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1. 发明申请

US20070275402A1 Novel markers for prenatal diagnosis and monitoring 有权
标题翻译：用于产前诊断和监测的新标记
公开(公告)号：US20070275402A1
公开(公告)日：2007-11-29
申请号：US11784499
申请日：2007-04-06
申请人： Yuk Lo , Rossa Chiu , Stephen Chim , Chunming Ding , Shengnan Jin , Tracy Lee , Fiona Lun
发明人： Yuk Lo , Rossa Chiu , Stephen Chim , Chunming Ding , Shengnan Jin , Tracy Lee , Fiona Lun
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q2600/154 , C12Q2600/156 , C12Q2523/125
摘要： This application provides the use of novel fetal markers for prenatal diagnosis and monitoring of certain pregnancy-related conditions. More specifically, the invention resides in the discovery that certain CpG islands located on fetal chromosome 21 demonstrate a methylation profile that is distinct from that of the corresponding CpG islands located on maternal chromosome 21. This application also provides kits for diagnosing or monitoring of the relevant conditions.
摘要翻译：该应用提供了新颖的胎儿标记物用于产前诊断和监测某些妊娠相关病症的用途。更具体地，本发明在于发现位于胎儿染色体21上的某些CpG岛表现出与位于母体染色体21上的相应CpG岛不同的甲基化谱。该应用还提供用于诊断或监测相关条件。

2. 发明申请

US20070207466A1 Method for non-invasive prenatal diagnosis 审中-公开
标题翻译：非侵入性产前诊断方法
公开(公告)号：US20070207466A1
公开(公告)日：2007-09-06
申请号：US11364294
申请日：2006-02-28
申请人： Charles Cantor , Chunming Ding , Yuk Lo , Rossa Chiu
发明人： Charles Cantor , Chunming Ding , Yuk Lo , Rossa Chiu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6872 , C12Q2600/156 , C12Q2600/172 , C12Q2535/125
摘要： The present invention is directed to methods of detecting nucleic acids in a biological sample. The method is based on a novel combination of a base extension reaction, which provides excellent analytical specificity, and a mass spectrometric analysis, which provides excellent specificity. The method can be used, for example, for diagnostic, prognostic and treatment purposes. The method allows accurate detection of nucleic acids that are present in very small amounts in a biological sample. For example, the method of the present invention is preferably used to detect fetal nucleic acid in a maternal blood sample; circulating tumor-specific nucleic acids in a blood, urine or stool sample; and donor-specific nucleic acids in transplant recipients. In another embodiment, one can detect viral, bacterial, fungal, or other foreign nucleic acids in a biological sample.
摘要翻译：本发明涉及检测生物样品中核酸的方法。该方法基于提供优异分析特异性的碱基延伸反应和提供优异特异性的质谱分析的新型组合。该方法可用于例如诊断，预后和治疗目的。该方法允许精确检测在生物样品中以非常少的量存在的核酸。例如，本发明的方法优选用于检测母体血液样品中的胎儿核酸; 在血液，尿液或粪便样品中循环肿瘤特异性核酸; 和供体特异性核酸。在另一个实施方案中，可以检测生物样品中的病毒，细菌，真菌或其它外来核酸。

3. 发明申请

US20060019278A1 Marker for prenatal diagnosis and monitoring 有权
标题翻译：产前诊断和监测的标记
公开(公告)号：US20060019278A1
公开(公告)日：2006-01-26
申请号：US11144951
申请日：2005-06-03
申请人： Yuk Ming Lo , Rossa Chiu , Stephen Chim , Yu-kwan Tong , Chunming Ding
发明人： Yuk Ming Lo , Rossa Chiu , Stephen Chim , Yu-kwan Tong , Chunming Ding
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q2600/154 , C12Q2600/156 , C12Q2521/331
摘要： The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.
摘要翻译：本发明涉及通过分析存在于母亲血液中的胎儿DNA来诊断妊娠相关疾病的新方法。更具体地说，本发明依赖于maspin基因在胎儿DNA和母体DNA中差异甲基化的发现，并提供了这些新的诊断方法，其将胎儿DNA与母体DNA区分开，并根据胎儿DNA水平和甲基化异常检测产前疾病状态。

4. 发明授权

US08748100B2 Methods and kits for selectively amplifying, detecting or quantifying target DNA with specific end sequences 有权
标题翻译：用于选择性扩增，检测或定量具有特定末端序列的靶DNA的方法和试剂盒
公开(公告)号：US08748100B2
公开(公告)日：2014-06-10
申请号：US11897654
申请日：2007-08-30
申请人： Yuk Ming Dennis Lo , Yu Kwan Tong , Wai Kwun Rossa Chiu , Chunming Ding
发明人： Yuk Ming Dennis Lo , Yu Kwan Tong , Wai Kwun Rossa Chiu , Chunming Ding
IPC分类号： C12Q1/68 , C07H21/04 , C12N9/16
CPC分类号： C12Q1/686 , C12Q2525/301 , C12Q2521/331
摘要： Disclosed herein are methods and kits for selectively amplifying, detecting or quantifying a DNA fragment with a specific end sequence, especially generated following restriction enzyme digestion. This method can be used, for example, to detect a hypomethylated DNA fragment. This methods and kits are especially useful in detecting or quantifying a hypomethylated fetal DNA fragment in a maternal plasma sample containing a corresponding hypermethylated maternal DNA fragment.
摘要翻译：本文公开了用于选择性扩增，检测或定量具有特异末端序列的DNA片段的方法和试剂盒，特别是在限制酶消化后产生。该方法可用于例如检测低甲基化DNA片段。该方法和试剂盒特别可用于检测或定量含有相应的高甲基化母体DNA片段的母体血浆样品中的低甲基化胎儿DNA片段。

