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1. 发明申请

US20140186436A1 ORAL DELIVERY OF ENZYMES BY NANOCAPSULES FOR TARGETED METABOLISM OF ALCOHOL OR TOXIC METABOLITES 审中-公开
标题翻译：通过纳豆酸酯对酒精或毒性代谢物的指定代谢进行口服递送
公开(公告)号：US20140186436A1
公开(公告)日：2014-07-03
申请号：US14131159
申请日：2012-07-06
申请人： Otto O. Yang , Yunfeng Lu , Cheng Ji , Ming Yan , Yang Liu
发明人： Otto O. Yang , Yunfeng Lu , Cheng Ji , Ming Yan , Yang Liu
IPC分类号： A61K38/44
CPC分类号： A61K38/443 , A61K38/44 , A61K47/549 , A61K47/64 , B82Y5/00 , C12N11/18
摘要： The invention disclosed herein includes nanocomplexes that are designed include enzymes that have complementary functional attributes and methods for using these nanocomplexes. Illustrative examples include nanocomplexes that comprise both an alcohol oxidase enzyme as well as a catalase enzyme. These nanocomplexes can be used in methods designed to lower blood alcohol levels in vivo, and/or to break down the toxic byproducts of alcohol metabolism. Consequently these nanocomplexes can be used to treat a variety of conditions resulting from the consumption of alcohol, including for example, acute alcohol intoxication.
摘要翻译：本文公开的本发明包括纳米复合物，其被设计为包括具有互补功能属性的酶和使用这些纳米复合物的方法。说明性实例包括纳米复合物，其包含醇氧化酶以及过氧化氢酶。这些纳米复合物可用于设计用于降低体内血液酒精含量和/或分解酒精代谢的有毒副产物的方法。因此，这些纳米复合物可用于治疗由于饮用酒精而引起的各种病症，包括例如急性酒精中毒。

2. 发明申请

US20140134700A1 MULTIPLE-ENZYME NANOCOMPLEXES 有权
标题翻译：多元酶纳米复合物
公开(公告)号：US20140134700A1
公开(公告)日：2014-05-15
申请号：US14130873
申请日：2012-07-06
申请人： Yunfeng Lu , Ming Yan , Yang Liu
发明人： Yunfeng Lu , Ming Yan , Yang Liu
IPC分类号： C12N11/18
CPC分类号： A61K38/443 , A61K38/44 , A61K47/549 , A61K47/64 , B82Y5/00 , C12N11/18
摘要： Provided are nanocomplexes having at least two different enzymes and a polymeric network anchored to at least one of the enzymes. In some embodiments, the activities of the enzymes catalyze a cascade reaction.
摘要翻译：提供了具有至少两种不同酶的纳米复合物和锚定至至少一种酶的聚合物网络。在一些实施方案中，酶的活性催化级联反应。

3. 发明授权

US10016490B2 Multiple-enzyme nanocomplexes 有权
公开(公告)号：US10016490B2
公开(公告)日：2018-07-10
申请号：US14130873
申请日：2012-07-06
申请人： Yunfeng Lu , Ming Yan , Yang Liu
发明人： Yunfeng Lu , Ming Yan , Yang Liu
IPC分类号： C12N11/18 , A61K38/44 , A61K47/48 , B82Y5/00
CPC分类号： A61K38/443 , A61K38/44 , A61K47/549 , A61K47/64 , B82Y5/00 , C12N11/18
摘要： Provided are nanocomplexes having at least two different enzymes and a polymeric network anchored to at least one of the enzymes. In some embodiments, the activities of the enzymes catalyze a cascade reaction.

4. 发明授权

US10179112B2 Viral vector nanocapsule for targeting gene therapy and its preparation 有权
公开(公告)号：US10179112B2
公开(公告)日：2019-01-15
申请号：US14651945
申请日：2013-12-16
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , Yunfeng Lu , Ming Yan , Irvin S. Y. Chen , Min Liang
发明人： Yunfeng Lu , Ming Yan , Irvin S. Y. Chen , Min Liang
IPC分类号： A61K9/51 , A61K35/76 , A61K48/00 , C12N15/86 , A61K31/7088 , A61K47/62 , A61K47/69
摘要： The invention provides novel methods, materials and systems that can be used to generate viral vectors having altered tissue and cell targeting abilities. In illustrative embodiments of the invention, the specificity of lentiviral vectors was modulated by a thin polymer shell that synthesized and coupled to the viral envelope in situ. The polymer shell can confers such vectors with new targeting ability via agents such as cyclic RGD (cRGD) peptides that are coupled to the polymer shell. These polymer encapsulated viral vectors exhibit a number of highly desirable characteristics including a higher thermal stability, resistance to serum inactivation in vivo, and an ability to infect dividing and non-dividing cells with high efficiencies.

