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1. 发明申请

US20110038911A1 PROSTHETIC MATERIAL FOR LIVING ORGAN 审中-公开
标题翻译：生活用品的前体材料
公开(公告)号：US20110038911A1
公开(公告)日：2011-02-17
申请号：US12672017
申请日：2008-07-25
申请人： Yuki Sakamoto , Shojiro Matsuda , Toshiharu Shinoka , Yuki Ichihara , Yoshito Ikada
发明人： Yuki Sakamoto , Shojiro Matsuda , Toshiharu Shinoka , Yuki Ichihara , Yoshito Ikada
IPC分类号： A61F2/02 , A61K35/32 , B32B3/26 , D04H13/00
CPC分类号： A61L27/507 , A61L27/3804 , A61L27/3834 , A61L27/56 , A61L27/58 , Y10T428/249953 , Y10T442/60
摘要： It is an object of the invention to provide a prosthetic material for living organs, which can sufficiently withstand the arterial pressure and thereby can prevent leakage of blood or rupture of blood vessels, and which serves as a scaffold for vascular tissue regeneration, and does not necessitate repeated surgeries or the like.The invention is a prosthetic material for living organs, which comprises a laminate including a film layer and a porous layer, said film layer comprising a bioabsorbable material, said porous layer comprising a bioabsorbable material.
摘要翻译：本发明的目的是提供一种用于活体器官的假体材料，其可以充分地承受动脉压，从而可以防止血液渗漏或血管破裂，并且其用作血管组织再生的支架，并且不需要重复手术等。本发明是一种活体器官的假体材料，其包括由薄膜层和多孔层组成的层压体，所述薄膜层包含生物可吸收材料，所述多孔层包含生物可吸收材料。

2. 发明申请

US20080176206A1 Cardiovascular tissue culture substrate 审中-公开
标题翻译：心血管组织培养基质
公开(公告)号：US20080176206A1
公开(公告)日：2008-07-24
申请号：US11769080
申请日：2007-06-27
申请人： Toshiharu Shinoka , Goki Matsumura , Yoshito Ikada , Shojiro Matsuda , Yuki Sakamoto , Tsuguyoshi Taira
发明人： Toshiharu Shinoka , Goki Matsumura , Yoshito Ikada , Shojiro Matsuda , Yuki Sakamoto , Tsuguyoshi Taira
IPC分类号： A01N1/00 , C12N5/02
CPC分类号： C12N5/0068 , A61L27/3839 , A61L27/48 , A61L27/507 , A61L27/56 , A61L27/58 , C12N2533/40 , C08L67/04
摘要： The substrate for culturing a cardiovascular tissue of the present invention is a substrate for culturing a cardiovascular tissue, which is tubular, and comprises a foam comprising a bioabsorbable material reinforced with a reinforcing material comprising a bioabsorbable material, the foam comprising lactide (D, L, DL isomer)-ε-caprolactone copolymer containing lactide (D, L, DL isomer) in a content of 50 to 54 mole % and ε-caprolactone in a content of 50 to 46 mole %, and the reinforcing material being covered with the foam.
摘要翻译：用于培养本发明的心血管组织的底物是用于培养心管组织的底物，其为管状，并且包含泡沫，其包含用包含生物可吸收材料的增强材料增强的生物可吸收材料，所述泡沫包含丙交酯（D，L ，DL异构体） - 含有50〜54摩尔％的丙交酯（D，L，DL异构体）的ε-己内酯共聚物和50〜46摩尔％的ε-己内酯，并且所述增强材料被泡沫。

3. 发明授权

US08372433B2 Substrate for culture of cardiovascular tissue 有权
标题翻译：心血管组织培养基质
公开(公告)号：US08372433B2
公开(公告)日：2013-02-12
申请号：US12523124
申请日：2008-01-18
申请人： Toshiharu Shinoka , Goki Matsumura , Yoshito Ikada , Shojiro Matsuda , Yuki Sakamoto , Tsuguyoshi Taira
发明人： Toshiharu Shinoka , Goki Matsumura , Yoshito Ikada , Shojiro Matsuda , Yuki Sakamoto , Tsuguyoshi Taira
IPC分类号： C12N5/00
CPC分类号： C12N5/0068 , A61L27/3839 , A61L27/48 , A61L27/507 , A61L27/56 , A61L27/58 , C12N2533/40 , C08L67/04
摘要： The scaffold for culturing a cardiovascular tissue of the present invention is a scaffold for culturing a cardiovascular tissue, which is tubular, and comprises a foamed polymer comprising a bioabsorbable material reinforced with a reinforcing material comprising a bioabsorbable material, the foamed polymer comprising lactide (D, L, DL isomer)-ε-caprolactone copolymer containing lactide (D, L, DL isomer) in a content of 50 to 54 mole % and ε-caprolactone in a content of 50 to 46 mole %, and the reinforcing material being covered with the foamed polymer.
摘要翻译：用于培养本发明的心血管组织的支架是用于培养心管组织的支架，其是管状的，并且包括发泡聚合物，其包含用包含生物可吸收材料的增强材料增强的生物可吸收材料，所述发泡聚合物包含丙交酯（D ，L，DL异构体）含有50〜54摩尔％的丙交酯（D，L，DL异构体）和含量为50〜46摩尔％的ε-己内酯的ε-己内酯共聚物，以及增强材料被泡沫聚合物覆盖。

