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1. 发明申请

US20110166063A1 POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES 审中-公开
标题翻译：治疗肽的聚合物结合
公开(公告)号：US20110166063A1
公开(公告)日：2011-07-07
申请号：US13119297
申请日：2009-09-17
申请人： Mary J. Bossard , Steven O. Roczniak , Harold Zappe , Yujun Wang , Ping Zhang , Dawei Sheng , C. Simone Jude-Fishburn , Elizabeth Louise Minamitani , Xiaofeng Liu , Haim Moskowitz , Dennis G. Fry , Cherie F. Ali , Christine Taylor Brew
发明人： Mary J. Bossard , Steven O. Roczniak , Harold Zappe , Yujun Wang , Ping Zhang , Dawei Sheng , C. Simone Jude-Fishburn , Elizabeth Louise Minamitani , Xiaofeng Liu , Haim Moskowitz , Dennis G. Fry , Cherie F. Ali , Christine Taylor Brew
IPC分类号： A61K38/28 , A61K38/16 , A61K38/08 , A61K38/06 , A61K38/07 , A61K38/10 , C07K5/08 , C07K7/06 , C07K7/08 , C07K14/00 , A61P3/10
CPC分类号： A61K38/10 , A61K38/16 , A61K38/28 , A61K47/60 , A61K47/61
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
摘要翻译：本发明提供了通过共价连接水溶性低聚物进行化学修饰的肽。本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。

2. 发明申请

US20110171161A1 POLYMER CONJUGATES OF PROTEGRIN PEPTIDES 审中-公开
标题翻译：聚合物蛋白质聚合物的结合
公开(公告)号：US20110171161A1
公开(公告)日：2011-07-14
申请号：US13119216
申请日：2009-09-17
申请人： Yujun Wang , Haim Moskowitz , Xiaofeng Liu , Steven O. Roczniak , Mary J. Bossard
发明人： Yujun Wang , Haim Moskowitz , Xiaofeng Liu , Steven O. Roczniak , Mary J. Bossard
IPC分类号： A61K38/10 , C08G65/333 , A61P31/00
CPC分类号： A61K38/10 , A61K47/60 , C07K7/08
摘要： The invention provides protegrin that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention has enhanced half-life and/or reduced clearance.
摘要翻译：本发明提供了通过共价连接水溶性寡聚物进行化学修饰的整合素。本发明的共轭物具有增强的半衰期和/或减少的间隙。

3. 发明申请

US20120195847A1 POLYMER CONJUGATES OF BIPHALIN PEPTIDES 审中-公开
标题翻译： BIPHALIN肽的聚合物结合
公开(公告)号：US20120195847A1
公开(公告)日：2012-08-02
申请号：US13119214
申请日：2009-09-17
申请人： Yujun Wang , Ping Zhang , Mary J. Bossard , Steven O. Roczniak
发明人： Yujun Wang , Ping Zhang , Mary J. Bossard , Steven O. Roczniak
IPC分类号： A61K31/765 , A61K38/08 , A61K31/787 , C08F226/08 , C08F226/06 , C08F216/06 , A61K31/79 , C07K7/06
CPC分类号： C07K5/1016 , A61K47/60
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
摘要翻译：本发明提供通过共价连接水溶性低聚物进行化学修饰的肽。本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。

4. 发明授权

US09861705B2 Conjugates of an IL-2 moiety and a polymer 有权
公开(公告)号：US09861705B2
公开(公告)日：2018-01-09
申请号：US13884901
申请日：2011-11-11
申请人： Mary J. Bossard , Cherie F. Ali , Xiaofeng Liu , Deborah H. Charych , Yujun Wang
发明人： Mary J. Bossard , Cherie F. Ali , Xiaofeng Liu , Deborah H. Charych , Yujun Wang
IPC分类号： A61K47/48 , C07K14/55 , A61K38/20 , A61K47/60
CPC分类号： A61K47/60 , A61K38/2013 , C07K14/55
摘要： Conjugates of an interleukin-2 (“IL-2”) moiety and one or more nonpeptidic, water-soluble polymers are provided. Typically, the nonpeptidic, water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, methods of administering compositions to an individual, nucleic acid sequences, expression systems, host cells, and methods for preparing IL-moieties.