5. 发明授权

US07901884B2 Markers for prenatal diagnosis and monitoring 有权
标题翻译：产前诊断和监测的标记
公开(公告)号：US07901884B2
公开(公告)日：2011-03-08
申请号：US11784499
申请日：2007-04-06
申请人： Yuk Ming Dennis Lo , Rossa Wai Kwun Chiu , Stephen Siu Chung Chim , Chunming Ding , Shengnan Jin , Tracy Yuen Han Lee , Fiona Miu Fun Lun
发明人： Yuk Ming Dennis Lo , Rossa Wai Kwun Chiu , Stephen Siu Chung Chim , Chunming Ding , Shengnan Jin , Tracy Yuen Han Lee , Fiona Miu Fun Lun
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q2600/154 , C12Q2600/156 , C12Q2523/125
摘要： This application provides the use of novel fetal markers for prenatal diagnosis and monitoring of certain pregnancy-related conditions. More specifically, the invention resides in the discovery that certain CpG islands located on fetal chromosome 21 demonstrate a methylation profile that is distinct from that of the corresponding CpG islands located on maternal chromosome 21. This application also provides kits for diagnosing or monitoring of the relevant conditions.
摘要翻译：该应用提供了新颖的胎儿标记物用于产前诊断和监测某些妊娠相关病症的用途。更具体地，本发明在于发现位于胎儿染色体21上的某些CpG岛表现出与位于母体染色体21上的相应CpG岛不同的甲基化谱。该应用还提供用于诊断或监测相关条件。

6. 发明申请

US20060252071A1 Method for the detection of chromosomal aneuploidies 有权
标题翻译：染色体非整倍体检测方法
公开(公告)号：US20060252071A1
公开(公告)日：2006-11-09
申请号：US11384128
申请日：2006-03-17
申请人： Yuk-Ming Lo , Rossa Chiu , Bo Tsui , Chunming Ding , Charles Cantor
发明人： Yuk-Ming Lo , Rossa Chiu , Bo Tsui , Chunming Ding , Charles Cantor
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6851 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2545/101
摘要： The non-invasive detection of fetal chromosomal aneuploidies is demonstrated. Alleles of fetal RNA-SNPs present in a biological sample (e.g. maternal blood) containing fetal RNA are detected and quantified in order to determine the ratio of the alleles. This ratio is compared to a standard control consisting of euploid fetuses. Deviation of allele ratio indicates the presence of chromosomal aneuploidy.
摘要翻译：证明了胎儿染色体非整倍体的非侵入性检测。检测并定量存在于含有胎儿RNA的生物样品（例如母体血液）中的胎儿RNA-SNP的等位基因，以确定等位基因的比例。将该比率与由整倍体胎儿组成的标准对照进行比较。等位基因比率的偏差表明存在染色体非整倍体。

7. 发明申请

US20090061425A1 Methods and kits for selectively amplifying, detecting or quantifying target DNA with specific end sequences 有权
标题翻译：用于选择性扩增，检测或定量具有特定末端序列的靶DNA的方法和试剂盒
公开(公告)号：US20090061425A1
公开(公告)日：2009-03-05
申请号：US11897654
申请日：2007-08-30
申请人： Yuk Ming Dennis Lo , Yu Kwan Tong , Wai Kwun Rossa Chiu , Chunming Ding
发明人： Yuk Ming Dennis Lo , Yu Kwan Tong , Wai Kwun Rossa Chiu , Chunming Ding
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/686 , C12Q2525/301 , C12Q2521/331
摘要： Disclosed herein are methods and kits for selectively amplifying, detecting or quantifying a DNA fragment with a specific end sequence, especially generated following restriction enzyme digestion. This method can be used, for example, to detect a hypomethylated DNA fragment. This methods and kits are especially useful in detecting or quantifying a hypomethylated fetal DNA fragment in a maternal plasma sample containing a corresponding hypermethylated maternal DNA fragment.
摘要翻译：本文公开了用于选择性扩增，检测或定量具有特异末端序列的DNA片段的方法和试剂盒，特别是在限制酶消化后产生。该方法可用于例如检测低甲基化DNA片段。该方法和试剂盒特别可用于检测或定量含有相应的高甲基化母体DNA片段的母体血浆样品中的低甲基化胎儿DNA片段。