4. 发明申请

US20100055781A1 SUBSTRATE FOR CULTURE OF CARDIOVASCULAR TISSUE 有权
标题翻译：心血管组织培养基础
公开(公告)号：US20100055781A1
公开(公告)日：2010-03-04
申请号：US12523124
申请日：2008-01-18
申请人： Toshiharu Shinoka , Goki Matsumura , Yoshito Ikada , Shojiro Matsuda , Yuki Sakamoto , Tsuguyoshi Taira
发明人： Toshiharu Shinoka , Goki Matsumura , Yoshito Ikada , Shojiro Matsuda , Yuki Sakamoto , Tsuguyoshi Taira
IPC分类号： C12N5/071 , C12N5/02
CPC分类号： C12N5/0068 , A61L27/3839 , A61L27/48 , A61L27/507 , A61L27/56 , A61L27/58 , C12N2533/40 , C08L67/04
摘要： The scaffold for culturing a cardiovascular tissue of the present invention is a scaffold for culturing a cardiovascular tissue, which is tubular, and comprises a foamed polymer comprising a bioabsorbable material reinforced with a reinforcing material comprising a bioabsorbable material, the foamed polymer comprising lactide (D, L, DL isomer)-ε-caprolactone copolymer containing lactide (D, L, DL isomer) in a content of 50 to 54 mole % and ε-caprolactone in a content of 50 to 46 mole %, and the reinforcing material being covered with the foamed polymer.
摘要翻译：用于培养本发明的心血管组织的支架是用于培养心管组织的支架，其是管状的，并且包括发泡聚合物，其包含用包含生物可吸收材料的增强材料增强的生物可吸收材料，所述发泡聚合物包含丙交酯（D ，L，DL异构体）含有50〜54摩尔％的丙交酯（D，L，DL异构体）和含量为50〜46摩尔％的ε-己内酯的ε-己内酯共聚物，以及增强材料被泡沫聚合物覆盖。

5. 发明授权

US08496714B2 Base material for revascularization 有权
标题翻译：血运重建的基础材料
公开(公告)号：US08496714B2
公开(公告)日：2013-07-30
申请号：US13056239
申请日：2009-07-28
申请人： Goki Matsumura , Yoshito Ikada , Yuki Sakamoto , Shojiro Matsuda
发明人： Goki Matsumura , Yoshito Ikada , Yuki Sakamoto , Shojiro Matsuda
IPC分类号： A61F2/82
CPC分类号： A61L27/507 , A61L27/48 , A61L27/56 , A61L27/58 , C08L67/04
摘要： The present invention aims to provide a material for revascularization which enables the regeneration of a blood vessel at an extremely high efficiency by being transplanted into a defect of the blood vessel.The present invention provides a tubular material for revascularization comprising a foamed body comprising a bioabsorbable material, a reinforcing member comprising a bioabsorbable material for reinforcing the foamed body, and a reinforcing yarn comprising a bioabsorbable material for reinforcing the foamed body, wherein the reinforcing yarn and the reinforcing member are located at the center or outer face of the foamed body, the inner face thereof is the foamed body, the reinforcing yarn is wound around in a spiral-shaped, ring-shaped or X-shaped manner, and the reinforcing yarn comprises a glycolide-ε-caprolactone copolymer.
摘要翻译：本发明的目的在于提供一种用于血运重建的材料，其能够通过移植到血管的缺陷中而以非常高的效率使血管再生。本发明提供了一种用于血运重建的管状材料，其包括包含生物可吸收材料的发泡体，包括用于增强发泡体的生物可吸收材料的加强构件，以及包含用于增强发泡体的生物可吸收材料的增强纱线，其中，加强构件位于发泡体的中心或外表面，其内表面是发泡体，增强纱线以螺旋形，环形或X形缠绕，并且增强纱线包括乙交酯-ε-己内酯共聚物。

