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1. 发明申请

US20050176073A1 Cell proliferation associated with CCX CKR expression 审中-公开
标题翻译：与CCX CKR表达相关的细胞增殖
公开(公告)号：US20050176073A1
公开(公告)日：2005-08-11
申请号：US10773380
申请日：2004-02-06
申请人： Yu Wang , Brett Premack , Thomas Schall
发明人： Yu Wang , Brett Premack , Thomas Schall
IPC分类号： G01N33/50 , G01N33/574
CPC分类号： G01N33/5011 , G01N2333/715
摘要： Methods for screening agents to identify an agent that modulates CCX CKR proliferative activity are provided. Tissue generation methods are also disclosed that involve activating CCX CKR expression and activity levels, as are methods for promoting angiogenesis. Methods for treating various diseases associated with cell proliferation are also described.
摘要翻译：提供筛选试剂鉴定调节CCX CKR增殖活性的试剂的方法。还公开了包括活化CCX CKR表达和活性水平的组织产生方法，以及用于促进血管生成的方法。还描述了治疗与细胞增殖相关的各种疾病的方法。

2. 发明申请

US20060034863A1 Compositions useful as ligands for the formyl peptide receptor like 1 receptor and methods of use thereof 有权
标题翻译：可用作甲酰肽受体如1受体的配体的组合物及其使用方法
公开(公告)号：US20060034863A1
公开(公告)日：2006-02-16
申请号：US11175003
申请日：2005-07-05
申请人： Thomas Schall , Zhenhua Miao , Robert Berahovich , Zheng Wei , Maureen Howard , Brett Premack
发明人： Thomas Schall , Zhenhua Miao , Robert Berahovich , Zheng Wei , Maureen Howard , Brett Premack
IPC分类号： A61K39/02 , A61K38/10
CPC分类号： C07K14/523 , A61K38/00 , A61K39/39 , A61K2039/55522 , Y02A50/39 , Y02A50/401 , Y02A50/466 , Y02A50/484
摘要： The inventors have discovered that a CKβ8-1 truncation variant, CKβ8-1 (25-116), is a bifunctional ligand for two distinct GPCRs, chemokine receptor CCR1 and formyl peptide receptor like 1 (FPRL1). Hence, the inventors have discovered that, in addition to its functional activity on CCR1, CKβ8-1(25-116) is also a functional ligand for the GPCR receptor FPRL1 that is involved in inflammatory reactions and innate immunity by recruiting monocytes and neutrophils. In addition, the inventors have discovered an alternatively spliced exon of CKβ8-1, named SHAAGtide. SHAAGtide, along with its parent chemokine CKβ8-1 (25-116), is fully functional on both monocytes and neutrophils that are known to express FPRL1. This application relates generally to enhancing immune responses. Such immune responses may be elicited by vaccine administration. Compositions and methods for inducing or enhancing an immune response to an antigen are provided. The compositions and methods are useful for vaccine formulations for therapeutic and prophylactic use (immunization) and for production of antibodies.
摘要翻译：本发明人已经发现CKbeta8-1截短变体CKbeta8-1（25-116）是两种不同GPCR，趋化因子受体CCR1和甲酰肽受体1（FPRL1）的双功能配体。因此，本发明人发现除了CCR1的功能活性外，CKbeta8-1（25-116）也是通过募集单核细胞和嗜中性粒细胞参与炎症反应和先天免疫的GPCR受体FPRL1的功能性配体。此外，本发明人已经发现了称为SHAAGTIDE的CKbeta8-1的可变剪接外显子。 SHAAGTIDE与其母体趋化因子CKbeta8-1（25-116）一起在已知表达FPRL1的单核细胞和嗜中性粒细胞上完全起作用。本申请一般涉及增强免疫应答。这种免疫应答可以通过疫苗施用引起。提供了诱导或增强对抗原的免疫应答的组合物和方法。组合物和方法可用于治疗和预防用途（免疫）和产生抗体的疫苗制剂。

