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1. 发明授权

US5409815A DNA's encoding signal peptides 失效
标题翻译： DNA编码信号肽
公开(公告)号：US5409815A
公开(公告)日：1995-04-25
申请号：US311556
申请日：1989-02-16
申请人： Yukimitsu Nakagawa , Naofumi Hayasuke , Atsushi Masaki , Yutaka Ishida , Kohji Murakami , Ken Okabayashi , Kiyoshi Tsutsui , Hitoshi Minamino , Kazuo Ikegaya , Kaoru Kobayashi , Haruhide Kawabe , Sadao Ueda
发明人： Yukimitsu Nakagawa , Naofumi Hayasuke , Atsushi Masaki , Yutaka Ishida , Kohji Murakami , Ken Okabayashi , Kiyoshi Tsutsui , Hitoshi Minamino , Kazuo Ikegaya , Kaoru Kobayashi , Haruhide Kawabe , Sadao Ueda
IPC分类号： C12N15/09 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/705 , C07K14/765 , C07K19/00 , C12N1/16 , C12N15/62 , C12N15/81 , C12P21/02 , C12R1/865 , C12P21/06 , C07H21/04
CPC分类号： C12N15/81 , C07K14/765 , C12N15/625 , C07K2319/02 , C07K2319/55 , C07K2319/61
摘要： Novel signal peptides capable of functioning in yeasts have the amino acid sequence:Met-A.sub.1 -A.sub.2 -X-B-C-D-E-Fwherein A.sub.1 is a peptide chain composed of 1-3 amino acids each selected from the group consisting of Arg, Ser, Lys and His, A.sub.2 is a peptide chain composed of 1-3 amino acids, X is a peptide chain composed of 8-10 hydrophobic amino acids, B is Pro or Ser, C is Gly or Pro, D Cys, Ala, Leu, Ser, Thr and Val, E is Trp or Gln and F is Ala or Gly. DNA sequences coding for these signal peptides can be used for the secretory expression of heterologous proteins in yeasts.
摘要翻译：能够在酵母中起作用的新型信号肽具有氨基酸序列：Met-A1-A2-XBCDEF，其中A1是由1-3个氨基酸组成的肽链，每个氨基酸选自Arg，Ser，Lys和His，A2 是由1-3个氨基酸组成的肽链，X是由8-10个疏水性氨基酸组成的肽链，B是Pro或Ser，C是Gly或Pro，D Cys，Ala，Leu，Ser，Thr和Val ，E是Trp或Gln，F是Ala或Gly。编码这些信号肽的DNA序列可用于酵母中异源蛋白质的分泌表达。

2. 发明授权

US4945046A Yeast promoter and process for preparing heterologous protein 失效
标题翻译：酵母启动子和异源蛋白质的制备方法
公开(公告)号：US4945046A
公开(公告)日：1990-07-31
申请号：US57143
申请日：1987-06-03
申请人： Hajime Horii , Haruhide Kawabe , Hirofumi Arimura , Hiromichi Mukai , Kaoru Kobayashi , Muneo Tsujikawa , Masayuki Nishida , Tadakazu Suyama
发明人： Hajime Horii , Haruhide Kawabe , Hirofumi Arimura , Hiromichi Mukai , Kaoru Kobayashi , Muneo Tsujikawa , Masayuki Nishida , Tadakazu Suyama
IPC分类号： C07K14/02 , C12N15/81
CPC分类号： C07K14/005 , C12N15/81 , C12N2730/10122
摘要： A method of producing a heterologous protein in yeast is disclosed, which comprises transforming a yeast Saccharomyces cerevisiae with recombinant DNA comprising a promoter selected from the group consisting of a yeast promoter or a hybrid promoter derived from a yeast promoter, particularly a hybrid promoter containing the enhancer region of SV40 virus, and a gene coding for a heterologous protein such as HBsAg and Pre S-HBsAg, particularly full length Pre S-HBsAg culturing, the resulting transformed cells to express the gene coding the heterologous protein, and isolating the heterologous protein from the cultured medium. GAP-DH and PH05 promoters and miniaturized ones can be used as the yeast promoter. The expression of the full length Pre S-HBsAg is carried out in the same expression system as that for 2nd or 3rd Pre S-ABsAg.
摘要翻译：公开了一种在酵母中产生异源蛋白质的方法，其包括用包含启动子的重组DNA转化酵母酿酒酵母，所述启动子选自酵母启动子或源自酵母启动子的杂合启动子，特别是含有 SV40病毒的增强子区和编码异源蛋白如HBsAg和Pre S-HBsAg的基因，特别是全长Pre S-HBsAg培养，所得转化细胞表达编码异源蛋白的基因，并分离异源蛋白从培养基中。 GAP-DH和PH05启动子和小型化可用作酵母启动子。全长前S-HBsAg的表达在与第2或第3前S-ABsAg相同的表达系统中进行。