5. 发明授权

US08954397B2 Creation and replay of a simulation workload using captured workloads 有权
标题翻译：使用捕获的工作负载创建和重播模拟工作负载
公开(公告)号：US08954397B2
公开(公告)日：2015-02-10
申请号：US13538278
申请日：2012-06-29
申请人： Yujun Wang , Leonidas Galanis , Konstantinos Morfonios , Karl Dias , John Mark Beresniewicz
发明人： Yujun Wang , Leonidas Galanis , Konstantinos Morfonios , Karl Dias , John Mark Beresniewicz
IPC分类号： G06F7/00
CPC分类号： G06F17/30289
摘要： A method for replaying a simulation workload is provided. The simulation workload identifies a plurality of workload parts. Each workload part is at least a portion of a respective captured workload. In an embodiment, a first workload part is a portion of a first workload executed relative to a first capture database server and a second workload part is a portion of a second workload executed relative to a second capture database server. A portion of the first workload part and a portion of the second workload part may be replayed concurrently.
摘要翻译：提供了一种重放模拟工作负载的方法。模拟工作负载识别多个工作负载部分。每个工作负载部分至少是相应捕获的工作负载的一部分。在一个实施例中，第一工作负载部分是相对于第一捕获数据库服务器执行的第一工作负载的一部分，并且第二工作负荷部分是相对于第二捕获数据库服务器执行的第二工作负载的一部分。可以同时重放第一工作负荷部分的一部分和第二工作负荷部分的一部分。

6. 发明授权

US08492523B2 Dragline protein 失效
标题翻译：拉链蛋白
公开(公告)号：US08492523B2
公开(公告)日：2013-07-23
申请号：US13226157
申请日：2011-09-06
申请人： Tianfu Zhao , Yujun Wang , Masao Nakagaki
发明人： Tianfu Zhao , Yujun Wang , Masao Nakagaki
IPC分类号： A61K38/17
CPC分类号： C07K14/43586 , C07K14/43518
摘要： To provide a new natural fiber material with excellent physical properties. Any one of the following nucleic acids (a) to (d): (a) a nucleic acid having a base sequence of SEQ ID NO: 1 or 19; (b) a nucleic acid encoding a protein having an amino acid sequence of SEQ ID NO: 2 or 20; (c) a nucleic acid encoding a dragline protein and having a sequence identity of 90% or more with the nucleic acid (a); (d) a nucleic acid which encodes a dragline protein and hybridizes with a complementary chain of the nucleic acid (a) under stringent conditions.
摘要翻译：提供具有优异物理性能的新型天然纤维材料。以下核酸（a）至（d）中的任一种：（a）具有SEQ ID NO：1或19的碱基序列的核酸; （b）编码具有SEQ ID NO：2或20的氨基酸序列的蛋白质的核酸; （c）与核酸（a）具有90％或更高的序列同一性的编码牵引蛋白的核酸; （d）编码牵引蛋白并在严格条件下与核酸（a）的互补链杂交的核酸。

7. 发明申请

US20120054245A1 TRANSACTIONALLY CONSISTENT DATABASE REPLAY IN AN ENVIRONMENT WITH CONNECTION POOLING 有权
标题翻译：在连接池的环境中进行一致的数据库重复
公开(公告)号：US20120054245A1
公开(公告)日：2012-03-01
申请号：US12870736
申请日：2010-08-27
申请人： Romain COLLE , Karl Dias , Leonidas Galanis , Supiti Buranawatanachoke , Jonathan Giloni , Efstratios Papadomanolakis , Yujun Wang
发明人： Romain COLLE , Karl Dias , Leonidas Galanis , Supiti Buranawatanachoke , Jonathan Giloni , Efstratios Papadomanolakis , Yujun Wang
IPC分类号： G06F17/30
CPC分类号： G06F17/303
摘要： A method, apparatus, and computer-readable medium is provided for replaying captured workload data in a database environment with connection pools. A replay system includes a dispatcher that manages a connection pool. In one aspect, the dispatcher selects available connections for sending database commands that are ready to be executed against a database, but prevents from being sent, or holds, commands that are not ready to be executed against the database. Commands may be stored at the dispatcher until the database advances to a state that allows the commands to be executed. In another aspect, the dispatcher may use an available connection to send a command to a database instance even though the command is not ready to be executed, as long as at least a threshold number or percentage of connections remains available.
摘要翻译：提供了一种方法，装置和计算机可读介质，用于在具有连接池的数据库环境中重放捕获的工作负载数据。重播系统包括管理连接池的调度器。在一个方面，调度员选择可用的连接，用于发送准备对数据库执行的数据库命令，但是防止发送或保留尚未准备好针对数据库执行的命令。命令可以存储在调度器中，直到数据库进入允许执行命令的状态。在另一方面，调度员可以使用可用的连接来发送命令到数据库实例，即使该命令尚未准备好被执行，只要至少一个阈值数量或百分比的连接仍然可用。

