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1. 发明授权

US06563002B2 Biscyclopropanecarboxamide compounds and pharmaceutical use thereof 失效
公开(公告)号：US06563002B2
公开(公告)日：2003-05-13
申请号：US10085073
申请日：2002-03-01
申请人： Yukio Iino , Kohichi Fujita , Takashi Yamamoto , Kenji Takehana , Tsuyoshi Kobayashi
发明人： Yukio Iino , Kohichi Fujita , Takashi Yamamoto , Kenji Takehana , Tsuyoshi Kobayashi
IPC分类号： C07C23357
CPC分类号： C07D213/75 , C07C233/60 , C07C233/62 , C07C317/22 , C07C2601/02
摘要： The present invention discloses biscyclopropanecarboxamide compounds and pharmaceutically acceptable salts thereof; and also NF-kappa B activation inhibitors, Inflammatory cytokine production inhibitors, matrix metalloprotease production inhibitors, inflammatory cell adhesion molecules incidence inhibitors, antiinflammatory agents, antirheumatic agents, immunosuppressive agents, cancerous metastasis inhibitors or antiviral agents each containing such a compound as the active ingredient.

2. 发明授权

US07459585B2 Benzene derivatives and pharmaceutical use thereof 失效
标题翻译：苯衍生物及其药物用途
公开(公告)号：US07459585B2
公开(公告)日：2008-12-02
申请号：US11087531
申请日：2005-03-24
申请人： Yukio Iino , Kohichi Fujita , Takashi Tsuji , Ariko Kodaira , Kenji Takehana , Tsuyoshi Kobayashi , Takashi Yamamoto
发明人： Yukio Iino , Kohichi Fujita , Takashi Tsuji , Ariko Kodaira , Kenji Takehana , Tsuyoshi Kobayashi , Takashi Yamamoto
IPC分类号： C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C309/66 , C07C311/21 , C07D209/38 , C07D209/48 , C07D211/78
CPC分类号： C07D209/48 , C07B2200/05 , C07B2200/07 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/38 , C07C235/56 , C07C237/20 , C07C237/42 , C07C247/10 , C07C251/48 , C07C255/44 , C07C309/66 , C07C311/46 , C07C317/40 , C07C323/40 , C07C2601/02 , C07D207/16 , C07D209/76 , C07D213/81
摘要： The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammatory agent, antirheumatic agent, immunosuppressant, cancer metastasis inhibitor, remedy for arteriosclerosis and antiviral agent which contain the benzene derivative of the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明提供了AP-1活化抑制剂，NF-κB活化抑制剂，炎性细胞因子产生抑制剂，基质金属蛋白酶产生抑制剂，炎症细胞粘附分子表达抑制剂，抗炎剂，抗风湿剂，免疫抑制剂，癌症转移抑制剂用于含有下列通式（I）的苯衍生物或其药学上可接受的盐作为活性成分的动脉硬化和抗病毒剂。

3. 发明授权

US06703379B2 Benzene derivatives and pharmaceutical use thereof 失效
标题翻译：苯衍生物及其药物用途
公开(公告)号：US06703379B2
公开(公告)日：2004-03-09
申请号：US09803107
申请日：2001-03-12
申请人： Yukio Iino , Kohichi Fujita , Takashi Tsuji , Ariko Kodaira , Kenji Takehana , Tsuyoshi Kobayashi , Takashi Yamamoto
发明人： Yukio Iino , Kohichi Fujita , Takashi Tsuji , Ariko Kodaira , Kenji Takehana , Tsuyoshi Kobayashi , Takashi Yamamoto
IPC分类号： C07C23360
CPC分类号： C07D209/48 , C07B2200/05 , C07B2200/07 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/38 , C07C235/56 , C07C237/20 , C07C237/42 , C07C247/10 , C07C251/48 , C07C255/44 , C07C309/66 , C07C311/46 , C07C317/40 , C07C323/40 , C07C2601/02 , C07D207/16 , C07D209/76 , C07D213/81
摘要： The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammatory agent, antirheumatic agent, immunosuppressant, cancer metastasis inhibitor, remedy for arteriosclerosis and antiviral agent which contain the benzene derivative of the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明提供了AP-1活化抑制剂，NF-κB活化抑制剂，炎性细胞因子产生抑制剂，基质金属蛋白酶产生抑制剂，炎症细胞粘附分子表达抑制剂，抗炎剂，抗风湿剂，免疫抑制剂，癌症转移抑制剂用于含有下列通式（I）的苯衍生物或其药学上可接受的盐作为活性成分的动脉硬化和抗病毒剂。