3. 发明申请

US20120218048A1 OSCILLATION DEVICE 失效
标题翻译：振荡器件
公开(公告)号：US20120218048A1
公开(公告)日：2012-08-30
申请号：US13406694
申请日：2012-02-28
申请人： Kazuo Akaike , Kaoru Kobayashi
发明人： Kazuo Akaike , Kaoru Kobayashi
IPC分类号： H03L7/00
CPC分类号： H03L1/00
摘要： Provided is an oscillation device capable of obtaining a stable oscillation frequency by compensating for a change in oscillation frequency caused with an elapse of operating time of a quartz-crystal oscillator. A difference value ΔF between a frequency difference between first and second quartz-crystal oscillators after a predetermined period of time has elapsed from a reference time and a frequency difference between the first and second quartz-crystal oscillators at the reference time is determined.
摘要翻译：提供一种能够通过补偿由石英晶体振荡器的经过时间引起的振荡频率变化而获得稳定的振荡频率的振荡装置。确定从参考时间起经过了预定时间段之后的第一和第二石英晶体振荡器之间的频率差与基准时刻的第一和第二石英晶体振荡器之间的频率差的差值Dgr; F。

4. 发明授权

US08228970B2 Signal processing device and wireless apparatus 有权
标题翻译：信号处理装置和无线装置
公开(公告)号：US08228970B2
公开(公告)日：2012-07-24
申请号：US12213881
申请日：2008-06-25
申请人： Kaoru Kobayashi , Shigeru Takegishi , Nobuo Tsukamoto
发明人： Kaoru Kobayashi , Shigeru Takegishi , Nobuo Tsukamoto
IPC分类号： H04B1/00
CPC分类号： H04B1/707
摘要： There is provided a signal processing device and a wireless apparatus capable of not erroneously determining polarity, appropriately performing a spread modulation process, a carrier modulation process, and reception data demodulation process, improving reception accuracy, and miniaturizing a circuit, even when IF carrier frequency shift occurs. The signal processing device and the wireless apparatus includes a spread modulation unit which includes a first differential encoding process section for performing a differential encoding process on a reception data, a differential encoding process section for performing a second differential encoding process on the output, and a spread modulation process section for performing a spread modulation process on the output using a spread code; a carrier modulation unit which quadrature-modulates a transmission data spread modulation signal and a continuous wave; and a reception data decoding unit which performs a correlation process twice and a delay detection process twice.
摘要翻译：提供了一种能够不错误地确定极性的信号处理装置和无线装置，适当地执行扩频调制处理，载波调制处理和接收数据解调处理，提高接收精度和使电路小型化，即使在IF载波频率班次发生。信号处理装置和无线装置包括扩展调制部，其包括对接收数据进行差分编码处理的第一差分编码处理部，对输出进行第二差分编码处理的差分编码处理部，扩展调制处理部分，用于使用扩展码对输出进行扩展调制处理; 载波调制单元，对发送数据扩展调制信号和连续波进行正交调制; 以及接收数据解码单元，其执行两次相关处理和延迟检测处理两次。

