专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20140193431A1 ANTI-C-MET ANTIBODY HAVING HGF ACTIVITY AND USE THEREOF 有权
标题翻译：具有HGF活性的抗C-MET抗体及其用途
公开(公告)号：US20140193431A1
公开(公告)日：2014-07-10
申请号：US14123533
申请日：2012-06-04
申请人： Young Woo Park , KiWon Jo , Chan Woong Park , Seok Ho Yoo , Myeoung Hee Jang , Hye Nan Kim , Seon Ha Yun , Kyu Won Cho , Mi Ra Park
发明人： Young Woo Park , KiWon Jo , Chan Woong Park , Seok Ho Yoo , Myeoung Hee Jang , Hye Nan Kim , Seon Ha Yun , Kyu Won Cho , Mi Ra Park
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , A61K2039/505 , C07K2317/21 , C07K2317/622 , C07K2317/75 , C07K2317/92 , C07K2317/94
摘要： Disclosed are a human antibody comprising a human complementarity-determining region (CDR), which binds specifically to c-Met, and a framework region (FR), a polynucleotide encoding the human antibody, an expression vector comprising the polynucleotide, a transformant transformed with the expression vector, a method of producing the human antibody B7 by culturing the transformant, a wound healing composition comprising the human antibody as an active ingredient, a cell regeneration composition comprising the antibody as an active ingredient, and a drug conjugate comprising a drug linked to the human antibody. The c-Met-specific human antibody can function as an HGF mimic that can be used as a wound healing composition. The antibody can be widely used to determine the treatment and prognosis of various diseases, including neuronal infarction, progressive nephropathy, liver cirrhosis, lung fibrosis, kidney injury, liver injury, lung injury, and ulcerative wounds, which are treated by activation of HGF or c-Met.
摘要翻译：公开了包含与c-Met特异性结合的人互补决定区（CDR）的人抗体和框架区（FR），编码人抗体的多核苷酸，包含多核苷酸的表达载体，转化了表达载体，通过培养转化体生产人抗体B7的方法，包含人抗体作为活性成分的伤口愈合组合物，包含抗体作为活性成分的细胞再生组合物和包含药物连接的药物偶联物对人抗体。 c-Met特异性人抗体可用作可用作伤口愈合组合物的HGF模拟物。该抗体可广泛用于确定通过激活HGF或其他疾病治疗的各种疾病的治疗和预后，包括神经元梗死，进行性肾病，肝硬化，肺纤维化，肾损伤，肝损伤，肺损伤和溃疡性创伤 c-Met。

2. 发明授权

US09631020B2 Anti-c-Met antibody having HGF activity and use thereof 有权
公开(公告)号：US09631020B2
公开(公告)日：2017-04-25
申请号：US14123533
申请日：2012-06-04
申请人： Young Woo Park , Ki Won Jo , Chan Woong Park , Seok Ho Yoo , Myeoung Hee Jang , Hye Nan Kim , Seon Ha Yun , Kyu Won Cho , Mi Ra Park
发明人： Young Woo Park , Ki Won Jo , Chan Woong Park , Seok Ho Yoo , Myeoung Hee Jang , Hye Nan Kim , Seon Ha Yun , Kyu Won Cho , Mi Ra Park
IPC分类号： C07K16/28 , A61K39/00
CPC分类号： C07K16/2863 , A61K2039/505 , C07K2317/21 , C07K2317/622 , C07K2317/75 , C07K2317/92 , C07K2317/94
摘要： Disclosed are a human antibody comprising a human complementarity-determining region (CDR), which binds specifically to c-Met, and a framework region (FR), a polynucleotide encoding the human antibody, an expression vector comprising the polynucleotide, a transformant transformed with the expression vector, a method of producing the human antibody B7 by culturing the transformant, a wound healing composition comprising the human antibody as an active ingredient, a cell regeneration composition comprising the antibody as an active ingredient, and a drug conjugate comprising a drug linked to the human antibody. The c-Met-specific human antibody can function as an HGF mimic that can be used as a wound healing composition. The antibody can be widely used to determine the treatment and prognosis of various diseases, including neuronal infarction, progressive nephropathy, liver cirrhosis, lung fibrosis, kidney injury, liver injury, lung injury, and ulcerative wounds, which are treated by activation of HGF or c-Met.