8. 发明授权

US08435764B2 Multiplex detection of hepatitis virus variations 失效
标题翻译：多发性肝炎病毒变异检测
公开(公告)号：US08435764B2
公开(公告)日：2013-05-07
申请号：US12773095
申请日：2010-05-04
申请人： Chunming Ding , Ju Luan , Boping Zhou , Jing Yuan , Xinchun Chen , Hongmei Zhang
发明人： Chunming Ding , Ju Luan , Boping Zhou , Jing Yuan , Xinchun Chen , Hongmei Zhang
IPC分类号： C12P19/34 , C12Q1/68 , C07H21/04
CPC分类号： C12Q1/706 , C12Q2600/156
摘要： Disclosed is a method for the detection of virus variations. Disclosed also is a method for the treatment of virus infection in a subject based on the detection of virus variations. Additionally, a kit is provided for the detection of virus variations.
摘要翻译：公开了一种用于检测病毒变异的方法。还公开了一种基于病毒变异检测来治疗受试者的病毒感染的方法。另外，提供了一个用于检测病毒变体的工具箱。

9. 发明申请

US20130084566A1 FETAL METHYLATION MARKERS 有权
标题翻译：方法甲基标记
公开(公告)号：US20130084566A1
公开(公告)日：2013-04-04
申请号：US13618527
申请日：2012-09-14
申请人： YUK MING DENNIS LO , Rossa Wai Kwun Chiu , Stephen Siu Chung Chim , Chunming Ding , Kwan Chee Chan , Hing Nam Ivy Wong , Ka Chun Ryan Yuen
发明人： YUK MING DENNIS LO , Rossa Wai Kwun Chiu , Stephen Siu Chung Chim , Chunming Ding , Kwan Chee Chan , Hing Nam Ivy Wong , Ka Chun Ryan Yuen
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , C12Q1/6876 , C12Q1/6883 , C12Q2600/154 , C12Q2600/156
摘要： This application describes the discovery that, in a pregnant woman, certain genes (such as RASSF1A, APC, CASP8, RARB, SCGB3A1, DAB2IP, PTPN6, THY1, TMEFF2, and PYCARD) originated from a fetus are highly methylated, whereas the same genes of maternal origin are unmethylated. This discovery allows the easy detection of one or more of these methylated fetal genes in a biological sample from a pregnant woman, serving as a universal indicator of the presence of fetal DNA in the sample. These fetal methylation markers are particularly useful as positive controls for a non-invasive analytical process during which the quality and quantity of fetal DNA are monitored. These newly identified fetal markers can also be measured directly for diagnosis of certain pregnancy-related conditions.
摘要翻译：该应用描述了在孕妇中发现来自胎儿的某些基因（如RASSF1A，APC，CASP8，RARB，SCGB3A1，DAB2IP，PTPN6，THY1，TMEFF2和PYCARD）高度甲基化，而相同的基因产妇来源是未甲基化。该发现允许从孕妇的生物样品中容易地检测这些甲基化胎儿基因中的一种或多种，作为样品中胎儿DNA存在的通用指标。这些胎儿甲基化标记物作为非侵入性分析过程的阳性对照特别有用，在此过程中监测胎儿DNA的质量和数量。这些新确定的胎儿标记物也可以直接测量以诊断某些妊娠相关病症。

10. 发明授权

US08318460B2 Haplotype analysis 有权
标题翻译：单倍型分析
公开(公告)号：US08318460B2
公开(公告)日：2012-11-27
申请号：US12704043
申请日：2010-02-11
申请人： Charles R Cantor , Chunming Ding
发明人： Charles R Cantor , Chunming Ding
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6827 , C12Q1/6858 , C12Q2600/156 , C12Q2527/137 , C12Q2537/143 , C12Q2565/627
摘要： The present invention provides an efficient way for high throughput haplotype analysis. Several polymorphic nucleic acid markers, such as SNPs, can be simultaneously and reliably determined through multiplex PCR of single nucleic acid molecules in several parallel single molecule dilutions and the consequent statistical analysis of the results from these parallel single molecule multiplex PCR reactions results in reliable determination of haplotypes present in the subject. The nucleic acid markers can be of any distance to each other on the chromosome. In addition, an approach wherein overlapping DNA markers are analyzed can be used to link smaller haplotypes into larger haplotypes. Consequently, the invention provides a powerful new tool for diagnostic haplotyping and identifying novel haplotypes.
摘要翻译：本发明提供了高通量单倍型分析的有效方法。可以通过多个平行的单分子稀释物中的单个核酸分子的多重PCR来同时并可靠地测定几种多态性核酸标记，例如SNP，并且随后对来自这些平行的单分子多重PCR反应的结果的统计分析导致可靠的测定的单倍体存在于受试者。核酸标记在染色体上可以彼此有任何距离。此外，分析重叠的DNA标记物的方法可用于将较小的单倍型连接到较大的单元型中。因此，本发明为诊断单倍型和鉴定新型单体型提供了强大的新工具。

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