3. 发明申请

US20050234004A1 Compositions and methods of use of W-peptides 审中-公开
标题翻译：组合物和使用W肽的方法
公开(公告)号：US20050234004A1
公开(公告)日：2005-10-20
申请号：US11043020
申请日：2005-01-25
申请人： Brett Premack , Thomas Schall
发明人： Brett Premack , Thomas Schall
IPC分类号： A61K39/07 , A61K39/39 , A61K48/00
CPC分类号： A61K39/07 , A61K39/39 , A61K2039/55516
摘要： The present invention relates to compositions and methods to modulating immune responses, such as those elicited by vaccination with W peptides. The compositions and methods are useful for, among other things, vaccine formulation for therapeutic and prophylactic vaccination (immunization) and for production of useful antibodies (e.g., monoclonal antibodies, for therapeutic or diagnostic use).
摘要翻译：本发明涉及调节免疫应答的组合物和方法，例如用W肽接种引发的那些。组合物和方法尤其可用于治疗性和预防性接种疫苗（免疫）和生产有用抗体（例如用于治疗或诊断用途的单克隆抗体）的疫苗制剂。

4. 发明申请

US20050137179A1 Bis-aryl sulfonamides 有权
标题翻译：双芳基磺酰胺
公开(公告)号：US20050137179A1
公开(公告)日：2005-06-23
申请号：US10848836
申请日：2004-05-19
申请人： Solomon Ungashe , Zheng Wei , J. J. Wright , Andrew Pennell , Brett Premack , Thomas Schall
发明人： Solomon Ungashe , Zheng Wei , J. J. Wright , Andrew Pennell , Brett Premack , Thomas Schall
IPC分类号： A61K31/18 , A61K31/195 , A61K31/397 , A61K31/445 , A61K31/55 , C07D213/26 , C07D213/50 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D241/12 , C07D413/12
CPC分类号： C07D213/26 , A61K31/18 , A61K31/195 , A61K31/397 , A61K31/4245 , A61K31/433 , A61K31/445 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D213/50 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D241/12 , C07D413/12
摘要： Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.
摘要翻译：提供了作为趋化因子受体的有效拮抗剂的化合物。化合物通常为芳基磺酰胺衍生物，可用于药物组合物，治疗趋化因子受体介导的疾病的方法，以及用于鉴定趋化因子拮抗剂的测定中的对照。

5. 发明申请

US20110257183A1 BIS-ARYL SULFONAMIDES 有权
公开(公告)号：US20110257183A1
公开(公告)日：2011-10-20
申请号：US13092615
申请日：2011-04-22
申请人： Solomon Ungashe , Zheng Wei , J.J. Wright , Andrew Pennell , Brett Premack , Thomas Schall
发明人： Solomon Ungashe , Zheng Wei , J.J. Wright , Andrew Pennell , Brett Premack , Thomas Schall
IPC分类号： A61K31/535 , C07C311/21 , A61K31/18 , A61K31/4406 , A61K31/381 , C07D211/72 , C07D333/08 , C07D307/87 , A61K31/343 , A61K31/415 , C07D231/12 , C07D263/32 , A61K31/421 , A61K31/24 , C07D265/30 , C12N5/02
CPC分类号： C07D213/26 , A61K31/4245 , A61K31/433 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D213/50 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D241/12 , C07D413/12
摘要： Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.
摘要翻译：提供了作为趋化因子受体的有效拮抗剂的化合物。化合物通常为芳基磺酰胺衍生物，可用于药物组合物，治疗趋化因子受体介导的疾病的方法，以及用于鉴定趋化因子拮抗剂的测定中的对照。

6. 发明申请

US20070087986A1 Compositions and methods for enhancing immunity by chemoattractant adjuvants 审中-公开
标题翻译：用于增强化学吸引剂佐剂免疫力的组合物和方法
公开(公告)号：US20070087986A1
公开(公告)日：2007-04-19
申请号：US11496267
申请日：2006-07-31
申请人： Brett Premack , Matthew Walters , Thomas Schall
发明人： Brett Premack , Matthew Walters , Thomas Schall
IPC分类号： A61K48/00 , A61K38/19
CPC分类号： A61K39/07 , A61K39/39 , A61K2039/543 , A61K2039/55516 , A61K2039/55561 , C12N2710/00088
摘要： The invention is directed to methods and compositions for enhancing immunity, including mucosal immunity. The compositions include an antigen or immunogen, a ligand for a Toll-like receptor and at least one chemoattractant.
摘要翻译：本发明涉及用于增强免疫力的方法和组合物，包括粘膜免疫。组合物包括抗原或免疫原，Toll样受体的配体和至少一种化学引诱物。