5. 发明授权

US08138335B2 Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient 有权
标题翻译：羧酸化合物和含有与活性成分相同的药物组合物
公开(公告)号：US08138335B2
公开(公告)日：2012-03-20
申请号：US12551860
申请日：2009-09-01
申请人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , Seiji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
发明人： Atsushi Naganawa , Maki Iwahashi , Atsushi Kinoshita , Atsushi Shimabukuro , Seiji Ogawa , Koji Yano , Kaoru Kobayashi , Yutaka Okada , Yoko Kishida , Shouji Kawauchi , Kohki Tsukamoto , Yoko Matsunaga , Fumio Nambu
IPC分类号： C07D265/36 , A61K31/535
CPC分类号： C07D307/80 , A61K31/343 , A61K31/538 , C07D265/36 , C07D317/48
摘要： A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.
摘要翻译：由式（I）表示的化合物，其中式中的符号与说明书中的符号相同，其盐，溶剂合物或其前药与DP受体结合并显示DP受体的拮抗活性。因此，它可用于预防和/或治疗过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有全身性肥大细胞活化的病症，过敏性休克，支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），伴随瘙痒的行为的结果产生的疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍）（例如，搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿关节炎，胸膜炎，溃疡性结肠炎等。由于其特异性结合DP受体并且弱结合到其他前列腺素受体，它们可以是具有小副作用。

6. 发明授权

US08026273B2 8-azaprostaglandin derivative compound and agent comprising the compound as active ingredient 失效
标题翻译： 8-氮杂的前列腺素衍生物化合物和包含该化合物作为活性成分的试剂
公开(公告)号：US08026273B2
公开(公告)日：2011-09-27
申请号：US12683609
申请日：2010-01-07
申请人： Kousuke Tani , Kaoru Kobayashi , Toru Maruyama , Tohru Kambe , Mikio Ogawa , Tsutomu Shiroya
发明人： Kousuke Tani , Kaoru Kobayashi , Toru Maruyama , Tohru Kambe , Mikio Ogawa , Tsutomu Shiroya
IPC分类号： A61K31/40 , A61K31/405 , C07D207/00 , C07D209/00
CPC分类号： C07D413/06 , C07D207/26 , C07D263/24 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/12 , C07D417/06 , C07D417/12
摘要： An 8-azaprostaglandin represented by formula (I) (wherein all symbols have the same meanings as described in the specification), a pharmaceutically acceptable salt thereof or a cyclodextrin clathrate thereof. Since the compound represented by formula (I) binds to EP2 subtype among PGE receptor strongly, it is useful for preventive and/or treatment for immune diseases, allergic diseases, neuronal cell death, dysmenorrhea, premature birth, abortion, baldness, retinal neuropathy such as glaucoma, erectile dysfunction, arthritis, pulmonary injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, hepatic injury, acute hepatitis, liver cirrhosis, shock, nephritis, renal failure, circulatory diseases, systemic inflammatory response syndrome, sepsis, hemophagocytosis syndrome, macrophage activation syndrome, still disease, Kawasaki Disease, burn, systemic granuloma, ulcerative colitis, Crohn disease, hypercytokinemia at dialysis, multiple organ failure, or bone diseases etc.
摘要翻译：由式（I）（其中所有符号具有与说明书中所述相同的含义）表示的8-氮杂前列腺素，其药学上可接受的盐或其环糊精包合物。由于式（I）表示的化合物强烈地与PGE受体中的EP2亚型结合，因此可用于免疫疾病，过敏性疾病，神经元细胞死亡，痛经，早产，流产，秃发，视网膜神经病变等的预防和/或治疗青光眼，勃起功能障碍，关节炎，肺损伤，肺纤维化，肺气肿，支气管炎，慢性阻塞性肺病，肝损伤，急性肝炎，肝硬化，休克，肾炎，肾衰竭，循环系统疾病，全身性炎症反应综合征，败血症，血细胞增多综合征，巨噬细胞活化综合征，静止病，川崎病，烧伤，全身肉芽肿，溃疡性结肠炎，克罗恩病，透析中的高细胞因子血症，多器官功能衰竭或骨骼疾病等。

