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1. 发明申请

US20130072554A1 Novel Method For Delivery and Use of Isothiocyanates For Prophylaxis and/or Therapy of Bladder Cancer 有权
标题翻译：用于递送和使用异硫氰酸酯进行膀胱癌预防和/或治疗的新方法
公开(公告)号：US20130072554A1
公开(公告)日：2013-03-21
申请号：US13609531
申请日：2012-09-11
申请人： Yuesheng Zhang , Arup Bhattacharya , Li Tang , Yun Li , Joseph D. Paonessa , Feng Geng , Yi Ding
发明人： Yuesheng Zhang , Arup Bhattacharya , Li Tang , Yun Li , Joseph D. Paonessa , Feng Geng , Yi Ding
IPC分类号： A61K31/26 , A61K36/31
CPC分类号： A61K31/26 , A61K36/31 , A61K2236/10
摘要： Provided is a composition that contains a mixture of broccoli seed and mustard seed. Before mixing the broccoli seed with the mustard seed, the broccoli seed is subjected to baking and a pressurized heat treatment. The broccoli seed is baked at a temperature of at least 200 degrees Fahrenheit for at least 60 minutes, and is subjected to a pressurized heat treatment of at least 200 degrees Fahrenheit at a pressure of at least 10 pounds/square inch for at least 5 minutes. Also provided is a method for therapy and/or prophylaxis of bladder cancer in an individual. The method entails administering orally to the individual a composition that contains an isothiocyanate (ITC) or a derivative thereof such that the administration inhibits the growth and/or recurrence of bladder cancer. Nutraceutical compositions are also provided.
摘要翻译：本发明提供一种含有西兰花籽和芥菜籽混合物的组合物。在将西兰花种子与芥菜种子混合之前，将花椰菜种子进行烘烤和加压热处理。将青花菜种子在至少200华氏度的温度下烘烤至少60分钟，并在至少10磅/平方英寸的压力下进行至少200华氏度的加压热处理至少5分钟。还提供了治疗和/或预防个体中膀胱癌的方法。该方法需要向个体口服含有异硫氰酸酯（ITC）或其衍生物的组合物，使得该给药抑制膀胱癌的生长和/或复发。还提供营养组合物。

2. 发明授权

US09486434B2 Method for delivery and use of isothiocyanates for prophylaxis and/or therapy of bladder cancer 有权
标题翻译：用于预防和/或治疗膀胱癌的异硫氰酸酯的递送和使用方法
公开(公告)号：US09486434B2
公开(公告)日：2016-11-08
申请号：US13609531
申请日：2012-09-11
申请人： Yuesheng Zhang , Arup Bhattacharya , Li Tang , Yun Li , Joseph D. Paonessa , Feng Geng , Yi Ding
发明人： Yuesheng Zhang , Arup Bhattacharya , Li Tang , Yun Li , Joseph D. Paonessa , Feng Geng , Yi Ding
IPC分类号： A61K36/31 , A61K31/26
CPC分类号： A61K31/26 , A61K36/31 , A61K2236/10
摘要： Provided is a composition that contains a mixture of broccoli seed and mustard seed. Before mixing the broccoli seed with the mustard seed, the broccoli seed is subjected to baking and a pressurized heat treatment. The broccoli seed is baked at a temperature of at least 200 degrees Fahrenheit for at least 60 minutes, and is subjected to a pressurized heat treatment of at least 200 degrees Fahrenheit at a pressure of at least 10 pounds/square inch for at least 5 minutes. Also provided is a method for therapy and/or prophylaxis of bladder cancer in an individual. The method entails administering orally to the individual a composition that contains an isothiocyanate (ITC) or a derivative thereof such that the administration inhibits the growth and/or recurrence of bladder cancer. Nutraceutical compositions are also provided.
摘要翻译：本发明提供一种含有西兰花籽和芥菜籽混合物的组合物。在将西兰花种子与芥菜种子混合之前，将花椰菜种子进行烘烤和加压热处理。将青花菜种子在至少200华氏度的温度下烘烤至少60分钟，并在至少10磅/平方英寸的压力下进行至少200华氏度的加压热处理至少5分钟。还提供了治疗和/或预防个体中膀胱癌的方法。该方法需要向个体口服含有异硫氰酸酯（ITC）或其衍生物的组合物，使得该给药抑制膀胱癌的生长和/或复发。还提供营养组合物。