6. 发明申请

US20110172757A1 BASE MATERIAL FOR REVASCULARIZATION 有权
标题翻译：基础材料进行重新整形
公开(公告)号：US20110172757A1
公开(公告)日：2011-07-14
申请号：US13056239
申请日：2009-07-28
申请人： Goki Matsumura , Yoshito Ikada , Yuki Sakamoto , Shojiro Matsuda
发明人： Goki Matsumura , Yoshito Ikada , Yuki Sakamoto , Shojiro Matsuda
IPC分类号： A61F2/82
CPC分类号： A61L27/507 , A61L27/48 , A61L27/56 , A61L27/58 , C08L67/04
摘要： The present invention aims to provide a material for revascularization which enables the regeneration of a blood vessel at an extremely high efficiency by being transplanted into a defect of the blood vessel.The present invention provides a tubular material for revascularization comprising a foamed body comprising a bioabsorbable material, a reinforcing member comprising a bioabsorbable material for reinforcing the foamed body, and a reinforcing yarn comprising a bioabsorbable material for reinforcing the foamed body, wherein the reinforcing yarn and the reinforcing member are located at the center or outer face of the foamed body, the inner face thereof is the foamed body, the reinforcing yarn is wound around in a spiral-shaped, ring-shaped or X-shaped manner, and the reinforcing yarn comprises a glycolide-ε-caprolactone copolymer.
摘要翻译：本发明的目的在于提供一种用于血运重建的材料，其能够通过移植到血管的缺陷中而以非常高的效率使血管再生。本发明提供了一种用于血运重建的管状材料，其包括包含生物可吸收材料的发泡体，包括用于增强发泡体的生物可吸收材料的加强构件，以及包含用于增强发泡体的生物可吸收材料的增强纱线，其中，加强构件位于发泡体的中心或外表面，其内表面是发泡体，增强纱线以螺旋形，环形或X形缠绕，并且增强纱线包括乙交酯 - 己内酯共聚物。

7. 发明授权

US08703627B2 Antiadhesive material 有权
标题翻译：防粘材料
公开(公告)号：US08703627B2
公开(公告)日：2014-04-22
申请号：US10480744
申请日：2002-06-12
申请人： Shojiro Matsuda , Yoshimi Tanaka , Yoshito Ikada
发明人： Shojiro Matsuda , Yoshimi Tanaka , Yoshito Ikada
IPC分类号： B32B27/04 , B32B27/12
CPC分类号： A61L31/148 , A61L31/045 , A61L31/129 , Y10T428/1362 , Y10T428/31504 , Y10T428/31786 , Y10T442/2525 , Y10T442/45
摘要： An antiadhesive material that is excellent in biocompatibility and bioabsorbability, as well as excellent strength in suturing and bonding, is provided. A reinforcing material 12 made of a biodegradable polymer is placed in a gelatin solution so that the reinforcing material 12 is impregnated with the solution, and the gelatin is caused to gelate and dried. By so doing, an antiadhesive material in which a gelatin film 11 and the reinforcing material 12 are integrated is obtained. The reinforcing material 12 preferably is arranged in a portion of the gelatin film 11 to be subjected to suturing, and preferably is arranged along a periphery of the gelatin film 11. The gelatin film 11 preferably is a cross-linked gelatin film, and the reinforcing material 12 preferably is a nonwoven fabric.
摘要翻译：提供了生物相容性和生物吸收性优异，以及优异的缝合和粘合强度的防粘附材料。将由可生物降解的聚合物制成的增强材料12放置在明胶溶液中，使得增强材料12被溶液浸渍，并使明胶凝胶化并干燥。通过这样做，获得其中将明胶膜11和增强材料12一体化的防粘附材料。增强材料12优选布置在明胶膜11的一部分中以进行缝合，并且优选沿着明胶膜11的周边布置。明胶膜11优选为交联明胶膜，并且增强材料12优选为无纺布。

8. 发明申请

US20100049250A1 STITCHING REINFORCEMENT MATERIAL FOR AUTOMATIC STITCHING DEVICE 审中-公开
标题翻译：用于自动缝合装置的刺绣加固材料
公开(公告)号：US20100049250A1
公开(公告)日：2010-02-25
申请号：US12519327
申请日：2007-12-21
申请人： Shojiro Matsuda , Yuki Sakamoto
发明人： Shojiro Matsuda , Yuki Sakamoto
IPC分类号： A61B17/04
CPC分类号： A61L17/00 , A61B2017/0406 , A61L17/12 , A61L17/145
摘要： It is an object of the present invention to provide a suture reinforcement material for an automatic suturing device, which has excellent loadability into an automatic suturing device and excellent cuttability with a cutter.The present invention is a suture reinforcement material for an automatic suturing device, which comprises a tubular body comprising an inner layer and an outer layer, the inner layer comprising a nonwoven fabric, the outer layer comprising a foamed polymer, wherein the nonwoven fabric of the inner layer and the foamed polymer of the outer layer are integrated together.
摘要翻译：本发明的目的是提供一种用于自动缝合装置的缝合增强材料，其对自动缝合装置具有优异的负载能力，并且与切割器具有优异的可切割性。本发明是一种用于自动缝合装置的缝合增强材料，其包括一个包括一个内层和一个外层的管体，该内层包括无纺织物，该外层包括一个泡沫聚合物，其中该无纺织物内层和外层的发泡聚合物结合在一起。