4. 发明申请

US20050165114A1 Benzene derivatives and pharmaceutical use thereof 失效
标题翻译：苯衍生物及其药物用途
公开(公告)号：US20050165114A1
公开(公告)日：2005-07-28
申请号：US11087531
申请日：2005-03-24
申请人： Yukio Iino , Kohichi Fujita , Takashi Tsuji , Ariko Kodaira , Kenji Takehana , Tsuyoshi Kobayashi , Takashi Yamamoto
发明人： Yukio Iino , Kohichi Fujita , Takashi Tsuji , Ariko Kodaira , Kenji Takehana , Tsuyoshi Kobayashi , Takashi Yamamoto
IPC分类号： C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/38 , C07C235/56 , C07C237/20 , C07C237/42 , C07C247/10 , C07C251/48 , C07C255/44 , C07C309/66 , C07C311/46 , C07C317/40 , C07C323/40 , C07D207/16 , C07D209/48 , C07D209/76 , C07D213/81 , C07D491/18 , A61K31/165
CPC分类号： C07D209/48 , C07B2200/05 , C07B2200/07 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/38 , C07C235/56 , C07C237/20 , C07C237/42 , C07C247/10 , C07C251/48 , C07C255/44 , C07C309/66 , C07C311/46 , C07C317/40 , C07C323/40 , C07C2601/02 , C07D207/16 , C07D209/76 , C07D213/81
摘要： The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammatory agent, antirheumatic agent, immunosuppressant, cancer metastasis inhibitor, remedy for arteriosclerosis and antiviral agent which contain the benzene derivative of the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明提供了AP-1活化抑制剂，NF-κB活化抑制剂，炎性细胞因子产生抑制剂，基质金属蛋白酶产生抑制剂，炎症细胞粘附分子表达抑制剂，抗炎剂，抗风湿剂，免疫抑制剂，癌症转移抑制剂用于含有下列通式（I）的苯衍生物或其药学上可接受的盐作为活性成分的动脉硬化和抗病毒剂。

5. 发明授权

US06794378B2 Heterocyclic compounds and medical use thereof 失效
标题翻译：杂环化合物及其医疗用途
公开(公告)号：US06794378B2
公开(公告)日：2004-09-21
申请号：US10029871
申请日：2001-12-31
申请人： Yukio Iino , Koichi Fujita , Ariko Kodaira , Toshihiro Hatanaka , Kenji Takehana , Tsuyoshi Kobayashi , Atsushi Konishi , Takashi Yamamoto
发明人： Yukio Iino , Koichi Fujita , Ariko Kodaira , Toshihiro Hatanaka , Kenji Takehana , Tsuyoshi Kobayashi , Atsushi Konishi , Takashi Yamamoto
IPC分类号： A61K3133
CPC分类号： C07D213/75 , C07D211/58 , C07D237/22 , C07D239/48 , C07D277/46
摘要： The present invention provides an AP-1 activation inhibitor, a NF-kappaB activation inhibitor, an inflammatory cytokine production inhibitor, a production inhibitor for matrix metalloprotease or an inflammatory cell adhesion factor expression inhibitor, which contains a heterocyclic compound or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明提供了含有杂环化合物或其药学上可接受的盐的AP-1活化抑制剂，NF-κB活化抑制剂，炎性细胞因子产生抑制剂，基质金属蛋白酶的产生抑制剂或炎症细胞粘附因子表达抑制剂作为活性成分。