3. 发明授权

US08772533B1 Organoleptic compound 有权
标题翻译：感官化合物
公开(公告)号：US08772533B1
公开(公告)日：2014-07-08
申请号：US13775393
申请日：2013-02-25
申请人： Richard K. Payne , Feng Geng , Gary J. Mertz
发明人： Richard K. Payne , Feng Geng , Gary J. Mertz
IPC分类号： C07C69/56 , A61K8/00
CPC分类号： C11B9/0019 , C07C69/56
摘要： The present invention is directed to a novel compound, but-2-enoic acid 1-ethyl-2-methyl-propyl ester, and a method of improving, enhancing or modifying a fragrance formulation through the addition of an olfactory acceptable amount of but-2-enoic acid 1-ethyl-2-methyl-propyl ester.
摘要翻译：本发明涉及一种新型化合物异丁烯-1-乙基-2-甲基丙基酯，以及通过添加嗅觉可接受量的丁二酸改进，增强或改性香料制剂的方法， 2-烯酸1-乙基-2-甲基 - 丙基酯。

4. 发明申请

US20110286965A1 ETHENYL-SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS 有权
标题翻译：乙基取代的吡啶和吡嗪衍生物及其在治疗病毒感染中的应用
公开(公告)号：US20110286965A1
公开(公告)日：2011-11-24
申请号：US13059199
申请日：2009-08-19
申请人： Cecil D. Kwong , F. George Njoroge , Subramaniam Ananthan , Jeremy Clark , Feng Geng , Hollis S. Kezar, III , Joseph A. Maddry , John J. Piwinski , Robert C. Reynolds , Abhijit Roychowdhury , John A. Secrist, III , Neng-Yang Shih
发明人： Cecil D. Kwong , F. George Njoroge , Subramaniam Ananthan , Jeremy Clark , Feng Geng , Hollis S. Kezar, III , Joseph A. Maddry , John J. Piwinski , Robert C. Reynolds , Abhijit Roychowdhury , John A. Secrist, III , Neng-Yang Shih
IPC分类号： A61K31/505 , A61P31/12 , A61K39/00 , A61K39/395 , C07D239/48 , A61K38/21
CPC分类号： C07D239/48
摘要： The present invention provides compounds of Formula (A): (Chemical formula should be inserted here as it appears on abstract in paper form) (A) and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19, R22, R23, and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
摘要翻译：本发明提供了式（A）化合物：（化学式应该插在这里，它以纸质形式的摘要出现）（A）和所述化合物的互变异构体，异构体和酯以及药学上可接受的盐，溶剂合物和前药的所述化合物，其中R，R1，X，Y，Z，R2，R3，R4，R5，R6，R7，R8，R9，R18，R19，R22，R23和n各自独立地和定义这里。还提供了包含这些化合物的组合物。本发明的化合物作为HCV的抑制剂是有效的，并且单独和与其它治疗剂一起用于治疗或预防疾病或病症如病毒感染和病毒相关疾病。

5. 发明授权

US08697694B2 Substituted pyridine and pyrimidine derivatives and their use in treating viral infections 有权
标题翻译：取代的吡啶和嘧啶衍生物及其在治疗病毒感染中的应用
公开(公告)号：US08697694B2
公开(公告)日：2014-04-15
申请号：US13059193
申请日：2009-08-19
申请人： Ashok Arasappan , F. George Njoroge , Cecil D. Kwong , Subramaniam Ananthan , Frank Bennett , Jeremy Clark , Hollis S. Kezar, III , Vinay M. Girijavallabhan , Yuhua Huang , Regina Huelgas , Joseph A. Maddry , John J. Piwinski , Robert C. Reynolds , Abhijit Roychowdhury , Anita T. Fowler , Feng Geng , John A. Secrist, III , Neng-Yang Shih , Vishal Verma , Francisco Velazquez , Srikanth Venkatraman
发明人： Ashok Arasappan , F. George Njoroge , Cecil D. Kwong , Subramaniam Ananthan , Frank Bennett , Jeremy Clark , Hollis S. Kezar, III , Vinay M. Girijavallabhan , Yuhua Huang , Regina Huelgas , Joseph A. Maddry , John J. Piwinski , Robert C. Reynolds , Abhijit Roychowdhury , Anita T. Fowler , Feng Geng , John A. Secrist, III , Neng-Yang Shih , Vishal Verma , Francisco Velazquez , Srikanth Venkatraman
IPC分类号： C07D239/48 , C07D491/04 , A61K31/506
CPC分类号： C07D239/48 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D491/04
摘要： The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
摘要翻译：本发明提供式（I）的化合物：所述化合物的互变异构体，异构体和酯，以及所述化合物的药学上可接受的盐，溶剂合物和前药，其中R，R 1，X，Y，Z，R 2， R3，R4，R5，R6，R7，R8，R9，R18，R19和n独立选择和如本文所定义。还提供了包含这些化合物的组合物。本发明的化合物作为HCV的抑制剂是有效的，并且单独和与其它治疗剂一起用于治疗或预防疾病或病症如病毒感染和病毒相关疾病。

