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1. 发明申请

US20050202492A1 Microarray having probe polynucleotide spots capable of binding to the same target polynucleotide fragment maximally separated from each other and a method of producing the same 审中-公开
标题翻译：具有能够结合相互最大限度分离的相同靶多核苷酸片段的探针多核苷酸点的微阵列及其制备方法
公开(公告)号：US20050202492A1
公开(公告)日：2005-09-15
申请号：US11078601
申请日：2005-03-11
申请人： Yun-sun Nam , Nam Huh , Hyeong-sop Shim , Ji-young Oh
发明人： Yun-sun Nam , Nam Huh , Hyeong-sop Shim , Ji-young Oh
IPC分类号： C12Q1/68 , A61L2/00 , C12M1/34
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00659 , B01J2219/00693 , B01J2219/00722 , C12Q2565/507 , C12Q2565/513
摘要： The present invention relates to a microarray having probe polynucleotide spots capable of binding to the same target polynucleotide fragment maximally separated from each other, and a method of producing the same.
摘要翻译：本发明涉及具有能够结合相互最大限度分离的相同靶多核苷酸片段的探针多核苷酸斑点的微阵列及其制造方法。

2. 发明授权

US07536263B2 Robust genotyping method using DNA chip having discriminating probe and amplicon probe immobilized thereon and DNA chip used therein 失效
标题翻译：使用固定有鉴别探针和扩增子探针的DNA芯片的稳健基因分型方法和其中使用的DNA芯片
公开(公告)号：US07536263B2
公开(公告)日：2009-05-19
申请号：US11019011
申请日：2004-12-21
申请人： Hyeong-sop Shim , Jong-min Kim , Ji-young Oh
发明人： Hyeong-sop Shim , Jong-min Kim , Ji-young Oh
IPC分类号： G06F19/00 , C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6837 , G06F19/20 , C12Q2565/501 , C12Q2545/101 , C12Q2535/131
摘要： Provided is a genotyping method. The genotyping method includes using a DNA chip on which just an optimal probe set is immobilized, the optimal probe sets composed of a discriminating probe which perfectly matches a mutant type gene or a wild type gene for each of at least one identified mutation site in each of at least one amplicon contained in a sample and an amplicon probe having a sequence which perfectly matches a region excluding a nucleotide sequence at a mutation site in each amplicon and is absent from the other amplicons, in order to identify which one of a wild type gene and a mutant type gene is present in each mutation site. In this genotyping method, the number of probes used can be reduced and reliability of genotyping results can be increased.
摘要翻译：提供了一种基因分型方法。基因分型方法包括使用仅固定有最佳探针组的DNA芯片，由每个中至少一个鉴定的突变位点中的每一个完全匹配突变型基因或野生型基因的鉴别探针组成的最佳探针组的样品中包含的至少一个扩增子和扩增子探针，其具有与每个扩增子中的突变位点之外的不包括核苷酸序列的区域完全匹配的序列，并且不存在于其他扩增子中的扩增子探针，以便鉴定野生型中哪一种基因和突变型基因存在于每个突变位点。在这种基因分型方法中，可以减少使用的探针的数量，并且可以提高基因分型结果的可靠性。

3. 发明申请

US20050142599A1 Robust genotyping method using DNA chip having discriminating probe and amplicon probe immobilized thereon and DNA chip used therein 失效
标题翻译：使用固定有鉴别探针和扩增子探针的DNA芯片的稳健基因分型方法和其中使用的DNA芯片
公开(公告)号：US20050142599A1
公开(公告)日：2005-06-30
申请号：US11019011
申请日：2004-12-21
申请人： Hyeong-sop Shim , Jong-min Kim , Ji-young Oh
发明人： Hyeong-sop Shim , Jong-min Kim , Ji-young Oh
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12Q1/6827 , C12Q1/6837 , G06F19/20 , C12Q2565/501 , C12Q2545/101 , C12Q2535/131
摘要： Provided is a genotyping method. The genotyping method includes using a DNA chip on which just an optimal probe set is immobilized, the optimal probe sets composed of a discriminating probe which perfectly matches a mutant type gene or a wild type gene for each of at least one identified mutation site in each of at least one amplicon contained in a sample and an amplicon probe having a sequence which perfectly matches a region excluding a nucleotide sequence at a mutation site in each amplicon and is absent from the other amplicons, in order to identify which one of a wild type gene and a mutant type gene is present in each mutation site. In this genotyping method, the number of probes used can be reduced and reliability of genotyping results can be increased.
摘要翻译：提供了一种基因分型方法。基因分型方法包括使用仅固定有最佳探针组的DNA芯片，由每个中至少一个鉴定的突变位点中的每一个完全匹配突变型基因或野生型基因的鉴别探针组成的最佳探针组的样品中包含的至少一个扩增子和扩增子探针，其具有与每个扩增子中的突变位点之外的不包括核苷酸序列的区域完全匹配的序列，并且不存在于其他扩增子中的扩增子探针，以便鉴定野生型中哪一种基因和突变型基因存在于每个突变位点。在这种基因分型方法中，可以减少使用的探针的数量，并且可以提高基因分型结果的可靠性。

