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1. 发明授权

US09089543B2 Anti-inflammatory composition containing macrolactin A and a derivative thereof as active ingredients 有权
标题翻译：含有促乳素A及其衍生物作为活性成分的抗炎组合物
公开(公告)号：US09089543B2
公开(公告)日：2015-07-28
申请号：US13321112
申请日：2010-05-24
申请人： Young-Hoon Ji , Dong-Hee Kim , Jae-Seon Kang , Chun-Gyu Kim , Sung-Uk Chung , Sung-Woo Hwang , Kyung-Ran Kang
发明人： Young-Hoon Ji , Dong-Hee Kim , Jae-Seon Kang , Chun-Gyu Kim , Sung-Uk Chung , Sung-Woo Hwang , Kyung-Ran Kang
IPC分类号： A61K31/335 , A61K31/365
CPC分类号： A61K31/335 , A61K31/365
摘要： The present invention relates to an anti-inflammatory use of macrolactin compounds such as macrolactin A, 7-O-malonyl macrolactin A and 7-O-succinyl macrolactin A, which are produced from a novel Bacillus strain of Bacillus polyfermenticus KJS-2 (KCCM10769P). The macrolactin compounds provided by the present invention were confirmed to greatly suppress the expression and formation of inducible nitric oxide synthetase (iNOS) and cyclooxygenase-2 (COX-2) which are proteins related to the formation of inflammatory mediators, and to accordingly inhibit the formation of nitric oxide (NO) and of prostaglandin E2 (PGE2) which are the metabolites of the proteins. In addition, the macrolactin compounds provided by the present invention were confirmed to have excellent effects in inhibiting the formation of tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and granulocyte macrophage colony-stimulating factor (GM-CSF), which are pro-inflammatory cytokines. Therefore, the macrolactin compounds produced by the Bacillus polyfermenticus KJS-2 strain according to the present invention can provide excellent anti-inflammatory agents.
摘要翻译：本发明涉及由新生芽孢杆菌（Bacillus polyfermenticus）KJS-2（KCCM10769P）的芽孢杆菌菌株生产的大多数内消旋用途的大多数乳糖素A，7-O-丙二酰基大内酰胺A和7-O-琥珀酰基大内酰胺素A ）。证实本发明提供的大内酰胺化合物能够大大抑制与形成炎症介质相关的蛋白质的诱导型一氧化氮合成酶（iNOS）和环氧合酶-2（COX-2）的表达和形成，并因此抑制形成一氧化氮（NO）和作为蛋白质代谢物的前列腺素E2（PGE2）。此外，本发明提供的大多数内消旋化合物被证实在抑制肿瘤坏死因子-α（TNF-α），白细胞介素-1和bgr的形成方面具有优异的效果。（IL-1和bgr），白介素-6（IL-6）和粒细胞巨噬细胞集落刺激因子（GM-CSF），其是促炎细胞因子。因此，本发明的由芽孢杆菌属多发性支原体KJS-2株产生的大分子内酯化合物可提供优异的抗炎剂。

2. 发明申请

US20120071549A1 ANTI-INFLAMMATORY COMPOSITION CONTAINING MACROLACTIN A AND A DERIVATIVE THEREOF AS ACTIVE INGREDIENTS 有权
标题翻译：含有MACROLACTIN A及其衍生物作为活性成分的抗炎组合物
公开(公告)号：US20120071549A1
公开(公告)日：2012-03-22
申请号：US13321112
申请日：2010-05-24
申请人： Young-Hoon Ji , Dong-Hee Kim , Jae-Seon Kang , Chun-Gyu Kim , Sung-Uk Chung , Sung-Woo Hwang , Kyung-Ran Kang
发明人： Young-Hoon Ji , Dong-Hee Kim , Jae-Seon Kang , Chun-Gyu Kim , Sung-Uk Chung , Sung-Woo Hwang , Kyung-Ran Kang
IPC分类号： A61K31/365 , C12P17/08 , A61P29/00 , C07D313/00
CPC分类号： A61K31/335 , A61K31/365
摘要： The present invention relates to an anti-inflammatory use of macrolactin compounds such as macrolactin A, 7-O-malonyl macrolactin A and 7-O-succinyl macrolactin A, which are produced from a novel Bacillus strain of Bacillus polyfermenticus KJS-2 (KCCM10769P). The macrolactin compounds provided by the present invention were confirmed to greatly suppress the expression and formation of inducible nitric oxide synthetase (iNOS) and cyclooxygenase-2 (COX-2) which are proteins related to the formation of inflammatory mediators, and to accordingly inhibit the formation of nitric oxide (NO) and of prostaglandin E2 (PGE2) which are the metabolites of the proteins. In addition, the macrolactin compounds provided by the present invention were confirmed to have excellent effects in inhibiting the formation of tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and granulocyte macrophage colony-stimulating factor (GM-CSF), which are pro-inflammatory cytokines. Therefore, the macrolactin compounds produced by the Bacillus polyfermenticus KJS-2 strain according to the present invention can provide excellent anti-inflammatory agents.
摘要翻译：本发明涉及由新生芽孢杆菌（Bacillus polyfermenticus）KJS-2（KCCM10769P）的芽孢杆菌菌株生产的大多数内消旋用途的大多数乳糖素A，7-O-丙二酰基大内酰胺素A和7-O-琥珀酰基大内酰胺素A ）。证实本发明提供的大内酰胺化合物能够大大抑制与形成炎症介质相关的蛋白质的诱导型一氧化氮合成酶（iNOS）和环氧合酶-2（COX-2）的表达和形成，并因此抑制形成一氧化氮（NO）和作为蛋白质代谢物的前列腺素E2（PGE2）。此外，本发明提供的大多数内消旋化合物被证实在抑制肿瘤坏死因子-α（TNF-α），白细胞介素-1和bgr的形成方面具有优异的效果。（IL-1和bgr），白介素-6（IL-6）和粒细胞巨噬细胞集落刺激因子（GM-CSF），其是促炎细胞因子。因此，本发明的由芽孢杆菌属多发性支原体KJS-2株产生的大分子内酯化合物可提供优异的抗炎剂。

