标题翻译：液体喷头和液体喷射装置
公开(公告)号：US08636335B2
公开(公告)日：2014-01-28
申请号：US13075142
申请日：2011-03-29
申请人： Akira Hotta , Shunsuke Watanabe
发明人： Akira Hotta , Shunsuke Watanabe
IPC分类号： B41J2/175
CPC分类号： B41J2/14274 , B41J2002/14362
摘要： A liquid ejecting head includes a main liquid ejecting head body, a head holder, and a sealing member, disposed between the main liquid ejecting head body and the head holder, that has a communication opening that communicates between a first liquid flow channel and a second liquid flow channel. The sealing member further has a close-contact portion provided at the circumferential edge of the communication opening; a first contact portion, provided in correspondence with the external circumferential portion of the main liquid ejecting head body, that protrudes toward the main liquid ejecting head body and makes contact with the main liquid ejecting head body; and a second contact portion that protrudes toward the head holder and makes contact with the head holder.
摘要翻译：液体喷射头包括设置在主液体喷射头主体和头部保持器之间的主液体喷射头主体，头部保持器和密封构件，其具有连通第一液体流道和第二液体流道之间的连通孔液流通道。密封构件还具有设置在连通开口的圆周边缘处的紧密接触部分; 与主液体喷射头本体的外周部对应地设置的与主液体喷射头主体突出并与主液体喷射头主体接触的第一接触部; 以及朝向头部保持器突出并与头部保持器接触的第二接触部。

9. 发明授权

US08534815B2 Flow path member, liquid ejecting head, and liquid ejecting apparatus 有权
标题翻译：流路构件，液体喷射头和液体喷射装置
公开(公告)号：US08534815B2
公开(公告)日：2013-09-17
申请号：US13332174
申请日：2011-12-20
申请人： Shunsuke Watanabe
发明人： Shunsuke Watanabe
IPC分类号： B41J2/175
CPC分类号： B41J2/175
摘要： A seal member is held in tight contact with a first inner wall of a first opening of a flow-in path section (ink inlet hole) by a fixing member. An ink supply pipe is urged and held into a holding hole of the seal member, so that the ink supply pipe is held in a predetermined position with respect to the first inner wall of the first opening of the ink inlet hole and a second inner wall of a second opening of the ink inlet hole. As a result, the ink supply pipe is held in the ink inlet hole with the first opening of the ink inlet hole being kept airtight.
摘要翻译：密封构件通过固定构件与流入路径部分的第一开口的第一内壁（墨入口孔）紧密接触。供墨管被推压并保持在密封构件的保持孔中，使得供墨管相对于墨水入口孔的第一开口的第一内壁保持在预定位置，第二内壁的墨水入口孔的第二开口。结果，在墨水入口孔的第一开口保持气密的情况下，供墨管被保持在墨水入口孔中。

10. 发明申请

US20120256989A1 LIQUID EJECTING HEAD, LIQUID EJECTING HEAD UNIT AND LIQUID EJECTING APPARATUS 有权
标题翻译：液体喷射头，液体喷射头和液体喷射装置
公开(公告)号：US20120256989A1
公开(公告)日：2012-10-11
申请号：US13526299
申请日：2012-06-18
申请人： Haruhisa UEZAWA , Shunsuke Watanabe
发明人： Haruhisa UEZAWA , Shunsuke Watanabe
IPC分类号： B41J2/045
CPC分类号： B41J2/18 , B41J2/14233 , B41J2/17593 , B41J2202/12
摘要： A liquid ejecting head includes a liquid channel having a pressure generating chamber communicated with a nozzle opening that ejects liquid, and a first liquid chamber installed at one end of the pressure generating chamber to communicate a plurality of pressure generating chambers; a pressure generating unit for changing pressure in the pressure generating chamber so that liquid is discharged from the nozzle opening; a heating unit for heating liquid in the liquid channel at an upstream of the pressure generating chamber; a second liquid chamber installed at the other end of the pressure generating chamber; and a circulating channel formed among a pressure generating chamber group having at least one pressure generating chamber to connect the first liquid chamber and the second liquid chamber.
摘要翻译：液体喷射头包括具有与喷射液体的喷嘴开口连通的压力产生室的液体通道，以及安装在压力发生室的一端以连通多个压力产生室的第一液体室; 压力发生单元，用于改变压力发生室中的压力，使得液体从喷嘴开口排出; 加热单元，用于在压力发生室的上游加热液体通道中的液体; 安装在所述压力发生室的另一端的第二液体室; 以及在具有至少一个压力发生室的压力发生室组之间形成的循环通道，以连接第一液体室和第二液体室。

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