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1. 发明授权

US07229986B2 Melanin-concentrating hormone antagonist 失效
标题翻译：黑色素浓缩激素拮抗剂
公开(公告)号：US07229986B2
公开(公告)日：2007-06-12
申请号：US10276288
申请日：2001-05-15
申请人： Yuji Ishihara , Jun Terauchi , Nobuhiro Suzuki , Shiro Takekawa , Kazuyoshi Aso
发明人： Yuji Ishihara , Jun Terauchi , Nobuhiro Suzuki , Shiro Takekawa , Kazuyoshi Aso
IPC分类号： C07D209/08 , C07D209/14 , C07D401/12 , A61K31/404 , A61P3/04
CPC分类号： C07D223/16 , A61K31/404 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/538 , A61K31/541 , A61K31/55 , A61K31/551 , C07D209/08 , C07D215/12 , C07D215/14 , C07D231/12 , C07D233/56 , C07D249/08 , C07D265/36 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/12 , C07D417/06
摘要： A melanin-concentrating hormone antagonist comprising a compound of the formula: wherein R is hydrogen atom or a cyclic group which may be substituted; X is a bond or a spacer having a main chain of 1 to 10 atoms; Y is a spacer having a main chain of 1 to 6 atoms; ring A is benzene ring which may be further substituted; ring B is a 5- to 9-membered nitrogen-containing non-aromatic heterocyclic ring which may be further substituted; R1 and R2 are the same or different and are hydrogen atom, a hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; or R1 and R2, together with the adjacent nitrogen atom, may form a nitrogen-containing heterocyclic ring which may be substituted; or R2, together with the adjacent nitrogen atom and Y, may form a nitrogen-containing heterocyclic ring which may be substituted; or a salt thereof is useful as a preventive or therapeutic agent for obesity, etc.
摘要翻译：一种黑色素浓缩激素拮抗剂，其包含下式化合物：其中R为氢原子或可被取代的环状基团; X是具有1至10个原子的主链的键或间隔基; Y是具有1至6个原子的主链的间隔物; 环A是可以被进一步取代的苯环; 环B是可以进一步取代的5至9元含氮非芳族杂环; R 1和R 2相同或不同，为氢原子，可被取代的烃基或可被取代的杂环基; 或R 1和R 2以及相邻的氮原子可以形成可以被取代的含氮杂环; 或R 2与相邻的氮原子和Y一起形成可以被取代的含氮杂环; 或其盐可用作肥胖症等的预防或治疗剂。

2. 发明授权

US07115750B1 Melanin concentrating hormone antagonist 失效
标题翻译：黑色素浓缩激素拮抗剂
公开(公告)号：US07115750B1
公开(公告)日：2006-10-03
申请号：US10088771
申请日：2000-09-19
申请人： Kaneyoshi Kato , Jun Terauchi , Masaaki Mori , Nobuhiro Suzuki , Yukio Shimomura , Shiro Takekawa , Yuji Ishihara
发明人： Kaneyoshi Kato , Jun Terauchi , Masaaki Mori , Nobuhiro Suzuki , Yukio Shimomura , Shiro Takekawa , Yuji Ishihara
IPC分类号： C09B5/00 , A61K3/41 , C07D209/56 , C07D487/00 , C07D491/00
CPC分类号： C07D207/277 , C07C217/74 , C07C219/28 , C07C233/29 , C07C233/44 , C07C233/80 , C07C235/42 , C07C235/50 , C07C235/56 , C07C235/64 , C07C235/84 , C07C237/40 , C07C271/28 , C07C275/42 , C07C311/21 , C07C2602/10 , C07C2602/12 , C07D209/18 , C07D209/22 , C07D209/42 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/26 , C07D211/32 , C07D211/52 , C07D211/62 , C07D211/70 , C07D213/56 , C07D213/81 , C07D213/82 , C07D215/14 , C07D215/38 , C07D233/24 , C07D239/28 , C07D239/30 , C07D261/18 , C07D263/14 , C07D263/34 , C07D265/28 , C07D271/06 , C07D295/096 , C07D295/13 , C07D295/185 , C07D307/68 , C07D307/81 , C07D311/58 , C07D317/60 , C07D319/20 , C07D333/24 , C07D333/28 , C07D333/38 , C07D335/16 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D493/04
摘要： A melanin-concentrating hormone antagonist which comprises a compound of the formula: wherein Ar1 is a cyclic group which may have substituents; X is a spacer having a main chain of 1 to 6 atoms; Y is a bond or a spacer having a main chain of 1 to 6 atoms; Ar is a monocyclic aromatic ring which may be condensed with a 4 to 8 membered non-aromatic ring, and may have further substituents; R1 and R2 are independently hydrogen atom or a hydrocarbon group which may have substituents; R1 and R2, together with the adjacent nitrogen atom, may form a nitrogen-containing hetero ring which may have substituents; R2 may form a spiro ring together with Ar; or R2, together with the adjacent nitrogen atom and Y, may form a nitrogen-containing hetero ring which may have substituents; or a salt thereof; which is useful as an agent for preventing or treating obesity, etc.
摘要翻译：一种黑色素浓缩激素拮抗剂，其包含下式化合物：其中Ar 1是可以具有取代基的环状基团; X是具有1至6个原子的主链的间隔物; Y是具有1至6个原子的主链的键或间隔基; Ar是可以与4至8元非芳族环稠合的单环芳环，并且可以具有其它取代基; R 1和R 2独立地是氢原子或可以具有取代基的烃基; R 1和R 2与相邻的氮原子一起可以形成可以具有取代基的含氮杂环; R 2可以与Ar一起形成螺环; 或R 2连同相邻的氮原子和Y可以形成可具有取代基的含氮杂环; 或其盐; 其可用作预防或治疗肥胖症等的药剂。

