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1. 发明授权

US07056430B1 Detachable cell-delivery system for patch-clamp unit 有权
标题翻译：用于膜片钳单元的可拆卸细胞递送系统
公开(公告)号：US07056430B1
公开(公告)日：2006-06-06
申请号：US10339142
申请日：2003-01-09
申请人： Yuri Osipchuk , Yuriy Roll , Alan S. Finkel , Alexander A. Dromaretsky , Branko Bem
发明人： Yuri Osipchuk , Yuriy Roll , Alan S. Finkel , Alexander A. Dromaretsky , Branko Bem
IPC分类号： G01N33/487
CPC分类号： G01N33/48728
摘要： The cell-delivery unit of a high-throughput electrophysiological testing system is implemented as a reusable movable unit suitable for repetitive delivery of cells to a disposable, multi-aperture patch-clamp tray. An electric field emanating from the patch aperture is used to align the dispenser with the aperture. A set of electrodes in the nozzle of the dispenser is used to detect the electric field and effect the alignment. According to another aspect of the invention, dielectrophoretic fields produced by sets of electrodes in the nozzle form a retaining cage that is used first to suspend a test cell directly above the patch aperture and then to urge the cell toward it. A movable cell sorter may also be coupled to the cell-delivery unit.
摘要翻译：高通量电生理测试系统的细胞传递单元被实施为可重复使用的可移动单元，其适用于将细胞重复地递送到一次性多孔膜片钳夹盘。使用从贴片孔发出的电场使分配器与孔对准。使用分配器喷嘴中的一组电极来检测电场并进行对准。根据本发明的另一方面，通过喷嘴中的电极组产生的介电电泳场形成保持架，其首先用于将测试电池直接悬挂在贴片孔的上方，然后将电池推向电池。移动细胞分选器也可以耦合到细胞递送单元。

2. 发明授权

US06833916B2 High efficiency, large field scanning microscope 有权
标题翻译：高效率，大场扫描显微镜
公开(公告)号：US06833916B2
公开(公告)日：2004-12-21
申请号：US10656728
申请日：2003-09-04
申请人： Yuri Osipchuk , Sasha Dromaretsky , Yuriy Roll , Stephen Smith
发明人： Yuri Osipchuk , Sasha Dromaretsky , Yuriy Roll , Stephen Smith
IPC分类号： G01N2164
CPC分类号： G02B21/18 , G02B21/002 , G02B21/082
摘要： A fluorescent optical imaging system (10) produces two separate spots (S1 and S2) on a sample (12) by a pair of excitation laser beams (B1 and B2) that are generated by first and second lasers (L1 and L2). Excitation laser beams (B1 and B2) pass at slightly different angles, first through an aperture (15) of a 45° fold mirror (13), and then through an objective element (14). As a result, emission light beams (16, 18) are generated from each illuminated spot (S1 and S2) and are reflected and redirected by mirror (13) through a secondary lens (19) before reaching one of two detectors (PMT 1 and PMT 2). Emission beam (16) reflects off a second 45° mirror (22) prior to reaching detector (PMT 1), while emission beam (18) travels directly to (PMT 2). If desired, optical separation elements (24), such as dichroic filters, prisms, or gratings, can be positioned in front of each detector (PMT 1 and PMT 2). Fluorescent optical imaging system (10) may employ a scanning system (17) for illuminating and imaging the entire area of sample (12).
摘要翻译：荧光光学成像系统（10）通过由第一和第二激光器（L1和L2）产生的一对激发激光束（B1和B2）在样品（12）上产生两个分开的点（S1和S2）。激发激光束（B1和B2）以稍微不同的角度通过，首先穿过45°反射镜（13）的孔（15），然后穿过物镜元件（14）。结果，从每个照明光点（S1和S2）产生发射光束（16,18），并且在到达两个检测器（PMT 1和2）之一之前通过次级透镜（19）被反射镜（13）反射和重定向 PMT 2）。发射束（16）在到达检测器（PMT 1）之前反射离开第二个45°反射镜（22），而发射光束（18）直接传播到（PMT 2）。如果需要，诸如二向色滤光器，棱镜或光栅的光学分离元件（24）可以位于每个检测器（PMT 1和PMT 2）的前面。荧光光学成像系统（10）可以采用扫描系统（17）来照射和成像样品（12）的整个区域。

3. 发明授权

US06628385B1 High efficiency, large field scanning microscope 有权
标题翻译：高效率，大场扫描显微镜
公开(公告)号：US06628385B1
公开(公告)日：2003-09-30
申请号：US09479310
申请日：2000-01-06
申请人： Yuri Osipchuk , Sasha Dromaretsky , Yuriy Roll , Stephen Smith
发明人： Yuri Osipchuk , Sasha Dromaretsky , Yuriy Roll , Stephen Smith
IPC分类号： G01N2164
CPC分类号： G02B21/18 , G02B21/002 , G02B21/082
摘要： A fluorescent optical imaging system (10) produces two separate spots (S1 and S2) on a sample (12) by a pair of excitation laser beams (B1 and B2) that are generated by first and second lasers (L1 and L2). Excitation laser beams (B1 and B2) pass at slightly different angles, first through an aperture (15) of a 45° fold mirror (13), and then through an objective element (14). As a result, emission light beams (16, 18) are generated from each illuminated spot (S1 and S2) and are reflected and redirected by mirror (13) through a secondary lens (19) before reaching one of two detectors (PMT 1 and PMT 2). Emission beam (16) reflects off a second 45° mirror (22) prior to reaching detector (PMT 1), while emission beam (18) travels directly to (PMT 2). If desired, optical separation elements (24), such as dichroic filters, prisms, or gratings, can be positioned in front of each detector (PMT 1 and PMT 2). Fluorescent optical imaging system (10) may employ a scanning system (17) for illuminating and imaging the entire area of sample (12).
摘要翻译：荧光光学成像系统（10）通过由第一和第二激光器（L1和L2）产生的一对激发激光束（B1和B2）在样品（12）上产生两个分开的点（S1和S2）。激发激光束（B1和B2）以稍微不同的角度通过，首先穿过45°反射镜（13）的孔（15），然后穿过物镜元件（14）。结果，从每个照明光点（S1和S2）产生发射光束（16,18），并且在到达两个检测器（PMT 1和2）之一之前通过次级透镜（19）被反射镜（13）反射和重定向 PMT 2）。发射束（16）在到达检测器（PMT 1）之前反射离开第二个45°反射镜（22），而发射光束（18）直接传播到（PMT 2）。如果需要，诸如二向色滤光器，棱镜或光栅的光学分离元件（24）可以位于每个检测器（PMT 1和PMT 2）的前面。荧光光学成像系统（10）可以采用扫描系统（17）来照射和成像样品（12）的整个区域。

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