7. 发明申请

US20100010222A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF DISEASES ASSOCIATED WITH DECREASE IN BONE MASS COMPRISING EP4 AGONIST AS ACTIVE INGREDIENT 有权
标题翻译：用于治疗与包含EP4激动剂作为主动成分的骨质疏松相关的疾病的药物组合物
公开(公告)号：US20100010222A1
公开(公告)日：2010-01-14
申请号：US12549136
申请日：2009-08-27
申请人： Toru MARUYAMA , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
发明人： Toru MARUYAMA , Kaoru Kobayashi , Tohru Kambe , Takayuki Maruyama , Hideyuki Yoshida , Akio Nishiura , Nobutaka Abe
IPC分类号： C07D241/04 , C07C405/00 , C07D207/12 , C07D401/12
CPC分类号： C07C405/0033 , A61K9/0019 , A61K9/1647 , A61K9/19 , A61K9/2054 , A61K31/4015 , A61K31/41 , A61K31/5575 , A61K31/559
摘要： A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).
摘要翻译：用于预防和/或治疗与包含EP4激动剂作为活性成分的骨量减少相关的疾病的局部施用的药物组合物。包含具有前列腺素骨架的化合物作为代表的EP4激动剂具有促进骨形成的作用，因此可用于预防和/或治疗与骨质量减少有关的疾病（骨疾病如原发性骨质疏松症，继发性骨质疏松症骨质疏松症，癌症的骨转移，高钙血症，佩吉特氏病，骨丢失和骨坏死，术后成骨，骨移植的替代疗法）。

8. 发明申请

US20090279646A1 Wireless communication device 审中-公开
标题翻译：无线通信设备
公开(公告)号：US20090279646A1
公开(公告)日：2009-11-12
申请号：US12458678
申请日：2009-07-20
申请人： Kaoru Kobayashi , Shigeru Takegishi
发明人： Kaoru Kobayashi , Shigeru Takegishi
IPC分类号： H04L27/06
CPC分类号： H04L27/0014 , H04B1/70752
摘要： A wireless communication device is provided to carry out correlation peak detection processing properly and efficiently in intermittent receiving unit. If a correlation peak is not detected in a first period in which a correlation peak detecting unit detects the correlation peak at a default frequency and a first frequency in a detecting period of a coarse frequency deviation detecting unit in the first period, a control unit makes the correlation peak detecting unit carry out the peak detection at the first frequency in a second period. If the correlation peak is detected in the correlation peak detecting unit and a second frequency is detected in a detecting period of a fine frequency deviation detecting unit in the first period, the control unit makes the correlation peak detecting unit carry out the peak detection at the first and second frequencies in a third period.
摘要翻译：提供一种无线通信装置，用于在间歇接收单元中适当且有效地执行相关峰值检测处理。如果在第一期间中相关峰值检测部检测到粗略频率偏差检测部的检测期间的默认频率的相关峰值和第一频率的第一期间没有检测到相关峰值，则控制部相关峰值检测单元在第二周期中以第一频率执行峰值检测。如果在相关峰值检测单元中检测到相关峰值，并且在第一周期内在精细频率偏差检测单元的检测周期中检测到第二频率，则控制单元使相关峰值检测单元在第一和第二频率在第三个时期。