3. 发明授权

US06930185B2 Melanin-concentrating hormone antagonist 失效
标题翻译：黑色素浓缩激素拮抗剂
公开(公告)号：US06930185B2
公开(公告)日：2005-08-16
申请号：US10258492
申请日：2001-04-26
申请人： Yuji Ishihara , Nobuhiro Suzuki , Shiro Takekawa
发明人： Yuji Ishihara , Nobuhiro Suzuki , Shiro Takekawa
IPC分类号： C07C233/80 , C07C235/66 , C07C237/48 , C07C271/30 , C07D207/06 , C07D209/12 , C07D215/38 , C07D295/096 , C07D295/135 , C07D401/06 , C07D401/12 , C07D401/14 , C07D417/06 , C07D471/04 , A61K31/47 , C07D215/16
CPC分类号： C07D295/096 , C07C233/80 , C07C235/66 , C07C237/48 , C07C271/30 , C07D207/06 , C07D209/12 , C07D215/38 , C07D295/135 , C07D401/06 , C07D401/12 , C07D401/14 , C07D417/06 , C07D471/04
摘要： A melanin-concentrating hormone antagonist comprising a compound of the formula (I): wherein Ar1 is a cyclic group which may be substituted; X and Y are the same or different and are a spacer having a main chain of 1 to 6 atoms; Ar is a condensed polycyclic aromatic ring which may be substituted; R1 and R2 are the same or different and are hydrogen atom or a hydrocarbon group which may be substituted; or R1 and R2, together with the adjacent nitrogen atom, may form a nitrogen-containing heterocyclic ring which may be substituted; or R2, together with the adjacent nitrogen atom and Y, may form a nitrogen-containing heterocyclic ring which may be substituted; or R2, together with the adjacent nitrogen atom, Y and Ar, may form a condensed ring; or a salt thereof is useful as an agent for preventing or treating obesity, etc.
摘要翻译：包含式（I）化合物的黑色素浓缩激素拮抗剂：其中Ar 1是可被取代的环状基团; X和Y相同或不同，是具有1至6个原子的主链的间隔基; Ar是可以被取代的稠合多环芳香环; R 1和R 2相同或不同，为氢原子或可被取代的烃基; 或R 1和R 2以及相邻的氮原子可以形成可以被取代的含氮杂环; 或R 2与相邻的氮原子和Y一起形成可以被取代的含氮杂环; 或R 2与相邻的氮原子Y和Ar一起形成稠环; 或其盐可用作预防或治疗肥胖症等的药剂。