6. 发明授权

US08736658B2 Image-based video conference control method, terminal, and system 有权
标题翻译：基于图像的视频会议控制方法，终端和系统
公开(公告)号：US08736658B2
公开(公告)日：2014-05-27
申请号：US13270461
申请日：2011-10-11
申请人： Jing Zhang , Feng Geng
发明人： Jing Zhang , Feng Geng
IPC分类号： H04N7/14
CPC分类号： H04N7/15 , H04L12/1822 , H04L12/1827 , H04N7/152
摘要： Embodiments of the present invention disclose an image-based video conference control method, terminal, and system. The method includes the following steps: sending a control request message to a network-side device (101); dynamically displaying image information according to a control message fed back by the network-side device (102); and editing an image according to the image information to complete video conference control (103). Through the embodiments of the present invention, an image of a single or multiple conference site pictures can be directly selected for operation according to abundant information provided by each conference site picture in combination with an operation of a remote controller, so that all kinds of conference control operations in a video conference are implemented, and a need of entering a multi-level menu to carry out complicated video conference control is avoided.
摘要翻译：本发明的实施例公开了一种基于图像的视频会议控制方法，终端和系统。该方法包括以下步骤：向网络侧设备（101）发送控制请求消息; 根据由所述网络侧设备（102）反馈的控制消息来动态地显示图像信息; 以及根据图像信息编辑图像以完成视频会议控制（103）。通过本发明的实施例，可以根据每个会场图片提供的丰富的信息，结合遥控器的操作，直接选择单个或多个会场图片的图像进行操作，从而使各种会议实现视频会议中的控制操作，并且避免了进入多级菜单以执行复杂的视频会议控制的需要。

7. 发明申请

US20120038740A1 IMAGE-BASED VIDEO CONFERENCE CONTROL METHOD, TERMINAL, AND SYSTEM 有权
标题翻译：基于图像的视频会议控制方法，终端和系统
公开(公告)号：US20120038740A1
公开(公告)日：2012-02-16
申请号：US13270461
申请日：2011-10-11
申请人： Jing ZHANG , Feng Geng
发明人： Jing ZHANG , Feng Geng
IPC分类号： H04N7/15
CPC分类号： H04N7/15 , H04L12/1822 , H04L12/1827 , H04N7/152
摘要： Embodiments of the present invention disclose an image-based video conference control method, terminal, and system. The method includes the following steps: sending a control request message to a network-side device (101); dynamically displaying image information according to a control message fed back by the network-side device (102); and editing an image according to the image information to complete video conference control (103). Through the embodiments of the present invention, an image of a single or multiple conference site pictures can be directly selected for operation according to abundant information provided by each conference site picture in combination with an operation of a remote controller, so that all kinds of conference control operations in a video conference are implemented, and a need of entering a multi-level menu to carry out complicated video conference control is avoided.
摘要翻译：本发明的实施例公开了一种基于图像的视频会议控制方法，终端和系统。该方法包括以下步骤：向网络侧设备（101）发送控制请求消息; 根据由所述网络侧设备（102）反馈的控制消息来动态地显示图像信息; 以及根据图像信息编辑图像以完成视频会议控制（103）。通过本发明的实施例，可以根据每个会场图片提供的丰富的信息，结合遥控器的操作，直接选择单个或多个会场图片的图像进行操作，从而使各种会议实现视频会议中的控制操作，并且避免了进入多级菜单以执行复杂的视频会议控制的需要。