5. 发明授权

US09283194B2 Methods for protease assisted protein delivery 有权
标题翻译：蛋白酶辅助蛋白递送的方法
公开(公告)号：US09283194B2
公开(公告)日：2016-03-15
申请号：US13089117
申请日：2011-04-18
申请人： Yi Tang , Zhen Gu , Yunfeng Lu , Ming Yan , Anuradha Biswas , Guoping Fan
发明人： Yi Tang , Zhen Gu , Yunfeng Lu , Ming Yan , Anuradha Biswas , Guoping Fan
IPC分类号： A61K9/51 , A61K31/7088 , A61K41/00 , A61K47/48
CPC分类号： A61K9/5169 , A61K9/5138 , A61K9/5192 , A61K31/7088 , A61K38/02 , A61K41/0042 , A61K47/48176 , A61K47/58 , A61K48/00
摘要： A method for intracellular delivery of single proteins or other cargo molecules by encapsulation within nanocapsules formed by interfacial polymerization of one or more types of monomers and selected protease cleavable cross-linkers is provided. The thin positively charged capsules are readily brought into the cytosol of target cells by endocytosis. The capsules are degraded by the action of endogenous proteases or co-delivered proteases on the cross-linkers releasing the functional cargo unaltered. The cross-linkers can be adapted to be cleavable by specific enzymes selected from available intracellular enzymes within the target cell or co-delivered or self-cleaving when the cargo itself is a protease. The nanocapsules produced by the methods have been shown to have long-term stability, high cell penetration capability, low toxicity and efficient protease-modulated specific degradability without affecting cargo protein function.
摘要翻译：提供了通过包封在由一种或多种类型的单体和选择的可切割蛋白酶切割交联剂的界面聚合形成的纳米胶囊内单细胞或其他货物分子的细胞内递送的方法。细胞带正电的胶囊容易通过内吞作用进入靶细胞的胞质溶胶。通过内源性蛋白酶或共同递送的蛋白酶对交联物的作用降解胶囊，释放功能性货物未改变。当货物本身是蛋白酶时，交联剂可以被适应成可以通过选自目标细胞内可用的细胞内酶的特定酶或共同递送或自分离的特异性酶切割。通过该方法生产的纳米胶囊已被证明具有长期稳定性，高细胞穿透能力，低毒性和有效的蛋白酶调节特异性降解性，而不影响货物蛋白质功能。

6. 发明申请

US20110274682A1 METHODS FOR PROTEASE ASSISTED PROTEIN DELIVERY 有权
标题翻译：蛋白质辅助蛋白质递送方法
公开(公告)号：US20110274682A1
公开(公告)日：2011-11-10
申请号：US13089117
申请日：2011-04-18
申请人： Yi Tang , Zhen Gu , Yunfeng Lu , Ming Yan , Anuradha Biswas , Guoping Fan
发明人： Yi Tang , Zhen Gu , Yunfeng Lu , Ming Yan , Anuradha Biswas , Guoping Fan
IPC分类号： A61K9/51 , A61K38/43 , C12N5/071 , A61K31/7088 , A61K38/48 , A61P35/00 , A61K38/19 , A61K38/02
CPC分类号： A61K9/5169 , A61K9/5138 , A61K9/5192 , A61K31/7088 , A61K38/02 , A61K41/0042 , A61K47/48176 , A61K47/58 , A61K48/00
摘要： A method for intracellular delivery of single proteins or other cargo molecules by encapsulation within nanocapsules formed by interfacial polymerization of one or more types of monomers and selected protease cleavable cross-linkers is provided. The thin positively charged capsules are readily brought into the cytosol of target cells by endocytosis. The capsules are degraded by the action of endogenous proteases or co-delivered proteases on the cross-linkers releasing the functional cargo unaltered. The cross-linkers can be adapted to be cleavable by specific enzymes selected from available intracellular enzymes within the target cell or co-delivered or self-cleaving when the cargo itself is a protease. The nanocapsules produced by the methods have been shown to have long-term stability, high cell penetration capability, low toxicity and efficient protease-modulated specific degradability without affecting cargo protein function.
摘要翻译：提供了通过包封在由一种或多种类型的单体和选择的可切割蛋白酶切割交联剂的界面聚合形成的纳米胶囊内单细胞或其他货物分子的细胞内递送的方法。细胞带正电的胶囊容易通过内吞作用进入靶细胞的胞质溶胶。通过内源性蛋白酶或共同递送的蛋白酶对交联物的作用降解胶囊，释放功能性货物未改变。当货物本身是蛋白酶时，交联剂可以被适应成可以通过选自目标细胞内可用的细胞内酶的特定酶或共同递送或自分离的特异性酶切割。通过该方法生产的纳米胶囊已被证明具有长期稳定性，高细胞穿透能力，低毒性和有效的蛋白酶调节特异性降解性，而不影响货物蛋白质功能。