4. 发明申请

US20050209213A1 Quinoline compound 失效
标题翻译：喹啉化合物
公开(公告)号：US20050209213A1
公开(公告)日：2005-09-22
申请号：US10493427
申请日：2002-10-24
申请人： Yuji Ishihara , Makoto Kamata , Shiro Takekawa , Nobuhiro Suzuki , Koki Kato
发明人： Yuji Ishihara , Makoto Kamata , Shiro Takekawa , Nobuhiro Suzuki , Koki Kato
IPC分类号： A61K31/4015 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/55 , A61P3/04 , A61P5/04 , A61P25/22 , A61P25/24 , A61P43/00 , C07D215/38 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D413/02 , C07D41/02
CPC分类号： C07D401/06 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D215/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： A compound, which has a melanin-concentrating hormone antagonistic action and useful as an agent for preventing or treating obesity, and which is represented by the formula: wherein Ar is a cyclic group optionally having substituent(s); X is a bond or a spacer having a main chain of 1 to 6 atoms; R1 and R2 are the same or different and each is a hydrogen atom or a hydrocarbon group optionally having substituent(s), or R1 and R2 may form, together with the adjacent nitrogen atom, a nitrogen-containing heterocycle optionally having substituent(s); Y is a divalent hydrocarbon group optionally having substituent(s) (except CO); R3 is a hydrogen atom or a hydrocarbon group optionally having substituent(s); and ring A and ring B may further have substituents, and when ring B further has a substituent, the substituent may be linked to R1 to form a ring, or a salt thereof, or a prodrug thereof, is provided.
摘要翻译：一种化合物，其具有黑色素浓集激素拮抗作用并且可用作预防或治疗肥胖症的药剂，并且其由下式表示：其中Ar是任选具有取代基的环状基团; X是具有1至6个原子的主链的键或间隔基; R 1和R 2相同或不同，各自为氢原子或任选具有取代基的烃基，或R 1〜 >和R 2可以与相邻的氮原子一起形成任选具有取代基的含氮杂环; Y是任选具有取代基（CO除外）的二价烃基; R 3是氢原子或任选具有取代基的烃基; 并且环A和环B可以进一步具有取代基，并且当环B还具有取代基时，取代基可以与R 1连接形成环，或其盐或其前药，被提供。

5. 发明申请

US20070173498A1 Melanin concentrating hormone antagonist 审中-公开
标题翻译：黑色素浓缩激素拮抗剂
公开(公告)号：US20070173498A1
公开(公告)日：2007-07-26
申请号：US11224744
申请日：2005-09-12
申请人： Kaneyoshi Kato , Jun Terauchi , Masaaki Mori , Nobuhiro Suzuki , Yukio Shimomura , Shiro Takekawa , Yuji Ishihara
发明人： Kaneyoshi Kato , Jun Terauchi , Masaaki Mori , Nobuhiro Suzuki , Yukio Shimomura , Shiro Takekawa , Yuji Ishihara
IPC分类号： A61K31/538 , A61K31/4706 , A61K31/40 , A61K31/165 , A61K31/353
CPC分类号： C07D207/277 , C07C217/74 , C07C219/28 , C07C233/29 , C07C233/44 , C07C233/80 , C07C235/42 , C07C235/50 , C07C235/56 , C07C235/64 , C07C235/84 , C07C237/40 , C07C271/28 , C07C275/42 , C07C311/21 , C07C2602/10 , C07C2602/12 , C07D209/18 , C07D209/22 , C07D209/42 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/26 , C07D211/32 , C07D211/52 , C07D211/62 , C07D211/70 , C07D213/56 , C07D213/81 , C07D213/82 , C07D215/14 , C07D215/38 , C07D233/24 , C07D239/28 , C07D239/30 , C07D261/18 , C07D263/14 , C07D263/34 , C07D265/28 , C07D271/06 , C07D295/096 , C07D295/13 , C07D295/185 , C07D307/68 , C07D307/81 , C07D311/58 , C07D317/60 , C07D319/20 , C07D333/24 , C07D333/28 , C07D333/38 , C07D335/16 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D493/04
摘要： A melanin-concentrating hormone antagonist which comprises a compound of the formula: wherein Ar1 is a cyclic group which may have substituents; X is a spacer having a main chain of 1 to 6 atoms; Y is a bond or a spacer having a main chain of 1 to 6 atoms; Ar is a monocyclic aromatic ring which may be condensed with a 4 to 8 membered non-aromatic ring, and may have further substituents; R1 and R2 are independently hydrogen atom or a hydrocarbon group which may have substituents; R1 and R2, together with the adjacent nitrogen atom, may form a nitrogen-containing hetero ring which may have substituents; R2 may form a spiro ring together with Ar; or R2, together with the adjacent nitrogen atom and Y, may form a nitrogen-containing hetero ring which may have substituents; or a salt thereof; which is useful as an agent for preventing or treating obesity, etc.
摘要翻译：一种黑色素浓缩激素拮抗剂，其包含下式化合物：其中Ar 1是可以具有取代基的环状基团; X是具有1至6个原子的主链的间隔物; Y是具有1至6个原子的主链的键或间隔基; Ar是可以与4至8元非芳族环稠合的单环芳环，并且可以具有其它取代基; R 1和R 2独立地是氢原子或可以具有取代基的烃基; R 1和R 2与相邻的氮原子一起可以形成可以具有取代基的含氮杂环; R 2可以与Ar一起形成螺环; 或R 2连同相邻的氮原子和Y可以形成可具有取代基的含氮杂环; 或其盐; 其可用作预防或治疗肥胖症等的药剂。

