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1. 发明申请

US20060251583A1 DTPA derivatives and metal complexes thereof, and radiation source and contrast agent including the metal complexes 失效
标题翻译： DTPA衍生物及其金属络合物，以及包括金属络合物的辐射源和造影剂
公开(公告)号：US20060251583A1
公开(公告)日：2006-11-09
申请号：US11411643
申请日：2006-04-25
申请人： Young-Don Hong , Sun-Ju Choi , Ok Choi
发明人： Young-Don Hong , Sun-Ju Choi , Ok Choi
IPC分类号： A61K49/10 , C07F5/00
CPC分类号： A61K49/0002 , A61K49/0438 , A61K49/103 , A61K51/0478 , C07C237/46
摘要： The present invention relates to diethylenetriamine pentaacetic acid (DTPA) derivates and metal complexes thereof, and radiation sources and contrast agents including the metal complexes. More particularly, the present invention relates to DTPA derivatives, which contain iodine and are useful as contrast agents for diagnosing renal function, metal complexes of the DTPA derivatives with 99mTc, 166Ho, 111In, 90Y, 153Sm, 186Re, 188Re, 68Ga, or 177Lu, which are useful as liquid radiation sources for treating vascular stenosis and contrast agents for diagnosing renal function, and radiation sources and contrast agents including the metal complexes. The DTPA derivatives and metal complexes thereof are safe because the metal complexes are excreted via the kidneys and bladder within several minutes from the time of use as liquid radiation sources for treating vascular stenosis, and are cost-effective because they are potentially useful as contrast agents and as agents for diagnosing renal function.
摘要翻译：本发明涉及二亚乙基三胺五乙酸（DTPA）衍生物及其金属络合物，以及包括金属络合物的辐射源和造影剂。更具体地，本发明涉及含有碘的DTPA衍生物，其可用作诊断肾功能的造影剂，DTPA衍生物与99m Tc的金属配合物， Ho，111 In，90 Y，153 Sm，186 Re，188和/ Re，68 Ga或177 Lu，其可用作用于治疗血管狭窄的液体辐射源和用于诊断肾功能的造影剂，以及辐射源和造影剂，包括金属配合物。 DTPA衍生物及其金属络合物是安全的，因为金属络合物在用作治疗血管狭窄的液体辐射源之后的几分钟内通过肾和膀胱排出，并且是成本有效的，因为它们潜在地用作造影剂并作为诊断肾功能的药剂。

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