3. 发明申请

US20130109745A1 ANTI-ANGIOGENIC COMPOSITION CONTAINING MACROLACTIN A AND A DERIVATIVE THEREOF AS ACTIVE INGREDIENTS 审中-公开
标题翻译：含有MACROLACTIN A及其衍生物作为活性成分的抗血清组合物
公开(公告)号：US20130109745A1
公开(公告)日：2013-05-02
申请号：US13809752
申请日：2011-02-23
申请人： Young-Hoon Ji , Dong-Hee Kim , Jung-Ae Kim , Jae-Seon Kang , Sung-Uk Chung , Sung-Woo Hwang , Kyung-Ran Kang , You-Ra Kang
发明人： Young-Hoon Ji , Dong-Hee Kim , Jung-Ae Kim , Jae-Seon Kang , Sung-Uk Chung , Sung-Woo Hwang , Kyung-Ran Kang , You-Ra Kang
IPC分类号： A61K31/365
CPC分类号： A61K31/365 , A61K31/335
摘要： The present invention relates to an anti-angiogenic composition containing macrolactin compounds such as macrolactin A, 7-O-malonyl macrolactin A, and 7-O-succinyl macrolactin A as active ingredients. The macrolactin compounds according to the present invention strongly suppress angiogenesis in in vivo experiments and can be used as a pharmaceutical composition for preventing or treating diseases caused by angiogenesis.
摘要翻译：本发明涉及一种抗血管生成组合物，其含有作为有效成分的作为活性成分的作为活性成分的作为活性成分的作为有效成分的作为活性成分的作为有效成分的作为有效成分的作为有效成分的作为有效成分的作为有效成分的，根据本发明的本发明的大内酰脲化合物在体内实验中强烈地抑制血管生成，并且可以用作预防或治疗由血管发生引起的疾病的药物组合物。

4. 发明授权

US08940788B2 Anti-angiogenic composition containing macrolactin A and a derivative thereof as active ingredients 有权
标题翻译：含有促乳素A及其衍生物作为活性成分的抗血管生成组合物
公开(公告)号：US08940788B2
公开(公告)日：2015-01-27
申请号：US13941932
申请日：2013-07-15
申请人： Young-Hoon Ji , Dong-Hee Kim , Jung-Ae Kim , Jae-Seon Kang , Sung-Uk Chung , Sung-Woo Hwang , Kyung-Ran Kang , You-Ra Kang
发明人： Young-Hoon Ji , Dong-Hee Kim , Jung-Ae Kim , Jae-Seon Kang , Sung-Uk Chung , Sung-Woo Hwang , Kyung-Ran Kang , You-Ra Kang
IPC分类号： A01N43/02 , A61K31/335 , A61K31/365
CPC分类号： A61K31/365 , A61K31/335
摘要： The present invention relates to an anti-angiogenic composition containing macrolactin compounds such as macrolactin A, 7-O-malonyl macrolactin A, and 7-O-succinyl macrolactin A as active ingredients. The macrolactin compounds according to the present invention strongly suppress angiogenesis in in vivo experiments and can be used as a pharmaceutical composition for preventing or treating diseases caused by angiogenesis.
摘要翻译：本发明涉及一种抗血管生成组合物，其含有作为有效成分的作为活性成分的作为活性成分的作为活性成分的作为有效成分的作为活性成分的作为有效成分的作为有效成分的作为有效成分的作为有效成分的作为有效成分的，根据本发明的本发明的大内酰脲化合物在体内实验中强烈地抑制血管生成，并且可以用作预防或治疗由血管发生引起的疾病的药物组合物。

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