6. 发明授权

US07183415B2 Quinoline compound 失效
标题翻译：喹啉化合物
公开(公告)号：US07183415B2
公开(公告)日：2007-02-27
申请号：US10493427
申请日：2002-10-24
申请人： Yuji Ishihara , Makoto Kamata , Shiro Takekawa , Nobuhiro Suzuki , Koki Kato
发明人： Yuji Ishihara , Makoto Kamata , Shiro Takekawa , Nobuhiro Suzuki , Koki Kato
IPC分类号： C07D215/38 , C07D215/14
CPC分类号： C07D401/06 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D215/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： A compound, which has a melanin-concentrating hormone antagonistic action and useful as an agent for preventing or treating obesity, and which is represented by the formula: wherein Ar is a cyclic group optionally having substituent(s); X is a bond or a spacer having a main chain of 1 to 6 atoms; R1 and R2 are the same or different and each is a hydrogen atom or a hydrocarbon group optionally having substituent(s), or R1 and R2 may form, together with the adjacent nitrogen atom, a nitrogen-containing heterocycle optionally having substituent(s); Y is a divalent hydrocarbon group optionally having substituent(s) (except CO); R3 is a hydrogen atom or a hydrocarbon group optionally having substituent(s); and ring A and ring B may further have substituents, and when ring B further has a substituent, the substituent may be linked to R1 to form a ring, or a salt thereof, or a prodrug thereof, is provided.
摘要翻译：一种化合物，其具有黑色素浓集激素拮抗作用并且可用作预防或治疗肥胖症的药剂，并且其由下式表示：其中Ar是任选具有取代基的环状基团; X是具有1至6个原子的主链的键或间隔基; R 1和R 2相同或不同，各自为氢原子或任选具有取代基的烃基，或R 1〜 >和R 2可以与相邻的氮原子一起形成任选具有取代基的含氮杂环; Y是任选具有取代基（CO除外）的二价烃基; R 3是氢原子或任选具有取代基的烃基; 并且环A和环B可以进一步具有取代基，并且当环B还具有取代基时，取代基可以与R 1连接形成环，或其盐或其前药，被提供。