6. 发明申请

US20140123158A1 MOLD FOR TAPE-SHAPED OPTICAL RECORDING MEDIUM, TAPE-SHAPED OPTICAL RECORDING MEDIUM, AND CUTTING DEVICE THEREFOR 审中-公开
标题翻译：胶带形光学记录介质，带状光学记录介质及其切割装置的模具
公开(公告)号：US20140123158A1
公开(公告)日：2014-05-01
申请号：US14128418
申请日：2012-07-26
申请人： Yoshifumi Makino , Mitsuhiro Tanaka , Kenji Takehana
发明人： Yoshifumi Makino , Mitsuhiro Tanaka , Kenji Takehana
IPC分类号： G11B7/003 , G11B3/00
CPC分类号： G11B7/0031 , G11B3/00 , G11B7/24009 , G11B7/263 , Y10T83/141
摘要： There is provided a mold for a tape-shaped optical recording medium with which precise cutting can be performed along a cutting guide groove, the mold forming a recording groove in a tape-shaped optical recording medium, and having a plurality of recording and reproduction bumps that form a recording and reproduction groove, and a guide whose shape is different from that of the recording and reproduction bumps.
摘要翻译：提供了一种用于带状光学记录介质的模具，可以沿着切割引导槽进行精确的切割，模具在带状光学记录介质中形成记录槽，并且具有多个记录和再现凸块形成记录和再现凹槽，以及与记录和再现凸块的形状不同的引导件。

7. 发明申请

US20080175837A1 DPP4 INHIBITOR AND PHARMACEUTICAL USE THEREOF 审中-公开
标题翻译： DPP4抑制剂及其药物用途
公开(公告)号：US20080175837A1
公开(公告)日：2008-07-24
申请号：US11927051
申请日：2007-10-29
申请人： Chiori Ijichi , Naoyuki Yamada , Toshihiro Hatanaka , Kenji Takehana , Giovanni Miotto , Oriano Marin , Andrea Carpi , Denis Bertaggia
发明人： Chiori Ijichi , Naoyuki Yamada , Toshihiro Hatanaka , Kenji Takehana , Giovanni Miotto , Oriano Marin , Andrea Carpi , Denis Bertaggia
IPC分类号： A61K39/395 , A61K38/05 , A61P3/10 , A61P3/04 , C07C229/04 , G01N33/53 , A61P25/22 , C07K16/40
CPC分类号： A61K31/195 , C07K16/2896 , C07K16/40
摘要： The present invention provides a Dpp4 inhibitor which comprises a leucine derivative of the following formula (1) or a methionine derivative of the following formula (2): wherein each R1 and R3 represents a hydrogen atom (H) and an L-amino acid residue; R2 represents a hydroxyl group (OH), alkoxy group having 1 to 6 carbon atoms, amino group (NH2), alkylamino group having 1 to 6 carbon atoms, glycine residue, β-alanine residue, L-amino acid (except for proline, alanine and phenylalanine) residue or L-amino-acid amide (except for proline amide, alanine amide and phenylalanine amide) residue; and R4 represents a hydroxyl group (OH), alkoxy group having 1 to 6 carbon atoms, amino group (NH2), alkylamino group having 1 to 6 carbon atoms, glycine residue, β-alanine residue, L-amino acid (except for proline and alanine) residue or L-amino-acid amide (except for proline amide and alanine amide) residue. These derivatives also act as autophagy regulators.
摘要翻译：本发明提供一种Dpp4抑制剂，其包含下式（1）的亮氨酸衍生物或下式（2）的甲硫氨酸衍生物：其中R 1和R 3表示氢原子（H）和L-氨基酸残基 ; R2表示羟基（OH），碳原子数1〜6的烷氧基，氨基（NH2），碳原子数1〜6的烷基氨基，甘氨酸残基，β-丙氨酸残基，L-氨基酸（脯氨酸，丙氨酸和苯丙氨酸）残基或L-氨基酸酰胺（脯氨酸酰胺，丙氨酸酰胺和苯丙氨酸酰胺除外）残基; R 4表示羟基（OH），碳原子数1〜6的烷氧基，氨基（NH 2），碳原子数1〜6的烷基氨基，甘氨酸残基，β-丙氨酸残基，L-氨基酸（脯氨酸和丙氨酸）残基或L-氨基酸酰胺（除脯氨酰胺和丙氨酸酰胺除外）残基。这些衍生物也作为自噬调节剂。