4. 发明申请

US20050186609A1 Method and system of replacing missing genotyping data 审中-公开
标题翻译：替代缺失基因分型数据的方法和系统
公开(公告)号：US20050186609A1
公开(公告)日：2005-08-25
申请号：US11061016
申请日：2005-02-18
申请人： Ji-young Oh , Kyoung-a Kim , Yun-sun Nam , Jeong-gun Lee
发明人： Ji-young Oh , Kyoung-a Kim , Yun-sun Nam , Jeong-gun Lee
IPC分类号： C12Q1/68 , G06F19/18 , G01N33/48 , G01N33/50
CPC分类号： G16B20/00
摘要： A system and method of replacing a missing genotyping data are provided. The method includes: constructing a sample group consisting of a genotyping data with respect to SNP sites of at least one gene samples; comparing a similarity between a sample of the sample group having a missing genotyping data of an SNP site with the other samples of the sample group, and selecting a predetermined number of the samples in order of high similarity; and checking a genotyping data having a greatest frequency occurring in an SNP site disposed at the same position as the SNP site having the missing genotyping data among the selected samples, and replacing the missing genotyping data with the genotyping data having the greatest frequency. It is possible to prevent an incorrect analysis result due to data mismatch, which is caused by data loss.
摘要翻译：提供了一种替代缺失的基因分型数据的系统和方法。该方法包括：构建由至少一个基因样品的SNP位点组成的基因分型数据的样品组; 比较具有SNP位点的缺失基因分型数据的样本组的样本与样本组的其他样本之间的相似性，并且以相似度高的顺序选择预定数量的样本; 并且检查具有最大频率的基因分型数据，其在与选择的样本中具有缺失基因分型数据的SNP位点相同的位置处发生SNP位点，并用具有最大频率的基因分型数据替换丢失的基因分型数据。可以防止由于数据丢失导致的数据不匹配造成的不正确的分析结果。

5. 发明申请

US20050244871A1 Polynucleotide probe having enhanced binding specificity, microarray having the probe immobilized thereon, and method of designing the probe 审中-公开
标题翻译：具有增强的结合特异性的多核苷酸探针，其上固定有探针的微阵列，以及设计探针的方法
公开(公告)号：US20050244871A1
公开(公告)日：2005-11-03
申请号：US11110281
申请日：2005-04-20
申请人： Ji-young Oh , Nam Huh
发明人： Ji-young Oh , Nam Huh
IPC分类号： G01N33/53 , C12M1/00 , C12N15/09 , G01N37/00 , C12Q1/68 , G06F19/00 , G01N33/48 , G01N33/50
CPC分类号： C12Q1/6832 , C12Q2527/107
摘要： An oligonucleotide probe, a microarray having the probe immobilized thereon, and a method of designing the probe are provided. In the oligonucleotide probe, a difference between a hybridization temperature (Tm) of an oligonucleotide sequence including the first nucleotide in the direction of 5′ end from a nucleotide corresponding to a target site through 5′ end nucleotide and an oligonucleotide sequence complementary thereto and a hybridization temperature (Tm) of an oligonucleotide sequence including the first nucleotide in the direction of 3′ end from the nucleotide corresponding to the target site through 3′ end nucleotide and an oligonucleotide sequence complementary thereto is not greater than 5° C.
摘要翻译：提供寡核苷酸探针，其上固定有探针的微阵列和设计探针的方法。在寡核苷酸探针中，从对应于目标部位至5'末端核苷酸的核苷酸的核苷酸对应的5'末端方向的第一核苷酸的寡核苷酸序列与其互补的寡核苷酸序列的杂交温度（Tm）与通过3'末端核苷酸对应于目标部位的核苷酸和与其互补的寡核苷酸序列，在3'末端方向上包含第1个核苷酸的寡核苷酸序列的杂交温度（Tm）不大于5℃。