7. 发明申请

US20060128690A1 Amine derivative 失效
标题翻译：胺衍生物
公开(公告)号：US20060128690A1
公开(公告)日：2006-06-15
申请号：US10545120
申请日：2004-02-12
申请人： Yuji Ishihara , Makoto Kamata , Shiro Takekawa
发明人： Yuji Ishihara , Makoto Kamata , Shiro Takekawa
IPC分类号： A61K31/55 , A61K31/401 , A61K31/445
CPC分类号： C07D211/16 , A61K31/55 , C07C233/73 , C07C235/42 , C07D207/09 , C07D207/12 , C07D211/14 , C07D213/82 , C07D233/24 , C07D295/135
摘要： The present invention provides a compound represented by the formula wherein Ar1 is a cyclic group optionally having substituent(s); R is a hydrogen atom, an optionally halogenated C1-6 alkyl, a phenyl optionally having substituent(s) or a pyridyl optionally having substituent(s); Ra1, Ra2, Ra3 and Ra4 are the same or different and each is a hydrogen atom, an optionally halogenated C1-6 alkyl or the like; Ar is a monocyclic aromatic ring optionally having substituent(s); Y is an optionally halogenated alkylene group; and R1 and R2 are (1) the same or different and each is a hydrogen atom or a C1-6 alkyl, (2) R1 and R2 form a nitrogen-containing heterocycle optionally having substituent(s) together with the adjacent nitrogen atom, or (3) R1 and Y form a nitrogen-containing heterocycle optionally having substituent(s) together with the adjacent nitrogen atom, and R2 is a hydrogen atom or a C1-6 alkyl; provided that when the nitrogen-containing heterocycle formed by R1 and R2 together with the adjacent nitrogen atom is a piperazine, or when R is a C1-4 alkyl, Ar1 is a cyclic group having substituent(s), or a salt thereof, having a melanin-concentrating hormone antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like.
摘要翻译：本发明提供由下式表示的化合物：其中Ar 1是任选具有取代基的环状基团; R是氢原子，任选卤代的C 1-6烷基，任选具有取代基的苯基或任选具有取代基的吡啶基; Ra 1，R 2，R 3，R 3和R 4相同或不同，各自为氢原子，任选卤代的C 1-6烷基等; Ar是任选具有取代基的单环芳环; Y是任选卤代的亚烷基; 且R 1和R 2均为（1）相同或不同，并且各自为氢原子或C 1-6烷基，（ 2）R 1和R 2 2形成任选具有取代基的氮杂环与相邻的氮原子，或（3）R 1， Y和Y形成任选具有取代基的氮杂环与相邻的氮原子一起形成，R 2是氢原子或C 1-6 烷基; 条件是当由R 1和R 2与相邻氮原子一起形成的含氮杂环是哌嗪时，或当R是C 1〜 4个烷基，Ar 1是具有取代基的环状基团或其盐，其具有黑色素浓缩激素拮抗作用并且可用作预防或治疗的药剂肥胖等。

8. 发明授权

US07601868B2 Amine derivative 失效
标题翻译：胺衍生物
公开(公告)号：US07601868B2
公开(公告)日：2009-10-13
申请号：US10545120
申请日：2004-02-12
申请人： Yuji Ishihara , Makoto Kamata , Shiro Takekawa
发明人： Yuji Ishihara , Makoto Kamata , Shiro Takekawa
IPC分类号： C07C233/65 , C07D207/06 , A61K31/165 , A61K31/40
CPC分类号： C07D211/16 , A61K31/55 , C07C233/73 , C07C235/42 , C07D207/09 , C07D207/12 , C07D211/14 , C07D213/82 , C07D233/24 , C07D295/135
摘要： The present invention provides a compound represented by the formula or salts thereof, wherein, Ar1, Ar, R, R1, R2, Ra1, Ra2, Ra3, Ra4 and Y have meanings described in the specification, having a melanin-concentrating hormone antagonistic, action and useful as an agent for the prophylaxis or treatment of obesity and the like.
摘要翻译：本发明提供由下式表示的化合物或其盐，其中Ar1，Ar，R，R1，R2，Ra1，Ra2，Ra3，Ra4和Y具有说明书中描述的具有黑色素浓缩激素拮抗作用的含义，作用并用作预防或治疗肥胖症等的药剂。

