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    • 2. 发明授权
    • Indole derivative for treating overproduction of dihydrotestosterone
    • 用于治疗二氢睾酮过量产生的吲哚衍生物
    • US5760040A
    • 1998-06-02
    • US714079
    • 1997-05-05
    • Kiyoshi YoshidaTadashi KurimotoMineo TakeiHiroki Sato
    • Kiyoshi YoshidaTadashi KurimotoMineo TakeiHiroki Sato
    • C07D209/12A61K31/405A61K31/495C07D403/10
    • C07D209/12
    • The present invention relates to an indole derivative represented by formula (1) or a salt thereof, and a pharmaceutical containing the derivative or the salt: ##STR1## wherein R.sup.1 represents lower alkyl; R.sup.2 represents hydrogen or phenyl which may be substituted by at least one lower alkyl, lower alkoxy or a halogen atom; R.sup.3 represents hydrogen, lower alkyl, lower alkoxy, or phenylalkyloxy which may be substituted by halogen or lower alkyl; R.sup.4 represents hydrogen, lower alkyl or lower alkoxy; R.sup.5 represents hydrogen or lower alkyl; and n represents an integer of 1 to 5. This compound has the effects of both blocking .alpha..sub.1 -adrenergic receptors and inhibiting testosterone 5.alpha.-reductases, and is useful as a remedy and/or a preventive for diseases caused by dihydrotestosterone overproduction, such as prostatic hypertrophy, and diseases accompanying the same, such as urination disorder, male pattern alopecia, acne, and so forth.
    • PCT No.PCT / JP95 / 00599 Sec。 371日期:1997年5月5日 102(e)日期1997年5月5日PCT提交1995年3月29日PCT公布。 第WO95 / 26955号公报 日期:1995年10月12日本发明涉及式(1)表示的吲哚衍生物或其盐,以及含有该衍生物或其盐的药物:其中R1表示低级烷基; R2代表氢或可被至少一个低级烷基,低级烷氧基或卤原子取代的苯基; R 3表示可被卤素或低级烷基取代的氢,低级烷基,低级烷氧基或苯基烷氧基; R4代表氢,低级烷基或低级烷氧基; R5代表氢或低级烷基; 并且n表示1至5的整数。该化合物具有阻断α1-肾上腺素能受体和抑制睾酮5α-还原酶的作用,并且可用作二氢睾酮过量产生引起的疾病的补救和/或预防,例如 作为前列腺肥大,以及伴随的疾病,例如排尿障碍,男性脱发,痤疮等。
    • 3. 发明授权
    • Solid-state image pickup device and signal processing method therefor
    • 固态摄像装置及其信号处理方法
    • US09041827B2
    • 2015-05-26
    • US11655201
    • 2007-01-19
    • Hiroki SatoKeiji MabuchiNobuo NakamuraTetsuya Iizuka
    • Hiroki SatoKeiji MabuchiNobuo NakamuraTetsuya Iizuka
    • H04N5/228H04N5/335H04N3/14
    • H04N5/335
    • The invention makes it possible to perform effective A/D conversion on pixel signals read from a pixel array part, to achieve a reduction in power consumption and reductions in the size and the price of an image pickup device as well as simplification of the construction of the device, and to realize a high-quality image output. The device includes an pixel array part having a plurality of unit pixels, a CDS (correlated double sampling) circuit, and an A/D converter. A pixel signal read from a pixel array part via a signal line is subjected to CDS processing (noise elimination processing) in the CDS circuit, and then this pixel signal is inputted into the A/D converter which performs A/D conversion on the pixel signal. The A/D converter includes a ΔΣ modulator and a digital filter to perform highly accurate A/D conversion. The invention can also be applied to a construction in which an A/D converter is provided at the front stage of the CDS circuit.
    • 本发明使得可以对从像素阵列部分读取的像素信号进行有效的A / D转换,以实现图像拾取装置的功耗的降低和尺寸和价格的降低以及简化的 该设备,并实现高质量的图像输出。 该装置包括具有多个单位像素的像素阵列部分,CDS(相关双采样)电路和A / D转换器。 经由信号线从像素阵列部分读取的像素信号在CDS电路中进行CDS处理(噪声消除处理),然后将该像素信号输入到对像素进行A / D转换的A / D转换器 信号。 A / D转换器包括&Dgr& 调制器和数字滤波器,以执行高精度的A / D转换。 本发明也可以应用于在CDS电路的前级设置A / D转换器的结构。