6. 发明申请

US20060246473A1 Primer set capable of specifically amplifying a target sequence found in 10 bacterial species and probe oligonucleotide specifically hybridizable with each target sequence of the 10 bacterial species 有权
公开(公告)号：US20060246473A1
公开(公告)日：2006-11-02
申请号：US11317601
申请日：2005-12-23
申请人： Ji-young Oh , Nam Huh , Sang-hyun Peak , Sung-young Jeong
发明人： Ji-young Oh , Nam Huh , Sang-hyun Peak , Sung-young Jeong
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/689
摘要： Provided are a primer set for amplifying a target sequence specific to Bordetella pertussis, Chlamydophila pneumoniae, Haemophilus influenzae, Klebsiella pneumoniae, Legionella pneumophila, Moraxella catarrhalis, Mycoplasma pneumoniae, Pseudomonas aeruginosa, Stapylococcus aureus, and Streptococcus pneumoniae, the primer set including at least one oligonucleotide of 10 to 100 nucleotides in length, selected from the group consisting of oligonucleotides each of which comprises a fragment of at least 10 contiguous nucleotides present in a sequence as set forth in SEQ ID NO: 1 and at least one oligonucleotides of 10 to 100 nucleotides in length, selected from the group consisting of oligonucleotides each of which comprises a fragment of at least 10 contiguous nucleotides present in a sequence as set forth in SEQ ID NO: 2; and probes specific to a specific species of the 10 bacterial species.

7. 发明申请

US20060177849A1 Nucleic acid primer set, nucleic acid probe set and method for detecting respiratory disease virus using the primer set and probe set 审中-公开
标题翻译：核酸引物组，核酸探针组和使用引物组和探针组检测呼吸系统疾病病毒的方法
公开(公告)号：US20060177849A1
公开(公告)日：2006-08-10
申请号：US11318240
申请日：2005-12-23
申请人： Ji-young Oh , Nam Huh , Jung-nam Lee
发明人： Ji-young Oh , Nam Huh , Jung-nam Lee
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/701 , C12Q1/705
摘要： Provided are a nucleic acid primer set capable of simultaneously amplifying the target sequences of five or more respiratory disease viruses and including oligonucleotides each of which comprises a fragment of at least 10 contiguous nucleotides present in sequences as set forth SEQ ID NOS: 1-26, a nucleic acid probe set for detecting the amplified product and a method of simultaneously detecting five or more respiratory disease viruses using the primer set.
摘要翻译：提供了能够同时扩增五种或更多种呼吸道疾病病毒的靶序列并包括寡核苷酸的核酸引物组，其各自包含以SEQ ID NO：1-26所示的序列存在的至少10个连续核苷酸的片段，用于检测扩增产物的核酸探针组和使用引物组同时检测五种或更多种呼吸道疾病病毒的方法。