9. 发明授权

US06329389B1 Amine compounds, their production and use 失效
标题翻译：胺化合物，其生产和使用
公开(公告)号：US06329389B1
公开(公告)日：2001-12-11
申请号：US09424285
申请日：1999-11-19
申请人： Nobuhiro Suzuki , Kaneyoshi Kato , Shiro Takekawa , Jun Terauchi , Satoshi Endo
发明人： Nobuhiro Suzuki , Kaneyoshi Kato , Shiro Takekawa , Jun Terauchi , Satoshi Endo
IPC分类号： A01N4342
CPC分类号： C07D401/06 , C07D215/12 , C07D215/18 , C07D215/20 , C07D215/38 , C07D215/58 , C07D241/42 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/06 , C07D409/10 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14 , C07D471/10
摘要： The present invention provides a compound of the formula: wherein Ar represents an aromatic group which may be substituted; X represents methylene, S, SO, SO2 or CO; Y represents a spacer having a main chain of 2 to 5 atoms; n represents an integer of 1 to 5; i) R1 and R2 each represents a hydrogen atom or a lower alkyl which may be substituted, ii) R1 and R2 form, taken together with the adjacent nitrogen atom, a nitrogen-containing heterocyclic ring which may be substituted, or iii) R1 or R2 together with —(CH2)n—N═ form, bonded to a component atom of Ring B, a spiro-ring which may be substituted; Ring A represents an aromatic ring which may be substituted; Ring B represents a 4- to 7-membered nitrogen-containing non-aromatic ring which may be further substituted by alkyl or acyl, with a proviso that X represents S, SO, SO2 or CO when Ring A has as a substituent a group represented by the formula: —NHCOR11 where R11 represents alkyl, alkoxyalkyl, alkylthioalkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl or a group represented by the formula: —NHR12 where R12 represents alkyl, cycloalkyl, cycloalkylalkyl, aryl or arylalkyl, or a salt thereof; which has an excellent somatostatin receptor binding inhibition action.
摘要翻译：本发明提供下式的化合物：其中Ar表示可被取代的芳族基团; X表示亚甲基，S，SO，SO 2或CO; Y表示主链为2至5个原子的间隔基; n表示 1至5的整数; i）R 1和R 2各自表示氢原子或可被取代的低级烷基，ii）R 1和R 2与相邻的氮原子一起形成可被取代的含氮杂环，oriii）R1或R2与 - （CH2）nN =形成键合，键合到环B的组分原子，可被取代的螺环;环A表示可被取代的芳环;环B表示4 - 可以进一步被烷基或酰基取代的7-元含氮非芳香环，条件是当环A具有由下式表示的基团作为取代基时，X表示S，SO，SO 2或CO：其中 R11表示烷基，烷氧基烷基，烷硫基烷基，环烷基，环烷基烷基，芳基，芳基烷基或由下式表示的基团：其中R 12表示烷基，环烷基，环烷基烷基，芳基或芳基烷基或其盐; 其具有优异的生长抑素受体结合抑制作用。

10. 发明授权

US06991908B1 Antiobestic agents methods for screening antiobestic agents and kits comprising same 失效
标题翻译：用于筛选抗生物剂的抗生物剂方法和包含其的试剂盒
公开(公告)号：US06991908B1
公开(公告)日：2006-01-31
申请号：US09869540
申请日：1999-12-27
申请人： Masaaki Mori , Yukio Shimomura , Shiro Takekawa , Tsukasa Sugo , Yoshihiro Ishibashi , Chieko Kitada , Nobuhiro Suzuki
发明人： Masaaki Mori , Yukio Shimomura , Shiro Takekawa , Tsukasa Sugo , Yoshihiro Ishibashi , Chieko Kitada , Nobuhiro Suzuki
IPC分类号： G01N33/53
CPC分类号： C07K7/08 , A61K38/10 , G01N33/74 , G01N2333/575 , G01N2333/726 , G01N2500/00 , G01N2500/02 , Y10S436/808
摘要： The present invention provides a method for screening a compound or its salt that alters the binding property between MCH or its salt and SLC-1 or its salt, characterized by using MCH or its derivative or a salt thereof and SLC-1 or its salt is useful for screening an SLC-1 agonist which can be used not only as an appetite (eating) promoting agent but also as a prophylactic/therapeutic agent for weak pains, atonic bleeding, before and after expulsion, subinvolution of uterus, cesarean section, induced abortion, galactostasis, and the like, and an SLC-1 antagonist which can be used not only as an antiobestic agents (drug), an appetite (eating) modulator, and the like, but also as a prophylactic/therapeutic agent for hyperstimulation, ankylosing uterine contractions, fetal distress, uterine rupture, cervical laceration, preterm delivery, Prader-Wili syndrome and the like.
摘要翻译：本发明提供一种筛选化合物或其盐的方法，其改变MCH或其盐与SLC-1或其盐之间的结合性质，其特征在于使用MCH或其衍生物或其盐，SLC-1或其盐是可用于筛选SLC-1激动剂，其不仅可以用作食欲（进食）促进剂，而且可用作弱疼痛，无症状出血，驱除前后，子宫切除，剖宫产，诱导流产，半乳糖淀粉酶等，以及不仅可以用作抗生素（药物），食欲调节剂等的SLC-1拮抗剂，而且可以用作过度刺激的预防/治疗剂，强直性子宫收缩，胎儿窘迫，子宫破裂，子宫颈撕裂，早产，Prader-Wili综合征等。

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