8. 发明授权

US07890458B2 Capturing database workload while preserving original transactional and concurrency characteristics for replay 有权
标题翻译：捕获数据库工作负载，同时保留用于重放的原始事务和并发特性
公开(公告)号：US07890458B2
公开(公告)日：2011-02-15
申请号：US11800239
申请日：2007-05-03
申请人： Karl Dias , Leonidas Galanis , Jonathan Klein , Venkateshwaran Venkataramani , Yujun Wang
发明人： Karl Dias , Leonidas Galanis , Jonathan Klein , Venkateshwaran Venkataramani , Yujun Wang
IPC分类号： G06F7/00 , G06F17/00
CPC分类号： G06F11/3414 , G06F11/3419 , G06F11/3495 , G06F11/3688 , G06F2201/805 , G06F2201/87
摘要： A method and apparatus for capturing database system workload and replaying that workload in a database system is provided. According to one aspect, in order to subject a test database system to the same workload to which the production database system actually would be subjected, a database server in the production system captures and records workload that the database server receives from external entities. This captured workload is processed. Processes external to a database server in the test database system send the processed workload to that database server. As a result, the test database system is subjected to the same workload to which the production database system originally was subjected. The foregoing technique permits a database administrator to determine how the production database system will fare if the difference that is present in the test database system is introduced into the production database system.
摘要翻译：提供了一种用于捕获数据库系统工作负载并在数据库系统中重播该工作负载的方法和装置。根据一个方面，为了使测试数据库系统处于生产数据库系统实际受到的相同工作负载，生产系统中的数据库服务器捕获并记录数据库服务器从外部实体接收的工作负载。处理此捕获的工作负载。测试数据库系统中数据库服务器外部的进程将处理的工作负载发送到该数据库服务器。因此，测试数据库系统受到生产数据库系统最初遭受的相同工作量的影响。如果将测试数据库系统中存在的差异引入到生产数据库系统中，则上述技术允许数据库管理员确定生产数据库系统将如何展示。

9. 发明申请

US20080097996A1 Transactionally consistent database workload replay 有权
标题翻译：事务一致的数据库工作负载重播
公开(公告)号：US20080097996A1
公开(公告)日：2008-04-24
申请号：US11800238
申请日：2007-05-03
申请人： Karl Dias , Leonidas Galanis , Jonathan Klein , Venkateshwaran Venkataramani , Yujun Wang
发明人： Karl Dias , Leonidas Galanis , Jonathan Klein , Venkateshwaran Venkataramani , Yujun Wang
IPC分类号： G06F17/30
CPC分类号： G06F17/30377
摘要： A method and apparatus for capturing database system workload and replaying that workload in a database system is provided. According to one aspect, in order to subject a test database system to the same workload to which the production database system actually would be subjected, a database server in the production system captures and records workload that the database server receives from external entities. This captured workload is processed. Processes external to a database server in the test database system send the processed workload to that database server. As a result, the test database system is subjected to the same workload to which the production database system originally was subjected. The foregoing technique permits a database administrator to determine how the production database system will fare if the difference that is present in the test database system is introduced into the production database system.
摘要翻译：提供了一种用于捕获数据库系统工作负载并在数据库系统中重播该工作负载的方法和装置。根据一个方面，为了使测试数据库系统处于生产数据库系统实际受到的相同工作负载，生产系统中的数据库服务器捕获并记录数据库服务器从外部实体接收的工作负载。处理此捕获的工作负载。测试数据库系统中数据库服务器外部的进程将处理的工作负载发送到该数据库服务器。因此，测试数据库系统受到生产数据库系统最初遭受的相同工作量的影响。如果将测试数据库系统中存在的差异引入到生产数据库系统中，则上述技术允许数据库管理员确定生产数据库系统将如何展示。

10. 发明申请

US20080097960A1 Client-driven functionally equivalent database replay 有权
标题翻译：客户端驱动的功能等效数据库重播
公开(公告)号：US20080097960A1
公开(公告)日：2008-04-24
申请号：US11800224
申请日：2007-05-03
申请人： Karl Dias , Leonidas Galanis , Jonathan Klein , Venkateshwaran Venkataramani , Yujun Wang
发明人： Karl Dias , Leonidas Galanis , Jonathan Klein , Venkateshwaran Venkataramani , Yujun Wang
IPC分类号： G06F17/30
CPC分类号： G06F17/30286
摘要： A method and apparatus for capturing database system workload and replaying that workload in a database system is provided. According to one aspect, in order to subject a test database system to the same workload to which the production database system actually would be subjected, a database server in the production system captures and records workload that the database server receives from external entities. This captured workload is processed. Processes external to a database server in the test database system send the processed workload to that database server. As a result, the test database system is subjected to the same workload to which the production database system originally was subjected. The foregoing technique permits a database administrator to determine how the production database system will fare if the difference that is present in the test database system is introduced into the production database system.
摘要翻译：提供了一种用于捕获数据库系统工作负载并在数据库系统中重播该工作负载的方法和装置。根据一个方面，为了使测试数据库系统处于生产数据库系统实际受到的相同工作负载，生产系统中的数据库服务器捕获并记录数据库服务器从外部实体接收的工作负载。处理此捕获的工作负载。测试数据库系统中数据库服务器外部的进程将处理的工作负载发送到该数据库服务器。因此，测试数据库系统受到生产数据库系统最初遭受的相同工作量的影响。如果将测试数据库系统中存在的差异引入到生产数据库系统中，则上述技术允许数据库管理员确定生产数据库系统将如何展示。

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