3. 发明申请

US20140072558A1 Activin Receptor Type II B Inhibitors Comprising DLK1 Extracellular Water-Soluble Domain 审中-公开
标题翻译：包含DLK1细胞外水溶性结构域的激活素受体II型B抑制剂
公开(公告)号：US20140072558A1
公开(公告)日：2014-03-13
申请号：US14009037
申请日：2012-04-03
申请人： Young Woo Park , Ki Won Jo , Donghee Lee , Eun Kyung Lee , Seil Jang , Chan Woong Park , Dong-Jin Kim , Hye Nan Kim , Yun Jung Park , Jae Eun Park , Ji Hyun Park , Seok Ho Yoo , Myeoung Hee Jang
发明人： Young Woo Park , Ki Won Jo , Donghee Lee , Eun Kyung Lee , Seil Jang , Chan Woong Park , Dong-Jin Kim , Hye Nan Kim , Yun Jung Park , Jae Eun Park , Ji Hyun Park , Seok Ho Yoo , Myeoung Hee Jang
IPC分类号： A61K39/395 , G01N33/68 , A61K38/17
CPC分类号： A61K39/3955 , A61K38/1709 , A61K38/177 , A61K39/39558 , C07K14/705 , C07K16/28 , C07K2317/21 , C07K2317/622 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/6893 , G01N33/74 , G01N2333/485 , A61K2300/00
摘要： The present invention relates to an activin receptor type II B (ACVR2B) inhibitor which comprises the delta-like 1 homolog (DLK1) extracellular water-soluble domain. More specifically, the present invention relates to an extracellular soluble domain of DLK1; fragments of the extracellular soluble domain of DLK1; mutants of the extracellular soluble domain of DLK1; a composition for suppressing ligand linkage with the ACVR2B receptor, which includes a fragment of the mutants as an active ingredient; and a pharmaceutical composition for prevention and treatment of diseases which comprises the same. The composition of the present invention competitively binds to the ACVR2B receptor and inhibits the binding of an ACVR2B ligand to the ACVR2B receptor, which inhibits protein signalling associated with such ligands, and will be useful for prevention and treatment of diseases associated therewith.
摘要翻译：本发明涉及包含δ-样1同系物（DLK1）细胞外水溶性结构域的激活素受体IIB型（ACVR2B）抑制剂。更具体地，本发明涉及DLK1的细胞外可溶性结构域; DLK1细胞外可溶性结构域的片段; DLK1细胞外可溶性结构域的突变体; 用于抑制与ACVR2B受体的配体键合的组合物，其包含突变体的片段作为活性成分; 以及用于预防和治疗包含该疾病的疾病的药物组合物。本发明的组合物竞争性地结合ACVR2B受体并且抑制ACVR2B配体与ACVR2B受体的结合，所述ACVR2B受体抑制与这种配体相关的蛋白质信号，并且将可用于预防和治疗与之相关的疾病。