7. 发明申请

US20060063223A1 Enzymatic activities in chemokine-mediated inflammation 有权
公开(公告)号：US20060063223A1
公开(公告)日：2006-03-23
申请号：US11198935
申请日：2005-08-04
申请人： Robert Berahovich , Zhenhua Miao , Brett Premack , Thomas Schall
发明人： Robert Berahovich , Zhenhua Miao , Brett Premack , Thomas Schall
IPC分类号： C12Q1/37
CPC分类号： G01N33/6863 , A61K38/00 , C07K14/7158 , C12Q1/37 , G01N2500/00 , G01N2800/52
摘要： Truncated chemokines lacking an N-terminal region that activate CCR1 and/or FPRL1 and compositions containing the truncated chemokines are provided. Methods of identifying agents that modulate CCR1 and/or FPRL1 activity either by modulating the production of the truncated chemokines or the ability of the truncated chemokines to activate CCR1 and/or FPRL1 are also disclosed. Methods using the truncated chemokines to inhibit or activate CCR1 and/or FPRL1 mediated biological activities are also disclosed.

8. 发明申请

US20050214287A1 Methods and compositions for modulating angiogenesis 审中-公开
标题翻译：调节血管生成的方法和组合物
公开(公告)号：US20050214287A1
公开(公告)日：2005-09-29
申请号：US11050345
申请日：2005-02-02
申请人： Jennifer Burns , Bretton Summers , Yu Wang , Maureen Howard , Thomas Schall , Zhenhua Miao
发明人： Jennifer Burns , Bretton Summers , Yu Wang , Maureen Howard , Thomas Schall , Zhenhua Miao
IPC分类号： A61K38/00 , A61K38/17 , A61K38/19 , A61K39/395 , C07K16/28
CPC分类号： A61K38/195 , A61K45/06 , C07K16/2866 , A61K2300/00
摘要： The present invention provides method and compositions for modulating angiogenesis.
摘要翻译：本发明提供调节血管发生的方法和组合物。

9. 发明申请

US20100247540A1 Methods and Compositions For Modulating Angiogenesis 审中-公开
标题翻译：调节血管发生的方法和组成
公开(公告)号：US20100247540A1
公开(公告)日：2010-09-30
申请号：US12506199
申请日：2009-07-20
申请人： Jennifer Burns , Bretton Summers , Yu Wang , Maureen Howard , Thomas Schall , Zhenhua Miao
发明人： Jennifer Burns , Bretton Summers , Yu Wang , Maureen Howard , Thomas Schall , Zhenhua Miao
IPC分类号： A61K39/395 , A61P19/02 , A61P17/02
CPC分类号： C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2300/00
摘要： The present invention provides method and compositions for modulating angiogenesis.
摘要翻译：本发明提供调节血管发生的方法和组合物。

10. 发明申请

US20100144720A1 INHIBITORS OF HUMAN TUMOR-EXPRESSED CCXCKR2 审中-公开
标题翻译：人类肿瘤表达CCXCKR2的抑制剂
公开(公告)号：US20100144720A1
公开(公告)日：2010-06-10
申请号：US12636212
申请日：2009-12-11
申请人： Anita Melikian , Jennifer Burns , Brian E. McMaster , Thomas Schall , John J. Wright
发明人： Anita Melikian , Jennifer Burns , Brian E. McMaster , Thomas Schall , John J. Wright
IPC分类号： A61K31/54 , C07D207/04 , A61K31/40 , C12N5/00 , C07D405/12 , A61K31/4025 , C07D211/32 , A61K31/445 , C07C233/64 , A61K31/165 , C07D241/04 , A61K31/495 , C07D401/06 , A61K31/4439 , C07D401/04 , A61K31/454 , C07D295/00 , A61P35/00
CPC分类号： C07D241/04 , C07C235/48 , C07C235/50 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/14 , C07D211/42 , C07D211/56 , C07D241/42 , C07D295/13 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14
摘要： Pharmaceutical compositions containing organic compounds or salts thereof that serve as modulators for the SDF-1 or I-TAC chemokines are disclosed. The compounds and compositions are useful in the treatment of cancer, especially in the inhibition of cancer proliferation, growth, and metastasis. Methods of interfering with SDF-1 and/or I-TAC binding to the CCXCKR2 receptor and treating cancer using the compounds and pharmaceutical compositions of the present invention are also disclosed.
摘要翻译：公开了含有作为SDF-1或I-TAC趋化因子调节剂的有机化合物或其盐的药物组合物。化合物和组合物可用于治疗癌症，特别是抑制癌细胞增殖，生长和转移。还公开了使用本发明的化合物和药物组合物干扰SDF-1和/或I-TAC与CCXCKR2受体结合并治疗癌症的方法。

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