8. 发明申请

US20110286964A1 AZO-SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS 有权
标题翻译： AZO取代的吡啶和吡嗪衍生物及其在治疗病毒感染中的应用
公开(公告)号：US20110286964A1
公开(公告)日：2011-11-24
申请号：US13059197
申请日：2009-08-19
申请人： Cecil D. Kwong , F. George Njoroge , Subramaniam Ananthan , Feng Geng , Hollis S. Kezar, III , Joseph A. Maddry , John J. Piwinski , Robert C. Reynolds , John A. Secrist, III , Neng-Yang Shih
发明人： Cecil D. Kwong , F. George Njoroge , Subramaniam Ananthan , Feng Geng , Hollis S. Kezar, III , Joseph A. Maddry , John J. Piwinski , Robert C. Reynolds , John A. Secrist, III , Neng-Yang Shih
IPC分类号： A61K38/21 , C07D405/12 , C07D403/04 , A61K31/655 , A61K39/00 , A61P31/14 , A61K31/7088 , A61K39/29 , A61P31/12 , A61P37/04 , A61P37/06 , C07D239/50 , A61K39/395
CPC分类号： C07D239/50
摘要： The present invention provides compounds of Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19, and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing dieases or disorders such as viral infections and virus-related disorders.
摘要翻译：本发明提供了式（I）化合物：（化学式应该插在这里，它以纸的形式出现）（I）和所述化合物的互变异构体，异构体和酯以及药学上可接受的盐，溶剂合物和前药的所述化合物，其中R，R 1，X，Y，Z，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 18，R 19和n各自独立地并如本文所定义。还提供了包含这些化合物的组合物。本发明的化合物作为HCV的抑制剂是有效的，并且可单独使用和与其它治疗剂一起用于治疗或预防死亡或病症如病毒感染和病毒相关疾病。

9. 发明授权

US08470834B2 AZO-substituted pyridine and pyrimidine derivatives and their use in treating viral infections 有权
标题翻译： AZO取代的吡啶和嘧啶衍生物及其在治疗病毒感染中的应用
公开(公告)号：US08470834B2
公开(公告)日：2013-06-25
申请号：US13059197
申请日：2009-08-19
申请人： Cecil D. Kwong , F. George Njoroge , Subramaniam Ananthan , Feng Geng , Hollis S. Kezar, III , Joseph A. Maddry , John J. Piwinski , Robert C. Reynolds , John A. Secrist, III , Neng-Yang Shih
发明人： Cecil D. Kwong , F. George Njoroge , Subramaniam Ananthan , Feng Geng , Hollis S. Kezar, III , Joseph A. Maddry , John J. Piwinski , Robert C. Reynolds , John A. Secrist, III , Neng-Yang Shih
IPC分类号： C07D239/50 , C07D213/72 , C07D405/02 , A61K31/505 , A61K31/443 , A61K31/497
CPC分类号： C07D239/50
摘要： The present invention provides compounds of Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19, and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
摘要翻译：本发明提供了式（I）化合物：（化学式应该插在这里，它以纸的形式出现）（I）和所述化合物的互变异构体，异构体和酯以及药学上可接受的盐，溶剂合物和前药的所述化合物，其中R，R 1，X，Y，Z，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 18，R 19和n各自独立地并如本文所定义。还提供了包含这些化合物的组合物。本发明的化合物作为HCV的抑制剂是有效的，并且单独和与其它治疗剂一起用于治疗或预防疾病或病症如病毒感染和病毒相关疾病。

10. 发明授权

US08178485B2 Hexahydro ethanochromenes and related compounds and their use in fragrance compositions 有权
标题翻译：六氢乙烯色烯及其相关化合物及其在香料组合物中的应用
公开(公告)号：US08178485B2
公开(公告)日：2012-05-15
申请号：US12855049
申请日：2010-08-12
申请人： Feng Geng , Richard M. Boden
发明人： Feng Geng , Richard M. Boden
IPC分类号： A61K8/49 , C11D3/50 , C07D311/78
CPC分类号： C07D311/78
摘要： The present invention relates to novel compounds and their use in fragrance compositions. Novel hexahydro ethanochromene and related hexahydro ethanochromane compounds of the present invention are represented by formula: wherein R1 is hydrogen or methyl; R2 and R2′ are identical and are hydrogen or methyl; R3 and R3′ are identical and are hydrogen or methyl; R4 and R5 are independently hydrogen or methyl; R6 is methyl, ethyl, or isopropyl, with the proviso that when R1 is H, R2 and R3′ form an alkylene bridge containing 1 or 2 carbon atoms, and wherein the broken line represents a single or double bond.
摘要翻译：本发明涉及新型化合物及其在香料组合物中的用途。本发明的新型六氢乙炔色烯和相关六氢乙炔色烯烃化合物由下式表示：其中R1是氢或甲基; R2和R2'相同，为氢或甲基; R3和R3'相同，为氢或甲基; R4和R5独立地是氢或甲基; R6为甲基，乙基或异丙基，条件是当R 1为H时，R 2和R 3'形成含有1或2个碳原子的亚烷基桥，其中虚线表示单键或双键。

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