7. 发明授权

US09289504B2 Single protein nanocapsules for protein delivery with long-term effect 有权
标题翻译：用于蛋白质递送的单一蛋白质纳米胶囊具有长期作用
公开(公告)号：US09289504B2
公开(公告)日：2016-03-22
申请号：US13255229
申请日：2010-03-09
申请人： Yunfeng Lu , Ming Yan , Juanjuan Du
发明人： Yunfeng Lu , Ming Yan , Juanjuan Du
IPC分类号： A61K31/74 , A61K47/48 , A61K9/51 , A61K9/00
CPC分类号： A61K47/48176 , A61K9/0019 , A61K9/5169 , A61K47/58
摘要： A protein nanocapsule having a single-protein core and a thin polymer shell anchored covalently to the protein core.
摘要翻译：具有单蛋白核心和与蛋白质核心共价锚定的薄聚合物壳的蛋白质纳米胶囊。

8. 发明申请

US20110318297A1 SINGLE PROTEIN NANOCAPSULES FOR PROTEIN DELIVERY WITH LONG-TERM EFFECT 有权
标题翻译：用于蛋白质递送的单一蛋白质纳米粒子具有长期影响
公开(公告)号：US20110318297A1
公开(公告)日：2011-12-29
申请号：US13255229
申请日：2010-03-09
申请人： Yunfeng Lu , Ming Yan , Juanjuan Du
发明人： Yunfeng Lu , Ming Yan , Juanjuan Du
IPC分类号： A61K47/48 , C08F290/00
CPC分类号： A61K47/48176 , A61K9/0019 , A61K9/5169 , A61K47/58
摘要： A protein nanocapsule having a single-protein core and a thin polymer shell anchored covalently to the protein core.
摘要翻译：具有单蛋白核心和与蛋白质核心共价锚定的薄聚合物壳的蛋白质纳米胶囊。

9. 发明授权

US09993440B2 Enzyme responsive nanocapsules for protein delivery 有权
公开(公告)号：US09993440B2
公开(公告)日：2018-06-12
申请号：US14342524
申请日：2012-09-04
申请人： Yunfeng Lu , Tatiana Segura , Suwei Zhu , Jing Wen
发明人： Yunfeng Lu , Tatiana Segura , Suwei Zhu , Jing Wen
IPC分类号： A61K47/65 , A61K9/51 , A61K38/18 , A61K9/19
CPC分类号： A61K9/5169 , A61K9/19 , A61K9/5138 , A61K9/5192 , A61K38/1866 , A61K47/65
摘要： The invention provides methods of making and using compositions comprising a polymer shell designed to deliver polypeptides to selected environments. In embodiments of the invention, different environmental conditions are harnessed to allow the selective degradation of the polymer shell and the consequential release of one or polypeptides encapsulated therein. In illustrative embodiments, polymer components of the shell are interconnected by peptide-containing crosslinker moieties, linkages which maintain the integrity of the polymer shell under certain environmental conditions, but can also be cleaved when combined with a selected protease.

10. 发明申请

US20080173344A1 NANOSTRUCTURED BULK THERMOELECTRIC MATERIAL 有权
标题翻译：纳米结构热膨胀材料
公开(公告)号：US20080173344A1
公开(公告)日：2008-07-24
申请号：US11933584
申请日：2007-11-01
申请人： Minjuan Zhang , Yunfeng Lu
发明人： Minjuan Zhang , Yunfeng Lu
IPC分类号： H01L35/02 , H01L35/34 , H01L21/04
CPC分类号： H01L35/16 , H01L35/02 , H01L35/12 , H01L35/14 , H01L35/18 , H01L35/22 , H01L35/26 , H01L35/34
摘要： A thermoelectric material includes a composite having a first electrically conducting component and second low thermal conductivity component. The first component may include a semiconductor and the second component may include an inorganic oxide. The thermoelectric composite includes a network of the first component having nanoparticles of the second component dispersed in the network.
摘要翻译：热电材料包括具有第一导电组分和第二低热导率组分的复合材料。第一组分可以包括半导体，第二组分可以包括无机氧化物。热电复合材料包括具有分散在网络中的第二组分的纳米颗粒的第一组分的网络。

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