4. 发明授权

US08877264B2 Composition of skin external application containing ginseng berry extracts 有权
标题翻译：含有人参浆果提取物的外用皮肤成分
公开(公告)号：US08877264B2
公开(公告)日：2014-11-04
申请号：US12602421
申请日：2008-05-30
申请人： Chan Woong Park , Myeong Hoon Yeom , Jin Young Lee , Hee Young Jeon , Sang Jun Lee , Nam Hoon Cho , Dong Sung Lee
发明人： Chan Woong Park , Myeong Hoon Yeom , Jin Young Lee , Hee Young Jeon , Sang Jun Lee , Nam Hoon Cho , Dong Sung Lee
IPC分类号： A61K36/258 , A23L1/30 , A61K8/97 , A61Q19/02 , A61Q19/08
CPC分类号： A23L1/3002 , A23L33/105 , A23V2002/00 , A61K8/97 , A61K36/258 , A61K2800/522 , A61Q19/02 , A61Q19/08 , A23V2250/2124 , A23V2200/318 , A23V2200/332
摘要： Disclosed herein is a. skin external composition containing ginseng berry extract. More specifically, disclosed is a skin external composition, which contains, as an active ingredient, ginseng berry extract having the specific components and compositions, among the above-ground parts of ginseng, and thus promotes the production of collagen in the skin, shows an MMP-I inhibitory effect and, at the same time, has skin-aging inhibitory and wrinkle-reducing effects, resulting from antioxidant effects and DNA damage-protecting effects. Also disclosed is a skin external composition, which contains, as an active ingredient, ginseng berry extract, which has a skin whitening effect resulting from the effects of inhibiting melanin production and reducing pigmentation caused by UV radiation, the effects of relieving dry skin symptoms and atopic symptoms by inducing and maintaining the normal differentiation of skin keratinocytes, the effect of relieving acne and skin troubles by the regulation of sebum secretion and an anti-inflammatory effect, and makes complexion ruddy through the improvement of peripheral blood circulation to make the skin clean and clear. Also disclosed is a food composition for reducing and preventing obesity, which contains, as an active ingredient, ginseng berry extract, which increases the expression of a carnitine palmitoyl transterase-1 (CPT-I) gene, serves to transport fatty acids into mitochondria in fatty acid oxidation and promotes fat oxidation.
摘要翻译：本文公开的是皮肤外用组合物含人参浆果提取物。更具体地，公开了皮肤外用组合物，其含有人参的地上部分中具有特定成分和组成的人参浆果提取物作为活性成分，从而促进皮肤中的胶原蛋白的生成，显示出 MMP-1抑制作用，同时具有由抗氧化作用和DNA损伤保护作用产生的皮肤衰老抑制和皱纹减轻作用。还公开了一种皮肤外用组合物，其含有作为活性成分的人参浆果提取物，其具有由抑制黑色素产生和减少由紫外线辐射引起的色素沉着的作用而产生的皮肤美白效果，减轻干性皮肤症状的效果和通过诱导和维持皮肤角质形成细胞的正常分化，减轻痤疮和皮肤麻烦的作用，通过调节皮脂分泌和抗炎作用而产生特应性症状，并通过改善外周血液循环使肤色变红，使皮肤清洁并清楚还公开了用于减少和预防肥胖的食物组合物，其包含增加肉碱棕榈酰转铁蛋白-1（CPT-1）基因表达的人参浆果提取物作为活性成分，用于将脂肪酸运输到线粒体中脂肪酸氧化并促进脂肪氧化。

5. 发明授权

US07936159B2 Method and apparatus for a high voltage power supply circuit 失效
标题翻译：高压电源电路的方法和装置
公开(公告)号：US07936159B2
公开(公告)日：2011-05-03
申请号：US12047129
申请日：2008-03-12
申请人： Chan Woong Park , Leif O. Lund
发明人： Chan Woong Park , Leif O. Lund
IPC分类号： G05F1/40
CPC分类号： H02M3/33507 , H02M3/156
摘要： A control circuit for use in a power supply is disclosed. An example control circuit according to aspects of the present invention includes a signal generator coupled to generate an output signal to control switching of a power switch to be coupled to the control circuit. A feedback circuit is coupled to receive a feedback signal, which is representative of an output of the power supply during a feedback portion of an off time of the power switch. The signal generator generates the output signal in response to the feedback circuit to control a fraction of the feedback portion of the off time of the power switch that the feedback signal is above a threshold and another fraction of the feedback portion of the off time of the power switch that the feedback signal is below the threshold.
摘要翻译：公开了一种用于电源的控制电路。根据本发明的方面的示例性控制电路包括耦合以产生输出信号以控制要耦合到控制电路的功率开关的开关的信号发生器。反馈电路被耦合以接收反馈信号，该反馈信号代表在电源开关关闭时间的反馈部分期间电源的输出。信号发生器响应于反馈电路产生输出信号，以控制反馈信号在功率开关的关断时间的反馈部分的一部分，反馈信号高于阈值，并且反馈部分的反馈部分的另一部分电源开关，反馈信号低于阈值。