8. 发明申请

US20080138846A1 Method for Analysis of Albumin in Sample Solution 有权
标题翻译：样品溶液中白蛋白的分析方法
公开(公告)号：US20080138846A1
公开(公告)日：2008-06-12
申请号：US12019675
申请日：2008-01-25
申请人： Kazuyuki Kubota , Naoyuki Yamada , Kenji Takehana , Asami Kawakami , Akira Nakayama
发明人： Kazuyuki Kubota , Naoyuki Yamada , Kenji Takehana , Asami Kawakami , Akira Nakayama
IPC分类号： C12Q1/37 , G01N33/50
CPC分类号： G01N30/88 , G01N2030/8813 , G01N2030/8822 , G01N2030/8831
摘要： The present invention provides a method of analyzing albumin in a sample solution, which is characterized by pretreating a sample solution before subjecting the sample solution to mass spectrometry or liquid chromatography. The present invention further provides a method of accurately and stably analyzing the amount and ratio of oxidized and reduced albumin in a sample solution, and an albumin standard accurate and controlled quantitative analysis of albumin.
摘要翻译：本发明提供一种分析样品溶液中的白蛋白的方法，其特征在于在对样品溶液进行质谱或液相色谱进行前处理样品溶液。本发明还提供了准确且稳定地分析样品溶液中氧化和还原白蛋白的量和比例以及白蛋白标准品精确和可控的白蛋白定量分析的方法。

9. 发明授权

US07833798B2 Method for analysis of albumin in sample solution 有权
标题翻译：样品溶液中白蛋白的分析方法
公开(公告)号：US07833798B2
公开(公告)日：2010-11-16
申请号：US12019675
申请日：2008-01-25
申请人： Kazuyuki Kubota , Naoyuki Yamada , Kenji Takehana , Asami Kawakami , Akira Nakayama
发明人： Kazuyuki Kubota , Naoyuki Yamada , Kenji Takehana , Asami Kawakami , Akira Nakayama
IPC分类号： G01N33/50 , G01N33/00 , C12Q1/37
CPC分类号： G01N30/88 , G01N2030/8813 , G01N2030/8822 , G01N2030/8831
摘要： The present invention provides a method of analyzing albumin in a sample solution, which is characterized by pretreating a sample solution before subjecting the sample solution to mass spectrometry or liquid chromatography. The present invention further provides a method of accurately and stably analyzing the amount and ratio of oxidized and reduced albumin in a sample solution, and an albumin standard accurate and controlled quantitative analysis of albumin.
摘要翻译：本发明提供一种分析样品溶液中的白蛋白的方法，其特征在于在对样品溶液进行质谱或液相色谱进行前处理样品溶液。本发明还提供了准确且稳定地分析样品溶液中氧化和还原白蛋白的量和比例以及白蛋白标准品精确和可控的白蛋白定量分析的方法。

10. 发明申请

US20090291928A1 COMPOSITION FOR AMELIORATION/PREVENTION OF ADVERSE SIDE EFFECT IN STEROID THERAPY 审中-公开
标题翻译：用于治疗或预防非甾体类药物不良反应的组合物
公开(公告)号：US20090291928A1
公开(公告)日：2009-11-26
申请号：US12483846
申请日：2009-06-12
申请人： Shinobu Nishitani , Kenji Takehana
发明人： Shinobu Nishitani , Kenji Takehana
IPC分类号： A61K31/56 , A61K31/198 , A61P21/00
CPC分类号： A61K31/198 , A23L33/175
摘要： Provided is a composition containing isoleucine, leucine and valine as active ingredients for improving or suppressing side effects associated with a steroid treatment and a composition for suppressing muscular atrophy-related gene. The composition improves or suppresses side effects in a steroid treatment such as muscular atrophy, muscular pain, arthritic pain, impaired glucose tolerance, decreased bone metabolism, impaired immunity, loss of appetite, body weight loss, fatigability and the like, and further suppresses muscular atrophy associated with various diseases. In addition, the composition suppresses muscular atrophy associated with promoted expression of muscular atrophy-related gene associated with glucocorticoid excess or renal failure pathology and the like. Therefore, the composition is effective form improving the QOL of patients.
摘要翻译：本发明提供含有异亮氨酸，亮氨酸，缬氨酸作为改善或抑制类固醇治疗副作用的有效成分的组合物和抑制肌萎缩相关基因的组合物。该组合物改善或抑制类固醇治疗中的副作用，例如肌肉萎缩，肌肉疼痛，关节炎疼痛，葡萄糖耐量降低，骨代谢减少，免疫力下降，食欲不振，体重减轻，疲劳等，并进一步抑制肌肉与各种疾病相关的萎缩。此外，该组合物抑制与促进与糖皮质激素过量或肾衰竭病理学相关的肌肉萎缩相关基因的表达相关的肌肉萎缩等。因此，组合物有效地改善了患者的生活质量。

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