9. 发明申请

US20090196331A1 Signal processing unit and wireless communication device 有权
标题翻译：信号处理单元和无线通信设备
公开(公告)号：US20090196331A1
公开(公告)日：2009-08-06
申请号：US12382158
申请日：2009-03-10
申请人： Kaoru Kobayashi , Shigeru Takegishi
发明人： Kaoru Kobayashi , Shigeru Takegishi
IPC分类号： H04B1/00
CPC分类号： H04L27/0014 , H04B1/70752 , H04L2027/0036 , H04L2027/0051 , H04L2027/0095
摘要： A signal processing unit and a wireless communication device are provided for making it possible to detect a frequency by means of a small scale operation circuit in a short time. The signal processing unit and the wireless communication device are comprised of a carrier data generating unit; a carrier demodulation unit; a matched filter unit that divides carrier demodulated data into a plurality of portions, carries out despread processing and accumulating operation processing as partial correlation processing, further carries out full addition processing for the partial correlation processing result, and outputs correlation detected data; a correlation peak detecting unit that detects a correlation peak from the correlation detected data and outputs correlation peak position information; a coarse frequency deviation detecting unit that outputs a frequency deviation amount with respect to the carrier demodulated data to the carrier data generating unit; and a fine frequency deviation detecting unit that outputs a fine frequency deviation amount from the correlation detected data and the correlation peak position information to the carrier data generating unit.
摘要翻译：提供信号处理单元和无线通信装置，以便能够在短时间内利用小规模的操作电路来检测频率。信号处理单元和无线通信设备包括载波数据生成单元; 载波解调单元; 将载波解调数据分割为多个部分的匹配滤波器单元，进行解扩处理并积累作为部分相关处理的运算处理，进一步执行部分相关处理结果的全相加处理，并输出相关检测数据; 相关峰值检测单元，根据相关检测数据检测相关峰值，并输出相关峰值位置信息; 粗频率偏差检测单元，向载波数据生成单元输出相对于载波解调数据的频率偏差量; 以及精细频率偏差检测单元，其将相关检测数据和相关峰值位置信息的精细频率偏差量输出到载波数据生成单元。

10. 发明授权

US07235667B2 N-phenylarylsulfonamide compound, pharmaceutical composition comprising the compound as active ingredient, synthetic intermediate for the compound and process for its preparation 有权
标题翻译： N-苯基芳基磺酰胺化合物，包含该化合物作为活性成分的药物组合物，该化合物的合成中间体及其制备方法
公开(公告)号：US07235667B2
公开(公告)日：2007-06-26
申请号：US10471673
申请日：2002-03-11
申请人： Atsushi Naganawa , Tetsuji Saito , Kaoru Kobayashi , Takayuki Maruyama , Yoshihiko Nakai , Shinsuke Hashimoto
发明人： Atsushi Naganawa , Tetsuji Saito , Kaoru Kobayashi , Takayuki Maruyama , Yoshihiko Nakai , Shinsuke Hashimoto
IPC分类号： C07D277/04 , A61K31/425
CPC分类号： C07D213/70 , C07D277/36 , C07D307/64 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： An N-phenylarylsulfonylamide compound of formula (I) (R1 is COOH etc.; R2 is hydrogen, methyl, etc.; R3 and R4 are a combination of methyl and methyl, etc.; R5 is isopropyl etc.; Ar is thiazolyl, pyridyl, 5-methyl-2-furyl each optionally substituted with methyl; n is zero or 1), a synthetic intermediate for the compound and a process for its preparation. The compound of formula (I) binds to a prostaglandin E2 receptor, especially an EP1 subtype receptor, and antagonizes it. It is less affected by protein binding, so it has a satisfactory in vivo activity. Therefore, it is considered to be useful as an analgesic, an antipyretic agent, an agent for the treatment of pollakiuria (frequent urination) and/or lower urinary tract disease syndrome or an antineoplastic agent.
摘要翻译：式（I）的N-苯基芳基磺酰胺化合物（R 1）是COOH等; R 2是氢，甲基等; R 3 O >和R 4是甲基和甲基等的组合; R 5是异丙基等; Ar是噻唑基，吡啶基，5-甲基-2-呋喃基任选被甲基取代; n为0或1），化合物的合成中间体及其制备方法。式（I）化合物与前列腺素E 2受体结合，特别是EP 1亚型受体，并拮抗它。蛋白质结合的影响较小，因此具有令人满意的体内活性。因此，认为可用作止痛剂，解热剂，治疗尿频（尿频）和/或下尿路疾病综合征或抗肿瘤药物的药剂。

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