6. 发明授权

US07760523B2 Method and apparatus to improve regulation of a power supply 有权
标题翻译：改善电源调节的方法和装置
公开(公告)号：US07760523B2
公开(公告)日：2010-07-20
申请号：US12491597
申请日：2009-06-25
申请人： Robert J. Mayell , Chan Woong Park
发明人： Robert J. Mayell , Chan Woong Park
IPC分类号： H02M1/12
CPC分类号： H02M3/3381 , H02M3/3385
摘要： Techniques are disclosed to regulate a power supply with a compensation signal generation circuit. One example regulated power supply includes a sense circuit coupled to sense an output voltage of the regulated power supply. The regulated power supply also includes a switching power converter circuit, which includes a switch coupled to be switched in response to a control signal received from the sense circuit to regulate the output voltage of the regulated power supply. The regulated power supply also includes a compensation signal generation circuit coupled to receive a switching signal representative of a switching of the switch in the switching power converter circuit. The compensation signal generation circuit is to generate a compensation signal responsive to the switching signal. The compensation signal is to be received by the sense circuit to modify the control signal.
摘要翻译：公开了用补偿信号发生电路调节电源的技术。一个示例性调节电源包括耦合以感测调节电源的输出电压的感测电路。调节电源还包括开关功率转换器电路，其包括耦合以响应于从感测电路接收的控制信号而被切换的开关，以调节稳压电源的输出电压。调节电源还包括补偿信号发生电路，其耦合以接收代表开关功率转换器电路中的开关的开关的开关信号。补偿信号生成电路根据切换信号生成补偿信号。补偿信号由感测电路接收以修改控制信号。

7. 发明申请

US20100110734A1 CIRCUIT FOR OUTPUT CURRENT DETECT, CIRCUIT FOR OUTPUT CURRENT FEEDBACK, AND SMPS WHICH LIMITS OUTPUT CURRENT BY PRIMARY SIDE FEEDBACK 有权
标题翻译：用于输出电流检测的电路，用于输出电流反馈的电路，以及主要反馈限制输出电流的电流
公开(公告)号：US20100110734A1
公开(公告)日：2010-05-06
申请号：US12513135
申请日：2007-10-22
申请人： Chan Woong Park
发明人： Chan Woong Park
IPC分类号： H02M3/335
CPC分类号： H02M3/33507 , H02M2001/0009
摘要： A discontinuous mode flyback converter for limiting output current using primary feedback is disclosed. A transformer stores magnetic energy using field current and transfers the magnetic energy using a primary winding and a secondary winding closely coupled to the primary winding. A switching element is coupled to one end of the primary winding of the transformer and controls the current of the primary winding of the transformer. A control unit controls the switching element. A voltage error feedback unit feeds back the error of the output voltage of the transformer to the control unit, thereby regulating the output voltage. An output current feedback circuit detects the flyback period of the transformer, detects the output current information of the transformer from the rate of a flyback period in a cycle, and feeds it back to the control unit, thereby limiting the output current of the transformer.
摘要翻译：公开了一种使用主反馈来限制输出电流的不连续模式反激转换器。变压器使用场电流存储磁能并且使用紧密耦合到初级绕组的初级绕组和次级绕组来传送磁能。开关元件耦合到变压器的初级绕组的一端并控制变压器的初级绕组的电流。控制单元控制开关元件。电压误差反馈单元将变压器的输出电压的误差反馈到控制单元，从而调节输出电压。输出电流反馈电路检测变压器的回扫周期，从循环中的回扫周期的速率检测变压器的输出电流信息，并将其反馈给控制单元，从而限制变压器的输出电流。

8. 发明申请

US20090303766A1 METHOD AND APPARATUS FOR INCREASING THE POWER CAPABILITY OF A POWER SUPPLY 失效
公开(公告)号：US20090303766A1
公开(公告)日：2009-12-10
申请号：US12542538
申请日：2009-08-17
申请人： Chan Woong Park , Alex B. Djenguerian , Kent Wong
发明人： Chan Woong Park , Alex B. Djenguerian , Kent Wong
IPC分类号： H02M7/06 , G05F1/10
CPC分类号： G06F1/324 , H02M3/335
摘要： Techniques are disclosed to extend an on time period of switch to regulate a transfer of energy from an input of a power supply to an output of a power supply. One example integrated circuit includes an energy transfer element coupled between an input and an output of the power supply. A switch is coupled to the input of the energy transfer element. A controller is coupled to the switch to control switching of the switch to regulate a transfer of energy from the input of the power supply to the output of the power supply in response to a feedback signal received from the output of the power supply. The controller is coupled to limit a maximum on time period of the switch a first maximum on time period in response to a first range of power supply operating conditions and to a second maximum on time period for a second range of power supply operating conditions.