8. 发明授权

US07553626B2 Primer set capable of specifically amplifying a target sequence found in 10 bacterial species and probe oligonucleotide specifically hybridizable with each target sequence of the 10 bacterial species 有权
标题翻译：能够特异性扩增在10种细菌物种中发现的靶序列的引物组和与10种细菌物种的每个靶序列特异性杂交的探针寡核苷酸
公开(公告)号：US07553626B2
公开(公告)日：2009-06-30
申请号：US11317601
申请日：2005-12-23
申请人： Ji-young Oh , Nam Huh , Sang-hyun Peak , Sung-young Jeong
发明人： Ji-young Oh , Nam Huh , Sang-hyun Peak , Sung-young Jeong
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/689
摘要： Provided are a primer set for amplifying a target sequence specific to Bordetella pertussis, Chlamydophila pneumoniae, Haemophilus influenzae, Klebsiella pneumoniae, Legionella pneumophila, Moraxella catarrhalis, Mycoplasma pneumoniae, Pseudomonas aeruginosa, Stapylococcus aureus, and Streptococcus pneumoniae, the primer set including at least one oligonucleotide of 10 to 100 nucleotides in length, selected from the group consisting of oligonucleotides each of which comprises a fragment of at least 10 contiguous nucleotides present in a sequence as set forth in SEQ ID NO: 1 and at least one oligonucleotides of 10 to 100 nucleotides in length, selected from the group consisting of oligonucleotides each of which comprises a fragment of at least 10 contiguous nucleotides present in a sequence as set forth in SEQ ID NO: 2; and probes specific to a specific species of the 10 bacterial species.
摘要翻译：本发明提供一种引物组，其用于扩增百日盛博氏杆菌，肺炎衣原体，流感嗜血杆菌，肺炎克雷伯杆菌，嗜肺军团杆菌，卡他莫拉菌，肺炎支原体，铜绿假单胞菌，金黄色葡萄球菌和肺炎链球菌特异性的靶序列，所述引物组包括至少一种长度为10至100个核苷酸的寡核苷酸，选自寡核苷酸，每个寡核苷酸包含存在于如SEQ ID NO：1所示的序列中的至少10个连续核苷酸的片段和10至100个的至少一个寡核苷酸长度的核苷酸，选自寡核苷酸，每个寡核苷酸包含存在于如SEQ ID NO：2所示的序列中的至少10个连续核苷酸的片段; 并探测10种细菌物种的特定物种。

9. 发明申请

US20060204995A1 Method of designing probe set, probe set designed by the method, microarray comprising the probe set, computer readable medium recorded thereon program to execute the method, and method of identifying target sequence using the probe set 审中-公开
标题翻译：设置探针组，通过该方法设计的探针组的方法，包括探针组的微阵列，在其上记录的计算机可读介质程序以执行该方法，以及使用探针组识别靶序列的方法
公开(公告)号：US20060204995A1
公开(公告)日：2006-09-14
申请号：US11370433
申请日：2006-03-08
申请人： Ji-young Oh , Kyu-sang Lee , Tae-joon Kwon
发明人： Ji-young Oh , Kyu-sang Lee , Tae-joon Kwon
IPC分类号： C12Q1/68 , G06F19/00 , C07H21/04 , C12M1/34
CPC分类号： G16B25/00 , G16B30/00
摘要： A method of designing a probe set for identification of target sequences is provided. Also, a probe set designed by the method, a microarray including the probe set, a computer readable medium recorded thereon a program to execute the method, and a method of identifying target sequences using the probe set are provided. Accordingly, a probe set which can rapidly identify a number of target sequences and accurately identify target sequences even when two or more target sequences coexist in a sample can be readily designed.
摘要翻译：提供了一种设计用于识别目标序列的探针组的方法。此外，提供了通过该方法设计的探针组，包括探针组的微阵列，在其上记录有执行该方法的程序的计算机可读介质，以及使用探针组识别靶序列的方法。因此，即使当两个或多个目标序列共存在样本中时，也可以容易地设计能够快速识别多个目标序列并准确地识别靶序列的探针组。

10. 发明申请

US20050186670A1 Method of detecting error spot in DNA chip and system using the method 审中-公开
标题翻译：使用该方法检测DNA芯片和系统误差点的方法
公开(公告)号：US20050186670A1
公开(公告)日：2005-08-25
申请号：US11061018
申请日：2005-02-18
申请人： Ji-young Oh
发明人： Ji-young Oh
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N37/00 , G06F19/00 , G06F19/20 , G11B7/00 , G01B11/26 , C12M1/34
CPC分类号： G16B25/00
摘要： Provided are a method of detecting an error spot and a system using the method. The method includes analyzing a difference in variances of a background intensity and a foreground intensity for each spot in a DNA chip, verifying whether the mean of the background intensity and the mean of the foreground intensity are significantly different from each other based on the difference in variances, and judging an error spot based on the results of the verifying operation. Thus, the reliability in statistical analysis can be increased by excluding the error spot in the statistical analysis.
摘要翻译：提供了一种使用该方法检测错误点的方法和系统。该方法包括分析DNA芯片中每个斑点的背景强度和前景强度的差异的差异，验证背景强度的平均值和前景强度的平均值是否彼此显着不同根据验证操作的结果判断错误点。因此，可以通过排除统计分析中的误差点来增加统计分析中的可靠性。

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