9. 发明申请

US20060094318A1 Medical film 有权
标题翻译：医疗电影
公开(公告)号：US20060094318A1
公开(公告)日：2006-05-04
申请号：US10536590
申请日：2003-12-08
申请人： Shojiro Matsuda , Hitoshi Ohtani , Yoshimi Tanaka , Hideki Tadokoro
发明人： Shojiro Matsuda , Hitoshi Ohtani , Yoshimi Tanaka , Hideki Tadokoro
IPC分类号： B32B27/04 , B32B27/12 , B32B5/02
CPC分类号： A61L31/148 , A61L31/045 , A61L31/129 , Y10T442/2484 , Y10T442/2525 , Y10T442/2861 , Y10T442/3854 , Y10T442/45 , Y10T442/674
摘要： A medical film that is excellent in biocompatibility and bioabsorbability and has an excellent strength in suturing and bonding is provided. A reinforcing material 12 made of a biodegradable polymer is placed in a gelatin solution so as to allow the solution to infiltrate in the reinforcing material 12 and then the gelatin is dried. This allows the gelatin that has infiltrated entirely in an internal part of the reinforcing material 12 to gel, thereby forming a gelatin film 11. Thus, a medical film 1 in which the reinforcing material 12 and the gelatin film 11 are integrated is obtained. The gelatin film 11 preferably is a cross-linked gelatin film.
摘要翻译：提供生物相容性和生物吸收性优异，缝合接合强度优异的医用膜。将由可生物降解的聚合物制成的增强材料12放置在明胶溶液中，以使溶液渗透到增强材料12中，然后将明胶干燥。由此，能够将完全渗透到增强材料12的内部的凝胶凝胶化，从而形成明胶膜11.因此，得到了增强材料12和明胶膜11一体化的医疗用膜1。明胶膜11优选为交联明胶膜。

10. 发明授权

US08741969B2 Anti-adhesion membrane 有权
标题翻译：防粘膜
公开(公告)号：US08741969B2
公开(公告)日：2014-06-03
申请号：US11989701
申请日：2006-08-02
申请人： Hitoshi Otani , Shojiro Matsuda , Tsuguyoshi Taira , Noriyuki Morikawa
发明人： Hitoshi Otani , Shojiro Matsuda , Tsuguyoshi Taira , Noriyuki Morikawa
IPC分类号： A61K47/42 , C07K1/00 , C07K14/78 , A61P19/04
CPC分类号： A61K47/42 , A61L31/045 , C07K1/00 , C07K14/78
摘要： An object of the present invention is to provide an anti-adhesion membrane that has no toxicity to a living body, has flexibility allowing itself to fit an affected part as a hydrated gel, is uniformly crosslinked, and is immediately absorbed in a living body after maintaining its shape in the living body for a certain period of time.The present invention provides anti-adhesion material, which comprises a thermally crosslinked gelatin film, and has a water content of 60 to 85% calculated by the following formula (1): water content (%)=[(Ws−Wd)/Ws]×100(%) (1), in the formula (1), Ws representing a weight (wet weight) of the anti-adhesion material immersed in a phosphate buffered saline solution at a temperature of 25° C. for one hour, and Wd representing a weight (dry weight) of the anti-adhesion material dried completely using a vacuum drying apparatus.
摘要翻译：本发明的目的是提供一种对生物体无毒性的抗粘附膜，具有使其自身适合作为水合凝胶的患部的柔软性，均匀交联，并且立即被吸收在生物体内保持其在生命体中的形状一段时间。本发明提供一种抗粘连材料，其包含热交联明胶膜，并且通过下式（1）计算的水含量为60-85％：水含量（％）= [（Ws-Wd）/ Ws ]×100（％）（1）在式（1）中，Ws表示浸渍在磷酸盐缓冲盐水溶液中的温度为25℃的抗粘附材料的重量（湿重）1小时， Wd表示使用真空干燥装置完全干燥的防粘附材料的重量（干重）。

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