9. 发明申请

US20090251930A1 METHOD AND APPARATUS FOR REGULATING AN OUTPUT CURRENT FROM A POWER CONVERTER 有权
标题翻译：用于调节功率转换器的输出电流的方法和装置
公开(公告)号：US20090251930A1
公开(公告)日：2009-10-08
申请号：US12487457
申请日：2009-06-18
申请人： Chan Woong Park
发明人： Chan Woong Park
IPC分类号： H02M3/335
CPC分类号： H02M3/33507 , H02M3/156
摘要： Techniques are disclosed to regulate an output current through a load coupled to a power converter using a current source coupled to the load. For instance, one power converter according to the teachings of the present invention includes an energy transfer element coupled between an input of the power converter and an output of the power converter. A power converter controller is coupled to the energy transfer element to control a transfer of energy from the input of the power converter to the output of the power converter. A load is to be coupled to the output of the power converter. A current source is to be coupled to the load. The current source regulates the current flowing through the load to a threshold current value. The current source is coupled to sense a current through the load. A switch having a first and second end is also included. The first end is to be coupled to the load and the second end is coupled to the current source. The switch is coupled to be switched on and off at a duty cycle to control an average current through the load. The current through the load is substantially equal to a current through the switch and the current source.
摘要翻译：公开了技术来调节通过耦合到功率转换器的负载使用耦合到负载的电流源的负载的输出电流。例如，根据本发明的教导的一个功率转换器包括耦合在功率转换器的输入端和功率转换器的输出端之间的能量传递元件。电力转换器控制器耦合到能量传递元件以控制从功率转换器的输入到功率转换器的输出的能量传递。负载将耦合到功率转换器的输出。电流源将耦合到负载。电流源将流过负载的电流调节到阈值电流值。电流源被耦合以感测通过负载的电流。还包括具有第一端和第二端的开关。第一端被耦合到负载，并且第二端耦合到电流源。开关被耦合以在占空比下接通和关断以控制通过负载的平均电流。通过负载的电流基本上等于通过开关和电流源的电流。

10. 发明申请

US20090251273A1 METHOD AND APPARATUS FOR SUBSTANTIALLY REDUCING ELECTRICAL EARTH DISPLACEMENT CURRENT FLOW GENERATED BY WOUND COMPONENTS WITHOUT REQUIRING ADDITIONAL WINDINGS 有权
标题翻译：用于大幅降低电气位移的方法和装置由不需要附加绕组的组件组成的电流
公开(公告)号：US20090251273A1
公开(公告)日：2009-10-08
申请号：US12488483
申请日：2009-06-19
申请人： Chan Woong Park
发明人： Chan Woong Park
IPC分类号： H01F27/28
CPC分类号： H01F27/289 , H01F17/043 , H01F19/04 , H01F21/12 , H01F27/345 , H01F27/38 , H01F41/064 , Y10T29/4902 , Y10T29/49071
摘要： Apparatus for reducing electrical earth displacement current flow generated by wound components is disclosed. In one aspect, an apparatus includes a plurality of layers of an input winding wound around an energy transfer element core. An outer layer of the plurality of layers of the input winding is wound with a number of turns different than the number of turns in substantially each of the inner layers of the plurality of layers of the input winding. An output winding is wound around the energy transfer element core with substantially the same number of turns as the number of turns of the outer layer of the plurality of layers of the input winding to reduce substantially a capacitive displacement current flowing between the input and output windings.
摘要翻译：公开了一种用于减少由伤口部件产生的电位移电流的装置。在一个方面，一种装置包括围绕能量传递元件芯缠绕的多个输入绕组层。输入绕组的多个层的外层以与输入绕组的多个层的基本上每个内层中的匝数不同的多个匝卷绕。输出绕组缠绕在能量传递元件芯上，与输入绕组的多个层的外层的匝数大致相同的匝数，以基本上减小在输入和输出绕组之间流动的容性位移电流。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式